{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:55:52Z","timestamp":1782561352627,"version":"3.54.5"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Accumulating evidences indicated that voltage-gated calcium channels (VDCC), including L-, T-, N-, and P\/Q-type, are present in kidney and contribute to renal injury during various chronic diseases trough different mechanisms. As a voltage-gated calcium channel, N-type calcium channel was firstly been founded predominately distributed on nerve endings which control neurotransmitter releases. Since sympathetic nerve is distributed along renal afferent and efferent arterioles, N-type calcium channel blockade on sympathetic nerve terminals would bring renal dynamic improvement by dilating both arterioles and reducing glomerular pressure. In addition, large body of scientific research indicated that neurotransmitters, such as norepinephrine, releases by activating N-type calcium channel can trigger inflammatory and fibrotic signaling pathways in kidney. Interestingly, we recently demonstrated that N-type calcium channel is also expressed on podocytes and may directly contribute to podocyte injury in denervated animal models. In this paper, we will summarize our current knowledge regarding renal N-type calcium channels, and discuss how they might contribute to the river that terminates in renal injury.<\/jats:p>","DOI":"10.1007\/s11255-022-03183-8","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T06:03:21Z","timestamp":1649829801000},"page":"2871-2879","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["N-type calcium channel and renal injury"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0977-7735","authenticated-orcid":false,"given":"Lei","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"issue":"3","key":"3183_CR1","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0896-6273(00)81057-0","volume":"25","author":"EA Ertel","year":"2000","unstructured":"Ertel EA et al (2000) Nomenclature of voltage-gated calcium channels. Neuron 25(3):533\u2013535","journal-title":"Neuron"},{"issue":"5","key":"3183_CR2","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1097\/HJH.0b013e328336ade3","volume":"28","author":"YY Fan","year":"2010","unstructured":"Fan YY et al (2010) Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte. J Hypertens 28(5):1034\u20131043","journal-title":"J Hypertens"},{"issue":"4835","key":"3183_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1126\/science.2447647","volume":"239","author":"LD Hirning","year":"1988","unstructured":"Hirning LD et al (1988) Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 239(4835):57\u201361","journal-title":"Science"},{"issue":"1","key":"3183_CR4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1476-5381.1989.tb11789.x","volume":"96","author":"B Clasbrummel","year":"1989","unstructured":"Clasbrummel B, Osswald H, Illes P (1989) Inhibition of noradrenaline release by omega-conotoxin GVIA in the rat tail artery. Br J Pharmacol 96(1):101\u2013110","journal-title":"Br J Pharmacol"},{"issue":"1","key":"3183_CR5","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/j.1476-5381.1990.tb12073.x","volume":"100","author":"D Pruneau","year":"1990","unstructured":"Pruneau D, Angus JA (1990) Omega-conotoxin GVIA is a potent inhibitor of sympathetic neurogenic responses in rat small mesenteric arteries. Br J Pharmacol 100(1):180\u2013184","journal-title":"Br J Pharmacol"},{"issue":"2","key":"3183_CR6","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1111\/j.1471-4159.1991.tb08194.x","volume":"56","author":"AR Rittenhouse","year":"1991","unstructured":"Rittenhouse AR, Zigmond RE (1991) Omega-conotoxin inhibits the acute activation of tyrosine hydroxylase and the stimulation of norepinephrine release by potassium depolarization of sympathetic nerve endings. J Neurochem 56(2):615\u2013622","journal-title":"J Neurochem"},{"issue":"1","key":"3183_CR7","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/j.1476-5381.1993.tb13814.x","volume":"110","author":"F Fabi","year":"1993","unstructured":"Fabi F et al (1993) Evidence for sympathetic neurotransmission through presynaptic N-type calcium channels in human saphenous vein. Br J Pharmacol 110(1):338\u2013342","journal-title":"Br J Pharmacol"},{"issue":"7","key":"3183_CR8","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1038\/sj.bjp.0703701","volume":"131","author":"CE Wright","year":"2000","unstructured":"Wright CE et al (2000) Cardiovascular and autonomic effects of omega-conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays. Br J Pharmacol 131(7):1325\u20131336","journal-title":"Br J Pharmacol"},{"issue":"5","key":"3183_CR9","doi-asserted-by":"publisher","first-page":"G1077","DOI":"10.1152\/ajpgi.00006.2009","volume":"296","author":"MA Motagally","year":"2009","unstructured":"Motagally MA, Neshat S, Lomax AE (2009) Inhibition of sympathetic N-type voltage-gated Ca2+ current underlies the reduction in norepinephrine release during colitis. Am J Physiol Gastrointest Liver Physiol 296(5):G1077\u2013G1084","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"3183_CR10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1034\/j.1600-0773.2000.pto860106.x","volume":"86","author":"OA Nedergaard","year":"2000","unstructured":"Nedergaard OA (2000) Effect of omega-conotoxin GVIA on noradrenaline release from postganglionic sympathetic neurones in rabbit aorta. Pharmacol Toxicol 86(1):30\u201335","journal-title":"Pharmacol Toxicol"},{"issue":"2","key":"3183_CR11","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1159\/000210396","volume":"30","author":"T Konda","year":"2009","unstructured":"Konda T et al (2009) Different effects of L\/N-type and L-type calcium channel blockers on the renin-angiotensin-aldosterone system in SHR\/Izm. Am J Nephrol 30(2):155\u2013161","journal-title":"Am J Nephrol"},{"issue":"2","key":"3183_CR12","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/j.1755-5922.2009.00079.x","volume":"27","author":"A Takahara","year":"2009","unstructured":"Takahara A (2009) Cilnidipine: a new generation Ca channel blocker with inhibitory action on sympathetic neurotransmitter release. Cardiovasc Ther 27(2):124\u2013139","journal-title":"Cardiovasc Ther"},{"issue":"6","key":"3183_CR13","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s00380-007-0984-y","volume":"22","author":"T Shiga","year":"2007","unstructured":"Shiga T et al (2007) Influence of cilnidipine or nisoldipine on sympathetic activity in healthy male subjects. Heart Vessels 22(6):404\u2013409","journal-title":"Heart Vessels"},{"issue":"4","key":"3183_CR14","first-page":"421","volume":"40","author":"K Ito","year":"2003","unstructured":"Ito K et al (2003) Clinical usefulness of a dual L\/N-type Ca2+ channel blocker, cilnidipine, in patients with chronic heart failure: assessment with 123I-MIBG myocardial scintigraphy. Kaku Igaku 40(4):421\u2013430","journal-title":"Kaku Igaku"},{"issue":"6418","key":"3183_CR15","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/362318a0","volume":"362","author":"T Sollner","year":"1993","unstructured":"Sollner T et al (1993) SNAP receptors implicated in vesicle targeting and fusion. Nature 362(6418):318\u2013324","journal-title":"Nature"},{"issue":"Pt 2","key":"3183_CR16","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1113\/jphysiol.1997.sp021931","volume":"499","author":"AB Smith","year":"1997","unstructured":"Smith AB, Cunnane TC (1997) Multiple calcium channels control neurotransmitter release from rat postganglionic sympathetic nerve terminals. J Physiol 499(Pt 2):341\u2013349","journal-title":"J Physiol"},{"issue":"8","key":"3183_CR17","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/S0895-7061(02)02959-X","volume":"15","author":"S Ye","year":"2002","unstructured":"Ye S et al (2002) Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity. Am J Hypertens 15(8):717\u2013724","journal-title":"Am J Hypertens"},{"issue":"5 Suppl","key":"3183_CR18","doi-asserted-by":"publisher","first-page":"365","DOI":"10.4077\/CJP.2009.AMH083","volume":"52","author":"MS Wu","year":"2009","unstructured":"Wu MS et al (2009) Protection of ischemic preconditioning on renal neural function in rats with acute renal failure. Chin J Physiol 52(5 Suppl):365\u2013375","journal-title":"Chin J Physiol"},{"issue":"1\u20132","key":"3183_CR19","first-page":"33","volume":"15","author":"V Kon","year":"1989","unstructured":"Kon V (1989) Neural control of renal circulation. Miner Electrolyte Metab 15(1\u20132):33\u201343","journal-title":"Miner Electrolyte Metab"},{"issue":"9","key":"3183_CR20","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1056\/NEJMc0904179","volume":"361","author":"MP Schlaich","year":"2009","unstructured":"Schlaich MP et al (2009) Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med 361(9):932\u2013934","journal-title":"N Engl J Med"},{"issue":"6","key":"3183_CR21","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00380-010-0005-4","volume":"25","author":"S Aritomi","year":"2010","unstructured":"Aritomi S et al (2010) The N-type and L-type calcium channel blocker cilnidipine suppresses renal injury in Dahl rats fed a high-salt diet. Heart Vessels 25(6):549\u2013555","journal-title":"Heart Vessels"},{"issue":"6","key":"3183_CR22","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1536\/ihj.49.723","volume":"49","author":"Y Konno","year":"2008","unstructured":"Konno Y, Kimura K (2008) Vasodilatory effect of cilnidipine, an L-type and N-type calcium channel blocker, on rat kidney glomerular arterioles. Int Heart J 49(6):723\u2013732","journal-title":"Int Heart J"},{"issue":"21","key":"3183_CR23","doi-asserted-by":"publisher","first-page":"10494","DOI":"10.1073\/pnas.89.21.10494","volume":"89","author":"AS Yu","year":"1992","unstructured":"Yu AS et al (1992) Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney. Proc Natl Acad Sci USA 89(21):10494\u201310498","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6670","key":"3183_CR24","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/36110","volume":"391","author":"E Perez-Reyes","year":"1998","unstructured":"Perez-Reyes E et al (1998) Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature 391(6670):896\u2013900","journal-title":"Nature"},{"issue":"2 Pt 2","key":"3183_CR25","first-page":"F325","volume":"266","author":"DV Gordienko","year":"1994","unstructured":"Gordienko DV, Clausen C, Goligorsky MS (1994) Ionic currents and endothelin signaling in smooth muscle cells from rat renal resistance arteries. Am J Physiol 266(2 Pt 2):F325\u2013F341","journal-title":"Am J Physiol"},{"issue":"4","key":"3183_CR26","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1681\/ASN.V84569","volume":"8","author":"EW Inscho","year":"1997","unstructured":"Inscho EW et al (1997) Agonist-induced calcium regulation in freshly isolated renal microvascular smooth muscle cells. J Am Soc Nephrol 8(4):569\u2013579","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"3183_CR27","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1161\/01.RES.87.10.896","volume":"87","author":"PB Hansen","year":"2000","unstructured":"Hansen PB et al (2000) Vascular smooth muscle cells express the alpha(1A) subunit of a P-\/Q-type voltage-dependent Ca(2+)Channel, and It is functionally important in renal afferent arterioles. Circ Res 87(10):896\u2013902","journal-title":"Circ Res"},{"issue":"Pt. 2","key":"3183_CR28","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1113\/jphysiol.2006.126128","volume":"580","author":"E Nikitina","year":"2007","unstructured":"Nikitina E et al (2007) Voltage-dependent calcium channels of dog basilar artery. J Physiol 580(Pt. 2):523\u2013541","journal-title":"J Physiol"},{"issue":"27","key":"3183_CR29","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1056\/NEJM199212313272704","volume":"327","author":"RL Converse Jr","year":"1992","unstructured":"Converse RL Jr et al (1992) Sympathetic overactivity in patients with chronic renal failure. N Engl J Med 327(27):1912\u20131918","journal-title":"N Engl J Med"},{"issue":"1","key":"3183_CR30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/00004872-200201000-00002","volume":"20","author":"RA Augustyniak","year":"2002","unstructured":"Augustyniak RA et al (2002) Sympathetic overactivity as a cause of hypertension in chronic renal failure. J Hypertens 20(1):3\u20139","journal-title":"J Hypertens"},{"issue":"5","key":"3183_CR31","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1111\/j.1523-1755.2004.00552.x","volume":"65","author":"J Neumann","year":"2004","unstructured":"Neumann J et al (2004) Sympathetic hyperactivity in chronic kidney disease: pathogenesis, clinical relevance, and treatment. Kidney Int 65(5):1568\u20131576","journal-title":"Kidney Int"},{"issue":"3","key":"3183_CR32","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1002\/nau.21007","volume":"30","author":"IM Salman","year":"2011","unstructured":"Salman IM et al (2011) Renal sympathetic nervous system hyperactivity in early streptozotocin-induced diabetic kidney disease. Neurourol Urodyn 30(3):438\u2013446","journal-title":"Neurourol Urodyn"},{"issue":"2","key":"3183_CR33","doi-asserted-by":"publisher","first-page":"58","DOI":"10.2174\/157339910790909396","volume":"6","author":"K Masuo","year":"2010","unstructured":"Masuo K et al (2010) Cardiovascular and renal complications of type 2 diabetes in obesity: role of sympathetic nerve activity and insulin resistance. Curr Diabetes Rev 6(2):58\u201367","journal-title":"Curr Diabetes Rev"},{"issue":"6","key":"3183_CR34","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1291\/hypres.27.379","volume":"27","author":"S Kojima","year":"2004","unstructured":"Kojima S, Shida M, Yokoyama H (2004) Comparison between cilnidipine and amlodipine besilate with respect to proteinuria in hypertensive patients with renal diseases. Hypertens Res 27(6):379\u2013385","journal-title":"Hypertens Res"},{"issue":"6","key":"3183_CR35","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3109\/10641961003667914","volume":"32","author":"Y Miwa","year":"2010","unstructured":"Miwa Y et al (2010) Antiproteinuric effect of cilnidipine in hypertensive Japanese treated with renin-angiotensin-system inhibitors - a multicenter, open, randomized trial using 24-hour urine collection. Clin Exp Hypertens 32(6):400\u2013405","journal-title":"Clin Exp Hypertens"},{"issue":"12","key":"3183_CR36","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1038\/sj.ki.5002623","volume":"72","author":"T Fujita","year":"2007","unstructured":"Fujita T et al (2007) Antiproteinuric effect of the calcium channel blocker cilnidipine added to renin-angiotensin inhibition in hypertensive patients with chronic renal disease. Kidney Int 72(12):1543\u20131549","journal-title":"Kidney Int"},{"issue":"5","key":"3183_CR37","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/S0025-7125(05)70573-3","volume":"81","author":"LG Navar","year":"1997","unstructured":"Navar LG (1997) The kidney in blood pressure regulation and development of hypertension. Med Clin North Am 81(5):1165\u20131198","journal-title":"Med Clin North Am"},{"issue":"Suppl 12","key":"3183_CR38","first-page":"S266","volume":"10","author":"LG Navar","year":"1999","unstructured":"Navar LG et al (1999) Intrarenal angiotensin II generation and renal effects of AT1 receptor blockade. J Am Soc Nephrol 10(Suppl 12):S266\u2013S272","journal-title":"J Am Soc Nephrol"},{"issue":"Suppl 11","key":"3183_CR39","first-page":"S189","volume":"10","author":"LG Navar","year":"1999","unstructured":"Navar LG et al (1999) Concentrations and actions of intraluminal angiotensin II. J Am Soc Nephrol 10(Suppl 11):S189\u2013S195","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"3183_CR40","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1124\/pr.59.3.3","volume":"59","author":"H Kobori","year":"2007","unstructured":"Kobori H et al (2007) The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 59(3):251\u2013287","journal-title":"Pharmacol Rev"},{"issue":"1","key":"3183_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000085713","volume":"101","author":"T Konda","year":"2005","unstructured":"Konda T et al (2005) The N- and L-type calcium channel blocker cilnidipine suppresses renal injury in dahl rats fed a high-sucrose diet, an experimental model of metabolic syndrome. Nephron Physiol 101(1):1\u201313","journal-title":"Nephron Physiol"},{"issue":"5","key":"3183_CR42","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1248\/bpb.29.933","volume":"29","author":"T Konda","year":"2006","unstructured":"Konda T et al (2006) Effects of L\/N-type calcium channel antagonist, cilnidipine on progressive renal injuries in Dahl salt-sensitive rats. Biol Pharm Bull 29(5):933\u2013937","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"3183_CR43","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/hr.2010.279","volume":"34","author":"H Toba","year":"2011","unstructured":"Toba H et al (2011) L\/N-type calcium channel blocker cilnidipine ameliorates proteinuria and inhibits the renal renin-angiotensin-aldosterone system in deoxycorticosterone acetate-salt hypertensive rats. Hypertens Res 34(4):521\u2013529","journal-title":"Hypertens Res"},{"issue":"1","key":"3183_CR44","doi-asserted-by":"publisher","first-page":"F31","DOI":"10.1152\/ajprenal.00088.2010","volume":"300","author":"SC Clayton","year":"2011","unstructured":"Clayton SC, Haack KK, Zucker IH (2011) Renal denervation modulates angiotensin receptor expression in the renal cortex of rabbits with chronic heart failure. Am J Physiol Renal Physiol 300(1):F31\u2013F39","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"3183_CR45","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1046\/j.1523-1755.1998.00069.x","volume":"54","author":"TT Wang","year":"1998","unstructured":"Wang TT et al (1998) Molecular mechanism(s) of action of norepinephrine on the expression of the angiotensinogen gene in opossum kidney cells. Kidney Int 54(3):785\u2013795","journal-title":"Kidney Int"},{"issue":"4","key":"3183_CR46","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1097\/01.ASN.0000060804.40201.6E","volume":"14","author":"R Singh","year":"2003","unstructured":"Singh R et al (2003) Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucose. J Am Soc Nephrol 14(4):873\u2013880","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"3183_CR47","doi-asserted-by":"publisher","first-page":"F1039","DOI":"10.1152\/ajprenal.00371.2003","volume":"286","author":"DB Vidotti","year":"2004","unstructured":"Vidotti DB et al (2004) High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. Am J Physiol Renal Physiol 286(6):F1039\u2013F1045","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"3183_CR48","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1681\/ASN.V132302","volume":"13","author":"SL Zhang","year":"2002","unstructured":"Zhang SL et al (2002) Essential role(s) of the intrarenal renin-angiotensin system in transforming growth factor-beta1 gene expression and induction of hypertrophy of rat kidney proximal tubular cells in high glucose. J Am Soc Nephrol 13(2):302\u2013312","journal-title":"J Am Soc Nephrol"},{"key":"3183_CR49","first-page":"S100","volume":"39","author":"G Wolf","year":"1993","unstructured":"Wolf G, Neilson EG (1993) Angiotensin II as a hypertrophogenic cytokine for proximal tubular cells. Kidney Int Suppl 39:S100\u2013S107","journal-title":"Kidney Int Suppl"},{"issue":"3 Pt 2","key":"3183_CR50","first-page":"F435","volume":"268","author":"SS Tang","year":"1995","unstructured":"Tang SS et al (1995) Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system. Am J Physiol 268(3 Pt 2):F435\u2013F446","journal-title":"Am J Physiol"},{"issue":"1","key":"3183_CR51","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/ki.1997.325","volume":"52","author":"M Loghman-Adham","year":"1997","unstructured":"Loghman-Adham M et al (1997) A conditionally immortalized cell line from murine proximal tubule. Kidney Int 52(1):229\u2013239","journal-title":"Kidney Int"},{"issue":"1","key":"3183_CR52","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1523-1755.2004.00362.x","volume":"65","author":"RV Durvasula","year":"2004","unstructured":"Durvasula RV et al (2004) Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int 65(1):30\u201339","journal-title":"Kidney Int"},{"issue":"10","key":"3183_CR53","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1038\/sj.ki.5002195","volume":"71","author":"TH Yoo","year":"2007","unstructured":"Yoo TH et al (2007) Activation of the renin-angiotensin system within podocytes in diabetes. Kidney Int 71(10):1019\u20131027","journal-title":"Kidney Int"},{"issue":"4","key":"3183_CR54","doi-asserted-by":"publisher","first-page":"F830","DOI":"10.1152\/ajprenal.00266.2007","volume":"294","author":"RV Durvasula","year":"2008","unstructured":"Durvasula RV, Shankland SJ (2008) Activation of a local renin angiotensin system in podocytes by glucose. Am J Physiol Renal Physiol 294(4):F830\u2013F839","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"3183_CR55","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1161\/HYPERTENSIONAHA.110.158709","volume":"57","author":"KI Wu","year":"2011","unstructured":"Wu KI, Schmid-Schonbein GW (2011) Nuclear factor kappa B and matrix metalloproteinase induced receptor cleavage in the spontaneously hypertensive rat. Hypertension 57(2):261\u2013268","journal-title":"Hypertension"},{"issue":"47","key":"3183_CR56","doi-asserted-by":"publisher","first-page":"36509","DOI":"10.1074\/jbc.M005943200","volume":"275","author":"N Giannoukakis","year":"2000","unstructured":"Giannoukakis N et al (2000) Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor. J Biol Chem 275(47):36509\u201336513","journal-title":"J Biol Chem"},{"issue":"3","key":"3183_CR57","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1677\/joe.0.1730457","volume":"173","author":"JG Mabley","year":"2002","unstructured":"Mabley JG et al (2002) NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes. J Endocrinol 173(3):457\u2013464","journal-title":"J Endocrinol"},{"issue":"2","key":"3183_CR58","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nm1185","volume":"11","author":"MC Arkan","year":"2005","unstructured":"Arkan MC et al (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11(2):191\u2013198","journal-title":"Nat Med"},{"key":"3183_CR59","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/182958","author":"MD Sanchez-Nino","year":"2010","unstructured":"Sanchez-Nino MD et al (2010) TNF superfamily: a growing saga of kidney injury modulators. Mediators Inflamm. https:\/\/doi.org\/10.1155\/2010\/182958","journal-title":"Mediators Inflamm"},{"issue":"3","key":"3183_CR60","doi-asserted-by":"publisher","first-page":"F534","DOI":"10.1152\/ajprenal.00408.2007","volume":"294","author":"YJ Lee","year":"2008","unstructured":"Lee YJ, Han HJ (2008) Albumin-stimulated DNA synthesis is mediated by Ca2+\/PKC as well as EGF receptor-dependent p44\/42 MAPK and NF-kappaB signal pathways in renal proximal tubule cells. Am J Physiol Renal Physiol 294(3):F534\u2013F541","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1\u20132","key":"3183_CR61","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1023\/A:1007133710837","volume":"212","author":"AR Brasier","year":"2000","unstructured":"Brasier AR et al (2000) Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor. Mol Cell Biochem 212(1\u20132):155\u2013169","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"3183_CR62","first-page":"99","volume":"14","author":"M Jamaluddin","year":"2000","unstructured":"Jamaluddin M et al (2000) Angiotensin II induces nuclear factor (NF)-kappaB1 isoforms to bind the angiotensinogen gene acute-phase response element: a stimulus-specific pathway for NF-kappaB activation. Mol Endocrinol 14(1):99\u2013113","journal-title":"Mol Endocrinol"},{"issue":"3","key":"3183_CR63","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1161\/HYPERTENSIONAHA.110.165464","volume":"57","author":"OW Acres","year":"2011","unstructured":"Acres OW et al (2011) Contribution of a nuclear factor-kappaB binding site to human angiotensinogen promoter activity in renal proximal tubular cells. Hypertension 57(3):608\u2013613","journal-title":"Hypertension"},{"issue":"6","key":"3183_CR64","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.2337\/db08-0057","volume":"57","author":"JM Forbes","year":"2008","unstructured":"Forbes JM, Coughlan MT, Cooper ME (2008) Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 57(6):1446\u20131454","journal-title":"Diabetes"},{"issue":"5","key":"3183_CR65","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","volume":"12","author":"M Ott","year":"2007","unstructured":"Ott M et al (2007) Mitochondria, oxidative stress and cell death. Apoptosis 12(5):913\u2013922","journal-title":"Apoptosis"},{"issue":"12","key":"3183_CR66","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1681\/ASN.V12122585","volume":"12","author":"DM Attia","year":"2001","unstructured":"Attia DM et al (2001) Vitamin E alleviates renal injury, but not hypertension, during chronic nitric oxide synthase inhibition in rats. J Am Soc Nephrol 12(12):2585\u20132593","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"3183_CR67","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1161\/01.HYP.0000070028.99408.E8","volume":"41","author":"S Meng","year":"2003","unstructured":"Meng S et al (2003) Oxidative stress in Dahl salt-sensitive hypertension. Hypertension 41(6):1346\u20131352","journal-title":"Hypertension"},{"issue":"2","key":"3183_CR68","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1161\/hy0202.103264","volume":"39","author":"T Chabrashvili","year":"2002","unstructured":"Chabrashvili T et al (2002) Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Hypertension 39(2):269\u2013274","journal-title":"Hypertension"},{"issue":"3","key":"3183_CR69","first-page":"343","volume":"57","author":"L Jin","year":"2006","unstructured":"Jin L et al (2006) Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertensive rats. J Physiol Pharmacol 57(3):343\u2013357","journal-title":"J Physiol Pharmacol"},{"issue":"6","key":"3183_CR70","doi-asserted-by":"publisher","first-page":"F1348","DOI":"10.1152\/ajprenal.00028.2010","volume":"299","author":"M Sedeek","year":"2010","unstructured":"Sedeek M et al (2010) Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy. Am J Physiol Renal Physiol 299(6):F1348\u2013F1358","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"3183_CR71","doi-asserted-by":"publisher","first-page":"451","DOI":"10.2337\/db07-0013","volume":"57","author":"ML Brezniceanu","year":"2008","unstructured":"Brezniceanu ML et al (2008) Attenuation of interstitial fibrosis and tubular apoptosis in db\/db transgenic mice overexpressing catalase in renal proximal tubular cells. Diabetes 57(2):451\u2013459","journal-title":"Diabetes"},{"issue":"6","key":"3183_CR72","doi-asserted-by":"publisher","first-page":"F1144","DOI":"10.1152\/ajprenal.00221.2004","volume":"288","author":"M Satoh","year":"2005","unstructured":"Satoh M et al (2005) NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy. Am J Physiol Renal Physiol 288(6):F1144\u2013F1152","journal-title":"Am J Physiol Renal Physiol"},{"issue":"47","key":"3183_CR73","doi-asserted-by":"publisher","first-page":"39616","DOI":"10.1074\/jbc.M502412200","volume":"280","author":"Y Gorin","year":"2005","unstructured":"Gorin Y et al (2005) Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. J Biol Chem 280(47):39616\u201339626","journal-title":"J Biol Chem"},{"issue":"8","key":"3183_CR74","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1517\/14728222.11.8.1011","volume":"11","author":"A Tojo","year":"2007","unstructured":"Tojo A, Asaba K, Onozato ML (2007) Suppressing renal NADPH oxidase to treat diabetic nephropathy. Expert Opin Ther Targets 11(8):1011\u20131018","journal-title":"Expert Opin Ther Targets"},{"issue":"11","key":"3183_CR75","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1681\/ASN.V2111627","volume":"2","author":"RA Zager","year":"1992","unstructured":"Zager RA et al (1992) Evidence against increased hydroxyl radical production during oxygen deprivation-reoxygenation proximal tubular injury. J Am Soc Nephrol 2(11):1627\u20131633","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"3183_CR76","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1681\/ASN.V31116","volume":"3","author":"RA Zager","year":"1992","unstructured":"Zager RA et al (1992) Increased proximal tubular cell catalytic iron content: a result, not a mediator of, hypoxia-reoxygenation injury. J Am Soc Nephrol 3(1):116\u2013118","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"3183_CR77","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/01.RES.72.4.837","volume":"72","author":"RA Zager","year":"1993","unstructured":"Zager RA, Schimpf BA, Gmur DJ (1993) Physiological pH. Effects on posthypoxic proximal tubular injury. Circ Res 72(4):837\u201346","journal-title":"Circ Res"},{"issue":"8","key":"3183_CR78","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1681\/ASN.V481598","volume":"4","author":"BJ Nankivell","year":"1994","unstructured":"Nankivell BJ et al (1994) The role of tubular iron accumulation in the remnant kidney. J Am Soc Nephrol 4(8):1598\u20131607","journal-title":"J Am Soc Nephrol"},{"key":"3183_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.01.001","author":"L Zhang","year":"2012","unstructured":"Zhang L et al (2012) High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK\/NF-kappaB\/NADPH oxidase\/ROS pathway, which is inhibited by resveratrol. Int J Biochem Cell Biol. https:\/\/doi.org\/10.1016\/j.biocel.2012.01.001","journal-title":"Int J Biochem Cell Biol"},{"issue":"5","key":"3183_CR80","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1097\/01.ASN.0000064500.89551.76","volume":"14","author":"M Haneda","year":"2003","unstructured":"Haneda M et al (2003) Overview of glucose signaling in mesangial cells in diabetic nephropathy. J Am Soc Nephrol 14(5):1374\u20131382","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"3183_CR81","doi-asserted-by":"publisher","first-page":"E1280","DOI":"10.1152\/ajpendo.00223.2007","volume":"293","author":"L Xia","year":"2007","unstructured":"Xia L et al (2007) Reactive oxygen species, PKC-beta1, and PKC-zeta mediate high-glucose-induced vascular endothelial growth factor expression in mesangial cells. Am J Physiol Endocrinol Metab 293(5):E1280\u2013E1288","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"3183_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.09.028","author":"Y Xu","year":"2011","unstructured":"Xu Y et al (2011) Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells. Toxicol Appl Pharmacol. https:\/\/doi.org\/10.1016\/j.taap.2011.09.028","journal-title":"Toxicol Appl Pharmacol"},{"issue":"34","key":"3183_CR83","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.2174\/092986710793348581","volume":"17","author":"N Kashihara","year":"2010","unstructured":"Kashihara N et al (2010) Oxidative stress in diabetic nephropathy. Curr Med Chem 17(34):4256\u20134269","journal-title":"Curr Med Chem"},{"issue":"2","key":"3183_CR84","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.mvr.2010.03.015","volume":"80","author":"Y Ide","year":"2010","unstructured":"Ide Y et al (2010) Pigment epithelium-derived factor inhibits advanced glycation end product-elicited mesangial cell damage by blocking NF-kappaB activation. Microvasc Res 80(2):227\u2013232","journal-title":"Microvasc Res"},{"issue":"3","key":"3183_CR85","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.bbrc.2004.12.087","volume":"328","author":"J Iqbal","year":"2005","unstructured":"Iqbal J, Zaidi M (2005) Molecular regulation of mechanotransduction. Biochem Biophys Res Commun 328(3):751\u2013755","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"3183_CR86","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1172\/JCI1026","volume":"101","author":"DA MacKenna","year":"1998","unstructured":"MacKenna DA et al (1998) Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts. J Clin Invest 101(2):301\u2013310","journal-title":"J Clin Invest"},{"issue":"5","key":"3183_CR87","doi-asserted-by":"publisher","first-page":"F1052","DOI":"10.1152\/ajprenal.00580.2007","volume":"296","author":"J Yatabe","year":"2009","unstructured":"Yatabe J et al (2009) Angiotensin II type 1 receptor blocker attenuates the activation of ERK and NADPH oxidase by mechanical strain in mesangial cells in the absence of angiotensin II. Am J Physiol Renal Physiol 296(5):F1052\u2013F1060","journal-title":"Am J Physiol Renal Physiol"},{"issue":"7","key":"3183_CR88","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1089\/ars.2009.2908","volume":"13","author":"Y Zhang","year":"2010","unstructured":"Zhang Y et al (2010) Mechanical strain-induced RhoA activation requires NADPH oxidase-mediated ROS generation in caveolae. Antioxid Redox Signal 13(7):959\u2013973","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"3183_CR89","doi-asserted-by":"publisher","first-page":"F741","DOI":"10.1152\/ajprenal.00313.2005","volume":"290","author":"NH Kim","year":"2006","unstructured":"Kim NH et al (2006) Redox dependence of glomerular epithelial cell hypertrophy in response to glucose. Am J Physiol Renal Physiol 290(3):F741\u2013F751","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"3183_CR90","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2337\/diabetes.55.01.06.db05-0894","volume":"55","author":"K Susztak","year":"2006","unstructured":"Susztak K et al (2006) Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 55(1):225\u2013233","journal-title":"Diabetes"},{"issue":"2","key":"3183_CR91","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/ki.2009.146","volume":"76","author":"K Hishikawa","year":"2009","unstructured":"Hishikawa K et al (2009) Comparison of antioxidant activity of cilnidipine and amlodipine. Kidney Int 76(2):230\u2013231","journal-title":"Kidney Int"},{"issue":"3","key":"3183_CR92","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0092-8674(03)00314-3","volume":"113","author":"Y Groemping","year":"2003","unstructured":"Groemping Y et al (2003) Molecular basis of phosphorylation-induced activation of the NADPH oxidase. Cell 113(3):343\u2013355","journal-title":"Cell"},{"issue":"1","key":"3183_CR93","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1582-4934.2007.00009.x","volume":"11","author":"M Neri","year":"2007","unstructured":"Neri M et al (2007) Correlation between cardiac oxidative stress and myocardial pathology due to acute and chronic norepinephrine administration in rats. J Cell Mol Med 11(1):156\u2013170","journal-title":"J Cell Mol Med"},{"issue":"3","key":"3183_CR94","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1161\/01.HYP.0000179088.57586.26","volume":"46","author":"VM Campese","year":"2005","unstructured":"Campese VM, Shaohua Y, Huiquin Z (2005) Oxidative stress mediates angiotensin II-dependent stimulation of sympathetic nerve activity. Hypertension 46(3):533\u2013539","journal-title":"Hypertension"},{"issue":"12","key":"3183_CR95","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1097\/00004872-200312000-00025","volume":"21","author":"T Helkamaa","year":"2003","unstructured":"Helkamaa T et al (2003) Entacapone protects from angiotensin II-induced inflammation and renal injury. J Hypertens 21(12):2353\u20132363","journal-title":"J Hypertens"},{"issue":"2","key":"3183_CR96","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/HJH.0b013e3280115b96","volume":"25","author":"K Miyagawa","year":"2007","unstructured":"Miyagawa K et al (2007) Increased oxidative stress impairs endothelial modulation of contractions in arteries from spontaneously hypertensive rats. J Hypertens 25(2):415\u2013421","journal-title":"J Hypertens"},{"key":"3183_CR97","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.064097","author":"K Rafiq","year":"2012","unstructured":"Rafiq K et al (2012) Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation. Circulation. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.064097","journal-title":"Circulation"},{"issue":"4","key":"3183_CR98","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1161\/01.HYP.0000203826.15076.4b","volume":"47","author":"S Ogawa","year":"2006","unstructured":"Ogawa S et al (2006) Angiotensin II type 1 receptor blockers reduce urinary oxidative stress markers in hypertensive diabetic nephropathy. Hypertension 47(4):699\u2013705","journal-title":"Hypertension"},{"issue":"1","key":"3183_CR99","doi-asserted-by":"publisher","first-page":"H22","DOI":"10.1152\/ajpheart.00626.2004","volume":"288","author":"WJ Welch","year":"2005","unstructured":"Welch WJ et al (2005) Angiotensin-induced defects in renal oxygenation: role of oxidative stress. Am J Physiol Heart Circ Physiol 288(1):H22\u2013H28","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"3183_CR100","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.1093\/ndt\/gfh499","volume":"19","author":"Q Fan","year":"2004","unstructured":"Fan Q et al (2004) Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK\/Ta mice. Nephrol Dial Transplant 19(12):3012\u20133020","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"3183_CR101","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/j.ajpath.2011.06.033","volume":"179","author":"T Nijenhuis","year":"2011","unstructured":"Nijenhuis T et al (2011) Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Am J Pathol 179(4):1719\u20131732","journal-title":"Am J Pathol"},{"issue":"2","key":"3183_CR102","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1182\/blood-2002-09-2785","volume":"102","author":"R El Bekay","year":"2003","unstructured":"El Bekay R et al (2003) Oxidative stress is a critical mediator of the angiotensin II signal in human neutrophils: involvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-kappaB. Blood 102(2):662\u2013671","journal-title":"Blood"},{"issue":"22","key":"3183_CR103","doi-asserted-by":"publisher","first-page":"5305","DOI":"10.1038\/sj.emboj.7601417","volume":"25","author":"N Onohara","year":"2006","unstructured":"Onohara N et al (2006) TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J 25(22):5305\u20135316","journal-title":"EMBO J"},{"issue":"3","key":"3183_CR104","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/ki.1997.383","volume":"52","author":"A Henger","year":"1997","unstructured":"Henger A et al (1997) Angiotensin II increases the cytosolic calcium activity in rat podocytes in culture. Kidney Int 52(3):687\u2013693","journal-title":"Kidney Int"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-022-03183-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-022-03183-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-022-03183-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T18:37:55Z","timestamp":1664995075000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-022-03183-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,13]]},"references-count":104,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["3183"],"URL":"https:\/\/doi.org\/10.1007\/s11255-022-03183-8","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,13]]},"assertion":[{"value":"16 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared that they have no conflicts of interest to this work. We declare that we do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}