{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:50:33Z","timestamp":1740124233234,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T00:00:00Z","timestamp":1667088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T00:00:00Z","timestamp":1667088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To investigate whether extensive renal artery isolation during robotic-assisted partial nephrectomy (RAPN) for renal cell carcinoma (RCC) affects blood pressure (BP) of patients with poorly controlled hypertension.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We included 60 patients diagnosed with poorly controlled hypertension who underwent RAPN by an experienced surgeon. The renal artery of the treated kidney was sufficiently isolated. Systolic BP (SBP), diastolic BP (DBP) and antihypertensive medication information were obtained at baseline and 3- and 6-month follow-up after surgery. Primary endpoints were changes in BP, and medications. Predictors of SBP reduction at 3\u00a0months were assessed by multivariable logistic regression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All 60 RAPN procedures were successful, with no major intra- or postoperative complications. Mean SBP and DBP decreased significantly at 3\u00a0months after surgery (SBP, \u22127.8\u2009\u00b1\u20096.3\u00a0mmHg, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; DBP, \u22124.2\u2009\u00b1\u20096.4\u00a0mmHg, <jats:italic>P<\/jats:italic>\u2009=\u20090.01). SBP and DBP did not differ between 3- and 6-month follow-up. The mean number of BP medications prescribed was lower at 3\u00a0months than baseline (1.7\u2009\u00b1\u20091.0 vs 2.1\u2009\u00b1\u20091.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.016). The only significant predictor of SBP reduction at 3\u00a0months was baseline SBP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Renal denervation with extensive renal artery isolation during RAPN may improve BP control among patients with poorly controlled hypertension in short term.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11255-022-03384-1","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T15:02:31Z","timestamp":1667142151000},"page":"29-36","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of extensive artery isolation during robotic-assisted partial nephrectomy on blood pressure of patients with poorly controlled hypertension: a preliminary study"],"prefix":"10.1007","volume":"55","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChangWei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8611-0870","authenticated-orcid":false,"given":"Hongqian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,30]]},"reference":[{"key":"3384_CR1","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.ejca.2018.07.005","volume":"103","author":"J Ferlay","year":"2018","unstructured":"Ferlay J, Colombet M, Soerjomataram I et al (2018) Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer 103:356\u2013387","journal-title":"Eur J Cancer"},{"key":"3384_CR2","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/MOU.0000000000000454","volume":"28","author":"R Tahbaz","year":"2018","unstructured":"Tahbaz R, Schmid M, Merseburger AS (2018) Prevention of kidney cancer incidence and recurrence: lifestyle, medication and nutrition. Curr Opin Urol 28:62\u201379","journal-title":"Curr Opin Urol"},{"key":"3384_CR3","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/S0140-6736(15)01225-8","volume":"387","author":"D Ettehad","year":"2016","unstructured":"Ettehad D, Emdin CA, Kiran A et al (2016) Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet 387:957\u2013967","journal-title":"Lancet"},{"key":"3384_CR4","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1093\/aje\/kwm321","volume":"167","author":"S Weikert","year":"2008","unstructured":"Weikert S, Boeing H, Pischon T et al (2008) Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition. Am J Epidemiol 167:438\u2013446","journal-title":"Am J Epidemiol"},{"key":"3384_CR5","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1161\/HYPERTENSIONAHA.113.02953","volume":"63","author":"KM Sanfilippo","year":"2014","unstructured":"Sanfilippo KM, McTigue KM, Fidler CJ et al (2014) Hypertension and obesity and the risk of kidney cancer in 2 large cohorts of US men and women. Hypertension 63:934\u2013941","journal-title":"Hypertension"},{"key":"3384_CR6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11936-019-0715-6","volume":"21","author":"LS Ranard","year":"2019","unstructured":"Ranard LS, Swaminathan RV (2019) Renal artery denervation for hypertension. Curr Treat Options Cardiovasc Med 21:7","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"3384_CR7","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.urology.2018.08.015","volume":"121","author":"X Zhao","year":"2018","unstructured":"Zhao X, Lu Q, Campi R et al (2018) Endoscopic robot-assisted simple enucleation versus laparoscopic simple enucleation with single-layer renorrhaphy in localized renal tumors: a propensity score-matched analysis from a high-volume centre. Urology 121:97\u2013103","journal-title":"Urology"},{"key":"3384_CR8","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604\u2013612","journal-title":"Ann Intern Med"},{"key":"3384_CR9","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1056\/NEJM199110103251502","volume":"325","author":"AC Novick","year":"1991","unstructured":"Novick AC, Gephardt G, Guz B et al (1991) Long-term follow-up after partial removal of a solitary kidney. N Engl J Med 325:1058\u20131062","journal-title":"N Engl J Med"},{"key":"3384_CR10","doi-asserted-by":"publisher","first-page":"154","DOI":"10.4111\/kju.2012.53.3.154","volume":"53","author":"N Lawrentschuk","year":"2012","unstructured":"Lawrentschuk N, Trottier G, Mayo K et al (2012) Effects of partial nephrectomy on postoperative blood pressure. Korean J Urol 53:154\u2013158","journal-title":"Korean J Urol"},{"key":"3384_CR11","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s00345-020-03354-1","volume":"39","author":"N Gupta","year":"2021","unstructured":"Gupta N, Ganesan V, Gao TM et al (2021) The effect of partial nephrectomy on blood pressure in patients with solitary kidney. World J Urol 39:1577\u20131582","journal-title":"World J Urol"},{"key":"3384_CR12","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/iju.12794","volume":"22","author":"M Inoue","year":"2015","unstructured":"Inoue M, Fujii Y, Yokoyama M et al (2015) Progression of hypertension after partial nephrectomy in patients with renal tumors: a preliminary report. Int J Urol 22:797\u2013798","journal-title":"Int J Urol"},{"key":"3384_CR13","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.urolonc.2017.06.057","volume":"35","author":"R Hutchinson","year":"2017","unstructured":"Hutchinson R, Singla N, Krabbe LM et al (2017) Increased use of antihypertensive medications after partial nephrectomy vs. radical nephrectomy. Urol Oncol 35:660","journal-title":"Urol Oncol"},{"key":"3384_CR14","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1016\/j.juro.2014.01.103","volume":"191","author":"H Zargar","year":"2014","unstructured":"Zargar H, Aning J, Legiehn G et al (2014) Renovascular hypertension after laparoscopic partial nephrectomy. J Urol 191:1418\u20131420","journal-title":"J Urol"},{"key":"3384_CR15","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.juro.2015.07.035","volume":"194","author":"M Kiczek","year":"2015","unstructured":"Kiczek M, Udayasankar U (2015) Page kidney. J Urol 194:1109\u20131110","journal-title":"J Urol"},{"key":"3384_CR16","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/iju.12815","volume":"22","author":"T Sakurai","year":"2015","unstructured":"Sakurai T (2015) Editorial comment to progression of hypertension after partial nephrectomy in patients with renal tumors: a preliminary report. Int J Urol 22:798\u2013799","journal-title":"Int J Urol"},{"key":"3384_CR17","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1161\/HYPERTENSIONAHA.109.138610","volume":"54","author":"MP Schlaich","year":"2009","unstructured":"Schlaich MP, Sobotka PA, Krum H et al (2009) Renal denervation as a therapeutic approach for hypertension: novel implications for an old concept. Hypertension 54:1195\u20131201","journal-title":"Hypertension"},{"key":"3384_CR18","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1056\/NEJMoa1402670","volume":"370","author":"DL Bhatt","year":"2014","unstructured":"Bhatt DL, Kandzari DE, O\u2019Neill WW et al (2014) A controlled trial of renal denervation for resistant hypertension. N Engl J Med 370:1393\u20131401","journal-title":"N Engl J Med"},{"key":"3384_CR19","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1016\/j.juro.2014.10.124","volume":"193","author":"MW Tellman","year":"2015","unstructured":"Tellman MW, Bahler CD, Shumate AM et al (2015) Management of pain in autosomal dominant polycystic kidney disease and anatomy of renal innervation. J Urol 193:1470\u20131478","journal-title":"J Urol"},{"key":"3384_CR20","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.jacc.2014.03.059","volume":"64","author":"K Sakakura","year":"2014","unstructured":"Sakakura K, Ladich E, Cheng Q et al (2014) Anatomic assessment of sympathetic peri-arterial renal nerves in man. J Am Coll Cardiol 64:635\u2013643","journal-title":"J Am Coll Cardiol"},{"key":"3384_CR21","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1093\/ndt\/gfu192","volume":"29","author":"EE Vink","year":"2014","unstructured":"Vink EE, Goldschmeding R, Vink A et al (2014) Limited destruction of renal nerves after catheter-based renal denervation: results of a human case study. Nephrol Dial Transplant 29:1608\u20131610","journal-title":"Nephrol Dial Transplant"},{"key":"3384_CR22","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1002\/ca.21280","volume":"25","author":"DS Atherton","year":"2012","unstructured":"Atherton DS, Deep NL, Mendelsohn FO (2012) Micro-anatomy of the renal sympathetic nervous system: a human postmortem histologic study. Clin Anat 25:628\u2013633","journal-title":"Clin Anat"},{"key":"3384_CR23","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1053\/j.ajkd.2016.01.021","volume":"68","author":"RC Gerber","year":"2016","unstructured":"Gerber RC, Bahler CD, Kraus MA et al (2016) Laparoscopic renal denervation for uncontrolled hypertension due to medication intolerance: a case report. Am J Kidney Dis 68:131\u2013133","journal-title":"Am J Kidney Dis"},{"key":"3384_CR24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1159\/000381799","volume":"131","author":"M Bai","year":"2015","unstructured":"Bai M, Yang C, Gao C et al (2015) Effects of renal denervation from the intima and the adventitia of renal arteries on renal sympathetic nerve activity in dogs: a comparative study. Cardiology 131:189\u2013196","journal-title":"Cardiology"},{"key":"3384_CR25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/02656736.2018.1468037","volume":"35","author":"E Ye","year":"2018","unstructured":"Ye E, Baik J, Lee S et al (2018) Design and simulation of novel laparoscopic renal denervation system: a feasibility study. Int J Hyperthermia 35:9\u201318","journal-title":"Int J Hyperthermia"},{"key":"3384_CR26","doi-asserted-by":"publisher","first-page":"567","DOI":"10.12659\/AJCR.908891","volume":"19","author":"K Okamura","year":"2018","unstructured":"Okamura K, Satou S, Setojima K et al (2018) Reduction of blood pressure following after renal artery adventitia stripping during total nephroureterectomy: potential effect of renal sympathetic denervation. Am J Case Rep 19:567\u2013572","journal-title":"Am J Case Rep"},{"key":"3384_CR27","doi-asserted-by":"publisher","first-page":"132","DOI":"10.5603\/KP.2015.0021","volume":"73","author":"K Kostka-Jeziorny","year":"2015","unstructured":"Kostka-Jeziorny K, Radziemski A, Tykarski A et al (2015) Effect of unilateral catheter-based renal sympathetic denervation in a patient with resistant hypertension. Kardiol Pol 73:132","journal-title":"Kardiol Pol"},{"key":"3384_CR28","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1038\/s41440-019-0237-3","volume":"42","author":"C Gao","year":"2019","unstructured":"Gao C, Zhao L, Zhu L et al (2019) Laparoscopic-based perivascular unilateral renal sympathetic nerve denervation for treating resistant hypertension: a case report. Hypertens Res 42:1162\u20131165","journal-title":"Hypertens Res"},{"key":"3384_CR29","doi-asserted-by":"publisher","first-page":"R886","DOI":"10.1152\/ajpregu.00269.2013","volume":"305","author":"AM Schiller","year":"2013","unstructured":"Schiller AM, Haack KK, Pellegrino PR et al (2013) Unilateral renal denervation improves autonomic balance in conscious rabbits with chronic heart failure. Am J Physiol Regul Integr Comp Physiol 305:R886-892","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"3384_CR30","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1016\/S0140-6736(17)32281-X","volume":"390","author":"RR Townsend","year":"2017","unstructured":"Townsend RR, Mahfoud F, Kandzari DE et al (2017) Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial. Lancet 390:2160\u20132170","journal-title":"Lancet"},{"key":"3384_CR31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/carcin\/bgh324","volume":"26","author":"M Fujita","year":"2005","unstructured":"Fujita M, Hayashi I, Yamashina S et al (2005) Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth. Carcinogenesis 26:271\u2013279","journal-title":"Carcinogenesis"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-022-03384-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-022-03384-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-022-03384-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T11:45:25Z","timestamp":1672659925000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-022-03384-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,30]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["3384"],"URL":"https:\/\/doi.org\/10.1007\/s11255-022-03384-1","relation":{},"ISSN":["1573-2584"],"issn-type":[{"type":"electronic","value":"1573-2584"}],"subject":[],"published":{"date-parts":[[2022,10,30]]},"assertion":[{"value":"4 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.\u00a0The abstract part of the paper were previously reported in the \u201cabstracts communication\u201d of the AUA annual meeting.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the procedure of this study was approved by the Medical Ethics Committee of the Affiliated Drum Tower Hospital of Nanjing University Medical School (Number: 2020\u2013090-0) and were in accordance with the Helsinki Declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}