{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:19:26Z","timestamp":1792783166677,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2017FE468 (-229)"],"award-info":[{"award-number":["2017FE468 (-229)"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Reserve Talents Training Program of Yunnan Provincial Health Commission of China","award":["H-2018053"],"award-info":[{"award-number":["H-2018053"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the therapeutic efficacy, feasibility, and safety of total parathyroidectomy (tPTX) in the treatment of secondary hyperparathyroidism (SHPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical data of 34 SHPT patients admitted to the Department of Nephrology, Yuxi People\u2019s Hospital, from January 2018 to January 2021 who had received tPTX, were retrospectively analyzed. The indications for tPTX were severe SHPT that did not respond to medical treatment and was ineligible for kidney transplantation. tPTX without autotransplantation was adopted to compare the level of symptom relief and changes in serum intact parathyroid hormone (iPTH), blood calcium, and blood phosphorus pre- and postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 34 patients, 142 parathyroid glands were removed, including 21 ectopic parathyroid glands (14.78%). Six patients (17.64%, 6\/34) had supernumerary parathyroid glands. At 6\u00a0h postoperatively, arthralgia and bone pain were significantly reduced to almost zero in 94.12% (32\/34) of patients. At 24\u00a0h postoperatively, relief of bone pain and improvement of limb movement were observed in 100% (34\/34) of patients, and pruritus almost disappeared in 86.36% (19\/22) of patients. There were significant differences in iPTH (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      2\u2009=\u2009134.93,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), calcium (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      2\u2009=\u200923.02,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), and phosphorus (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      2\u2009=\u2009102.11,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) levels preoperatively and 40\u00a0min, 24\u00a0h, 1\u00a0week, half a year, and last available (&gt;\u20091\u00a0year) postoperatively.\n                    <\/jats:p>\n                    <jats:p>The patients were followed up for 15\u201347\u00a0months (median 33\u00a0months). Hypoparathyroidism was observed in three patients, who underwent neck dissection or partial thymotomy concurrently for different reasons. No intractable hypocalcemia or adynamic bone disease occurred during the follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In SHPT patients who were ineligible for renal transplantation, tPTX was effective, safe, and reliable, with a low recurrence rate. However, when tPTX was performed alone without autologous transplantation, bilateral neck exploration was sufficient, and central neck dissection and thymic resection were inadvisable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11255-022-03401-3","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T07:04:18Z","timestamp":1667545458000},"page":"1239-1245","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of total parathyroidectomy in patients with secondary hyperparathyroidism: a retrospective study"],"prefix":"10.1007","volume":"55","author":[{"given":"Xixiang","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi An","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongwu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-375X","authenticated-orcid":false,"given":"Yongxin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"issue":"4","key":"3401_CR1","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/bjs.9661","volume":"102","author":"R Schneider","year":"2015","unstructured":"Schneider R, Bartsch DK (2015) Role of surgery in the treatment of renal secondary hyperparathyroidism[J]. BJS 102(4):289\u2013290. https:\/\/doi.org\/10.1002\/bjs.9661","journal-title":"BJS"},{"key":"3401_CR2","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/1471-2369-14-100","volume":"14","author":"JP Lafrance","year":"2013","unstructured":"Lafrance JP, Cardinal H, Leblanc M et al (2013) Effect of cinacalcet availability and formulary listing on parathyroidectomy rate trends[J]. BMC Nephrol 14:100. https:\/\/doi.org\/10.1186\/1471-2369-14-100","journal-title":"BMC Nephrol"},{"issue":"2","key":"3401_CR3","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/ki.2015.72","volume":"88","author":"H Komaba","year":"2015","unstructured":"Komaba H, Taniguchi M, Wada A et al (2015) Parathyroidectomy and survival among Japanese hemodialysis patients with secondary hyperparathyroidism[J]. Kidney Int 88(2):350\u2013359. https:\/\/doi.org\/10.1038\/ki.2015.72","journal-title":"Kidney Int"},{"issue":"3","key":"3401_CR4","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1590\/0100-69912016003003","volume":"43","author":"MG Toneto","year":"2016","unstructured":"Toneto MG, Prill S, Debon LM et al (2016) The history of the parathyroid surgery[J]. Rev Col Bras Cir 43(3):214\u2013222. https:\/\/doi.org\/10.1590\/0100-69912016003003","journal-title":"Rev Col Bras Cir"},{"issue":"7","key":"3401_CR5","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1080\/0886022X.2016.1184924","volume":"38","author":"K Wang","year":"2016","unstructured":"Wang K, Chen L, Yu S et al (2016) Long-term mortality after parathyroidectomy among chronic kidney disease patients with secondary hyperparathyroidism: a systematic review and meta-analysis[J]. Ren Fail 38(7):1050\u20131058","journal-title":"Ren Fail"},{"issue":"2","key":"3401_CR6","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1177\/0194599811428272","volume":"146","author":"A Ghani","year":"2012","unstructured":"Ghani A, Baxter P (2012) Surgical parathyroidectomy versus cinacalcet therapy: in the management of secondary hyperparathyroidism[J]. Otolaryngol Head Neck Surg 146(2):220\u2013225. https:\/\/doi.org\/10.1177\/0194599811428272","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"3401_CR7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.21037\/gs.2020.03.08","volume":"9","author":"C Gu","year":"2020","unstructured":"Gu C, Ye Z, Wang Y et al (2020) Therapeutic efficacy of two surgical methods on the secondary hyperparathyroidism[J]. Gland Surg 9(2):321\u2013328. https:\/\/doi.org\/10.21037\/gs.2020.03.08","journal-title":"Gland Surg"},{"issue":"8","key":"3401_CR8","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/s00423-018-1726-6","volume":"403","author":"WY van der Plas","year":"2018","unstructured":"van der Plas WY, Dulfer RR, Koh EY et al (2018) Safety and efficacy of subtotal or total parathyroidectomy for patients with secondary or tertiary hyperparathyroidism in four academic centers in the Netherlands[J]. Langenbecks Arch Surg 403(8):999\u20131005. https:\/\/doi.org\/10.1007\/s00423-018-1726-6","journal-title":"Langenbecks Arch Surg"},{"issue":"2","key":"3401_CR9","doi-asserted-by":"publisher","first-page":"102370","DOI":"10.1016\/j.amjoto.2019.102370","volume":"41","author":"J Hou","year":"2019","unstructured":"Hou J, Shan H, Zhang Y et al (2019) Network meta-analysis of surgical treatment for secondary hyperparathyroidism[J]. Am J Otolaryngol 41(2):102370. https:\/\/doi.org\/10.1016\/j.amjoto.2019.102370","journal-title":"Am J Otolaryngol"},{"key":"3401_CR10","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2019.20160","author":"L Steffen","year":"2019","unstructured":"Steffen L, Moffa G, Mller PC et al (2019) Secondary hyperparathyroidism: recurrence after total parathyroidectomy with autotransplantation[J]. Swiss Med Wkly. https:\/\/doi.org\/10.4414\/smw.2019.20160","journal-title":"Swiss Med Wkly"},{"key":"3401_CR11","unstructured":"Randolph GI (2013) Surgery of the thyroid and parathyroid glands[M]. In: Gregory W (ed) 2nd edn. ISBN 978-1-4377-2227-7"},{"issue":"5","key":"3401_CR12","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.biopha.2009.06.006","volume":"64","author":"M Puccini","year":"2010","unstructured":"Puccini M, Carpi A, Cupisti A et al (2010) Total parathyroidectomy without autotransplantation for the treatment of secondary hyperparathyroidism associated with chronic kidney disease: clinical and laboratory long-term follow-up[J]. Biomed Pharma 64(5):359\u2013362. https:\/\/doi.org\/10.1016\/j.biopha.2009.06.006","journal-title":"Biomed Pharma"},{"issue":"1","key":"3401_CR13","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1080\/0886022x.2017.1363779","volume":"39","author":"C Li","year":"2017","unstructured":"Li C, Lv L, Wang H et al (2017) Total parathyroidectomy versus total parathyroidectomy with autotransplantation for secondary hyperparathyroidism: systematic review and meta-analysis[J]. Ren Fail 39(1):678\u2013687. https:\/\/doi.org\/10.1080\/0886022x.2017.1363779","journal-title":"Ren Fail"},{"key":"3401_CR14","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.ijsu.2017.06.029","volume":"44","author":"ME Liu","year":"2017","unstructured":"Liu ME, Qiu NC, Zha SL et al (2017) To assess the effects of parathyroidectomy (TPTX versus TPTX+AT) for Secondary Hyperparathyroidism in chronic renal failure: a systematic review and meta-analysis[J]. Int J Surg 44:353\u2013362. https:\/\/doi.org\/10.1016\/j.ijsu.2017.06.029","journal-title":"Int J Surg"},{"issue":"5","key":"3401_CR15","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/SLA.0000000000001875","volume":"264","author":"K Schlosser","year":"2016","unstructured":"Schlosser K, Bartsch DK, Diener MK et al (2016) Total parathyroidectomy with routine thymectomy and autotransplantation versus total parathyroidectomy alone for secondary hyperparathyroidism: results of a nonconfirmatory multicenter prospective randomized controlled pilot Trial[J]. Ann Surg 264(5):745\u2013753. https:\/\/doi.org\/10.1097\/SLA.0000000000001875","journal-title":"Ann Surg"},{"issue":"Suppl 1","key":"3401_CR16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s40520-016-0669-4","volume":"29","author":"A Polistena","year":"2017","unstructured":"Polistena A, Sanguinetti A, Lucchini R et al (2017) Surgical treatment of secondary hyperparathyroidism in elderly patients: an institutional experience[J]. Aging Clin Exp Res 29(Suppl 1):23\u201328. https:\/\/doi.org\/10.1007\/s40520-016-0669-4","journal-title":"Aging Clin Exp Res"},{"issue":"8","key":"3401_CR17","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1001\/archsurg.143.8.756","volume":"143","author":"N Rayes","year":"2008","unstructured":"Rayes N, Seehofer D, Schindler R et al (2008) Long-term results of subtotal vs total parathyroidectomy without autotransplantation in kidney transplant recipients[J]. Arch Surg 143(8):756\u2013761. https:\/\/doi.org\/10.1001\/archsurg.143.8.756","journal-title":"Arch Surg"},{"issue":"2","key":"3401_CR18","doi-asserted-by":"publisher","first-page":"c102","DOI":"10.1159\/000191200","volume":"111","author":"S Stracke","year":"2009","unstructured":"Stracke S, Keller F, Steinbach G et al (2009) Long-term outcome after total parathyroidectomy for the management of secondary hyperparathyroidism[J]. Nephron Clin Pract 111(2):c102\u2013c109. https:\/\/doi.org\/10.1159\/000191200","journal-title":"Nephron Clin Pract"},{"key":"3401_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135195","volume":"735","author":"F Jia","year":"2020","unstructured":"Jia F, Xue Y, Liu K et al (2020) Effects of total parathyroidectomy treatment on parathyroid hormone levels, recurrent laryngeal nerve function, and the rate of infection complications of secondary hyperparathyroidism patients under image information health monitoring by magnetic resonance imaging[J]. Neurosci Lett 735:135195. https:\/\/doi.org\/10.1016\/j.neulet.2020.135195","journal-title":"Neurosci Lett"},{"issue":"1","key":"3401_CR20","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1080\/02656736.2019.1684576","volume":"36","author":"Z Hu","year":"2019","unstructured":"Hu Z, Han E, Chen W et al (2019) Feasibility and safety of ultrasound-guided percutaneous microwave ablation for tertiary hyperparathyroidism[J]. Int J Hyperth 36(1):1129\u20131136. https:\/\/doi.org\/10.1080\/02656736.2019.1684576","journal-title":"Int J Hyperth"},{"issue":"1","key":"3401_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.kisu.2017.04.001","volume":"7","author":"Kidney Disease: improving global outcomes","year":"2017","unstructured":"Kidney Disease: improving global outcomes (2017) KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)[J]. Kidney Int Suppl 7(1):1\u201359. https:\/\/doi.org\/10.1016\/j.kisu.2017.04.001","journal-title":"Kidney Int Suppl"},{"issue":"1","key":"3401_CR22","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3969\/j.issn.1006-298X.2019.01.012","volume":"28","author":"National renal disease clinical medical research center","year":"2019","unstructured":"National renal disease clinical medical research center (2019) Guidelines for diagnosis and treatment of mineral and bone abnormalities in chronic kidney disease in China [J]. J Kidney Dis Dial Kidney Transpl 28(1):52\u201357. https:\/\/doi.org\/10.3969\/j.issn.1006-298X.2019.01.012","journal-title":"J Kidney Dis Dial Kidney Transpl"},{"issue":"5","key":"3401_CR23","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1007\/s10157-015-1208-x","volume":"20","author":"N Iwamoto","year":"2016","unstructured":"Iwamoto N, Sato N, Nishida M et al (2016) Low parathyroid hormone levels after parathyroidectomy reduce cardiovascular mortality in chronic hemodialysis patients[J]. Clin Exp Nephrol 20(5):808\u2013814. https:\/\/doi.org\/10.1007\/s10157-015-1208-x","journal-title":"Clin Exp Nephrol"},{"key":"3401_CR24","doi-asserted-by":"publisher","first-page":"6934706","DOI":"10.1155\/2017\/6934706","volume":"2017","author":"QP Xi","year":"2017","unstructured":"Xi QP, Xie XS, Zhang L et al (2017) Impact of different levels of iPTH on all-cause mortality in dialysis patients with secondary hyperparathyroidism after parathyroidectomy[J]. Biomed Res Int 2017:6934706. https:\/\/doi.org\/10.1155\/2017\/6934706","journal-title":"Biomed Res Int"},{"key":"3401_CR25","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ijsu.2017.05.062","volume":"43","author":"CX Shan","year":"2017","unstructured":"Shan CX, Qiu NC, Zha SL et al (2017) A novel surgical strategy for secondary hyperparathyroidism: purge parathyroidectomy[J]. Int J Surg 43:112\u2013118. https:\/\/doi.org\/10.1016\/j.ijsu.2017.05.062","journal-title":"Int J Surg"},{"key":"3401_CR26","doi-asserted-by":"publisher","unstructured":"Guido G, Michele C, Nicola P (2016) Primary, Secondary and Tertiary Hyperparathyroidism Diagnostic and Therapeutic Updates\uff1bISSN 2280-9848\uff1bISBN 978-88-470-5757-9. https:\/\/doi.org\/10.1007\/978-88-470-5758-6","DOI":"10.1007\/978-88-470-5758-6"},{"issue":"1","key":"3401_CR27","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.surg.2017.09.014","volume":"163","author":"B Sunkara","year":"2018","unstructured":"Sunkara B, Cohen MS, Miller BS et al (2018) Influence of concurrent chronic kidney disease on intraoperative parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism[J]. Surgery 163(1):42\u201347. https:\/\/doi.org\/10.1016\/j.surg.2017.09.014","journal-title":"Surgery"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-022-03401-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-022-03401-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-022-03401-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T09:10:00Z","timestamp":1681549800000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-022-03401-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["3401"],"URL":"https:\/\/doi.org\/10.1007\/s11255-022-03401-3","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,4]]},"assertion":[{"value":"2 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Medical Ethics Committee of the People\u2019s Hospital of Yuxi City, and all participants provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This study was conducted with the consent of the patients who participated in the study and provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Agreed for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}