{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:02:43Z","timestamp":1780318963286,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-023-03540-1","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T12:02:37Z","timestamp":1677844957000},"page":"2295-2302","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The prevalence and clinical significance of loss of appetite in older patients with chronic kidney disease"],"prefix":"10.1007","volume":"55","author":[{"given":"Serkan","family":"Yildiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Heybeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-1718","authenticated-orcid":false,"given":"Pinar","family":"Soysal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumeyza","family":"Kazancioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"3540_CR1","first-page":"129","volume":"11","author":"BP de Souto","year":"2022","unstructured":"de Souto BP, Cesari M, Morley JE et al (2022) Appetite loss and anorexia of aging in clinical care: an ICFSR task force report. J Frailty Aging 11:129\u2013134","journal-title":"J Frailty Aging"},{"key":"3540_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1053\/j.jrn.2008.10.004","volume":"19","author":"JJ Carrero","year":"2009","unstructured":"Carrero JJ (2009) Identification of patients with eating disorders: clinical and biochemical signs of appetite loss in dialysis patients. J Ren Nutr 19:10\u201315","journal-title":"J Ren Nutr"},{"key":"3540_CR3","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12882-021-02659-6","volume":"23","author":"A Chewcharat","year":"2022","unstructured":"Chewcharat A, Phipps EA, Bhatia K et al (2022) The association between olfactory and gustatory dysfunction and chronic kidney disease. BMC Nephrol 23:36","journal-title":"BMC Nephrol"},{"key":"3540_CR4","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.1681\/ASN.2016121308","volume":"28","author":"SU Nigwekar","year":"2017","unstructured":"Nigwekar SU, Weiser JM, Kalim S et al (2017) Characterization and correction of olfactory deficits in kidney disease. J Am Soc Nephrol 28:3395\u20133403","journal-title":"J Am Soc Nephrol"},{"key":"3540_CR5","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1053\/j.jrn.2011.07.005","volume":"22","author":"Y Caliskan","year":"2012","unstructured":"Caliskan Y, Yelken B, Gorgulu N et al (2012) Comparison of markers of appetite and inflammation between hemodialysis patients with and without failed renal transplants. J Ren Nutr 22:258\u2013267","journal-title":"J Ren Nutr"},{"key":"3540_CR6","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1172\/JCI22521","volume":"115","author":"W Cheung","year":"2005","unstructured":"Cheung W, Yu PX, Little BM et al (2005) Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest 115:1659\u20131665","journal-title":"J Clin Invest"},{"key":"3540_CR7","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1053\/j.ajkd.2021.05.024","volume":"79","author":"HL MacLaughlin","year":"2022","unstructured":"MacLaughlin HL, Friedman AN, Ikizler TA (2022) Nutrition in kidney disease: core curriculum 2022. Am J Kidney Dis 79:437\u2013449","journal-title":"Am J Kidney Dis"},{"key":"3540_CR8","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/s41581-021-00498-0","volume":"18","author":"XH Wang","year":"2022","unstructured":"Wang XH, Mitch WE, Price SR (2022) Pathophysiological mechanisms leading to muscle loss in chronic kidney disease. Nat Rev Nephrol 18:138\u2013152","journal-title":"Nat Rev Nephrol"},{"key":"3540_CR9","doi-asserted-by":"publisher","first-page":"ii14","DOI":"10.1093\/ndt\/gfab284","volume":"37","author":"C Zoccali","year":"2021","unstructured":"Zoccali C, Ortiz A, Blumbyte IA et al (2021) Neuropeptide Y as a risk factor for cardiorenal disease and cognitive dysfunction in chronic kidney disease: translational opportunities and challenges. Nephrol Dial Transplant 37:ii14\u2013ii23","journal-title":"Nephrol Dial Transplant"},{"key":"3540_CR10","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s40520-021-01966-0","volume":"34","author":"C Heybeli","year":"2022","unstructured":"Heybeli C, Soysal P, Oktan MA et al (2022) Associations between nutritional factors and excessive daytime sleepiness in older patients with chronic kidney disease. Aging Clin Exp Res 34:573\u2013581","journal-title":"Aging Clin Exp Res"},{"key":"3540_CR11","doi-asserted-by":"crossref","unstructured":"Soysal P, Koc Okudur S, Kilic N et al (2022) The prevalence of undernutrition and associated factors in older obese patients. Aging Clin Exp Res 34:2023\u20132030","DOI":"10.1007\/s40520-022-02143-7"},{"key":"3540_CR12","doi-asserted-by":"crossref","unstructured":"Sung CC, Liao MT, Chao CT (2021) Independent determinants of appetite impairment among patients with stage 3 or higher chronic kidney disease: a prospective study. Nutrients 13:2863","DOI":"10.3390\/nu13082863"},{"key":"3540_CR13","unstructured":"Association AP (2013) 5TH edn: Washington, DC"},{"key":"3540_CR14","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1093\/ajcn\/82.5.1074","volume":"82","author":"MM Wilson","year":"2005","unstructured":"Wilson MM, Thomas DR, Rubenstein LZ et al (2005) Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 82:1074\u20131081","journal-title":"Am J Clin Nutr"},{"key":"3540_CR15","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/sleep\/34.5.601","volume":"34","author":"CM Morin","year":"2011","unstructured":"Morin CM, Belleville G, Belanger L et al (2011) The insomnia severity index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep 34:601\u2013608","journal-title":"Sleep"},{"key":"3540_CR16","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1056\/NEJMra2201153","volume":"386","author":"AS Levey","year":"2022","unstructured":"Levey AS, Grams ME, Inker LA (2022) Uses of GFR and albuminuria level in acute and chronic kidney disease. N Engl J Med 386:2120\u20132128","journal-title":"N Engl J Med"},{"key":"3540_CR17","doi-asserted-by":"publisher","first-page":"209","DOI":"10.5152\/turkjnephrol.2022.21068","volume":"31","author":"CSP Heybeli","year":"2022","unstructured":"Heybeli CSP, Smith L, Biberci Keskin E, Kazanc\u0131o\u011flu R (2022) Effects of a change in the definition of chronic kidney disease on geriatric assessment parameters. Turk J Nephrol 31:209\u2013217","journal-title":"Turk J Nephrol"},{"key":"3540_CR18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.kint.2019.08.033","volume":"97","author":"RJ Glassock","year":"2020","unstructured":"Glassock RJ, Delanaye P, Rule AD (2020) Should the definition of CKD be changed to include age-adapted GFR criteria? YES Kidney Int 97:34\u201337","journal-title":"YES Kidney Int"},{"key":"3540_CR19","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.kint.2019.08.032","volume":"97","author":"AS Levey","year":"2020","unstructured":"Levey AS, Inker LA, Coresh J (2020) \u201cShould the definition of CKD be changed to include age-adapted GFR criteria?\u201d: Con: the evaluation and management of CKD, not the definition, should be age-adapted. Kidney Int 97:37\u201340","journal-title":"Kidney Int"},{"key":"3540_CR20","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S1051-2276(99)90050-X","volume":"9","author":"J Bergstrom","year":"1999","unstructured":"Bergstrom J (1999) Mechanisms of uremic suppression of appetite. J Ren Nutr 9:129\u2013132","journal-title":"J Ren Nutr"},{"key":"3540_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.semnephrol.2008.10.003","volume":"29","author":"C Chazot","year":"2009","unstructured":"Chazot C (2009) Why are chronic kidney disease patients anorexic and what can be done about it? Semin Nephrol 29:15\u201323","journal-title":"Semin Nephrol"},{"key":"3540_CR22","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1097\/00000658-195010000-00014","volume":"132","author":"DR Webster","year":"1950","unstructured":"Webster DR, Henrikson HW, Currie DJ (1950) The effect of potassium deficiency on intestinal motility and gastric secretion. Ann Surg 132:779\u2013785","journal-title":"Ann Surg"},{"key":"3540_CR23","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.semnephrol.2013.04.005","volume":"33","author":"JH Youn","year":"2013","unstructured":"Youn JH (2013) Gut sensing of potassium intake and its role in potassium homeostasis. Semin Nephrol 33:248\u2013256","journal-title":"Semin Nephrol"},{"key":"3540_CR24","doi-asserted-by":"crossref","unstructured":"Cowen N, Bhatnagar A (2021) The potential role of activating the ATP-sensitive potassium channel in the treatment of hyperphagic obesity. Genes (Basel) 11(4):450","DOI":"10.3390\/genes11040450"},{"key":"3540_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234209","volume":"15","author":"H Ghrayeb","year":"2020","unstructured":"Ghrayeb H, Elias M, Nashashibi J et al (2020) Appetite and ghrelin levels in iron deficiency anemia and the effect of parenteral iron therapy: a longitudinal study. PLoS ONE 15:e0234209","journal-title":"PLoS ONE"},{"key":"3540_CR26","doi-asserted-by":"crossref","unstructured":"Mikami Y, Motokawa K, Shirobe M et al (2022) Relationship between eating alone and poor appetite using the simplified nutritional appetite questionnaire. Nutrients 14(2): 337","DOI":"10.3390\/nu14020337"},{"key":"3540_CR27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.2217\/ahe.09.90","volume":"6","author":"ME Payne","year":"2010","unstructured":"Payne ME (2010) Nutrition and late-life depression: etiological considerations. Aging health 6:133\u2013143","journal-title":"Aging health"},{"key":"3540_CR28","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.nutres.2012.03.009","volume":"32","author":"K Peuhkuri","year":"2012","unstructured":"Peuhkuri K, Sihvola N, Korpela R (2012) Diet promotes sleep duration and quality. Nutr Res 32:309\u2013319","journal-title":"Nutr Res"},{"key":"3540_CR29","first-page":"11","volume":"42","author":"L Cintra","year":"1994","unstructured":"Cintra L, Galvan A, Diaz-Cintra S et al (1994) Protein malnutrition on suprachiasmatic nucleus cells in rats of three ages. Bol Estud Med Biol 42:11\u201319","journal-title":"Bol Estud Med Biol"},{"key":"3540_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0166-4328(95)00009-I","volume":"69","author":"CA Everson","year":"1995","unstructured":"Everson CA (1995) Functional consequences of sustained sleep deprivation in the rat. Behav Brain Res 69:43\u201354","journal-title":"Behav Brain Res"},{"key":"3540_CR31","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.appet.2015.07.014","volume":"95","author":"Y Mossavar-Rahmani","year":"2015","unstructured":"Mossavar-Rahmani Y, Jung M, Patel SR et al (2015) Eating behavior by sleep duration in the Hispanic Community Health Study\/Study of Latinos. Appetite 95:275\u2013284","journal-title":"Appetite"},{"key":"3540_CR32","doi-asserted-by":"crossref","unstructured":"Asaad Abdou T, Esawy HI, Abdel Razek Mohamed G et al (2018) Sleep profile in anorexia and bulimia nervosa female patients. Sleep Med 48:113\u2013116","DOI":"10.1016\/j.sleep.2018.03.032"},{"key":"3540_CR33","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.peptides.2016.12.008","volume":"88","author":"S Tang","year":"2017","unstructured":"Tang S, Huang W, Lu S et al (2017) Increased plasma orexin-A levels in patients with insomnia disorder are not associated with prepro-orexin or orexin receptor gene polymorphisms. Peptides 88:55\u201361","journal-title":"Peptides"},{"key":"3540_CR34","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1111\/jocn.13220","volume":"25","author":"C Andreae","year":"2016","unstructured":"Andreae C, Stromberg A, Arestedt K (2016) Prevalence and associated factors for decreased appetite among patients with stable heart failure. J Clin Nurs 25:1703\u20131712","journal-title":"J Clin Nurs"},{"key":"3540_CR35","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1016\/j.jamda.2019.03.030","volume":"20","author":"P Soysal","year":"2019","unstructured":"Soysal P, Smith L, Dokuzlar O et al (2019) Relationship between nutritional status and insomnia severity in older adults. J Am Med Dir Assoc 20:1593\u20131598","journal-title":"J Am Med Dir Assoc"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-023-03540-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-023-03540-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-023-03540-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T17:19:25Z","timestamp":1691428765000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-023-03540-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["3540"],"URL":"https:\/\/doi.org\/10.1007\/s11255-023-03540-1","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,3]]},"assertion":[{"value":"22 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was approved by the local Ethics Committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was taken from all patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}