{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:50:50Z","timestamp":1740124250805,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Bond University Limited"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Radiotherapy is a prominent therapy for many malignant and non-malignant disorders, though it can cause side effects such as radiation-induced cystitis. Current research has highlighted a role for mast cells and macrophages in the prognosis of such radiation-induced toxicities. However, the prognostic value of these immune cells in the pathophysiology of radiation-induced cystitis is not clear. As such, a systematic review was conducted to assess myeloid-lineage immune cells for their prognostic value in radiation-induced cystitis to address this gap in literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The protocol was registered in PROSPERO, and searches were performed in PubMed, Embase and Web of Science databases for pre-clinical rodent studies on radiation-induced cystitis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After de-duplication, 153 articles were screened for relevancy by title and abstract. Title and abstract screening deemed 64 studies irrelevant. The remaining 85 studies were full-text screened, yielding seven unique articles for data extraction. Most included studies had an unclear risk of bias. The findings of this systematic review suggest that the prognostic value of myeloid-lineage immune cells in radiation-induced cystitis is still unclear, indicating a need for further research in this field.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Although the studies reviewed provide some insight into the role of these immune cells in disease pathology, the limited number of studies and unclear risk of bias further highlights a need for additional, high-quality research in this area. In summary, this systematic review highlights a need to understand the involvement of immune cells in radiation-induced cystitis pathophysiology and lay the groundwork for further research in this area.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>PROSPERO registration: CRD42022345960<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11255-023-03748-1","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T19:01:59Z","timestamp":1692903719000},"page":"3005-3014","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effects of radiation on myeloid lineage immune cells within the rodent urinary bladder: a systematic review"],"prefix":"10.1007","volume":"55","author":[{"given":"Jessica","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rimaz","family":"Toto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-8301","authenticated-orcid":false,"given":"Christian","family":"Moro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"3748_CR1","doi-asserted-by":"publisher","first-page":"346812","DOI":"10.1155\/2015\/346812","volume":"2015","author":"C Browne","year":"2015","unstructured":"Browne C et al (2015) A Narrative review on the pathophysiology and management for radiation cystitis. Adv Urol 2015:346812","journal-title":"Adv Urol"},{"issue":"2","key":"3748_CR2","first-page":"119","volume":"27","author":"DZ Li","year":"2012","unstructured":"Li DZ et al (2012) Comparison of total body irradiation before and after chemotherapy in pretreatment for hematopoietic stem cell transplantation. Cancer Biother Radiopharm 27(2):119\u2013123","journal-title":"Cancer Biother Radiopharm"},{"key":"3748_CR3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.urology.2015.11.001","volume":"88","author":"BM Zwaans","year":"2016","unstructured":"Zwaans BM, Chancellor MB, Lamb LE (2016) Modeling and Treatment of Radiation Cystitis. Urology 88:14\u201321","journal-title":"Urology"},{"issue":"2","key":"3748_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4103\/0970-1591.65380","volume":"26","author":"R Manikandan","year":"2010","unstructured":"Manikandan R, Kumar S, Dorairajan LN (2010) Hemorrhagic cystitis: a challenge to the urologist. Ind J Urol 26(2):159\u2013166","journal-title":"Ind J Urol"},{"issue":"4","key":"3748_CR5","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.chom.2009.09.004","volume":"6","author":"CP Shelburne","year":"2009","unstructured":"Shelburne CP et al (2009) Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues. Cell Host Microbe 6(4):331\u2013342","journal-title":"Cell Host Microbe"},{"issue":"1","key":"3748_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/cells10010021","volume":"10","author":"C Helissey","year":"2020","unstructured":"Helissey C et al (2020) Chronic inflammation and radiation-induced cystitis: molecular background and therapeutic perspectives. Cells 10(1):21","journal-title":"Cells"},{"issue":"3","key":"3748_CR7","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.3390\/ijms23031836","volume":"23","author":"C Brossard","year":"2022","unstructured":"Brossard C et al (2022) Understanding molecular mechanisms and identifying key processes in chronic radiation cystitis. Int J Mol Sci 23(3):1836","journal-title":"Int J Mol Sci"},{"issue":"4","key":"3748_CR8","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.adro.2016.07.004","volume":"1","author":"BM Zwaans","year":"2016","unstructured":"Zwaans BM et al (2016) Modeling of chronic radiation-induced cystitis in mice. Adv Radiat Oncol 1(4):333\u2013343","journal-title":"Adv Radiat Oncol"},{"issue":"2","key":"3748_CR9","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.ajpath.2010.10.003","volume":"178","author":"K Blirando","year":"2011","unstructured":"Blirando K et al (2011) Mast cells are an essential component of human radiation proctitis and contribute to experimental colorectal damage in mice. Am J Pathol 178(2):640\u2013651","journal-title":"Am J Pathol"},{"key":"3748_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02470","author":"E Strattan","year":"2019","unstructured":"Strattan E et al (2019) Mast cells are mediators of fibrosis and effector cell recruitment in dermal chronic graft-vs-host disease. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2019.02470","journal-title":"Front Immunol"},{"issue":"5 Pt 1","key":"3748_CR11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1667\/0033-7587(2000)153[0533:ROMCIE]2.0.CO;2","volume":"153","author":"H Zheng","year":"2000","unstructured":"Zheng H, Wang J, Hauer-Jensen M (2000) Role of mast cells in early and delayed radiation injury in rat intestine. Radiat Res 153(5 Pt 1):533\u2013539","journal-title":"Radiat Res"},{"issue":"5","key":"3748_CR12","doi-asserted-by":"publisher","first-page":"e12475","DOI":"10.1111\/cpr.12475","volume":"51","author":"P Conti","year":"2018","unstructured":"Conti P et al (2018) Critical role of inflammatory mast cell in fibrosis: Potential therapeutic effect of IL-37. Cell Prolif 51(5):e12475","journal-title":"Cell Prolif"},{"issue":"1","key":"3748_CR13","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.5213\/inj.2040174.087","volume":"25","author":"SJ Kim","year":"2021","unstructured":"Kim SJ et al (2021) Irreversible bladder remodeling induced by fibrosis. Int Neurourol J 25(1):S3-7","journal-title":"Int Neurourol J"},{"issue":"4","key":"3748_CR14","first-page":"S7","volume":"37","author":"CH Fry","year":"2018","unstructured":"Fry CH et al (2018) Fibrosis and the bladder, implications for function ICI-RS 2017. Neurourol Urodyn 37(4):S7-s12","journal-title":"Neurourol Urodyn"},{"issue":"2","key":"3748_CR15","first-page":"57","volume":"18","author":"BM Zwaans","year":"2016","unstructured":"Zwaans BM et al (2016) Challenges and opportunities in radiation-induced hemorrhagic cystitis. Rev Urol 18(2):57\u201365","journal-title":"Rev Urol"},{"issue":"2","key":"3748_CR16","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1667\/RR14190.1","volume":"185","author":"KR Park","year":"2016","unstructured":"Park KR et al (2016) Mast cells contribute to radiation-induced vascular Hyperpermeability. Radiat Res 185(2):182\u2013189","journal-title":"Radiat Res"},{"key":"3748_CR17","doi-asserted-by":"publisher","first-page":"g7647","DOI":"10.1136\/bmj.g7647","volume":"349","author":"L Shamseer","year":"2015","unstructured":"Shamseer L et al (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ Brit Med J 349:g7647","journal-title":"BMJ Brit Med J"},{"issue":"1","key":"3748_CR18","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2288-14-43","volume":"14","author":"CR Hooijmans","year":"2014","unstructured":"Hooijmans CR et al (2014) SYRCLE\u2019s risk of bias tool for animal studies. BMC Med Res Methodol 14(1):43","journal-title":"BMC Med Res Methodol"},{"key":"3748_CR19","doi-asserted-by":"publisher","first-page":"106334","DOI":"10.1016\/j.intimp.2020.106334","volume":"83","author":"L Podmol\u00edkov\u00e1","year":"2020","unstructured":"Podmol\u00edkov\u00e1 L et al (2020) Radiation of the urinary bladder attenuates the development of lipopolysaccharide-induced cystitis. Int Immunopharmacol 83:106334","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"3748_CR20","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1111\/1440-1681.12583","volume":"43","author":"D Giglio","year":"2016","unstructured":"Giglio D et al (2016) Downregulation of toll-like receptor 4 and IL-6 following irradiation of the rat urinary bladder. Clin Exp Pharmacol Physiol 43(7):698\u2013705","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"5","key":"3748_CR21","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1080\/09553002.2021.2009145","volume":"98","author":"Y Ito","year":"2022","unstructured":"Ito Y et al (2022) Ascorbic acid-2 glucoside mitigates intestinal damage during pelvic radiotherapy in a rat bladder tumor model. Int J Radiat Biol 98(5):942\u2013957","journal-title":"Int J Radiat Biol"},{"issue":"3","key":"3748_CR22","first-page":"1036","volume":"10","author":"YT Chen","year":"2018","unstructured":"Chen YT et al (2018) Extracorporeal shock wave markedly alleviates radiation-induced chronic cystitis in rat. Am J Transl Res 10(3):1036\u20131052","journal-title":"Am J Transl Res"},{"key":"3748_CR23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.micron.2013.01.001","volume":"47","author":"LM Barcellos","year":"2013","unstructured":"Barcellos LM et al (2013) Protective effects of l-glutamine on the bladder wall of rats submitted to pelvic radiation. Micron 47:18\u201323","journal-title":"Micron"},{"issue":"2","key":"3748_CR24","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/path.5830","volume":"256","author":"KA Lombardo","year":"2022","unstructured":"Lombardo KA et al (2022) BCG invokes superior STING-mediated innate immune response over radiotherapy in a carcinogen murine model of urothelial cancer. J Pathol 256(2):223\u2013234","journal-title":"J Pathol"},{"issue":"7","key":"3748_CR25","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.3324\/haematol.2009.016758","volume":"95","author":"P Silva Lde","year":"2010","unstructured":"Silva Lde P et al (2010) Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type. Haematologica 95(7):1183\u20131190","journal-title":"Haematologica"},{"issue":"6","key":"3748_CR26","doi-asserted-by":"publisher","first-page":"4953","DOI":"10.1007\/s00520-022-06916-8","volume":"30","author":"E Galli","year":"2022","unstructured":"Galli E et al (2022) Hemorrhagic cystitis in allogeneic stem cell transplantation: a role for age and prostatic hyperplasia. Supp Care Cancer 30(6):4953\u20134959","journal-title":"Supp Care Cancer"},{"issue":"3","key":"3748_CR27","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1152\/ajpcell.00102.2019","volume":"317","author":"Z Wu","year":"2019","unstructured":"Wu Z et al (2019) Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic E coli infection. Am J Physiol-Cell Physiol 317(3):544\u2013555","journal-title":"Am J Physiol-Cell Physiol"},{"issue":"7","key":"3748_CR28","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1038\/sj.bjp.0702223","volume":"125","author":"S He","year":"1998","unstructured":"He S, Walls AF (1998) Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo. Br J Pharmacol 125(7):1491\u20131500","journal-title":"Br J Pharmacol"},{"issue":"4","key":"3748_CR29","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00418-019-01803-6","volume":"152","author":"D Atiakshin","year":"2019","unstructured":"Atiakshin D, Buchwalow I, Tiemann M (2019) Mast cell chymase: morphofunctional characteristics. Histochem Cell Biol 152(4):253\u2013269","journal-title":"Histochem Cell Biol"},{"issue":"6","key":"3748_CR30","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1016\/j.immuni.2016.11.003","volume":"45","author":"HW Choi","year":"2016","unstructured":"Choi HW et al (2016) Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules. Immunity 45(6):1258\u20131269","journal-title":"Immunity"},{"key":"3748_CR31","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.4049\/jimmunol.179.5.3276","volume":"179","author":"BP Soule","year":"2007","unstructured":"Soule BP et al (2007) Effects of gamma radiation on Fc\u03b5RI and TLR-mediated mast cell activation. J Immunol 179:3276","journal-title":"J Immunol"},{"key":"3748_CR32","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/jrr\/rrv061","volume":"56","author":"S Murakami","year":"2015","unstructured":"Murakami S et al (2015) Effects of ionizing radiation on differentiation of murine bone marrow cells into mast cells. J Rad Res 56:865","journal-title":"J Rad Res"},{"issue":"10","key":"3748_CR33","doi-asserted-by":"publisher","first-page":"e1494488","DOI":"10.1080\/2162402X.2018.1494488","volume":"7","author":"L Meziani","year":"2018","unstructured":"Meziani L, Deutsch E, Mondini M (2018) Macrophages in radiation injury: a new therapeutic target. Oncoimmunology 7(10):e1494488","journal-title":"Oncoimmunology"},{"issue":"4","key":"3748_CR34","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.jpurol.2009.02.199","volume":"5","author":"DB Decker","year":"2009","unstructured":"Decker DB, Karam JA, Wilcox DT (2009) Pediatric hemorrhagic cystitis. J Pediatr Urol 5(4):254\u2013264","journal-title":"J Pediatr Urol"},{"issue":"2","key":"3748_CR35","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4103\/0970-1591.65380","volume":"26","author":"R Manikandan","year":"2010","unstructured":"Manikandan R, Kumar S, Dorairajan LN (2010) Hemorrhagic cystitis: a challenge to the urologist. Indian J Urol 26(2):159\u2013166","journal-title":"Indian J Urol"},{"issue":"1","key":"3748_CR36","doi-asserted-by":"publisher","first-page":"903","DOI":"10.3390\/curroncol28010089","volume":"28","author":"M Sabloff","year":"2021","unstructured":"Sabloff M et al (2021) Total body irradiation for hematopoietic stem cell transplantation: what can we agree on? Curr Oncol 28(1):903\u2013917","journal-title":"Curr Oncol"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-023-03748-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-023-03748-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-023-03748-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T13:20:56Z","timestamp":1698412856000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-023-03748-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":36,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3748"],"URL":"https:\/\/doi.org\/10.1007\/s11255-023-03748-1","relation":{},"ISSN":["1573-2584"],"issn-type":[{"type":"electronic","value":"1573-2584"}],"subject":[],"published":{"date-parts":[[2023,8,24]]},"assertion":[{"value":"15 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Permission to reproduce material from other sources"}}]}}