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The patients were randomly divided into two equal groups. Group A (silodosin group) included patients in whom F-URS was done with daily preoperative intake of 8\u00a0mg silodosin for 1 week and group B (placebo\/control group) included patients in whom F-URS was done with daily preoperative intake of placebo tablets.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In group A, a total of 23 (33.3%) experienced ureteral wall injury following UAS insertion, while in group B, this occurred in 40 patients (59.7%). There was a statistically significant difference in the grade of ureteral wall injury between the two groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the multiple regression analysis, age, operative time and silodosin were found to be significant risk factors for ureteral wall injury (<jats:italic>P<\/jats:italic>\u2009=\u20090.007, 0.041 and\u2009&lt;\u20090.001, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The administration of silodosin prior to retrograde intrarenal surgery (RIRS) effectively prevented significant ureteral wall damage and reduced initial postoperative discomfort.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11255-023-03824-6","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:02:22Z","timestamp":1698656542000},"page":"839-846","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Does preoperative silodosin administration facilitate ureteral dilatation during flexible ureterorenoscopy? A randomized clinical trial"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9936-567X","authenticated-orcid":false,"given":"Tamer","family":"Diab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"El-Shaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab","family":"El-Barky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abou","family":"Elezz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"3824_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.euros.2021.10.008","volume":"35","author":"J Lang","year":"2022","unstructured":"Lang J, Narendrula A, El-Zawahry A, Sindhwani P, Ekwenna O (2022) Global trends in incidence and burden of urolithiasis from 1990 to 2019: an analysis of global burden of disease study data. 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