{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:16:54Z","timestamp":1784891814940,"version":"3.55.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171285"],"award-info":[{"award-number":["32171285"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32101206"],"award-info":[{"award-number":["32101206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2023YFS0025"],"award-info":[{"award-number":["2023YFS0025"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2023YFS0102"],"award-info":[{"award-number":["2023YFS0102"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2023HXFH044"],"award-info":[{"award-number":["2023HXFH044"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Numerous observational epidemiological studies have reported a bidirectional relationship between periodontitis and urological cancers. However, the causal link between these two phenotypes remains uncertain. This study aimed to examine the bidirectional causal association between periodontitis and four types of urological tumors, specifically kidney cancer (KC), prostate cancer (PC), bladder cancer (BC), and testis cancer (TC).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Based on large-scale genome-wide association study (GWAS) data, we utilized the two-sample Mendelian randomization (MR) approach to evaluate causal relationships between periodontitis and urological cancers. Several MR methods covering various consistency assumptions were applied in this study, including contamination mixture and Robust Adjusted Profile Score to obtain robust results. Summary-level data of individuals with European ancestry were extracted from the UK Biobank, the Kaiser GERA cohorts, and the FinnGen consortium.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Our findings revealed significant positive genetic correlations between periodontitis and kidney cancer (OR 1.287; 95% CI 1.04, 1.594; <jats:italic>P<\/jats:italic>\u2009=\u20090.020). We did not find a significant association of periodontitis on prostate cancer, bladder cancer, and testis cancer. In reverse MR, no significant results were observed supporting the effect of urologic cancers on periodontitis (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our study provides the\u00a0evidence of a potential causal relationship between periodontitis and kidney cancer. However, large-scale studies are warranted to confirm and elucidate the underlying mechanisms of this association.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11255-023-03858-w","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T13:02:57Z","timestamp":1701176577000},"page":"1243-1251","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patients with periodontitis might increase the risk of urologic cancers: a bidirectional two-sample Mendelian randomization study"],"prefix":"10.1007","volume":"56","author":[{"given":"Bojia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banghua","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-2314","authenticated-orcid":false,"given":"Jin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"issue":"1","key":"3858_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin 72(1):7\u201333","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"3858_CR2","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.eururo.2015.10.024","volume":"69","author":"J Leal","year":"2016","unstructured":"Leal J, Luengo-Fernandez R, Sullivan R, Witjes JA (2016) Economic burden of bladder cancer across the European Union. Eur Urol 69(3):438\u2013447","journal-title":"Eur Urol"},{"issue":"12","key":"3858_CR3","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/S1470-2045(13)70442-X","volume":"14","author":"R Luengo-Fernandez","year":"2013","unstructured":"Luengo-Fernandez R, Leal J, Gray A, Sullivan R (2013) Economic burden of cancer across the European Union: a population-based cost analysis. Lancet Oncol 14(12):1165\u20131174","journal-title":"Lancet Oncol"},{"issue":"22","key":"3858_CR4","doi-asserted-by":"publisher","first-page":"9575","DOI":"10.7314\/APJCP.2014.15.22.9575","volume":"15","author":"M Daniyal","year":"2014","unstructured":"Daniyal M, Siddiqui ZA, Akram M, Asif HM, Sultana S, Khan A (2014) Epidemiology, etiology, diagnosis and treatment of prostate cancer. Asian Pacific J Cancer Prevent 15(22):9575\u20139578","journal-title":"Asian Pacific J Cancer Prevent"},{"issue":"5","key":"3858_CR5","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nrurol.2010.46","volume":"7","author":"WH Chow","year":"2010","unstructured":"Chow WH, Dong LM, Devesa SS (2010) Epidemiology and risk factors for kidney cancer. Nat Rev Urol 7(5):245\u2013257","journal-title":"Nat Rev Urol"},{"issue":"19","key":"3858_CR6","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1001\/jama.2020.17598","volume":"324","author":"AT Lenis","year":"2020","unstructured":"Lenis AT, Lec PM, Chamie K, Mshs MD (2020) Bladder cancer: a review. JAMA 324(19):1980\u20131991","journal-title":"JAMA"},{"issue":"1","key":"3858_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41572-018-0029-0","volume":"4","author":"L Cheng","year":"2018","unstructured":"Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ (2018) Testicular cancer. Nat Rev Dis Primers 4(1):29","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"3858_CR8","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"3858_CR9","doi-asserted-by":"publisher","first-page":"e459","DOI":"10.4317\/medoral.24308","volume":"26","author":"Y Wei","year":"2021","unstructured":"Wei Y, Zhong Y, Wang Y, Huang R (2021) Association between periodontal disease and prostate cancer: a systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal 26(4):e459\u2013e465","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"16","key":"3858_CR10","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.7150\/ijms.46812","volume":"17","author":"H Ma","year":"2020","unstructured":"Ma H, Zheng J, Li X (2020) Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population. Int J Med Sci 17(16):2531\u20132543","journal-title":"Int J Med Sci"},{"issue":"6","key":"3858_CR11","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1590\/s1677-5538.ibju.2020.0333","volume":"47","author":"Z Guo","year":"2021","unstructured":"Guo Z, Gu C, Li S, Gan S, Li Y, Xiang S, Gong L, Wang S (2021) Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies. Int Braz J Urol 47(6):1120\u20131130","journal-title":"Int Braz J Urol"},{"issue":"16","key":"3858_CR12","doi-asserted-by":"publisher","first-page":"4716","DOI":"10.7150\/jca.45369","volume":"11","author":"DH Kim","year":"2020","unstructured":"Kim DH, Jeong SN, Lee JH (2020) Chronic periodontal disease increases risk for prostate cancer in elderly individuals in South Korea: a retrospective nationwide population-based cohort study. J Cancer 11(16):4716\u20134723","journal-title":"J Cancer"},{"issue":"4","key":"3858_CR13","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s10552-020-01274-4","volume":"31","author":"H Oh","year":"2020","unstructured":"Oh H, Lee DH, Giovannucci EL, Keum N (2020) Gastric and duodenal ulcers, periodontal disease, and risk of bladder cancer in the Health Professionals Follow-up Study. Cancer Causes Control 31(4):383\u2013391","journal-title":"Cancer Causes Control"},{"issue":"5","key":"3858_CR14","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1902\/jop.2001.72.5.688","volume":"72","author":"A de Courten","year":"2001","unstructured":"de Courten A, Irle C, Samson J, Lombardi T (2001) Metastatic transitional cell carcinoma of the urinary bladder presenting as a mandibular gingival swelling. J Periodontol 72(5):688\u2013690","journal-title":"J Periodontol"},{"issue":"9","key":"3858_CR15","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1600-0714.1993.tb00128.x","volume":"22","author":"A Hirshberg","year":"1993","unstructured":"Hirshberg A, Leibovich P, Buchner A (1993) Metastases to the oral mucosa: analysis of 157 cases. J Oral Pathol Med 22(9):385\u2013390","journal-title":"J Oral Pathol Med"},{"issue":"18","key":"3858_CR16","doi-asserted-by":"publisher","first-page":"10571","DOI":"10.3390\/ijms231810571","volume":"23","author":"B Gajewska","year":"2022","unstructured":"Gajewska B, \u015aliwi\u0144ska-Mosso\u0144 M (2022) Association of MMP-2 and MMP-9 polymorphisms with diabetes and pathogenesis of diabetic complications. Int J Mol Sci 23(18):10571","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3858_CR17","doi-asserted-by":"publisher","first-page":"24812","DOI":"10.1038\/srep24812","volume":"6","author":"H Weng","year":"2016","unstructured":"Weng H, Yan Y, Jin Y-H, Meng X-Y, Mo Y-Y, Zeng X-T (2016) Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals. Sci Rep 6(1):24812","journal-title":"Sci Rep"},{"issue":"16","key":"3858_CR18","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1001\/jama.2021.18236","volume":"326","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, VanderWeele TJ, Higgins JPT, Timpson NJ, Dimou N, Langenberg C, Golub RM, Loder EW, Gallo V, Tybjaerg-Hansen A, Davey Smith G, Egger M, Richards JB (2021) Strengthening the reporting of observational studies in epidemiology using mendelian randomization: the STROBE-MR statement. JAMA 326(16):1614\u20131621","journal-title":"JAMA"},{"issue":"R1","key":"3858_CR19","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","volume":"23","author":"G Davey Smith","year":"2014","unstructured":"Davey Smith G, Hemani G (2014) Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23(R1):R89-98","journal-title":"Hum Mol Genet"},{"issue":"4","key":"3858_CR20","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/jrsm.1346","volume":"10","author":"J Bowden","year":"2019","unstructured":"Bowden J, Holmes MV (2019) Meta-analysis and mendelian randomization: a review. Res Synth Methods 10(4):486\u2013496","journal-title":"Res Synth Methods"},{"issue":"11","key":"3858_CR21","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1111\/jcpe.13544","volume":"48","author":"SE Baumeister","year":"2021","unstructured":"Baumeister SE, Freuer D, Nolde M, Kocher T, Baurecht H, Khazaei Y, Ehmke B, Holtfreter B (2021) Testing the association between tobacco smoking, alcohol consumption, and risk of periodontitis: a mendelian randomization study. J Clin Periodontol 48(11):1414\u20131420","journal-title":"J Clin Periodontol"},{"issue":"1","key":"3858_CR22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/ijc.30436","volume":"140","author":"C Brunner","year":"2017","unstructured":"Brunner C, Davies NM, Martin RM, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles G, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Donovan J, Hamdy FC, Pashayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park J, Kaneva R, Batra J, Teixeira MR, Pandha H, Consortium P, Zuccolo L (2017) Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study. Int J Cancer 140(1):75\u201385","journal-title":"Int J Cancer"},{"key":"3858_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10630-1","author":"D Shungin","year":"2019","unstructured":"Shungin D, Hawort S, Divaris K, Agler CS, Kamatani Y, Lee MK, Grinde K, Hindy G, Alaraudanjoki V, Pesonen P, Teumer A, Holtfreter B, Sakaue S, Hirata J, Yu Y-H, Ridker PM, Giulianini F, Chasman DI, Magnusson PKE, Sudo T, Okada Y, Voelker U, Kocher T, Anttonen V, Laitala M-L, Orho-Melander M, Sofer T, Shaffer JR, Vieira A, Marazita ML, Kubo M, Furuichi Y, North KE, Offenbacher S, Ingelsson E, Franks PW, Timpson NJ, Johansson I (2019) Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-019-10630-1","journal-title":"Nat Commun"},{"issue":"7","key":"3858_CR24","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/s41588-018-0142-8","volume":"50","author":"FR Schumacher","year":"2018","unstructured":"Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M, Saunders EJ, Dadaev T, Leongamornlert D, Anokian E, Cieza-Borrella C, Goh C, Brook MN, Sheng X, Fachal L, Dennis J, Tyrer J, Muir K, Lophatananon A, Stevens VL, Gapstur SM, Carter BD, Tangen CM, Goodman PJ, Thompson IM Jr, Batra J, Chambers S, Moya L, Clements J, Horvath L, Tilley W, Risbridger GP, Gronberg H, Aly M, Nordstrom T, Pharoah P, Pashayan N, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Albanes D, Weinstein S, Wolk A, Hakansson N, West CML, Dunning AM, Burnet N, Mucci LA, Giovannucci E, Andriole GL, Cussenot O, Cancel-Tassin G, Koutros S, Freeman LEB, Sorensen KD, Orntoft TF, Borre M, Maehle L, Grindedal EM, Neal DE, Donovan JL, Hamdy FC, Martin RM, Travis RC, Key TJ, Hamilton RJ, Fleshner NE, Finelli A, Ingles SA, Stern MC, Rosenstein BS, Kerns SL, Ostrer H, Lu Y-J, Zhang H-W, Feng N, Mao X, Guo X, Wang G, Sun Z, Giles GG, Southey MC, MacInnis RJ, FitzGerald LM, Kibel AS, Drake BF, Vega A, Gomez-Caamano A, Szulkin R, Eklund M, Kogevinas M, Llorca J, Castano-Vinyals G, Penney KL, Stampfer M, Park JY, Sellers TA, Lin H-Y, Stanford JL, Cybulski C, Wokolorczyk D, Lubinski J, Ostrander EA, Geybels MS, Nordestgaard BG, Nielsen SF, Weischer M, Bisbjerg R, Roder MA, Iversen P, Brenner H, Cuk K, Holleczek B, Maier C, Luedeke M, Schnoeller T, Kim J, Logothetis CJ, John EM, Teixeira MR, Paulo P, Cardoso M, Neuhausen SL, Steele L, Ding YC, De Ruyck K, De Meerleer G, Ost P, Razack A, Lim J, Teo S-H, Lin DW, Newcomb LF, Lessel D, Gamulin M, Kulis T, Kaneva R, Usmani N, Singhal S, Slavov C, Mitev V, Parliament M, Claessens F, Joniau S, Van den Broeck T, Larkin S, Townsend PA, Aukim-Hastie C, Dominguez MG, Castelao JE, Martinez ME, Roobol MJ, Jenster G, van Schaik RHN, Menegaux F, Truong T, Koudou YA, Xu J, Khaw K-T, Cannon-Albright L, Pandha H, Michael A, Thibodeau SN, McDonnell SK, Schaid DJ, Lindstrom S, Turman C, Ma J, Hunter DJ, Riboli E, Siddiq A, Canzian F, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Cui Z, Kraft P, Conti DV, Easton DF, Wiklund F, Chanock SJ, Henderson BE, Kote-Jarai Z, Haiman CA, Eeles RA, Profile S, Study I, Canary PI, Breast Prostate Canc Cohort, C.; As, P. P. C.; Canc Prostate Sweden, C.; Prostate Canc Genome-wide, A.; Genetic Assoc Mech Oncology, G (2018) Apcb; Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nat Genetics 50(7):928","journal-title":"Nat Genetics"},{"key":"3858_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18246-6","author":"SR Rashkin","year":"2020","unstructured":"Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH, Meyers TJ, Van den Eeden SK, Ziv E, Habel LA, Hoffmann TJ, Sakoda LC, Witte JS (2020) Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-020-18246-6","journal-title":"Nat Commun"},{"issue":"17","key":"3858_CR26","first-page":"2190","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer CJ, Li Y, Abecasis GR (2010) METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (Oxford, England) 26(17):2190\u20132191","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"1","key":"3858_CR27","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/s41467-019-14156-4","volume":"11","author":"S Burgess","year":"2020","unstructured":"Burgess S, Foley CN, Allara E, Staley JR, Howson JMM (2020) A robust and efficient method for Mendelian randomization with hundreds of genetic variants. Nat Commun 11(1):376","journal-title":"Nat Commun"},{"key":"3858_CR28","doi-asserted-by":"publisher","DOI":"10.1214\/19-AOS1866","author":"Q Zhao","year":"2018","unstructured":"Zhao Q, Wang J, Hemani G, Bowden J, Small DS (2018) Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score. Ann Stat. https:\/\/doi.org\/10.1214\/19-AOS1866","journal-title":"Ann Stat"},{"issue":"11","key":"3858_CR29","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1002\/sim.6835","volume":"35","author":"S Burgess","year":"2016","unstructured":"Burgess S, Dudbridge F, Thompson SG (2016) Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods. Stat Med 35(11):1880\u20131906","journal-title":"Stat Med"},{"issue":"7","key":"3858_CR30","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","volume":"30","author":"S Burgess","year":"2015","unstructured":"Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG (2015) Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30(7):543\u2013552","journal-title":"Eur J Epidemiol"},{"issue":"5","key":"3858_CR31","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","volume":"32","author":"S Burgess","year":"2017","unstructured":"Burgess S, Thompson SG (2017) Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol 32(5):377\u2013389","journal-title":"Eur J Epidemiol"},{"issue":"4","key":"3858_CR32","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/gepi.22295","volume":"44","author":"EAW Slob","year":"2020","unstructured":"Slob EAW, Burgess S (2020) A comparison of robust Mendelian randomization methods using summary data. Genet Epidemiol 44(4):313\u2013329","journal-title":"Genet Epidemiol"},{"issue":"4","key":"3858_CR33","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1007\/s40120-022-00398-w","volume":"11","author":"R Abuduxukuer","year":"2022","unstructured":"Abuduxukuer R, Niu PP, Guo ZN, Xu YM, Yang Y (2022) Circulating insulin-like growth factor 1 levels and migraine risk: a Mendelian randomization study. Neurol Ther 11(4):1677\u20131689","journal-title":"Neurol Ther"},{"issue":"14","key":"3858_CR34","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1017\/S0033291719002678","volume":"50","author":"RE Wootton","year":"2020","unstructured":"Wootton RE, Richmond RC, Stuijfzand BG, Lawn RB, Sallis HM, Taylor GMJ, Hemani G, Jones HJ, Zammit S, Davey Smith G, Munaf\u00f2 MR (2020) Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study. Psychol Med 50(14):2435\u20132443","journal-title":"Psychol Med"},{"issue":"9","key":"3858_CR35","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1007\/s00125-022-05725-2","volume":"65","author":"Y Wei","year":"2022","unstructured":"Wei Y, Zhan Y, L\u00f6fvenborg JE, Tuomi T, Carlsson S (2022) Birthweight, BMI in adulthood and latent autoimmune diabetes in adults: a Mendelian randomisation study. Diabetologia 65(9):1510\u20131518","journal-title":"Diabetologia"},{"issue":"6","key":"3858_CR36","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/S1470-2045(08)70106-2","volume":"9","author":"DS Michaud","year":"2008","unstructured":"Michaud DS, Liu Y, Meyer M, Giovannucci E, Joshipura K (2008) Periodontal disease, tooth loss, and cancer risk in male health professionals: a prospective cohort study. Lancet Oncol 9(6):550\u2013558","journal-title":"Lancet Oncol"},{"issue":"8","key":"3858_CR37","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1158\/1055-9965.EPI-17-0212","volume":"26","author":"NN Nwizu","year":"2017","unstructured":"Nwizu NN, Marshall JR, Moysich K, Genco RJ, Hovey KM, Mai X, LaMonte MJ, Freudenheim JL, Wactawski-Wende J (2017) Periodontal disease and incident cancer risk among postmenopausal women: results from the women\u2019s health initiative observational cohort. Cancer Epidemiol Biomark Prevent 26(8):1255\u20131265","journal-title":"Cancer Epidemiol Biomark Prevent"},{"issue":"4","key":"3858_CR38","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1093\/qjmed\/hct248","volume":"107","author":"BW Wen","year":"2014","unstructured":"Wen BW, Tsai CS, Lin CL, Chang YJ, Lee CF, Hsu CH, Kao CH (2014) Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study. QJM 107(4):283\u2013290","journal-title":"QJM"},{"issue":"12","key":"3858_CR39","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1080\/03007995.2017.1354829","volume":"33","author":"O Dizdar","year":"2017","unstructured":"Dizdar O, Hayran M, Guven DC, Y\u0131lmaz TB, Taheri S, Akman AC, Bilgin E, H\u00fcseyin B, Berker E (2017) Increased cancer risk in patients with periodontitis. Curr Med Res Opin 33(12):2195\u20132200","journal-title":"Curr Med Res Opin"},{"issue":"3","key":"3858_CR40","doi-asserted-by":"publisher","first-page":"826","DOI":"10.3906\/sag-1812-8","volume":"49","author":"DC G\u00fcven","year":"2019","unstructured":"G\u00fcven DC, Dizdar \u00d6, Akman AC, Berker E, Yeked\u00fcz E, Ceylan F, Ba\u015fp\u0131nar B, Akb\u0131y\u0131k \u0130, Akta\u015f BY, Y\u00fcce D, Erman M, Hayran M (2019) Evaluation of cancer risk in patients with periodontal diseases. Turkish J Med Sci 49(3):826\u2013831","journal-title":"Turkish J Med Sci"},{"issue":"5","key":"3858_CR41","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1093\/annonc\/mdw028","volume":"27","author":"DS Michaud","year":"2016","unstructured":"Michaud DS, Kelsey KT, Papathanasiou E, Genco CA, Giovannucci E (2016) Periodontal disease and risk of all cancers among male never smokers: an updated analysis of the Health Professionals Follow-up Study. Ann Oncol 27(5):941\u2013947","journal-title":"Ann Oncol"},{"issue":"8","key":"3858_CR42","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1093\/jnci\/djx278","volume":"110","author":"DS Michaud","year":"2018","unstructured":"Michaud DS, Lu J, Peacock-Villada AY, Barber JR, Joshu CE, Prizment AE, Beck JD, Offenbacher S, Platz EA (2018) Periodontal disease assessed using clinical dental measurements and cancer risk in the ARIC study. J Natl Cancer Inst 110(8):843\u2013854","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"3858_CR43","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1158\/1055-9965.EPI-07-2761","volume":"17","author":"A Hiraki","year":"2008","unstructured":"Hiraki A, Matsuo K, Suzuki T, Kawase T, Tajima K (2008) Teeth loss and risk of cancer at 14 common sites in Japanese. Cancer Epidemiol Biomark Prevent 17(5):1222\u20131227","journal-title":"Cancer Epidemiol Biomark Prevent"},{"key":"3858_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.901098","volume":"12","author":"EH Kim","year":"2022","unstructured":"Kim EH, Nam S, Park CH, Kim Y, Lee M, Ahn JB, Shin SJ, Park YR, Jung HI, Kim BI, Jung I, Kim HS (2022) Periodontal disease and cancer risk: a nationwide population-based cohort study. Front Oncol 12:901098","journal-title":"Front Oncol"},{"issue":"2","key":"3858_CR45","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1093\/aje\/kwp340","volume":"171","author":"M Arora","year":"2010","unstructured":"Arora M, Weuve J, Fall K, Pedersen NL, Mucci LA (2010) An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. Am J Epidemiol 171(2):253\u2013259","journal-title":"Am J Epidemiol"},{"issue":"1","key":"3858_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12221","volume":"75","author":"J Slots","year":"2017","unstructured":"Slots J (2017) Periodontitis: facts, fallacies and the future. Periodontol 2000 75(1):7\u201323","journal-title":"Periodontol 2000"},{"issue":"1","key":"3858_CR47","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1902\/annals.2003.8.1.54","volume":"8","author":"FA Scannapieco","year":"2003","unstructured":"Scannapieco FA, Bush RB, Paju S (2003) Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease. A systematic review. Ann Periodontol 8(1):54\u201369","journal-title":"Ann Periodontol"},{"issue":"2","key":"3858_CR48","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jdent.2009.10.007","volume":"38","author":"SG Fitzpatrick","year":"2010","unstructured":"Fitzpatrick SG, Katz J (2010) The association between periodontal disease and cancer: a review of the literature. J Dent 38(2):83\u201395","journal-title":"J Dent"},{"issue":"9","key":"3858_CR49","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1902\/jop.2017.160477","volume":"88","author":"J Estemalik","year":"2017","unstructured":"Estemalik J, Demko C, Bissada NF, Joshi N, Bodner D, Shankar E, Gupta S (2017) Simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases. J Periodontol 88(9):823\u2013829","journal-title":"J Periodontol"},{"issue":"1","key":"3858_CR50","first-page":"54","volume":"8","author":"S Yuan","year":"2021","unstructured":"Yuan S, Fang C, Leng WD, Wu L, Li BH, Wang XH, Hu H, Zeng XT (2021) Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers. Mil Med Res 8(1):54","journal-title":"Mil Med Res"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-023-03858-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-023-03858-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-023-03858-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T19:06:40Z","timestamp":1710184000000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-023-03858-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["3858"],"URL":"https:\/\/doi.org\/10.1007\/s11255-023-03858-w","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,28]]},"assertion":[{"value":"11 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}