{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:59:47Z","timestamp":1773262787022,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK103435"],"award-info":[{"award-number":["DK103435"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM103444"],"award-info":[{"award-number":["GM103444"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2139915"],"award-info":[{"award-number":["2139915"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-023-03900-x","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T15:02:13Z","timestamp":1703257333000},"page":"1565-1575","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enzyme-induced hypoxia leads to inflammation in urothelial cells in vitro"],"prefix":"10.1007","volume":"56","author":[{"given":"Britney N.","family":"Hudson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Todd","family":"Purves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis M.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0162-8943","authenticated-orcid":false,"given":"Jiro","family":"Nagatomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"3900_CR1","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1111\/j.1464-410X.2010.09993.x","volume":"108","author":"DE Irwin","year":"2011","unstructured":"Irwin DE, Kopp ZS, Agatep B et al (2011) Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU Int 108:1132\u20131138. https:\/\/doi.org\/10.1111\/j.1464-410X.2010.09993.x","journal-title":"BJU Int"},{"key":"3900_CR2","first-page":"S14","volume":"7","author":"VW Nitti","year":"2005","unstructured":"Nitti VW (2005) Pressure flow urodynamic studies: the gold standard for diagnosing bladder outlet obstruction. Rev Urol 7:S14\u2013S21","journal-title":"Rev Urol"},{"key":"3900_CR3","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1111\/j.1464-410X.2010.09445.x","volume":"106","author":"PD Metcalfe","year":"2010","unstructured":"Metcalfe PD, Wang J, Jiao H et al (2010) Bladder outlet obstruction: progression from inflammation to fibrosis. BJU Int 106:1686\u20131694. https:\/\/doi.org\/10.1111\/j.1464-410X.2010.09445.x","journal-title":"BJU Int"},{"key":"3900_CR4","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.juro.2015.12.068","volume":"195","author":"FM Hughes","year":"2016","unstructured":"Hughes FM, Hill HM, Wood CM et al (2016) The NLRP3 inflammasome mediates inflammation produced by bladder outlet obstruction. J Urol 195:1598\u20131605. https:\/\/doi.org\/10.1016\/j.juro.2015.12.068","journal-title":"J Urol"},{"key":"3900_CR5","doi-asserted-by":"publisher","first-page":"F603","DOI":"10.1152\/ajprenal.00128.2017","volume":"313","author":"FM Hughes","year":"2017","unstructured":"Hughes FM, Sexton SJ, Jin H et al (2017) Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1\u03b2. Am J Physiol Renal Physiol 313:F603\u2013F610. https:\/\/doi.org\/10.1152\/ajprenal.00128.2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"3900_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328","author":"N Kelley","year":"2019","unstructured":"Kelley N, Jeltema D, Duan Y, He Y (2019) The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20133328","journal-title":"Int J Mol Sci"},{"key":"3900_CR7","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1089\/ars.2014.5994","volume":"22","author":"JM Abais","year":"2015","unstructured":"Abais JM, Xia M, Zhang Y et al (2015) Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector? Antioxid Redox Signal 22:1111\u20131129. https:\/\/doi.org\/10.1089\/ars.2014.5994","journal-title":"Antioxid Redox Signal"},{"key":"3900_CR8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/cmi.2015.95","volume":"13","author":"E-K Jo","year":"2016","unstructured":"Jo E-K, Kim JK, Shin D-M, Sasakawa C (2016) Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol 13:148\u2013159. https:\/\/doi.org\/10.1038\/cmi.2015.95","journal-title":"Cell Mol Immunol"},{"key":"3900_CR9","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s11255-018-1948-0","volume":"50","author":"CL Dunton","year":"2018","unstructured":"Dunton CL, Purves JT, Hughes FM et al (2018) Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells. Int Urol Nephrol 50:1607\u20131617. https:\/\/doi.org\/10.1007\/s11255-018-1948-0","journal-title":"Int Urol Nephrol"},{"key":"3900_CR10","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1007\/s11255-021-02942-3","volume":"53","author":"CL Dunton","year":"2021","unstructured":"Dunton CL, Purves JT, Hughes FM, Nagatomi J (2021) BOO induces fibrosis and EMT in urothelial cells which can be recapitulated in vitro through elevated storage and voiding pressure cycles. Int Urol Nephrol 53:2007\u20132018. https:\/\/doi.org\/10.1007\/s11255-021-02942-3","journal-title":"Int Urol Nephrol"},{"key":"3900_CR11","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/j.1464-410X.2008.07593.x","volume":"102","author":"G Koritsiadis","year":"2008","unstructured":"Koritsiadis G, Stravodimos K, Koutalellis G et al (2008) Immunohistochemical estimation of hypoxia in human obstructed bladder and correlation with clinical variables. BJU Int 102:328\u2013332. https:\/\/doi.org\/10.1111\/j.1464-410X.2008.07593.x","journal-title":"BJU Int"},{"key":"3900_CR12","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1097\/01.LAB.0000021135.87203.92","volume":"82","author":"MA Ghafar","year":"2002","unstructured":"Ghafar MA, Anastasiadis AG, Olsson LE et al (2002) Hypoxia and an angiogenic response in the partially obstructed rat bladder. Lab Invest 82:903\u2013909. https:\/\/doi.org\/10.1097\/01.LAB.0000021135.87203.92","journal-title":"Lab Invest"},{"key":"3900_CR13","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/S0022-5347(05)65354-2","volume":"167","author":"MA Ghafar","year":"2002","unstructured":"Ghafar MA, Shabsigh A, Chichester P et al (2002) Effects of chronic partial outlet obstruction on blood flow and oxygenation of the rat bladder. J Urol 167:1508\u20131512","journal-title":"J Urol"},{"key":"3900_CR14","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1046\/j.1464-410X.2000.00611.x","volume":"85","author":"JE Greenland","year":"2000","unstructured":"Greenland JE, Hvistendahl JJ, Andersen H et al (2000) The effect of bladder outlet obstruction on tissue oxygen tension and blood flow in the pig bladder. BJU Int 85:1109\u20131114. https:\/\/doi.org\/10.1046\/j.1464-410X.2000.00611.x","journal-title":"BJU Int"},{"key":"3900_CR15","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1046\/j.1464-410x.2000.00519.x","volume":"85","author":"G Hohlbrugger","year":"2000","unstructured":"Hohlbrugger G, Frauscher F, Strasser H et al (2000) Evidence for the autoregulation of vesical circulation by intravesical potassium chloride and distension in the normal human bladder. BJU Int 85:412\u2013415. https:\/\/doi.org\/10.1046\/j.1464-410x.2000.00519.x","journal-title":"BJU Int"},{"key":"3900_CR16","doi-asserted-by":"publisher","first-page":"233","DOI":"10.2147\/RRU.S205383","volume":"11","author":"AI Volikova","year":"2019","unstructured":"Volikova AI, Marshall BJ, Yin JMA et al (2019) Structural, biomechanical and hemodynamic assessment of the bladder wall in healthy subjects. Res Rep Urol 11:233\u2013245. https:\/\/doi.org\/10.2147\/RRU.S205383","journal-title":"Res Rep Urol"},{"key":"3900_CR17","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0090-4295(03)00510-7","volume":"62","author":"A Belenky","year":"2003","unstructured":"Belenky A, Abarbanel Y, Cohen M et al (2003) Detrusor resistive index evaluated by doppler ultrasonography as a potential indicator of bladder outlet obstruction. Urology 62:647\u2013650. https:\/\/doi.org\/10.1016\/S0090-4295(03)00510-7","journal-title":"Urology"},{"key":"3900_CR18","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/S0022-5347(01)66471-1","volume":"155","author":"JE Batista","year":"1996","unstructured":"Batista JE, Wagner JR, Azadzoi KM et al (1996) Direct measurement of blood flow in the human bladder. J Urol 155:630\u2013633. https:\/\/doi.org\/10.1016\/S0022-5347(01)66471-1","journal-title":"J Urol"},{"key":"3900_CR19","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0022-5347(05)64843-4","volume":"168","author":"RT Kershen","year":"2002","unstructured":"Kershen RT, Azadzoi KM, Siroky MB (2002) Blood flow, pressure and compliance in the male human bladder. J Urol 168:121\u2013125. https:\/\/doi.org\/10.1016\/S0022-5347(05)64843-4","journal-title":"J Urol"},{"key":"3900_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s11626-0jiji16-0085-2","volume":"53","author":"B Wiafe","year":"2017","unstructured":"Wiafe B, Adesida A, Churchill T et al (2017) Hypoxia-increased expression of genes involved in inflammation, dedifferentiation, pro-fibrosis, and extracellular matrix remodeling of human bladder smooth muscle cells. In Vitro Cell Dev Biol Anim 53:58\u201366. https:\/\/doi.org\/10.1007\/s11626-0jiji16-0085-2","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"3900_CR21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.neuroscience.2020.09.036","volume":"448","author":"Q Jiang","year":"2020","unstructured":"Jiang Q, Geng X, Warren J et al (2020) Hypoxia inducible factor-1\u03b1 (HIF-1\u03b1) mediates NLRP3 inflammasome-dependent-pyroptotic and apoptotic cell death following ischemic stroke. Neuroscience 448:126\u2013139. https:\/\/doi.org\/10.1016\/j.neuroscience.2020.09.036","journal-title":"Neuroscience"},{"key":"3900_CR22","doi-asserted-by":"publisher","first-page":"2183026","DOI":"10.1155\/2016\/2183026","volume":"2016","author":"L Minutoli","year":"2016","unstructured":"Minutoli L, Puzzolo D, Rinaldi M et al (2016) ROS-mediated NLRP3 inflammasome activation in brain, heart, kidney, and testis ischemia\/reperfusion injury. Oxid Med Cell Longev 2016:2183026. https:\/\/doi.org\/10.1155\/2016\/2183026","journal-title":"Oxid Med Cell Longev"},{"key":"3900_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-022-01710-7","author":"X Xin","year":"2022","unstructured":"Xin X, Yang K, Liu H, Li Y (2022) Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation. Apoptosis. https:\/\/doi.org\/10.1007\/s10495-022-01710-7","journal-title":"Apoptosis"},{"key":"3900_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29659","author":"S Watanabe","year":"2020","unstructured":"Watanabe S, Usui-Kawanishi F, Karasawa T et al (2020) Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages. J Cell Physiol n\/a: https:\/\/doi.org\/10.1002\/jcp.29659","journal-title":"J Cell Physiol n\/a:"},{"key":"3900_CR25","doi-asserted-by":"publisher","first-page":"L1021","DOI":"10.1152\/ajplung.2001.281.4.L1021","volume":"281","author":"CB Allen","year":"2001","unstructured":"Allen CB, Schneider BK, White CW (2001) Limitations to oxygen diffusion and equilibration in in vitro cell exposure systems in hyperoxia and hypoxia. Am J Physiol-Lung Cell Mol Physiol 281:L1021\u2013L1027. https:\/\/doi.org\/10.1152\/ajplung.2001.281.4.L1021","journal-title":"Am J Physiol-Lung Cell Mol Physiol"},{"key":"3900_CR26","doi-asserted-by":"publisher","first-page":"15911","DOI":"10.1074\/jbc.M300463200","volume":"278","author":"Y Yuan","year":"2003","unstructured":"Yuan Y, Hilliard G, Ferguson T, Millhorn DE (2003) Cobalt inhibits the interaction between hypoxia-inducible factor-\u03b1 and von hippel-lindau protein by direct binding to hypoxia-inducible factor-\u03b1. J Biol Chem 278:15911\u201315916. https:\/\/doi.org\/10.1074\/jbc.M300463200","journal-title":"J Biol Chem"},{"key":"3900_CR27","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/jat.3749","volume":"39","author":"J Mu\u00f1oz-S\u00e1nchez","year":"2019","unstructured":"Mu\u00f1oz-S\u00e1nchez J, Ch\u00e1nez-C\u00e1rdenas ME (2019) The use of cobalt chloride as a chemical hypoxia model. J Appl Toxicol 39:556\u2013570. https:\/\/doi.org\/10.1002\/jat.3749","journal-title":"J Appl Toxicol"},{"key":"3900_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8050132","author":"Y Miyata","year":"2019","unstructured":"Miyata Y, Matsuo T, Mitsunari K et al (2019) A review of oxidative stress and urinary dysfunction caused by bladder outlet obstruction and treatments using antioxidants. Antioxidants. https:\/\/doi.org\/10.3390\/antiox8050132","journal-title":"Antioxidants"},{"key":"3900_CR29","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3390\/biom12030472","volume":"12","author":"JA Bauer","year":"2022","unstructured":"Bauer JA, Z\u00e1mock\u00e1 M, Majt\u00e1n J, Bauerov\u00e1-Hlinkov\u00e1 V (2022) Glucose oxidase, an enzyme \u201cferrari\u201d: its structure, function, production and properties in the light of various industrial and biotechnological applications. Biomolecules 12:472. https:\/\/doi.org\/10.3390\/biom12030472","journal-title":"Biomolecules"},{"key":"3900_CR30","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1667\/RR1431.1","volume":"170","author":"RP Baumann","year":"2008","unstructured":"Baumann RP, Penketh PG, Seow HA et al (2008) Generation of oxygen deficiency in cell culture using a two-enzyme system to evaluate agents targeting hypoxic tumor cells. Radiat Res 170:651\u2013660. https:\/\/doi.org\/10.1667\/RR1431.1","journal-title":"Radiat Res"},{"key":"3900_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s42247-019-00038-4","author":"BN Hudson","year":"2019","unstructured":"Hudson BN, Dawes CS, Liu H-Y et al (2019) Stabilization of enzyme-immobilized hydrogels for extended hypoxic cell culture. Emergent Mater. https:\/\/doi.org\/10.1007\/s42247-019-00038-4","journal-title":"Emergent Mater"},{"key":"3900_CR32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jbiotec.2017.03.007","volume":"248","author":"CS Dawes","year":"2017","unstructured":"Dawes CS, Konig H, Lin C-C (2017) Enzyme-immobilized hydrogels to create hypoxia for in vitro cancer cell culture. J Biotechnol 248:25\u201334. https:\/\/doi.org\/10.1016\/j.jbiotec.2017.03.007","journal-title":"J Biotechnol"},{"key":"3900_CR33","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1002\/ijc.2910550616","volume":"55","author":"H Kawamata","year":"1993","unstructured":"Kawamata H, Kameyama S, Nan L et al (1993) Effect of epidermal growth factor and transforming growth factor beta 1 on growth and invasive potentials of newly established rat bladder carcinoma cell lines. Int J Cancer 55:968\u2013973. https:\/\/doi.org\/10.1002\/ijc.2910550616","journal-title":"Int J Cancer"},{"key":"3900_CR34","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1007\/s11255-015-1126-6","volume":"47","author":"FM Hughes","year":"2015","unstructured":"Hughes FM, Turner DP, Purves JT (2015) The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells). Int Urol Nephrol 47:1953\u20131964. https:\/\/doi.org\/10.1007\/s11255-015-1126-6","journal-title":"Int Urol Nephrol"},{"key":"3900_CR35","doi-asserted-by":"publisher","first-page":"F299","DOI":"10.1152\/ajprenal.00297.2013","volume":"306","author":"FM Hughes","year":"2014","unstructured":"Hughes FM, Vivar NP, Kennis JG et al (2014) Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation. Am J Physiol - Ren Physiol 306:F299\u2013F308. https:\/\/doi.org\/10.1152\/ajprenal.00297.2013","journal-title":"Am J Physiol - Ren Physiol"},{"key":"3900_CR36","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.freeradbiomed.2008.09.043","volume":"46","author":"G Millonig","year":"2009","unstructured":"Millonig G, Heged\u00fcsch S, Becker L et al (2009) Hypoxia-inducible factor 1\u03b1 under rapid enzymatic hypoxia: cells sense decrements of oxygen but not hypoxia per se. Free Radic Biol Med 46:182\u2013191. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2008.09.043","journal-title":"Free Radic Biol Med"},{"key":"3900_CR37","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.79952","author":"Z Fabian","year":"2018","unstructured":"Fabian Z (2018) The signaling nature of cellular metabolism: the hypoxia signaling. Cell Signal. https:\/\/doi.org\/10.5772\/intechopen.79952","journal-title":"Cell Signal"},{"key":"3900_CR38","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.jacbts.2020.05.006","volume":"5","author":"M Packer","year":"2020","unstructured":"Packer M (2020) Mutual antagonism of hypoxia-inducible factor isoforms in cardiac, vascular, and renal disorders. JACC Basic Transl Sci 5:961\u2013968. https:\/\/doi.org\/10.1016\/j.jacbts.2020.05.006","journal-title":"JACC Basic Transl Sci"},{"key":"3900_CR39","doi-asserted-by":"publisher","first-page":"10961","DOI":"10.1007\/s11033-022-07802-6","volume":"49","author":"Q Liu","year":"2022","unstructured":"Liu Q, Palmgren VAC, Danen EH, Le D\u00e9v\u00e9dec SE (2022) Acute vs. chronic vs. intermittent hypoxia in breast cancer: a review on its application in in vitro research. Mol Biol Rep 49:10961\u201310973. https:\/\/doi.org\/10.1007\/s11033-022-07802-6","journal-title":"Mol Biol Rep"},{"key":"3900_CR40","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1042\/bse0430029","volume":"43","author":"A Galkin","year":"2007","unstructured":"Galkin A, Higgs A, Moncada S (2007) Nitric oxide and hypoxia. Essays Biochem 43:29\u201342. https:\/\/doi.org\/10.1042\/bse0430029","journal-title":"Essays Biochem"},{"key":"3900_CR41","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1183\/09031936.95.08040515","volume":"8","author":"V Hampl","year":"1995","unstructured":"Hampl V, Cornfield DN, Cowan NJ, Archer SL (1995) Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells. Eur Respir J 8:515\u2013522","journal-title":"Eur Respir J"},{"key":"3900_CR42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1757-5672.2011.00134.x","volume":"4","author":"ATL Lin","year":"2012","unstructured":"Lin ATL, Ischemia J-S (2012) Hypoxia and oxidative stress in bladder outlet obstruction and bladder overdistention injury. LUTS Low Urin Tract Symptoms 4:27\u201331. https:\/\/doi.org\/10.1111\/j.1757-5672.2011.00134.x","journal-title":"LUTS Low Urin Tract Symptoms"},{"key":"3900_CR43","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/cr.2013.6","volume":"23","author":"K Mao","year":"2013","unstructured":"Mao K, Chen S, Chen M et al (2013) Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res 23:201\u2013212. https:\/\/doi.org\/10.1038\/cr.2013.6","journal-title":"Cell Res"},{"key":"3900_CR44","doi-asserted-by":"publisher","first-page":"F357","DOI":"10.1152\/ajprenal.00261.2005","volume":"290","author":"W Conners","year":"2006","unstructured":"Conners W, Whitebeck C, Chicester P et al (2006) L-NAME, a nitric oxide synthase inhibitor, diminishes oxidative damage in urinary bladder partial outlet obstruction. Am J Physiol Renal Physiol 290:F357-363. https:\/\/doi.org\/10.1152\/ajprenal.00261.2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"3900_CR45","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/S0022-5347(01)66307-9","volume":"155","author":"KM Azadzoi","year":"1996","unstructured":"Azadzoi KM, Pontari M, Vlachiotis J, Siroky MB (1996) Canine bladder blood flow and oxygenation: changes induced by filling, contraction and outlet obstruction. J Urol 155:1459\u20131465. https:\/\/doi.org\/10.1016\/S0022-5347(01)66307-9","journal-title":"J Urol"},{"key":"3900_CR46","doi-asserted-by":"publisher","first-page":"11715","DOI":"10.1073\/pnas.95.20.11715","volume":"95","author":"NS Chandel","year":"1998","unstructured":"Chandel NS, Maltepe E, Goldwasser E et al (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A 95:11715\u201311720. https:\/\/doi.org\/10.1073\/pnas.95.20.11715","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3900_CR47","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cmet.2005.05.001","volume":"1","author":"RD Guzy","year":"2005","unstructured":"Guzy RD, Hoyos B, Robin E et al (2005) Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 1:401\u2013408. https:\/\/doi.org\/10.1016\/j.cmet.2005.05.001","journal-title":"Cell Metab"},{"key":"3900_CR48","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1016\/j.bbrc.2017.12.134","volume":"495","author":"C Chen","year":"2018","unstructured":"Chen C, Ma X, Yang C et al (2018) Hypoxia potentiates LPS-induced inflammatory response and increases cell death by promoting NLRP3 inflammasome activation in pancreatic \u03b2 cells. Biochem Biophys Res Commun 495:2512\u20132518. https:\/\/doi.org\/10.1016\/j.bbrc.2017.12.134","journal-title":"Biochem Biophys Res Commun"},{"key":"3900_CR49","doi-asserted-by":"publisher","first-page":"319","DOI":"10.2147\/RRU.S225767","volume":"11","author":"SN Harper","year":"2019","unstructured":"Harper SN, Leidig PD, Hughes FM et al (2019) Calcium pyrophosphate and monosodium urate activate the NLRP3 inflammasome within bladder urothelium via reactive oxygen species and TXNIP. Res Rep Urol 11:319\u2013325. https:\/\/doi.org\/10.2147\/RRU.S225767","journal-title":"Res Rep Urol"},{"key":"3900_CR50","doi-asserted-by":"publisher","first-page":"a008656","DOI":"10.1101\/cshperspect.a008656","volume":"5","author":"DR McIlwain","year":"2013","unstructured":"McIlwain DR, Berger T, Mak TW (2013) Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol 5:a008656. https:\/\/doi.org\/10.1101\/cshperspect.a008656","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3900_CR51","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12944-020-01220-y","volume":"19","author":"MD Molla","year":"2020","unstructured":"Molla MD, Ayelign B, Dessie G et al (2020) Caspase-1 as a regulatory molecule of lipid metabolism. Lipids Health Dis 19:34. https:\/\/doi.org\/10.1186\/s12944-020-01220-y","journal-title":"Lipids Health Dis"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-023-03900-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-023-03900-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-023-03900-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T12:09:45Z","timestamp":1712578185000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-023-03900-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,22]]},"references-count":51,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["3900"],"URL":"https:\/\/doi.org\/10.1007\/s11255-023-03900-x","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,22]]},"assertion":[{"value":"26 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare that are relevant to the content of this article. This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}