{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:50:17Z","timestamp":1740124217332,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-024-04274-4","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T18:22:28Z","timestamp":1731349348000},"page":"981-988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sodium\u2013chloride difference is not strongly correlated with base excess in chronic kidney disease: an anion gap problem"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1114-7106","authenticated-orcid":false,"given":"Moritz","family":"Kerbl-Knapp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg-Christian","family":"Funk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"issue":"2","key":"4274_CR1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1681\/ASN.2017040422","volume":"29","author":"KL Raphael","year":"2018","unstructured":"Raphael KL (2018) Metabolic acidosis and subclinical metabolic acidosis in CKD. J Am Soc Nephrol 29(2):376\u2013382","journal-title":"J Am Soc Nephrol"},{"key":"4274_CR2","doi-asserted-by":"crossref","unstructured":"Chapter 3: Management of progression and complications of CKD. Kidney Int Suppl (2011). 2013;3(1):73\u201390.","DOI":"10.1038\/kisup.2012.66"},{"issue":"1","key":"4274_CR3","doi-asserted-by":"publisher","first-page":"16139","DOI":"10.1038\/s41598-019-52499-6","volume":"9","author":"HJ Kim","year":"2019","unstructured":"Kim HJ, Kang E, Ryu H, Han M, Lee KB, Kim YS et al (2019) Metabolic acidosis is associated with pulse wave velocity in chronic kidney disease: Results from the KNOW-CKD Study. Sci Rep 9(1):16139","journal-title":"Sci Rep"},{"issue":"15","key":"4274_CR4","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1056\/NEJMra1003327","volume":"371","author":"K Berend","year":"2014","unstructured":"Berend K, de Vries APJ, Gans ROB (2014) Physiological approach to assessment of acid-base disturbances. Engl J Med 371(15):1434\u20131445","journal-title":"Engl J Med"},{"issue":"1","key":"4274_CR5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/bja\/aeh018","volume":"92","author":"DA Story","year":"2004","unstructured":"Story DA, Morimatsu H, Bellomo R (2004) Strong ions, weak acids and base excess: a simplified Fencl-Stewart approach to clinical acid\u2013base disorders\u2020. British J Anaesth 92(1):54\u201360","journal-title":"British J Anaesth"},{"issue":"2","key":"4274_CR6","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1213\/ANE.0000000000001261","volume":"123","author":"DA Story","year":"2016","unstructured":"Story DA (2016) Stewart acid-base: a simplified bedside approach. Anesth Analg 123(2):511\u2013515","journal-title":"Anesth Analg"},{"issue":"13\u201314","key":"4274_CR7","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1007\/s00508-007-0811-6","volume":"119","author":"GC Funk","year":"2007","unstructured":"Funk GC (2007) Das S\u00e4ure-Basen-Modell nach Stewart. Wien Klin Wochenschr 119(13\u201314):390\u2013403","journal-title":"Wien Klin Wochenschr"},{"issue":"4","key":"4274_CR8","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0883-9441(93)90001-2","volume":"8","author":"BM Gilfix","year":"1993","unstructured":"Gilfix BM, Bique M, Magder S (1993) A physical chemical approach to the analysis of acid-base balance in the clinical setting. J Crit Care 8(4):187\u2013197","journal-title":"J Crit Care"},{"issue":"4","key":"4274_CR9","doi-asserted-by":"publisher","first-page":"e0250274","DOI":"10.1371\/journal.pone.0250274","volume":"16","author":"B Gucyetmez","year":"2021","unstructured":"Gucyetmez B, Tuzuner F, Atalan HK, Sezerman U, Gucyetmez K, Telci L (2021) Base-excess chloride; the best approach to evaluate the effect of chloride on the acid-base status: A retrospective study. PLoS ONE 16(4):e0250274","journal-title":"PLoS ONE"},{"issue":"5","key":"4274_CR10","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1053\/j.ajkd.2016.12.019","volume":"69","author":"J Havlin","year":"2017","unstructured":"Havlin J, Matousovic K, Sch\u00fcck O (2017) Sodium-chloride difference as a simple parameter for acid-base status assessment. Am J Kidney Dis 69(5):707\u2013708","journal-title":"Am J Kidney Dis"},{"issue":"15","key":"4274_CR11","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMra1711860","volume":"378","author":"K Berend","year":"2018","unstructured":"Berend K (2018) Diagnostic use of base excess in acid-base disorders. N Engl J Med 378(15):1419\u20131428","journal-title":"N Engl J Med"},{"issue":"19","key":"4274_CR12","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1056\/NEJMra1215672","volume":"371","author":"JL Seifter","year":"2014","unstructured":"Seifter JL (2014) Integration of acid-base and electrolyte disorders. N Engl J Med 371(19):1821\u20131831","journal-title":"N Engl J Med"},{"issue":"9","key":"4274_CR13","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang Y, Castro AF, Feldman HI et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150(9):604\u2013612","journal-title":"Ann Intern Med"},{"key":"4274_CR14","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. KDIGO 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Int. 2020;98(4S):S1\u2013115.","DOI":"10.1016\/j.kint.2020.06.019"},{"issue":"3","key":"4274_CR15","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1111\/j.1523-1755.2004.00481.x","volume":"65","author":"JA Eustace","year":"2004","unstructured":"Eustace JA, Astor B, Muntner PM, Ikizler TA, Coresh J (2004) Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Kidney Int 65(3):1031\u20131040","journal-title":"Kidney Int"},{"issue":"2","key":"4274_CR16","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/ki.2013.182","volume":"84","author":"LE Souza","year":"2013","unstructured":"Souza LE, de Queiroz REB, Lib\u00f3rio AB (2013) Unmeasured anions and cations in advanced chronic kidney disease. Kidney Int 84(2):413\u2013414","journal-title":"Kidney Int"},{"issue":"1","key":"4274_CR17","doi-asserted-by":"publisher","first-page":"162","DOI":"10.2215\/CJN.03020906","volume":"2","author":"JA Kraut","year":"2007","unstructured":"Kraut JA, Madias NE (2007) Serum anion gap: its uses and limitations in clinical medicine. Clin J Am Soc Nephrol 2(1):162","journal-title":"Clin J Am Soc Nephrol"},{"issue":"6","key":"4274_CR18","first-page":"F1244","volume":"316","author":"T Banerjee","year":"2019","unstructured":"Banerjee T, Crews DC, Wesson DE, McCulloch CE, Johansen KL, Saydah S et al (2019) Elevated serum anion gap in adults with moderate chronic kidney disease increases risk for progression to end-stage renal disease. Am J Physiol 316(6):F1244\u2013F1253","journal-title":"Am J Physiol"},{"issue":"3","key":"4274_CR19","first-page":"528","volume":"32","author":"M Marano","year":"2017","unstructured":"Marano M, Marano S, Gennari FJ (2017) Beyond bicarbonate: complete acid-base assessment in patients receiving intermittent hemodialysis. Nephrol Dial Transplant 32(3):528\u2013533","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"4274_CR20","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1681\/ASN.2008020159","volume":"20","author":"O Moranne","year":"2009","unstructured":"Moranne O, Froissart M, Rossert J, Gauci C, Boffa JJ, Haymann JP et al (2009) Timing of onset of CKD-related metabolic complications. J Am Soc Nephrol 20(1):164\u2013171","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"4274_CR21","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1093\/ckj\/sfad100","volume":"16","author":"HW Zijlstra","year":"2023","unstructured":"Zijlstra HW, Stegeman CA (2023) The elevation of the anion gap in steady state chronic kidney disease may be less prominent than generally accepted. Clin Kidney J 16(10):1684\u20131690","journal-title":"Clin Kidney J"},{"issue":"11","key":"4274_CR22","first-page":"1453","volume":"55","author":"C Gu\u00e9rin","year":"2010","unstructured":"Gu\u00e9rin C, Nesme P, Leray V, Wallet F, Bourdin G, Bayle F et al (2010) Quantitative analysis of acid-base disorders in patients with chronic respiratory failure in stable or unstable respiratory condition. Respir Care 55(11):1453\u20131463","journal-title":"Respir Care"},{"issue":"6","key":"4274_CR23","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/ki.2012.196","volume":"82","author":"MK Abramowitz","year":"2012","unstructured":"Abramowitz MK, Hostetter TH, Melamed ML (2012) The serum anion gap is altered in early kidney disease and associates with mortality. Kidney Int 82(6):701\u2013709","journal-title":"Kidney Int"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-024-04274-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-024-04274-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-024-04274-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T14:57:15Z","timestamp":1739372235000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-024-04274-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["4274"],"URL":"https:\/\/doi.org\/10.1007\/s11255-024-04274-4","relation":{},"ISSN":["1573-2584"],"issn-type":[{"type":"electronic","value":"1573-2584"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"3 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was approved by the Ethics Committee of the medical faculty of the Johannes Kepler University Linz, Austria (1267\/2020). Principles of ethical and professional conduct have been followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}