{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:31:55Z","timestamp":1772119915017,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-024-04297-x","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:56:45Z","timestamp":1732683405000},"page":"1143-1149","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative neutrophil-to-lymphocyte ratio (NLR) value as a predictor of recurrence of non-muscle-invasive bladder cancer"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8112-234X","authenticated-orcid":false,"given":"Davor","family":"Ivani\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4290-5849","authenticated-orcid":false,"given":"Haris","family":"\u0110ug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7980-9562","authenticated-orcid":false,"given":"Samed","family":"Jagodi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-3288","authenticated-orcid":false,"given":"Samir","family":"Delibegovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"4297_CR1","unstructured":"IARC, Cancer (2021) Today. Estimated number of new cases in 2020, worldwide, both sexes, all ages."},{"key":"4297_CR2","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00428-015-1739-2","volume":"466","author":"E Comp\u00e9rat","year":"2015","unstructured":"Comp\u00e9rat E, Larr\u00e9 S, Roupret M, Neuzillet Y, Pignot G, Quintens H et al (2015) Clinicopathological characteristics of urothelial bladder cancer in patients less than 40 years old. Virchows Arch 466:589\u2013594. https:\/\/doi.org\/10.1007\/s00428-015-1739-2","journal-title":"Virchows Arch"},{"key":"4297_CR3","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.eururo.2015.06.045","volume":"69","author":"S Cambier","year":"2016","unstructured":"Cambier S, Sylvester RJ, Collette L, Gontero P, Brausi MA, van Andel G et al (2016) EORTC Nomograms and Risk Groups for Predicting Recurrence, Progression, and Disease-specific and Overall Survival in Non-Muscle-invasive Stage Ta-T1 Urothelial Bladder Cancer Patients Treated with 1\u20133 Years of Maintenance Bacillus Calmette-Gu\u00e9rin. Eur Urol 69:60\u201369","journal-title":"Eur Urol"},{"key":"4297_CR4","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.urology.2011.11.070","volume":"79","author":"T Gondo","year":"2012","unstructured":"Gondo T, Nakashima J, Ohno Y, Choichiro O, Horiguchi Y, Namiki K et al (2012) Prognostic value of neutrophil-to-lymphocyte ratio and establishment of novel preoperative risk stratification model in bladder cancer patients treated with radical cystectomy. Urology 79:1085\u20131091","journal-title":"Urology"},{"key":"4297_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092079","volume":"9","author":"Y Wei","year":"2014","unstructured":"Wei Y, Jiang YZ, Qian WH (2014) Prognostic role of NLR in urinary cancers: a meta-analysis. PLoS ONE 9:e92079. https:\/\/doi.org\/10.1371\/journal.pone.0092079","journal-title":"PLoS ONE"},{"key":"4297_CR6","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.urolonc.2013.12.009","volume":"32","author":"A Potretzke","year":"2014","unstructured":"Potretzke A, Hillman L, Wong K, Shi F, Brower R, Mai S et al (2014) NLR is predictive of upstaging at the time of radical cystectomy for patients with urothelial carcinoma of the bladder. Urol Oncol 32:631\u2013636. https:\/\/doi.org\/10.1016\/j.urolonc.2013.12.009","journal-title":"Urol Oncol"},{"key":"4297_CR7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/(sici)1097-0258(20000115)19:1<61:aid-sim297>3.0.co;2-a","volume":"19","author":"D Faraggi","year":"2000","unstructured":"Faraggi D (2000) The effect of random measurement error on receiver operating characteristic (ROC) curves. Stat Med 19:61\u201370. https:\/\/doi.org\/10.1002\/(sici)1097-0258(20000115)19:1%3c61:aid-sim297%3e3.0.co;2-a","journal-title":"Stat Med"},{"issue":"1","key":"4297_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","volume":"3","author":"WJ Youden","year":"1950","unstructured":"Youden WJ (1950) Index for rating diagnostic tests. Cancer 3(1):32\u201335","journal-title":"Cancer"},{"key":"4297_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051862","volume":"7","author":"J Budczies","year":"2012","unstructured":"Budczies J, Klauschen F, Sinn BV, Gy\u0151rffy B, Schmitt WD, Darb-Esfahani S et al (2012) Cutoff Finder: A Comprehensive and Straightforward Web Application Enabling Rapid Biomarker Cutoff Optimization. PLoS ONE 7:e51862. https:\/\/doi.org\/10.1371\/journal.pone.0051862","journal-title":"PLoS ONE"},{"key":"4297_CR10","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.eururo.2016.05.041","volume":"71","author":"M Babjuk","year":"2017","unstructured":"Babjuk M, Burger M, Zigeuner R, Shariat SF, van Rhijn BW, Comp\u00e9rat E et al (2017) EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2016. Eur Urol 71:447\u2013461. https:\/\/doi.org\/10.1016\/j.eururo.2016.05.041","journal-title":"Eur Urol"},{"key":"4297_CR11","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1016\/j.juro.2011.07.076","volume":"186","author":"M Brausi","year":"2011","unstructured":"Brausi M, Witjes JA, Lamm D, Persad R, Palou J, Colombel M et al (2011) A review of current guidelines and best practice recommendations for the management of nonmuscle invasive bladder cancer by the International Bladder Cancer Group. J Urol 186:2158\u20132167","journal-title":"J Urol"},{"key":"4297_CR12","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1007\/s00432-022-04399-y","volume":"149","author":"P P\u0119czek","year":"2023","unstructured":"12. P\u0119czek P, Gajda M, Rutkowski K, Fudalej M, Depta\u0142a A, Badowska-Kozakiewicz AM (2023) Cancer-associated inflammation: pathophysiology and clinical significance. J Cancer Res Clin Oncol 149:2657\u20132672. https:\/\/doi.org\/10.1007\/s00432-022-04399-y","journal-title":"J Cancer Res Clin Oncol"},{"key":"4297_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2217\/fon.09.136","volume":"6","author":"CS Roxburgh","year":"2010","unstructured":"13. Roxburgh CS, McMillan DC (2010) Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol 6:149\u2013163. https:\/\/doi.org\/10.2217\/fon.09.136","journal-title":"Future Oncol"},{"key":"4297_CR14","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8345286","author":"HS Kim","year":"2016","unstructured":"Kim HS, Ku JH (2016) Systemic inflammatory response based on neutrophil-to-lymphocyte ratio as a prognostic marker in bladder cancer. Dis Markers. https:\/\/doi.org\/10.1155\/2016\/8345286","journal-title":"Dis Markers"},{"key":"4297_CR15","doi-asserted-by":"publisher","first-page":"67e61","DOI":"10.1016\/j.urolonc.2014.06.010","volume":"33","author":"R Mano","year":"2015","unstructured":"Mano R, Baniel J, Shoshany O, Margel D, Bar-On T, Nativ O et al (2015) Neutrophil-to-lymphocyte ratio predicts progression and recurrence of non-muscle-invasive bladder cancer. Urol Oncol 33:67e61-77","journal-title":"Urol Oncol"},{"key":"4297_CR16","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.urolonc.2016.05.013","volume":"34","author":"A Mbeutcha","year":"2016","unstructured":"Mbeutcha A, Shariat SF, Rieken M, Rink M, Xylinas E, Seitz C et al (2016) Prognostic significance of markers of systemic inflammatory response in patients with non-muscle-invasive bladder cancer. Urol Oncol 34:417\u2013424. https:\/\/doi.org\/10.1016\/j.urolonc.2016.05.013","journal-title":"Urol Oncol"},{"key":"4297_CR17","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.6004\/jnccn.2017.0156","volume":"15","author":"PE Spiess","year":"2017","unstructured":"Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Clark PE et al (2017) Bladder cancer, version 5. NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 15:1240\u20131267. https:\/\/doi.org\/10.6004\/jnccn.2017.0156","journal-title":"J Natl Compr Canc Netw"},{"key":"4297_CR18","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.aju.2018.10.006","volume":"16","author":"A Sempere","year":"2018","unstructured":"Sempere A, Samper P (2018) [53] Neutrophil-to-lymphocyte ratio in non-muscle-invasive bladder cancer. Arab J Urol 16:26. https:\/\/doi.org\/10.1016\/j.aju.2018.10.006","journal-title":"Arab J Urol"},{"key":"4297_CR19","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1590\/S1677-5538.IBJU.2015.0243","volume":"42","author":"V Favilla","year":"2016","unstructured":"Favilla V, Castelli T, Urz\u00ec D, Reale G, Privitera S, Salici A et al (2016) Neutrophil to lymphocyte ratio, a biomarker in non-muscle invasive bladder cancer: a single-institutional longitudinal study. Int Braz J Urol 42:685\u2013693. https:\/\/doi.org\/10.1590\/S1677-5538.IBJU.2015.0243","journal-title":"Int Braz J Urol"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-024-04297-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-024-04297-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-024-04297-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T21:26:19Z","timestamp":1741814779000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-024-04297-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["4297"],"URL":"https:\/\/doi.org\/10.1007\/s11255-024-04297-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5210552\/v1","asserted-by":"object"}]},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"5 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests. The authors have no competing interests to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethical Committee of University Clinic Center Tuzla (30.10.2018. No: 02\u201309\/2\u201356\/18).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all the individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}