{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T13:26:59Z","timestamp":1768742819845,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-025-04401-9","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T18:14:05Z","timestamp":1738865645000},"page":"2135-2142","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of intravesical alkalinized lignocaine for cystoscopy: a retrospective analysis"],"prefix":"10.1007","volume":"57","author":[{"given":"Kirti","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj Kumar","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swarnendu","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Tarigopula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sambit","family":"Tripathy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalandi","family":"Barik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasant","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"4401_CR1","doi-asserted-by":"publisher","first-page":"585","DOI":"10.17219\/acem\/37229","volume":"23","author":"H Goktug","year":"2014","unstructured":"Goktug H, Ozturk U, Sener N et al (2014) Do lubricants with 2% lidocaine gel have an effecton patient comfort in diagnostic cystoscopy? Adv Clin Exp Med 23:585\u2013587. https:\/\/doi.org\/10.17219\/acem\/37229","journal-title":"Adv Clin Exp Med"},{"key":"4401_CR2","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.juro.2007.10.065","volume":"179","author":"AR Patel","year":"2008","unstructured":"Patel AR, Jones JS, Babineau D (2008) Lidocaine 2% gel versus plain lubricating gel for pain reduction during flexible cystoscopy: a meta-analysis of prospective, randomized, controlled trials. J Urol 179:986\u2013990. https:\/\/doi.org\/10.1016\/j.juro.2007.10.065","journal-title":"J Urol"},{"key":"4401_CR3","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1046\/j.1442-2042.1999.611112.x","volume":"6","author":"R Yoshimura","year":"1999","unstructured":"Yoshimura R, Wada S, Kishimoto T (1999) Why the flexible cystoscope has not yet been widely introduced?: a questionnaire to Japanese urologists. Int J Urol 6:549\u2013561. https:\/\/doi.org\/10.1046\/j.1442-2042.1999.611112.x","journal-title":"Int J Urol"},{"key":"4401_CR4","doi-asserted-by":"publisher","DOI":"10.5114\/wiitm.2017.66506","author":"S Poletajew","year":"2017","unstructured":"Poletajew S, Bender S, Pude\u0142ko P et al (2017) Anaesthesia of the posterior urethra and pain reduction during cystoscopy\u2014a randomized controlled trial. Videosurgery Miniinvasive Tech. https:\/\/doi.org\/10.5114\/wiitm.2017.66506","journal-title":"Videosurgery Miniinvasive Tech"},{"key":"4401_CR5","doi-asserted-by":"publisher","first-page":"80","DOI":"10.5114\/wo.2021.106652","volume":"25","author":"J \u0141aszkiewicz","year":"2021","unstructured":"\u0141aszkiewicz J, Krajewski W, \u0141uczak M et al (2021) Pain reduction methods during transurethral cystoscopy. Wsp\u00f3\u0142czesna Onkol 25:80\u201387. https:\/\/doi.org\/10.5114\/wo.2021.106652","journal-title":"Wsp\u00f3\u0142czesna Onkol"},{"key":"4401_CR6","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0230","volume":"85","author":"JE Tetzlaff","year":"2010","unstructured":"Tetzlaff JE (2010) Cousins and Bridenbaugh\u2019s neural blockade in clinical anesthesia and pain medicine. Mayo Clin Proc 85:e51. https:\/\/doi.org\/10.4065\/mcp.2010.0230","journal-title":"Mayo Clin Proc"},{"key":"4401_CR7","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.juro.2008.01.068","volume":"179","author":"JS Wolf","year":"2008","unstructured":"Wolf JS, Bennett CJ, Dmochowski RR et al (2008) Best practice policy statement on urologic surgery antimicrobial prophylaxis. J Urol 179:1379\u20131390. https:\/\/doi.org\/10.1016\/j.juro.2008.01.068","journal-title":"J Urol"},{"key":"4401_CR8","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1007\/s11845-020-02458-2","volume":"1971\u2013190","author":"KG Keane","year":"2021","unstructured":"Keane KG, Redmond EJ, McIntyre C et al (2021) Does instillation of lidocaine gel following flexible cystoscopy decrease the severity of post procedure symptoms? a randomised controlled trial assessing the efficacy of lidocaine gel post flexible cystoscopy. Ir J Med Sci 1971\u2013190:1553\u20131559. https:\/\/doi.org\/10.1007\/s11845-020-02458-2","journal-title":"Ir J Med Sci"},{"key":"4401_CR9","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-200106000-00014","author":"R Henry","year":"2001","unstructured":"Henry R, Patterson L, Avery N et al (2001) Absorption of alkalized intravesical lidocaine in normal and inflamed bladders: a simple method for improving bladder anesthesia. J Urol. https:\/\/doi.org\/10.1097\/00005392-200106000-00014","journal-title":"J Urol"},{"key":"4401_CR10","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1046\/j.1464-4096.2001.01899.x","volume":"89","author":"DM Burke","year":"2002","unstructured":"Burke DM, Shackley DC, O\u2019Reilly PH (2002) The community-based morbidity of flexible cystoscopy. BJU Int 89:347\u2013349. https:\/\/doi.org\/10.1046\/j.1464-4096.2001.01899.x","journal-title":"BJU Int"},{"key":"4401_CR11","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1002\/cncr.31530","volume":"124","author":"AB Smith","year":"2018","unstructured":"Smith AB, Chisolm S, Deal A et al (2018) Patient-centered prioritization of bladder cancer research. Cancer 124:3136\u20133144. https:\/\/doi.org\/10.1002\/cncr.31530","journal-title":"Cancer"},{"key":"4401_CR12","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1089\/089277901750299366","volume":"15","author":"N McFarlane","year":"2001","unstructured":"McFarlane N, Denstedt J, Ganapathy S, Razvi H (2001) Randomized trial of 10 mL and 20 mL of 2% intraurethral lidocaine gel and placebo in men undergoing flexible cystoscopy. J Endourol 15:541\u2013544. https:\/\/doi.org\/10.1089\/089277901750299366","journal-title":"J Endourol"},{"key":"4401_CR13","doi-asserted-by":"publisher","first-page":"331","DOI":"10.2147\/RRU.S238746","volume":"12","author":"J Colemeadow","year":"2020","unstructured":"Colemeadow J, Sahai A, Malde S (2020) Clinical management of bladder pain syndrome\/interstitial cystitis: a review on current recommendations and emerging treatment options. Res Rep Urol 12:331\u2013343. https:\/\/doi.org\/10.2147\/RRU.S238746","journal-title":"Res Rep Urol"},{"key":"4401_CR14","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S0022-5347(17)36722-8","volume":"148","author":"D Pode","year":"1992","unstructured":"Pode D, Zylber-Katz E, Shapiro A (1992) intravesical lidocaine: topical anesthesia for bladder mucosal biopsies. J Urol 148:795\u2013796. https:\/\/doi.org\/10.1016\/S0022-5347(17)36722-8","journal-title":"J Urol"},{"key":"4401_CR15","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0022-5347(17)35477-0","volume":"150","author":"JB Thrasher","year":"1993","unstructured":"Thrasher JB, Kreder KJ, Peterson NE, Donatucci CF (1993) Lidocaine as topical anesthesia for bladder mappings and cold-cup biopsies. J Urol 150:335\u2013336. https:\/\/doi.org\/10.1016\/S0022-5347(17)35477-0","journal-title":"J Urol"},{"key":"4401_CR16","doi-asserted-by":"publisher","first-page":"S171","DOI":"10.21037\/tau.2017.06.18","volume":"6","author":"T Ha","year":"2017","unstructured":"Ha T, Xu JH (2017) Interstitial cystitis intravesical therapy. Transl Androl Urol 6:S171\u2013S179. https:\/\/doi.org\/10.21037\/tau.2017.06.18","journal-title":"Transl Androl Urol"},{"key":"4401_CR17","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2022.129","author":"E Sogutdelen","year":"2022","unstructured":"Sogutdelen E, Citamak B (2022) Efficacy of intravesical cocktail therapy with or without dimethyl sulphoxide in interstitial cystitis. Cent Eur J Urol. https:\/\/doi.org\/10.5173\/ceju.2022.129","journal-title":"Cent Eur J Urol"},{"key":"4401_CR18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3109\/00365599409180513","volume":"28","author":"BR Birch","year":"1994","unstructured":"Birch BR, Miller RA (1994) Absorption characteristics of lignocaine following intravesical instillation. Scand J Urol Nephrol 28:359\u2013364. https:\/\/doi.org\/10.3109\/00365599409180513","journal-title":"Scand J Urol Nephrol"},{"key":"4401_CR19","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1007\/s00192-019-03892-2","volume":"30","author":"I Offiah","year":"2019","unstructured":"Offiah I, Dilloughery E, McMahon SB, O\u2019Reilly BA (2019) Prospective comparative study of the effects of lidocaine on urodynamic and sensory parameters in bladder pain syndrome. Int Urogynecology J 30:1293\u20131301. https:\/\/doi.org\/10.1007\/s00192-019-03892-2","journal-title":"Int Urogynecology J"},{"key":"4401_CR20","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1111\/j.1464-410X.2008.08162.x","volume":"103","author":"JC Nickel","year":"2009","unstructured":"Nickel JC, Moldwin R, Lee S et al (2009) Intravesical alkalinized lidocaine (PSD597) offers sustained relief from symptoms of interstitial cystitis and painful bladder syndrome. BJU Int 103:910\u2013918. https:\/\/doi.org\/10.1111\/j.1464-410X.2008.08162.x","journal-title":"BJU Int"},{"key":"4401_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/nau.25061","volume":"42","author":"N Faure Walker","year":"2023","unstructured":"Faure Walker N, Macpherson F, Tasleem A, Rampal T (2023) Interventions to improve tolerability of local anesthetic intradetrusor Botulinum toxin injections: a systematic review. Neurourol Urodyn 42:23\u201332. https:\/\/doi.org\/10.1002\/nau.25061","journal-title":"Neurourol Urodyn"},{"key":"4401_CR22","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.mjafi.2018.11.002","volume":"75","author":"JS Sandhu","year":"2019","unstructured":"Sandhu JS, Singh AK, Bhatulkar A et al (2019) Safety and efficacy of total intraluminal topical anaesthesia for ureteroscopy. Is success worth the pain? Med J Armed Forces India 75:204\u2013210. https:\/\/doi.org\/10.1016\/j.mjafi.2018.11.002","journal-title":"Med J Armed Forces India"},{"key":"4401_CR23","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1590\/S1677-5538.IBJU.2014.04.13","volume":"40","author":"A Greenstein","year":"2014","unstructured":"Greenstein A, Greenstein I, Senderovich S, Mabjeesh NJ (2014) Is Diagnostic cystoscopy painful? analysis of 1,320 consecutive procedures. Int Braz J Urol 40:533\u2013538. https:\/\/doi.org\/10.1590\/S1677-5538.IBJU.2014.04.13","journal-title":"Int Braz J Urol"},{"key":"4401_CR24","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1159\/000092051","volume":"76","author":"AK Taghizadeh","year":"2006","unstructured":"Taghizadeh AK, El Madani A, Gard PR et al (2006) When does it hurt? pain during flexible cystoscopy in men. Urol Int 76:301\u2013303. https:\/\/doi.org\/10.1159\/000092051","journal-title":"Urol Int"},{"key":"4401_CR25","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1093\/jnci\/95.8.588","volume":"95","author":"D Schrag","year":"2003","unstructured":"Schrag D, Hsieh LJ, Rabbani F et al (2003) Adherence to surveillance among patients with superficial bladder cancer. JNCI J Natl Cancer Inst 95:588\u2013597. https:\/\/doi.org\/10.1093\/jnci\/95.8.588","journal-title":"JNCI J Natl Cancer Inst"},{"key":"4401_CR26","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003804","author":"JC Nickel","year":"2012","unstructured":"Nickel JC, Jain P, Shore N et al (2012) Continuous intravesical lidocaine treatment for interstitial cystitis\/bladder pain syndrome: safety and efficacy of a new drug delivery device. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.3003804","journal-title":"Sci Transl Med"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04401-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-025-04401-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04401-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T08:16:24Z","timestamp":1749888984000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-025-04401-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":26,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["4401"],"URL":"https:\/\/doi.org\/10.1007\/s11255-025-04401-9","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"6 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}