{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:31:02Z","timestamp":1791491462171,"version":"4.3.4"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2314-B-037-028"],"award-info":[{"award-number":["NSTC 113-2314-B-037-028"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","award":["KMUH113-3R53"],"award-info":[{"award-number":["KMUH113-3R53"]}],"id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-025-04452-y","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T06:16:15Z","timestamp":1742019375000},"page":"2725-2734","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Integrating biomarker clustering for improved diagnosis of interstitial cystitis\/bladder pain syndrome: a review"],"prefix":"10.1007","volume":"57","author":[{"given":"Yu-Chen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hann-Chorng","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,15]]},"reference":[{"key":"4452_CR1","unstructured":"EAU Guidelines. Edn. presented at the EAU Annual Congress Paris 2024. ISBN 978\u201394\u201392671\u201312\u20133."},{"issue":"1","key":"4452_CR2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.eururo.2007.09.019","volume":"53","author":"JP van de Merwe","year":"2008","unstructured":"van de Merwe JP, Nordling J, Bouchelouche P, Bouchelouche K, Cervigni M, Daha LK, Elneil S, Fall M, Hohlbrugger G, Irwin P, Mortensen S, van Ophoven A, Osborne JL, Peeker R, Richter B, Riedl C, Sairanen J, Tinzl M, Wyndaele JJ (2008) Diagnostic criteria, classification, and nomenclature for painful bladder syndrome\/interstitial cystitis: an ESSIC proposal. Eur Urol 53(1):60\u201367","journal-title":"Eur Urol"},{"key":"4452_CR3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3109\/01443615.2015.1060200","volume":"36","author":"SA Tirlapur","year":"2016","unstructured":"Tirlapur SA, Khan KS (2016) An assessment of clinicians\u2019 and patients\u2019 experiences in the management of bladder pain syndrome. J Obstet Gynaecol 36:241\u2013245","journal-title":"J Obstet Gynaecol"},{"issue":"17","key":"4452_CR4","doi-asserted-by":"publisher","first-page":"9359","DOI":"10.3390\/ijms25179359","volume":"25","author":"YC Chen","year":"2024","unstructured":"Chen YC, Jiang YH, Jhang JF et al (2024) Using urine biomarkers to differentiate bladder dysfunctions in women with sensory bladder disorders. Int J Mol Sci 25(17):9359","journal-title":"Int J Mol Sci"},{"issue":"6","key":"4452_CR5","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.3390\/jcm12062336","volume":"12","author":"YH Jiang","year":"2023","unstructured":"Jiang YH, Jhang JF, Kuo HC (2023) urinary oxidative stress biomarker levels might be useful in identifying functional bladder disorders in women with frequency and urgency syndrome. J Clin Med 12(6):2336. https:\/\/doi.org\/10.3390\/jcm12062336","journal-title":"J Clin Med"},{"issue":"15","key":"4452_CR6","doi-asserted-by":"publisher","first-page":"12055","DOI":"10.3390\/ijms241512055","volume":"24","author":"WR Yu","year":"2023","unstructured":"Yu WR, Jiang YH, Jhang JF et al (2023) Use of urinary biomarkers in discriminating interstitial cystitis\/bladder pain syndrome from male lower urinary tract dysfunctions. Int J Mol Sci 24(15):12055. https:\/\/doi.org\/10.3390\/ijms241512055","journal-title":"Int J Mol Sci"},{"key":"4452_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15856","author":"HJ Jeong","year":"2024","unstructured":"Jeong HJ, Kang YJ, Choo MS et al (2024) Excluding confusable diseases in patients with presumptive diagnosis of interstitial cystitis: a large patient cohort study. Int J Gynaecol Obstet. https:\/\/doi.org\/10.1002\/ijgo.15856","journal-title":"Int J Gynaecol Obstet"},{"key":"4452_CR8","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1016\/S0022-5347(01)66684-9","volume":"154","author":"JJ Bade","year":"1995","unstructured":"Bade JJ et al (1995) Interstitial cystitis in the netherlands: prevalence, diagnostic criteria and therapeutic preferences. J Urol 154:2035","journal-title":"J Urol"},{"key":"4452_CR9","first-page":"225","volume":"49","author":"RT Burkman","year":"2004","unstructured":"Burkman RT (2004) Chronic pelvic pain of bladder origin: epidemiology, pathogenesis and quality of life. J Reprod Med 49:225","journal-title":"J Reprod Med"},{"key":"4452_CR10","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S0022-5347(01)61947-5","volume":"161","author":"GC Curhan","year":"1999","unstructured":"Curhan GC et al (1999) Epidemiology of interstitial cystitis: a population based study. J Urol 161:549","journal-title":"J Urol"},{"key":"4452_CR11","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1097\/01.ju.0000165452.39125.98","volume":"174","author":"M Leppilahti","year":"2005","unstructured":"Leppilahti M et al (2005) Prevalence of clinically confirmed interstitial cystitis in women: a population based study in Finland. J Urol 174:581","journal-title":"J Urol"},{"key":"4452_CR12","first-page":"75","volume":"64","author":"KJ Oravisto","year":"1975","unstructured":"Oravisto KJ (1975) Epidemiology of interstitial cystitis. Ann Chir Gynaecol Fenn 64:75","journal-title":"Ann Chir Gynaecol Fenn"},{"key":"4452_CR13","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1046\/j.1464-410X.2003.04060.x","volume":"91","author":"RO Roberts","year":"2003","unstructured":"Roberts RO et al (2003) Incidence of physician-diagnosed interstitial cystitis in Olmsted County: a community-based study. BJU Int 91:181","journal-title":"BJU Int"},{"key":"4452_CR14","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.eururo.2006.08.028","volume":"51","author":"C Temml","year":"2007","unstructured":"Temml C et al (2007) Prevalence and correlates for interstitial cystitis symptoms in women participating in a health screening project. Eur Urol 51:803","journal-title":"Eur Urol"},{"key":"4452_CR15","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1016\/j.juro.2006.11.084","volume":"177","author":"JQ Clemens","year":"2007","unstructured":"Clemens JQ, Link CL, Eggers PW et al (2007) Prevalence of painful bladder symptoms and effect on quality of life in black, hispanic and white men and women. J Urol 177:1390","journal-title":"J Urol"},{"key":"4452_CR16","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/S0022-5347(05)65195-6","volume":"167","author":"NE Rothrock","year":"2002","unstructured":"Rothrock NE, Lutgendorf SK, Hoffman A et al (2002) Depressive symptoms and quality of life in patients with interstitial cystitis. J Urol 167:1763","journal-title":"J Urol"},{"key":"4452_CR17","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0022-5347(05)64075-X","volume":"169","author":"N Rothrock","year":"2003","unstructured":"Rothrock N, Lutgendorf SK, Kreder KJ (2003) Coping strategies in patients with interstitial cystitis: Relationships with quality of life and depression. J Urol 169:233","journal-title":"J Urol"},{"issue":"2","key":"4452_CR18","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/s0022-5347(01)61948-7","volume":"161","author":"PM Hanno","year":"1999","unstructured":"Hanno PM, Landis JR, Matthews-Cook, et al (1999) The diagnosis of interstitial cystitis revisited: lessons learned from the National institutes of health interstitial cystitis database study. J Urol 161(2):553\u2013557. https:\/\/doi.org\/10.1016\/s0022-5347(01)61948-7","journal-title":"J Urol"},{"issue":"1","key":"4452_CR19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/JU.0000000000002756","volume":"208","author":"JQ Clemens","year":"2022","unstructured":"Clemens JQ, Erickson DR, Varela NP et al (2022) Diagnosis and treatment of interstitial cystitis\/bladder pain syndrome. J Urol 208(1):34\u201342","journal-title":"J Urol"},{"issue":"12","key":"4452_CR20","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.3390\/diagnostics11122238","volume":"11","author":"Y Akiyama","year":"2021","unstructured":"Akiyama Y (2021) Biomarkers in interstitial cystitis\/bladder pain syndrome with and without hunner lesion: a review and future perspectives. Diagnostics (Basel) 11(12):2238. https:\/\/doi.org\/10.3390\/diagnostics11122238","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"4452_CR21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3390\/diagnostics12010075","volume":"12","author":"HY Lin","year":"2021","unstructured":"Lin HY, Lu JH, Chuang SM et al (2021) Urinary biomarkers in interstitial cystitis\/bladder pain syndrome and its impact on therapeutic outcome. Diagnostics (Basel) 12(1):75. https:\/\/doi.org\/10.3390\/diagnostics12010075","journal-title":"Diagnostics (Basel)"},{"issue":"6","key":"4452_CR22","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1007\/s00192-024-05778-4","volume":"35","author":"B Lemmon","year":"2024","unstructured":"Lemmon B, Kyrgiou M, Mullins E et al (2024) Cytokines in bladder pain syndrome: a review of the literature. Int Urogynecol J 35(6):1119\u20131129","journal-title":"Int Urogynecol J"},{"key":"4452_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.urology.2018.07.046","volume":"123","author":"C Mazeaud","year":"2019","unstructured":"Mazeaud C, Rigaud J, Levesque A et al (2019) Stratification of patients with interstitial cystitis\/bladder pain syndrome according to the anatomical bladder capacity. Urology 123:87\u201392","journal-title":"Urology"},{"issue":"Suppl 1","key":"4452_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/iju.13975","volume":"26","author":"M Ueda","year":"2019","unstructured":"Ueda M, Sengiku A, Kono J et al (2019) Low bladder capacity is an important predictor for comorbidity of interstitial cystitis with Hunner\u2019s lesion in patients with refractory chronic prostatitis\/chronic pelvic pain syndrome. Int J Urol 26(Suppl 1):53\u201356","journal-title":"Int J Urol"},{"issue":"3","key":"4452_CR25","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1097\/JU.0000000000001031","volume":"204","author":"HH Lai","year":"2020","unstructured":"Lai HH, Pickersgill NA, Vetter JM (2020) Hunner lesion phenotype in interstitial cystitis\/bladder pain syndrome: a systematic review and meta-analysis. J Urol 204(3):518\u2013523","journal-title":"J Urol"},{"issue":"2","key":"4452_CR26","first-page":"O141","volume":"11","author":"A Otsuka","year":"2019","unstructured":"Otsuka A, Suzuki T, Aki R et al (2019) Clinical characteristics of self-reported nocturia in patients with interstitial cystitis, and effects of bladder hydrodistention (with fulguration of Hunner lesions) on nocturia. Low Urin Tract Symptoms 11(2):O141\u2013O146","journal-title":"Low Urin Tract Symptoms"},{"issue":"10","key":"4452_CR27","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.3390\/biomedicines9101306","volume":"9","author":"JF Jhang","year":"2021","unstructured":"Jhang JF, Hsu YH, Ho HC et al (2021) Possible association between bladder wall morphological changes on computed tomography and bladder-centered interstitial cystitis\/bladder pain syndrome. Biomedicines 9(10):1306","journal-title":"Biomedicines"},{"issue":"6","key":"4452_CR28","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1016\/j.juro.2012.01.034","volume":"187","author":"P Tyagi","year":"2012","unstructured":"Tyagi P, Killinger K, Tyagi V et al (2012) Urinary chemokines as non-invasive predictors of ulcerative interstitial cystitis. J Urol 187(6):2243\u20132248","journal-title":"J Urol"},{"issue":"3","key":"4452_CR29","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1097\/AOG.0000000000001892","volume":"129","author":"MG Abernethy","year":"2017","unstructured":"Abernethy MG, Rosenfeld A, White JR et al (2017) Urinary microbiome and cytokine levels in women with interstitial cystitis. Obstet Gynecol 129(3):500\u2013506","journal-title":"Obstet Gynecol"},{"issue":"6","key":"4452_CR30","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.3390\/jcm9061935","volume":"9","author":"SK Saha","year":"2020","unstructured":"Saha SK, Jeon TI, Jang SB et al (2020) Bioinformatics approach for identifying novel biomarkers and their signaling pathways involved in interstitial cystitis\/bladder pain syndrome with hunner lesion. J Clin Med 9(6):1935","journal-title":"J Clin Med"},{"issue":"8","key":"4452_CR31","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1007\/s00192-023-05551-z","volume":"34","author":"S Uguzova","year":"2023","unstructured":"Uguzova S, Julieb\u00f8-Jones P, Beisland C et al (2023) Current status of patient-reported outcome measures and other subjective assessment grading tools in bladder pain syndrome. Int Urogynecol J 34(8):1677\u20131687","journal-title":"Int Urogynecol J"},{"key":"4452_CR32","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00345-012-0852-y","volume":"31","author":"AT Corcoran","year":"2013","unstructured":"Corcoran AT, Yoshimura N, Tyagi V, Jacobs B, Leng W, Tyagi P (2013) Mapping the cytokine profile of painful bladder syndrome\/interstitial cystitis in human bladder and urine specimens\". World J Urol 31:241\u2013246","journal-title":"World J Urol"},{"issue":"Suppl 1","key":"4452_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/iju.13972","volume":"26","author":"A Furuta","year":"2019","unstructured":"Furuta A, Suzuki Y, Igarashi T, Koike Y, Kimura T, Egawa S, Yoshimura N (2019) Angiogenesis in bladder tissues is strongly correlated with urinary frequency and bladder pain in patients with interstitial cystitis\/bladder pain syndrome\". Int J Urol 26(Suppl 1):35\u201340","journal-title":"Int J Urol"},{"key":"4452_CR34","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1097\/JU.0000000000000234","volume":"202","author":"Y Akiyama","year":"2019","unstructured":"Akiyama Y, Maeda D, Katoh H, Morikawa T, Niimi A, Nomiya A, Sato Y, Kawai T, Goto A, Fujimura T, Fukuhara H, Nakagawa T, Igawa Y, Ishikawa S, Fukayama M, Kume H, Homma Y (2019) Molecular taxonomy of interstitial cystitis\/bladder pain syndrome based on whole transcriptome profiling by next-generation RNA sequencing of bladder mucosal biopsies\". J Urol 202:290\u2013300","journal-title":"J Urol"},{"key":"4452_CR35","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1007\/s00192-019-04038-0","volume":"30","author":"JS Schachar","year":"2019","unstructured":"Schachar JS, Evans RJ, Parks GE, Zambon J, Badlani G, Walker SJ (2019) Histological evidence supports low anesthetic bladder capacity as a marker of a bladder-centric disease subtype in interstitial cystitis\/bladder pain syndrome\". Int Urogynecol J 30:1863\u20131870","journal-title":"Int Urogynecol J"},{"issue":"11","key":"4452_CR36","doi-asserted-by":"publisher","first-page":"e0143316","DOI":"10.1371\/journal.pone.0143316","volume":"10","author":"D Maeda","year":"2015","unstructured":"Maeda D, Akiyama Y, Morikawa T, Kunita A, Ota Y, Katoh H, Niimi A, Nomiya A, Ishikawa S, Goto A, Igawa Y, Fukayama M, Homma Y (2015) Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation. PLoS One 10(11):e0143316.","journal-title":"PLoS One"},{"issue":"1","key":"4452_CR37","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ucl.2022.09.006","volume":"50","author":"JM Masterson","year":"2023","unstructured":"Masterson JM, Casta\u00f1eda PR, Kim J (2023) Pathophysiology and clinical biomarkers in interstitial cystitis. Urol Clin North Am 50(1):39\u201352","journal-title":"Urol Clin North Am"},{"issue":"6","key":"4452_CR38","doi-asserted-by":"publisher","first-page":"F1391","DOI":"10.1152\/ajprenal.00051.2020","volume":"318","author":"YH Jiang","year":"2020","unstructured":"Jiang YH, Jhang JF, Hsu YH et al (2020) Urine cytokines as biomarkers for diagnosing interstitial cystitis\/bladder pain syndrome and mapping its clinical characteristics. Am J Physiol Renal Physiol 318(6):F1391\u2013F1399","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"4452_CR39","doi-asserted-by":"publisher","first-page":"353","DOI":"10.56434\/j.arch.esp.urol.20247704.48","volume":"77","author":"L Wang","year":"2024","unstructured":"Wang L, Gao J, Zheng S et al (2024) Potential urine and serum biomarkers in patients with bladder pain syndrome\/interstitial cystitis. Arch Esp Urol 77(4):353\u2013358. https:\/\/doi.org\/10.56434\/j.arch.esp.urol.20247704.48","journal-title":"Arch Esp Urol"},{"issue":"1","key":"4452_CR40","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12894-023-01353-z","volume":"23","author":"H Ke","year":"2023","unstructured":"Ke H, Zhu L, Wang Q, Xu K (2023) Neutrophil-to-lymphocyte ratio as a promising non-invasive biomarker for symptom assessment and diagnosis of interstitial cystitis\/bladder pain syndrome. BMC Urol 23(1):180. https:\/\/doi.org\/10.1186\/s12894-023-01353-z","journal-title":"BMC Urol"},{"issue":"10","key":"4452_CR41","doi-asserted-by":"publisher","first-page":"e76779","DOI":"10.1371\/journal.pone.0076779","volume":"8","author":"YH Jiang","year":"2013","unstructured":"Jiang YH, Peng CH, Liu HT et al (2013) Increased pro-inflammatory cytokines, C-reactive protein and nerve growth factor expressions in serum of patients with interstitial cystitis\/bladder pain syndrome. PLoS ONE 8(10):e76779","journal-title":"PLoS ONE"},{"issue":"9","key":"4452_CR42","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.pain.2014.05.029","volume":"155","author":"A Schrepf","year":"2014","unstructured":"Schrepf A, O\u2019Donnell M, Luo Y et al (2014) Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) research network. inflammation and inflammatory control in interstitial cystitis\/bladder pain syndrome: associations with painful symptoms. Pain 155(9):1755\u20131761","journal-title":"Pain"},{"issue":"5","key":"4452_CR43","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1097\/JU.0000000000000257","volume":"202","author":"NY Siddiqui","year":"2019","unstructured":"Siddiqui NY, Helfand BT, Andreev VP, Kowalski JT, Bradley MS, Lai HH, Berger MB, Mueller MG, Bickhaus JA, Packiam VT, Fenner D, Gillispie BW, Kirkali Z (2019) Symptoms of lower urinary tract dysfunction research network (LURN). biomarkers implicated in lower urinary tract symptoms: systematic review and pathway analyses. J Urol 202(5):880\u2013889","journal-title":"J Urol"},{"key":"4452_CR44","doi-asserted-by":"crossref","unstructured":"Deraison, C.; Bonnart, C.; Vergnolle, N. Proteases. In Inflammation: From Molecular and Cellular Mechanisms to the Clinic; Wiley: Hoboken, NJ, USA, 2017; pp. 727\u2013766","DOI":"10.1002\/9783527692156.ch28"},{"issue":"6","key":"4452_CR45","doi-asserted-by":"publisher","first-page":"26083","DOI":"10.1038\/srep26083","volume":"18","author":"A Braundmeier-Fleming","year":"2016","unstructured":"Braundmeier-Fleming A, Russell NT et al (2016) Stool-based biomarkers of interstitial cystitis\/bladder pain syndrome. Sci Rep 18(6):26083. https:\/\/doi.org\/10.1038\/srep26083","journal-title":"Sci Rep"},{"issue":"9","key":"4452_CR46","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/ncpuro1203","volume":"5","author":"DJ Klumpp","year":"2008","unstructured":"Klumpp DJ, Rudick CN (2008) Summation model of pelvic pain in interstitial cystitis. Nat Clin Pract Urol 5(9):494\u2013500","journal-title":"Nat Clin Pract Urol"},{"issue":"1","key":"4452_CR47","doi-asserted-by":"crossref","first-page":"54","DOI":"10.17925\/ENR.2009.04.01.54","volume":"4","author":"D Klumpp","year":"2009","unstructured":"Klumpp D, Rudick CN (2009) Dietary sensitivity of interstitial cystitis - bane and opportunity. European Urological Review 4(1):54\u201356","journal-title":"European Urological Review"},{"key":"4452_CR48","doi-asserted-by":"publisher","first-page":"12044","DOI":"10.3390\/ijms231912044","volume":"23","author":"YH Jiang","year":"2022","unstructured":"Jiang YH, Jhang JF, Hsu YH et al (2022) Usefulness of urinary biomarkers for assessing bladder condition and histopathology in patients with interstitial cystitis\/bladder pain syndrome. Int J Mol Sci 23:12044","journal-title":"Int J Mol Sci"},{"key":"4452_CR49","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","volume":"122","author":"SJ Forrester","year":"2018","unstructured":"Forrester SJ, Kikuchi DS, Hernandes MS, Xu Q, Griendling KK (2018) Reactive oxygen species in metabolic and inflammatory signaling. Circ Res 122:877\u2013902","journal-title":"Circ Res"},{"key":"4452_CR50","doi-asserted-by":"publisher","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","volume":"24","author":"M Schieber","year":"2014","unstructured":"Schieber M, Chandel NS (2014) ROS function in redox signaling and oxidative stress. Curr Biol 24:R453\u2013R462","journal-title":"Curr Biol"},{"key":"4452_CR51","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1161\/CIRCRESAHA.116.303584","volume":"116","author":"DI Brown","year":"2015","unstructured":"Brown DI, Griendling KK (2015) Regulation of signal transduction by reactive oxygen species in the cardiovascular system. Circ Res 116:531\u2013549","journal-title":"Circ Res"},{"issue":"Suppl. 3","key":"4452_CR52","first-page":"S16","volume":"39","author":"JE Speich","year":"2020","unstructured":"Speich JE, Tarcan T, Hashitani H, Vahabi B, McCloskey KD, Andersson KE, Wein AJ, Birder LA (2020) Are oxidative stress and ischemia significant causes of bladder damage leading to lower urinary tract dysfunction? Report from the ICI-RS 2019. Neurourol Urodyn 39(Suppl. 3):S16\u2013S22","journal-title":"Neurourol Urodyn"},{"issue":"7","key":"4452_CR53","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s00192-017-3547-5","volume":"29","author":"A Furuta","year":"2018","unstructured":"Furuta A, Yamamoto T, Suzuki Y et al (2018) Comparison of inflammatory urine markers in patients with interstitial cystitis and overactive bladder. Int Urogynecol J 29(7):961\u2013966","journal-title":"Int Urogynecol J"},{"issue":"1","key":"4452_CR54","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/s41598-020-80131-5","volume":"11","author":"YH Jiang","year":"2021","unstructured":"Jiang YH, Jhang JF, Hsu YH et al (2021) Urine biomarkers in ESSIC type 2 interstitial cystitis\/bladder pain syndrome and overactive bladder with developing a novel diagnostic algorithm. Sci Rep 11(1):914","journal-title":"Sci Rep"},{"key":"4452_CR55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044687","volume":"7","author":"HT Liu","year":"2012","unstructured":"Liu HT, Kuo HC (2012) Increased urine and serum nerve growth factor levels in interstitial cystitis suggest chronic inflammation is involved in the pathogenesis of disease. PLoS ONE 7:e44687","journal-title":"PLoS ONE"},{"key":"4452_CR56","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1111\/j.1464-410X.2009.08675.x","volume":"104","author":"HT Liu","year":"2009","unstructured":"Liu HT, Tyagi P, Chancellor MB, Kuo HC (2009) Urinary nerve growth factor level is increased in patients with interstitial cystitis\/bladder pain syndrome and decreased in responders to treatment. BJU Int 104:1476\u20131481","journal-title":"BJU Int"},{"issue":"3","key":"4452_CR57","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/j.1464-410X.2012.11672.x","volume":"111","author":"JH Seth","year":"2013","unstructured":"Seth JH, Sahai A, Khan MS, van der Aa F, de Ridder D, Panicker JN, Dasgupta P, Fowler CJ (2013) Nerve growth factor (NGF): a potential urinary biomarker for overactive bladder syndrome (OAB)? BJU Int 111(3):372\u2013380","journal-title":"BJU Int"},{"issue":"2","key":"4452_CR58","first-page":"110","volume":"36","author":"WR Yu","year":"2023","unstructured":"Yu WR, Jiang YH, Jhang JF, Kuo HC (2023) Urine biomarker could be a useful tool for differential diagnosis of a lower urinary tract dysfunction. Tzu Chi Med J 36(2):110\u2013119","journal-title":"Tzu Chi Med J"},{"issue":"9","key":"4452_CR59","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1007\/s00192-018-3817-x","volume":"30","author":"S Liu","year":"2019","unstructured":"Liu S, Feng S, Luo D (2019) Analysis of key genes and micro-RNA-mRNA regulatory networks in women with ulcerative interstitial cystitis\/pain bladder syndrome. Int Urogynecol J 30(9):1487\u20131495","journal-title":"Int Urogynecol J"},{"issue":"21","key":"4452_CR60","doi-asserted-by":"publisher","first-page":"12155","DOI":"10.18632\/aging.205170","volume":"15","author":"SQ Yang","year":"2023","unstructured":"Yang SQ, Peng L, Lin LD et al (2023) Identification of circRNA-miRNA-mRNA network as biomarkers for interstitial cystitis\/bladder pain syndrome. Aging (Albany NY) 15(21):12155\u201312170","journal-title":"Aging (Albany NY)"},{"key":"4452_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061935","author":"SK Saha","year":"2020","unstructured":"Saha SK, Jeon TI, Jang SB et al (2020) Bioinformatics approach for identifying novel biomarkers and their signaling pathways involved in interstitial cystitis\/bladder pain syndrome with Hunner lesion. J Clin Med. https:\/\/doi.org\/10.3390\/jcm9061935","journal-title":"J Clin Med"},{"issue":"5","key":"4452_CR62","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.eururo.2018.07.026","volume":"74","author":"PC Bosch","year":"2018","unstructured":"Bosch PC (2018) A randomized, double-blind, placebo-controlled trial of certolizumab pegol in women with refractory interstitial cystitis\/bladder pain syndrome. Eur Urol 74(5):623\u2013630. https:\/\/doi.org\/10.1016\/j.eururo.2018.07.026","journal-title":"Eur Urol"},{"issue":"2","key":"4452_CR63","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1002\/nau.23365","volume":"37","author":"Y Akiyama","year":"2018","unstructured":"Akiyama Y, Maeda D, Morikawa T, Niimi A, Nomiya A, Yamada Y, Igawa Y, Goto A, Fukayama M, Homma Y (2018) Digital quantitative analysis of mast cell infiltration in interstitial cystitis. Neurourol Urodyn 37(2):650\u2013657","journal-title":"Neurourol Urodyn"},{"issue":"11","key":"4452_CR64","doi-asserted-by":"publisher","first-page":"6869","DOI":"10.1097\/JS9.0000000000001961","volume":"110","author":"ZS Wu","year":"2024","unstructured":"Wu ZS, Lee WC, Chancellor MB, Wang HJ, Huang CC, Chuang YC (2024) Extracorporeal shock wave therapy modulates miRNA expression, reduces inflammation, and improves liposome retention in a rat model of cyclophosphamide-induced cystitis - experimental studies. Int J Surg 110(11):6869\u20136872","journal-title":"Int J Surg"},{"key":"4452_CR65","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ebiom.2016.03.040","volume":"7","author":"KS Parker","year":"2016","unstructured":"Parker KS, Crowley JR, Stephens-Shields AJ et al (2016) Urinary metabolomics identifies a molecular correlate of interstitial cystitis\/bladder pain Syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) research network cohort. EBioMedicine 7:167\u2013174","journal-title":"EBioMedicine"},{"issue":"6","key":"4452_CR66","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1124\/mol.106.033407","volume":"71","author":"P Li","year":"2007","unstructured":"Li P, Bracamontes J, Katona BW et al (2007) Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Mol Pharmacol 71(6):1582\u20131590. https:\/\/doi.org\/10.1124\/mol.106.033407","journal-title":"Mol Pharmacol"},{"issue":"1","key":"4452_CR67","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0261-5614(86)90037-3","volume":"5","author":"DW Wilmore","year":"1986","unstructured":"Wilmore DW (1986) Are the metabolic alterations associated with critical illness related to the hormonal environment? Clin Nutr 5(1):9\u201319. https:\/\/doi.org\/10.1016\/0261-5614(86)90037-3","journal-title":"Clin Nutr"},{"issue":"23","key":"4452_CR68","doi-asserted-by":"publisher","first-page":"12857","DOI":"10.3390\/ijms252312857","volume":"25","author":"YH Jiang","year":"2024","unstructured":"Jiang YH, Jhang JF, Wang JH, Wu YH, Kuo HC (2024) A Decision tree model using urine inflammatory and oxidative stress biomarkers for predicting lower urinary tract dysfunction in females. Int J Mol Sci 25(23):12857","journal-title":"Int J Mol Sci"},{"issue":"6","key":"4452_CR69","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","volume":"122","author":"SJ Forrester","year":"2018","unstructured":"Forrester SJ, Kikuchi DS, Hernandes MS, Xu Q, Griendling KK (2018) Reactive oxygen species in metabolic and inflammatory signaling. Circ Res 122(6):877\u2013902","journal-title":"Circ Res"},{"issue":"3","key":"4452_CR70","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1097\/JU.0000000000002278","volume":"207","author":"Y Akiyama","year":"2022","unstructured":"Akiyama Y, Miyakawa J, O\u2019Donnell MA, Kreder KJ, Luo Y, Maeda D, Ushiku T, Kume H, Homma Y (2022) Overexpression of HIF1alpha in Hunner lesions of interstitial cystitis: pathophysiological implications. J Urol 207(3):635\u2013646","journal-title":"J Urol"},{"key":"4452_CR71","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1046\/j.1464-410X.1997.00097.x","volume":"79","author":"EM Lowe","year":"1997","unstructured":"Lowe EM, Anand P, Terenghi G, Williams-Chestnut RE, Sinicropi DV, Osborne JL (1997) Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis. Br J Urol 79:572\u2013577","journal-title":"Br J Urol"},{"key":"4452_CR72","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000355175","volume":"92","author":"BL Liu","year":"2014","unstructured":"Liu BL, Yang F, Zhan HL et al (2014) Increased severity of inflammation correlates with elevated expression of TRPV1 nerve fibers and nerve growth factor on interstitial cystitis\/bladder pain syndrome. Urol Int 92:202\u2013208","journal-title":"Urol Int"},{"issue":"2","key":"4452_CR73","doi-asserted-by":"publisher","first-page":"e418","DOI":"10.1097\/SPV.0000000000000951","volume":"27","author":"A Soriano","year":"2021","unstructured":"Soriano A, Andy U, Hassani D et al (2021) Relationship of bladder pain with clinical and urinary markers of neuroinflammation in women with urinary urgency without urinary incontinence. Female Pelvic Med Reconstr Surg 27(2):e418\u2013e422","journal-title":"Female Pelvic Med Reconstr Surg"},{"issue":"3","key":"4452_CR74","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1002\/nau.23431","volume":"37","author":"A Niimi","year":"2018","unstructured":"Niimi A, Igawa Y, Aizawa N et al (2018) Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis. Neurourol Urodyn 37(3):1113\u20131119","journal-title":"Neurourol Urodyn"},{"issue":"1","key":"4452_CR75","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00345-024-04843-3","volume":"42","author":"JF Jhang","year":"2024","unstructured":"Jhang JF, Yu WR, Huang WT, Kuo HC (2024) Combination of urinary biomarkers and machine-learning models provided a higher predictive accuracy to predict long-term treatment outcomes of patients with interstitial cystitis\/bladder pain syndrome. World J Urol 42(1):173","journal-title":"World J Urol"},{"key":"4452_CR76","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.urology.2024.03.043","volume":"189","author":"LE Lamb","year":"2024","unstructured":"Lamb LE, Janicki JJ, Bartolone SN, Ward EP, Abraham N, Laudano M, Smith CP, Peters KM, Zwaans BMM, Chancellor MB (2024) Risk classification for interstitial cystitis\/bladder pain syndrome using machine learning based predictions. Urology 189:19\u201326","journal-title":"Urology"},{"issue":"23","key":"4452_CR77","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.3390\/diagnostics14232734","volume":"14","author":"JJ Janicki","year":"2024","unstructured":"Janicki JJ, Zwaans BMM, Bartolone SN, Ward EP, Chancellor MB (2024) Advancing interstitial cystitis\/bladder pain syndrome (IC\/BPS) diagnosis: a comparative analysis of machine learning methodologies. Diagnostics (Basel) 14(23):2734","journal-title":"Diagnostics (Basel)"},{"issue":"2","key":"4452_CR78","volume":"7","author":"F Tong","year":"2020","unstructured":"Tong F, Shahid M, Jin P, Jung S, Kim WH, Kim J (2020) Classification of the urinary metabolome using machine learning and potential applications to diagnosing interstitial cystitis. Bladder (San Franc) 7(2):e43","journal-title":"Bladder (San Franc)"},{"issue":"12","key":"4452_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.716564","volume":"14","author":"V Kumar","year":"2021","unstructured":"Kumar V, Kiran S, Shamran HA, Singh UP (2021) Differential expression of microRNAs correlates with the severity of experimental autoimmune cystitis. Front Immunol 14(12):716564","journal-title":"Front Immunol"},{"issue":"4","key":"4452_CR80","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13007","volume":"54","author":"Y Li","year":"2021","unstructured":"Li Y, Liu Y, Gao Z, Zhang L, Chen L, Wu Z, Liu Q, Wang S, Zhou N, Chai TC, Shi B (2021) Single-cell transcriptomes of mouse bladder urothelium uncover novel cell type markers and urothelial differentiation characteristics. Cell Prolif 54(4):e13007","journal-title":"Cell Prolif"}],"updated-by":[{"DOI":"10.1007\/s11255-025-04492-4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000}}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04452-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-025-04452-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04452-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T09:56:47Z","timestamp":1757152607000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-025-04452-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,15]]},"references-count":80,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["4452"],"URL":"https:\/\/doi.org\/10.1007\/s11255-025-04452-y","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s11255-025-04492-4","asserted-by":"object"}]},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,15]]},"assertion":[{"value":"20 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original article has been corrected. Reference citation numbers are corrected in Table 2.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2025","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11255-025-04492-4","URL":"https:\/\/doi.org\/10.1007\/s11255-025-04492-4","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The manuscript does not contain any individual personal data in any form. All authors reviewed and approved the final version of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}