{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T01:01:56Z","timestamp":1767142916654,"version":"build-2238731810"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008501","name":"East Carolina University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008501","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Intraductal carcinoma of the prostate is a rare subset of prostate cancer, for which no consensus treatment guidelines exist. We seek to investigate treatment and survival outcomes for IDC-P in the context of current NCCN guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patients with intraductal carcinoma of the prostate diagnosed between 2000 and 2020. Cox regression analysis and log-rank comparisons of both overall and cause-specific survival over 5- and 10-year timeframes were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      945 patients were identified. Cox regression analysis demonstrated treatment with unimodal surgery (hazard ratio (HR)\u2009=\u20093.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) was associated with decreased 10-year cause-specific survival, while unimodal treatment with radiotherapy was associated with decreased 5- and 10-year overall survival (HR\u2009=\u20092.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025; HR\u2009=\u20092.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005, respectively). Univariate survival subanalysis of treatment regimens demonstrated decreased 5-year cause-specific (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and overall (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019) survival among patients that received only radiotherapy as treatment. Radical prostatectomy alone was non-inferior to radical prostatectomy with adjuvant radiotherapy in the context of 10-year overall survival (90% vs 80%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.58).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Differences in both 5- and 10-year overall survival and cause-specific survival were present among patients diagnosed with IDC-P. Treatment with unimodal radiotherapy among patients with IDC-P was associated with decreased survival compared to treatment with radical prostatectomy\u2009\u00b1\u2009adjuvant radiotherapy, while radical prostatectomy alone was non-inferior to radical prostatectomy with adjuvant radiotherapy. Further research into the risk stratification and optimal treatment of these patients is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11255-025-04485-3","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T21:22:41Z","timestamp":1743888161000},"page":"3143-3149","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment outcomes and comparative survival analysis of intraductal carcinoma of the prostate"],"prefix":"10.1007","volume":"57","author":[{"given":"Taylor","family":"Stamey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Armel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew W.","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoujun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musharraf","family":"Navaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-8345","authenticated-orcid":false,"given":"Michael C.","family":"Larkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"key":"4485_CR1","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/his.12198","volume":"63","author":"K Watts","year":"2013","unstructured":"Watts K, Li J, Magi-Galluzzi C, Zhou M (2013) Incidence and clinicopathological characteristics of intraductal carcinoma detected in prostate biopsies: a prospective cohort study. 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Disclaimer statement has been included.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2025","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11255-025-04774-x","URL":"https:\/\/doi.org\/10.1007\/s11255-025-04774-x","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No Institutional Review Board approval was necessary for this project given the data are de-identified and publicly available. Patient consent was not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical\/patient consent statement"}},{"value":"The views and opinions expressed in this article\/presentation are those of the author(s) and do not necessarily reflect official policy or position of the United States Air Force, Defense Health Agency, Department of Defense, or U.S. Government.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}