{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:18:41Z","timestamp":1758845921793,"version":"3.44.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100015690","name":"Universitas Padjadjaran","doi-asserted-by":"publisher","award":["RPLK No. 1753\/UN631\/PT00\/2024","RPLK No. 1753\/UN631\/PT00\/2024"],"award-info":[{"award-number":["RPLK No. 1753\/UN631\/PT00\/2024","RPLK No. 1753\/UN631\/PT00\/2024"]}],"id":[{"id":"10.13039\/501100015690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-025-04537-8","type":"journal-article","created":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T07:55:57Z","timestamp":1745740557000},"page":"3409-3416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dental caries prevention as a modifiable precipitating factor of nephrotic syndrome relapse in children: an insight into simple-novel management"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-089X","authenticated-orcid":false,"given":"Ahmedz","family":"Widiasta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-2953","authenticated-orcid":false,"given":"Nanan","family":"Nur\u2019aeny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"issue":"3","key":"4537_CR1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.37796\/2211-8039.1205","volume":"11","author":"A Widiasta","year":"2021","unstructured":"Widiasta A, Wahyudi K, Sribudiani Y, Rachmadi D (2021) The level of transforming growth factor-\u03b2 as a possible predictor of cyclophosphamide response in children with steroid-resistant nephrotic syndrome. Biomedicine 11(3):68\u201375","journal-title":"Biomedicine"},{"issue":"2","key":"4537_CR2","first-page":"4223","volume":"13","author":"D Rachmadi","year":"2021","unstructured":"Rachmadi D, Widiasta A, Pusparani C, Wahyudi K (2021) Higher baseline integrin beta-1 level associated with possible increase in the remission of steroid-resistant nephrotic syndrome using cyclophosphamide treatment. Int J Pharm Res 13(2):4223\u201332","journal-title":"Int J Pharm Res"},{"key":"4537_CR3","doi-asserted-by":"crossref","unstructured":"Malaga-Dieguez L, Bouhassira D, Gipson D, Trachtman H (2015) Novel therapies for FSGS: preclinical and clinical studies. Adv Chronic Kidney Dis [Internet]. 22(2):e1\u20136. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25704355","DOI":"10.1053\/j.ackd.2014.10.001"},{"key":"4537_CR4","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2147\/IJNRD.S351053","volume":"15","author":"D Hilmanto","year":"2022","unstructured":"Hilmanto D (2022) Disease-associated systemic complications in childhood nephrotic syndrome: a systematic review. Int J Nephrol Renovasc Dis. 15:53","journal-title":"Int J Nephrol Renovasc Dis."},{"issue":"6","key":"4537_CR5","doi-asserted-by":"publisher","first-page":"8613","DOI":"10.3892\/mmr.2017.7697","volume":"16","author":"S Zhai","year":"2017","unstructured":"Zhai S, Hu L, Zhong L, Tao Y, Wang Z (2017) Low molecular weight heparin may benefit nephrotic remission in steroid-sensitive nephrotic syndrome via inhibiting elastase. Mol Med Rep 16(6):8613\u20138618","journal-title":"Mol Med Rep"},{"key":"4537_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0259211","volume":"16","author":"A Adhipatria","year":"2021","unstructured":"Adhipatria A, Amalia SN, Sekiguchi A, Bhattarai A, Taketomi-Takahashi A, Motegi SI et al (2021) Neutrophil elastase in the development of nephrogenic systemic fibrosis (NSF)-like skin lesion in renal failure mouse model. PLoS ONE [Internet] 16:1\u201315. https:\/\/doi.org\/10.1371\/journal.pone.0259211","journal-title":"PLoS ONE [Internet]"},{"key":"4537_CR7","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s00467-009-1362-z","volume":"25","author":"K Kaneko","year":"2010","unstructured":"Kaneko K, Hasui M, Hata A (2010) Focal segmental glomerulosclerosis in a boy with Dent-2 disease. Pediatr Nephrol 25:781\u20132","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"4537_CR8","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/s41390-020-1022-3","volume":"89","author":"S Tsuji","year":"2021","unstructured":"Tsuji S, Akagawa S, Akagawa Y, Yamaguchi T, Kino J, Yamanouchi S et al (2021) Idiopathic nephrotic syndrome in children: role of regulatory T cells and gut microbiota. Pediatr Res [Internet] 89(5):1185\u201391. https:\/\/doi.org\/10.1038\/s41390-020-1022-3","journal-title":"Pediatr Res [Internet]"},{"issue":"2","key":"4537_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu13020365","volume":"13","author":"T Yamaguchi","year":"2021","unstructured":"Yamaguchi T, Tsuji S, Akagawa S, Akagawa Y, Kino J, Yamanouchi S et al (2021) Clinical significance of probiotics for children with idiopathic nephrotic syndrome. Nutrients 13(2):1\u201310","journal-title":"Nutrients"},{"issue":"3","key":"4537_CR10","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1159\/000499876","volume":"44","author":"O Zakiyanov","year":"2019","unstructured":"Zakiyanov O, Kalousov\u00e1 M, Zima T, Tesa\u0159 V (2019) Matrix metalloproteinases in renal diseases: a critical appraisal. Kidney Blood Press Res 44(3):298\u2013330","journal-title":"Kidney Blood Press Res"},{"issue":"3","key":"4537_CR11","doi-asserted-by":"publisher","first-page":"502","DOI":"10.5301\/jn.5000136","volume":"26","author":"O Zakiyanov","year":"2013","unstructured":"Zakiyanov O, Kalousov\u00e1 M, Kratochvilov\u00e1 M, Kr\u00edha V, Zima T, Tesar V (2013) Changes in levels of matrix metalloproteinase-2 and -9, pregnancy-associated plasma protein-A in patients with various nephropathies. J Nephrol 26(3):502\u2013509","journal-title":"J Nephrol"},{"issue":"2","key":"4537_CR12","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.nefro.2018.08.009","volume":"39","author":"E Rodr\u00edguez-S\u00e1nchez","year":"2019","unstructured":"Rodr\u00edguez-S\u00e1nchez E, Navarro-Garc\u00eda JA, Aceves-Ripoll J, \u00c1lvarez-Llamas G, Segura J, Barderas MG et al (2019) Association between renal dysfunction and metalloproteinase (MMP)-9 activity in hypertensive patients. Nefrologia 39(2):184\u2013191","journal-title":"Nefrologia"},{"issue":"8","key":"4537_CR13","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009964","volume":"97","author":"B Bienia\u015b","year":"2018","unstructured":"Bienia\u015b B, Sikora P (2018) Urinary metalloproteinases and tissue inhibitors of metalloproteinases as potential early biomarkers for renal fibrosis in children with nephrotic syndrome. Medicine (Baltimore) 97(8):e9964","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"4537_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15171\/jnp.2019.33","volume":"8","author":"S Sreelatha","year":"2019","unstructured":"Sreelatha S, D\u2019Souza B, D\u2019Souza V (2019) Matrix metalloproteinases in nephrotic syndrome; a vital but obscure field of research. J Nephropathol 8(3):1\u201313","journal-title":"J Nephropathol"},{"key":"4537_CR15","doi-asserted-by":"publisher","first-page":"001","DOI":"10.17352\/2455-4634.000034","volume":"4","author":"MS Tong","year":"2018","unstructured":"Tong MS (2018) Dental caries status and relevant factors in children with primary nephrotic syndrome in national children hospital, Vietnam. Int J Oral Craniofacial Sci 4:001\u2013004","journal-title":"Int J Oral Craniofacial Sci"},{"issue":"4","key":"4537_CR16","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00467-017-3677-5","volume":"33","author":"M Colucci","year":"2018","unstructured":"Colucci M, Corpetti G, Emma F, Vivarelli M (2018) Immunology of idiopathic nephrotic syndrome. Pediatr Nephrol 33(4):573\u2013584","journal-title":"Pediatr Nephrol"},{"key":"4537_CR17","doi-asserted-by":"publisher","first-page":"332","DOI":"10.2215\/CJN.05000516","volume":"2","author":"M Vivarelli","year":"2017","unstructured":"Vivarelli M, Massella L, Ruggiero B, Emma F (2017) Minimal change disease. Clin J Am Soc Nephrol 2:332","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"4537_CR18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.5336\/dentalsci.2018-61371","volume":"24","author":"KG Ulu Guzel","year":"2018","unstructured":"Ulu Guzel KG, Yilmaz D, Abacigil F, Pirincci S (2018) Oral aspects in children with nephrotic syndrome. Turkiye Klin J Dent Sci 24(3):183\u2013189","journal-title":"Turkiye Klin J Dent Sci"},{"key":"4537_CR19","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12903-015-0042-6","volume":"15","author":"D Olczak-Kowalczyk","year":"2015","unstructured":"Olczak-Kowalczyk D, Pyr\u017cak B, D\u0105bkowska M, Pa\u0144czyk-Tomaszewska M, Miszkurka G, Rogozi\u0144ska I et al (2015) Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes. BMC Oral Health 15:57","journal-title":"BMC Oral Health"},{"key":"4537_CR20","doi-asserted-by":"publisher","DOI":"10.5812\/compreped.109912","author":"A Widiasta","year":"2021","unstructured":"Widiasta A, Wahyudi K, Nugrahapraja H, Sribudiani Y, Rachmadi D (2021) The unique difference between serum level of soluble urokinase plasminogen activator receptor (suPAR) in steroid-resistant nephrotic syndrome children treated with an alkylating agent and calcineurin inhibitors. J Compr Pediatr. https:\/\/doi.org\/10.5812\/compreped.109912","journal-title":"J Compr Pediatr"},{"key":"4537_CR21","doi-asserted-by":"publisher","unstructured":"Jakub Ku\u017aniar Tomasz J. Ku\u017aniar ZMJLBJRWK, Klinger M (2007) Elastase deposits in the kidney and urinary elastase excretion in patients with glomerulonephritis\u2014evidence for neutrophil involvement in renal injury. Scand J Urol Nephrol [Internet] 41(6):527\u2013534. https:\/\/doi.org\/10.1080\/00365590701430893","DOI":"10.1080\/00365590701430893"},{"issue":"10","key":"4537_CR22","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.7150\/ijbs.26111","volume":"14","author":"E Bronze-Da-Rocha","year":"2018","unstructured":"Bronze-Da-Rocha E, Santos-Silva A (2018) Neutrophil elastase inhibitors and chronic kidney disease. Int J Biol Sci 14(10):1343\u20131360","journal-title":"Int J Biol Sci"},{"issue":"8","key":"4537_CR23","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1681\/ASN.2016121271","volume":"28","author":"DJ Caster","year":"2017","unstructured":"Caster DJ, Powell DW, Miralda I, Ward RA, McLeish KR (2017) Re-examining neutrophil participation in GN. J Am Soc Nephrol 28(8):2275\u20132289","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"4537_CR24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s12903-020-01197-1","volume":"20","author":"U Kaczmarek","year":"2020","unstructured":"Kaczmarek U, Wrzyszcz-Kowalczyk A, Jankowska K, Pro\u015bciak K, Mysiak-D\u0119bska M, Przywitowska I et al (2020) Oral health conditions in children with idiopathic nephrotic syndrome: a cross-sectional study. BMC Oral Health 20(1):213","journal-title":"BMC Oral Health"},{"issue":"3","key":"4537_CR25","first-page":"1","volume":"6","author":"K HulyaCak\u0131r","year":"2020","unstructured":"HulyaCak\u0131r K, Ilknur O, Ozlem G, MuhlisCem A, ArifAtahan C, Ayd\u0131n T (2020) Comparison of oral findings of common variable immune deficiency and nephrotic syndrome patients with hypogammaglobulinemia to healthy individuals. Int J Oral Dent Heal 6(3):1\u20135","journal-title":"Int J Oral Dent Heal"},{"issue":"1","key":"4537_CR26","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12014-017-9153-1","volume":"14","author":"YW Choi","year":"2017","unstructured":"Choi YW, Kim YG, Song MY, Moon JY, Jeong KH, Lee TW et al (2017) Potential urine proteomics biomarkers for primary nephrotic syndrome. Clin Proteomics [Internet] 14(1):18. https:\/\/doi.org\/10.1186\/s12014-017-9153-1","journal-title":"Clin Proteomics [Internet]"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04537-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-025-04537-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04537-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:00:21Z","timestamp":1758808821000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-025-04537-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,27]]},"references-count":26,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["4537"],"URL":"https:\/\/doi.org\/10.1007\/s11255-025-04537-8","relation":{},"ISSN":["1573-2584"],"issn-type":[{"type":"electronic","value":"1573-2584"}],"subject":[],"published":{"date-parts":[[2025,4,27]]},"assertion":[{"value":"12 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare there was no conflict of interest regarding the present manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Participants provided signed informed consent prior to enrollment in the study. The research project was approved by institutional review boards at Universitas Padjadjaran No 1030\/UN6.KEP\/EC\/2024.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}