{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T20:21:04Z","timestamp":1760473264342,"version":"build-2065373602"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018"],"award-info":[{"award-number":["Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018","Ref No: BT\/PR30523\/ BIC\/101\/1121\/2018"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-025-04546-7","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T23:14:00Z","timestamp":1746486840000},"page":"3713-3723","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deciphering the urinary microRNAs landscape in nephrotic syndrome: implications as prognostic marker\u2014a non-invasive study"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-2241","authenticated-orcid":false,"given":"Pricilla","family":"Charmine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2827-8680","authenticated-orcid":false,"given":"Vettriselvi","family":"Venkatesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0734-1126","authenticated-orcid":false,"given":"Sangeetha","family":"Geminiganesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-1344","authenticated-orcid":false,"given":"Sudha","family":"Ekambaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. R.","family":"Nammalwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"Parameswari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6760-785X","authenticated-orcid":false,"given":"C. D.","family":"Mohana Priya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"4546_CR1","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/s41581-022-00608-6","volume":"18","author":"N Mahtal","year":"2022","unstructured":"Mahtal N, Lenoir O, Tinel C et al (2022) MicroRNAs in kidney injury and disease. Nat Rev Nephrol 18:643\u2013662. https:\/\/doi.org\/10.1038\/s41581-022-00608-6","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"4546_CR2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215\u2013233","journal-title":"Cell"},{"issue":"1","key":"4546_CR3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1101\/gr.082701.108","volume":"19","author":"RC Friedman","year":"2009","unstructured":"Friedman RC et al (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19(1):92\u2013105. https:\/\/doi.org\/10.1101\/gr.082701.108","journal-title":"Genome Res"},{"issue":"2","key":"4546_CR4","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/nrg2504","volume":"10","author":"M Ghildiyal","year":"2009","unstructured":"Ghildiyal M, Zamore PD (2009) Small silencing RNAs: an expanding universe. Nat Rev Genet 10(2):94\u2013108. https:\/\/doi.org\/10.1038\/nrg2504","journal-title":"Nat Rev Genet"},{"issue":"6078","key":"4546_CR5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1126\/science.1215691","volume":"336","author":"S Djuranovic","year":"2012","unstructured":"Djuranovic S et al (2012) miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science 336(6078):237\u2013240. https:\/\/doi.org\/10.1126\/science.1215691","journal-title":"Science"},{"issue":"2","key":"4546_CR6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrg2936","volume":"12","author":"E Huntzinger","year":"2011","unstructured":"Huntzinger E, Izaurralde E (2011) Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12(2):99\u2013110. https:\/\/doi.org\/10.1038\/nrg2936","journal-title":"Nat Rev Genet"},{"issue":"5","key":"4546_CR7","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","volume":"75","author":"RC Lee","year":"1993","unstructured":"Lee RC et al (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75(5):843\u2013854. https:\/\/doi.org\/10.1016\/0092-8674(93)90529-Y","journal-title":"Cell"},{"issue":"5","key":"4546_CR8","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","volume":"75","author":"B Wightman","year":"1993","unstructured":"Wightman B et al (1993) Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75(5):855\u2013862. https:\/\/doi.org\/10.1016\/0092-8674(93)90530-4","journal-title":"Cell"},{"issue":"11","key":"4546_CR9","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.tibs.2012.08.003","volume":"37","author":"A Turchinovich","year":"2012","unstructured":"Turchinovich A et al (2012) Extracellular miRNAs: the mystery of their origin and function. Trends Biochem Sci 37(11):460\u2013465. https:\/\/doi.org\/10.1016\/j.tibs.2012.08.003","journal-title":"Trends Biochem Sci"},{"issue":"100","key":"4546_CR10","doi-asserted-by":"publisher","first-page":"ra81","DOI":"10.1126\/scisignal.2000610","volume":"2","author":"A Zernecke","year":"2009","unstructured":"Zernecke A et al (2009) Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal 2(100):ra81","journal-title":"Sci Signal"},{"issue":"6","key":"4546_CR11","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi H et al (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9(6):654\u2013659. https:\/\/doi.org\/10.1038\/ncb1596","journal-title":"Nat Cell Biol"},{"issue":"30","key":"4546_CR12","doi-asserted-by":"publisher","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell PS et al (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105(30):10513\u201310518. https:\/\/doi.org\/10.1073\/pnas.0804549105","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"4546_CR13","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/cr.2008.282","volume":"18","author":"X Chen","year":"2008","unstructured":"Chen X et al (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18(10):997\u20131006. https:\/\/doi.org\/10.1038\/cr.2008.282","journal-title":"Cell Res"},{"issue":"6","key":"4546_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020769","volume":"6","author":"R Duttagupta","year":"2011","unstructured":"Duttagupta R et al (2011) Impact of cellular miRNAs on circulating miRNA biomarker signatures. PLoS ONE 6(6):e20769. https:\/\/doi.org\/10.1371\/journal.pone.0020769","journal-title":"PLoS ONE"},{"issue":"9","key":"4546_CR15","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.158277","volume":"7","author":"DM Cerqueira","year":"2022","unstructured":"Cerqueira DM, Tayeb M, Ho J (2022) MicroRNAs in kidney development and disease. JCI Insight 7(9):e158277. https:\/\/doi.org\/10.1172\/jci.insight.158277","journal-title":"JCI Insight"},{"issue":"3","key":"4546_CR16","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3390\/ncrna1030192","volume":"1","author":"S Mukhadi","year":"2015","unstructured":"Mukhadi S, Hull R, Mbita Z, Dlamini Z (2015) The role of MicroRNAs in kidney disease. Non-Coding RNA 1(3):192\u2013221. https:\/\/doi.org\/10.3390\/ncrna1030192","journal-title":"Non-Coding RNA"},{"issue":"4","key":"4546_CR17","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1177\/0300985813502820","volume":"51","author":"M Bhaskaran","year":"2014","unstructured":"Bhaskaran M, Mohan M (2014) MicroRNAs: history, biogenesis, and their evolving role in animal development and disease. Vet Pathol 51(4):759\u2013774. https:\/\/doi.org\/10.1177\/0300985813502820","journal-title":"Vet Pathol"},{"issue":"8","key":"4546_CR18","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrm3838","volume":"15","author":"M Ha","year":"2014","unstructured":"Ha M, Kim VN (2014) Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15(8):509\u2013524","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"4546_CR19","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/j.cell.2012.02.005","volume":"148","author":"JT Mendell","year":"2012","unstructured":"Mendell JT, Olson EN (2012) MicroRNAs in stress signaling and human disease. Cell 148(6):1172\u20131187","journal-title":"Cell"},{"issue":"7006","key":"4546_CR20","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature02871","volume":"431","author":"V Ambros","year":"2004","unstructured":"Ambros V (2004) The functions of animal microRNAs. Nature 431(7006):350\u2013355","journal-title":"Nature"},{"issue":"10","key":"4546_CR21","doi-asserted-by":"crossref","first-page":"10075","DOI":"10.1007\/s13277-014-2321-2","volume":"35","author":"Z Zhang","year":"2014","unstructured":"Zhang Z, Zhang Y, Sun XX, Ma X, Chen ZN (2014) MicroRNA-100a suppresses the proliferation, migration, and invasion of renal cell carcinoma cells through targeting VEGF. Tumour Biol 35(10):10075\u201310084","journal-title":"Tumour Biol"},{"issue":"11","key":"4546_CR22","first-page":"1679","volume":"24","author":"B Wang","year":"2013","unstructured":"Wang B, Koh P, Winbanks C et al (2013) MicroRNA-221 promotes renal fibrosis by targeting PTEN and suppressing autophagy in diabetic nephropathy. J Am Soc Nephrol 24(11):1679\u20131690","journal-title":"J Am Soc Nephrol"},{"key":"4546_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2119\/molmed.2015.00237","volume":"22","author":"R Mastrocola","year":"2016","unstructured":"Mastrocola R et al (2016) MicroRNA-222 contributes to glucotoxicity-induced apoptosis in LLC-PK1 renal tubular cells. Mol Med 22:23\u201333. https:\/\/doi.org\/10.2119\/molmed.2015.00237","journal-title":"Mol Med"},{"issue":"2","key":"4546_CR24","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/ncrna9020018","volume":"9","author":"D Luna Buitrago","year":"2023","unstructured":"Luna Buitrago D, Lovering RC, Caporali A (2023) Insights into online microRNA bioinformatics tools. Noncoding RNA 9(2):18. https:\/\/doi.org\/10.3390\/ncrna9020018","journal-title":"Noncoding RNA"},{"issue":"1","key":"4546_CR25","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3390\/ijms22010088","volume":"22","author":"K Tsuji","year":"2020","unstructured":"Tsuji K, Kitamura S, Wada J (2020) MicroRNAs as biomarkers for nephrotic syndrome. Int J Mol Sci 22(1):88","journal-title":"Int J Mol Sci"},{"key":"4546_CR26","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1261\/rna.965408","volume":"14","author":"X Wang","year":"2008","unstructured":"Wang X (2008) miRDB: a microRNA target prediction and functional annotation database with a wiki interface. RNA 14:1012\u20131017","journal-title":"RNA"},{"key":"4546_CR27","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1037\/0033-2909.99.1.100","volume":"99","author":"JA Swets","year":"1986","unstructured":"Swets JA (1986) Indices of discrimination or diagnostic accuracy: their ROCs and implied models. Psychol Bull 99:100\u2013117","journal-title":"Psychol Bull"},{"key":"4546_CR28","volume-title":"Signal detection theory and psychophysics","author":"DM Green","year":"1966","unstructured":"Green DM, Swets JA (1966) Signal detection theory and psychophysics, 1st edn. Wiley, New York","edition":"1"},{"key":"4546_CR29","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0001-2998(78)80014-2","volume":"8","author":"CE Metz","year":"1978","unstructured":"Metz CE (1978) Basic principles of ROC analysis. Semin Nucl Med 8:283\u2013298","journal-title":"Semin Nucl Med"},{"key":"4546_CR30","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1097\/00004424-198609000-00009","volume":"21","author":"CE Metz","year":"1986","unstructured":"Metz CE (1986) ROC methodology in radiological imaging. Invest Radiol 21:720\u2013733","journal-title":"Invest Radiol"},{"issue":"1","key":"4546_CR31","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/ckj\/sfw075","volume":"10","author":"A H\u00fcttenhofer","year":"2017","unstructured":"H\u00fcttenhofer A, Mayer G (2017) Circulating miRNAs as biomarkers of kidney disease. Clin Kidney J 10(1):27\u201329. https:\/\/doi.org\/10.1093\/ckj\/sfw075","journal-title":"Clin Kidney J"},{"issue":"2","key":"4546_CR32","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/cells9020276","volume":"9","author":"CE Condrat","year":"2020","unstructured":"Condrat CE, Thompson DC, Barbu MG, Bugnar OL, Boboc A, Cretoiu D, Suciu N, Cretoiu SM, Voinea SC (2020) miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis. Cells 9(2):276. https:\/\/doi.org\/10.3390\/cells9020276","journal-title":"Cells"},{"key":"4546_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13148-018-0587-8","volume":"11","author":"W Si","year":"2019","unstructured":"Si W, Shen J, Zheng H et al (2019) The role and mechanisms of action of microRNAs in cancer drug resistance. Clin Epigenet 11:25. https:\/\/doi.org\/10.1186\/s13148-018-0587-8","journal-title":"Clin Epigenet"},{"key":"4546_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119657","volume":"288","author":"C Yang","year":"2022","unstructured":"Yang C, Yang C, Huang Z, Zhang J, Chen N, Guo Y, Zahoor A, Deng G (2022) Reduced expression of MiR-125a-5p aggravates LPS-induced experimental acute kidney injury pathology by targeting TRAF6. Life Sci 288:119657","journal-title":"Life Sci"},{"key":"4546_CR35","doi-asserted-by":"publisher","first-page":"7639","DOI":"10.18632\/aging.102276","volume":"11","author":"X Xu","year":"2019","unstructured":"Xu X, Tao Y, Niu Y, Wang Z, Zhang C, Yu Y, Ma L (2019) miR-125a-5p inhibits tumorigenesis in hepatocellular carcinoma. Aging 11:7639","journal-title":"Aging"},{"issue":"12","key":"4546_CR36","doi-asserted-by":"publisher","first-page":"9793","DOI":"10.1007\/s11033-023-08846","volume":"50","author":"MS Abdel-Tawab","year":"2023","unstructured":"Abdel-Tawab MS, Mohamed MG, Doudar NA, Rateb EE, Reyad HR, Elazeem NAA (2023) Circulating hsa-miR-221 as a possible diagnostic and prognostic biomarker of diabetic nephropathy. Mol Biol Rep 50(12):9793\u20139803. https:\/\/doi.org\/10.1007\/s11033-023-08846","journal-title":"Mol Biol Rep"},{"key":"4546_CR37","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2147\/IJNRD.S258624","volume":"13","author":"SM Hejazian","year":"2020","unstructured":"Hejazian SM, Ardalan M, Shoja MM, Samadi N, Zununi VS (2020) Expression levels of miR-30c and miR-186 in adult patients with membranous glomerulonephritis and focal segmental glomerulosclerosis. Int J Nephrol Renovasc Dis 13:193\u2013201. https:\/\/doi.org\/10.2147\/IJNRD.S258624","journal-title":"Int J Nephrol Renovasc Dis"},{"issue":"2","key":"4546_CR38","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1053\/j.ajkd.2014.07.013","volume":"65","author":"C Zhang","year":"2015","unstructured":"Zhang C, Zhang W, Chen HM, Liu C, Wu J, Shi S, Liu ZH (2015) Plasma microRNA-186 and proteinuria in focal segmental glomerulosclerosis. Am J Kid Dis 65(2):223\u2013232","journal-title":"Am J Kid Dis"},{"key":"4546_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007826","volume":"4","author":"H Zhang","year":"2019","unstructured":"Zhang H, Luo XQ, Zhang P, Huang LB, Zheng YS, Wu J et al (2019) MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS ONE 4:e7826","journal-title":"PLoS ONE"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04546-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-025-04546-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04546-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T13:35:08Z","timestamp":1759844108000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-025-04546-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["4546"],"URL":"https:\/\/doi.org\/10.1007\/s11255-025-04546-7","relation":{},"ISSN":["1573-2584"],"issn-type":[{"type":"electronic","value":"1573-2584"}],"subject":[],"published":{"date-parts":[[2025,5,6]]},"assertion":[{"value":"6 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"MicroRNA analysis along with the targeted genes are not studied.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Limitations of the study"}}]}}