{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T01:34:52Z","timestamp":1770082492108,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-025-04672-2","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T16:37:58Z","timestamp":1753115878000},"page":"467-475","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survivin and Ki-67 immunohistochemical expression in penile squamous cell carcinoma: clinicopathological features and overall survival"],"prefix":"10.1007","volume":"58","author":[{"given":"Mateus W.","family":"De Bacco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iago Z.","family":"Pires","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josenel M. B.","family":"Mar\u00e7al","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio B.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 P.","family":"Fay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio A.","family":"Averbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo F.","family":"Carvalhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"4672_CR1","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1002\/cam4.4614","volume":"11","author":"X Zhan","year":"2022","unstructured":"Zhan X, Chen L, Jiang M, Fu B (2022) Get insight into the cause of death distribution and epidemiology of penile squamous cell carcinoma: a population-based study. Cancer med 11:2308\u20132319","journal-title":"Cancer med"},{"key":"4672_CR2","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.21037\/atm-20-1802","volume":"8","author":"F Qi","year":"2020","unstructured":"Qi F, Wei X, Zheng Y, Ren X, Li X, Zhao E (2020) Incidence trends and survival outcomes of penile squamous cell carcinoma: evidence from the Surveillance, Epidemiology and End Results population-based data. Ann Transl Med 8:1428","journal-title":"Ann Transl Med"},{"key":"4672_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41572-021-00246-5","volume":"7","author":"A Thomas","year":"2021","unstructured":"Thomas A, Necchi A, Muneer A, Tobias-Machado M, Tran ATH, Van Rompuy AS et al (2021) Penile cancer. Nat Rev Dis Primers 7:11","journal-title":"Nat Rev Dis Primers"},{"key":"4672_CR4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12894-018-0365-0","volume":"18","author":"RWP Coelho","year":"2018","unstructured":"Coelho RWP, Pinho JD, Moreno JS, Garbis DVEO, Do Nascimento AMT, Larges JS et al (2018) Penile cancer in Maranh\u00e3o, Northeast Brazil: the highest incidence globally? BMC Urol 18:50\u201357","journal-title":"BMC Urol"},{"key":"4672_CR5","first-page":"91","volume":"20","author":"L Iorga","year":"2020","unstructured":"Iorga L, Marcu RD, Diaconu CC, Stanescu AMA, Stoian AP, Mischianu DLD et al (2020) Penile carcinoma and HPV infection (Review). Exp Ther Med 20:91\u201396","journal-title":"Exp Ther Med"},{"key":"4672_CR6","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3390\/ijms23010251","volume":"23","author":"IR Cortada","year":"2021","unstructured":"Cortada IR, Pineda JG, Trias I, Veloza L, Garcia A, Marimon L et al (2021) Pathogenesis of penile squamous cell carcinoma: molecular update and systematic review. Int J Mol Sci 23:251","journal-title":"Int J Mol Sci"},{"key":"4672_CR7","first-page":"646","volume":"115","author":"OW Hakenberg","year":"2018","unstructured":"Hakenberg OW, Dr\u00e4ger DL, Erbersdobler A, Naumann CM, J\u00fcnemann KP, Protzel C (2018) The diagnosis and treatment of penile cancer. Dtsch Arztebl Int 115:646\u2013652","journal-title":"Dtsch Arztebl Int"},{"key":"4672_CR8","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.2147\/CMAR.S206579","volume":"11","author":"J Hu","year":"2019","unstructured":"Hu J, Cui Y, Liu P, Zhou X, Ren W, Chen J et al (2019) Predictors of inguinal lymph-node metastasis in penile cancer patients: a meta-analysis of retrospective studies. Cancer Manag Res 11:6425\u20136441","journal-title":"Cancer Manag Res"},{"key":"4672_CR9","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1590\/s1677-5538.ibju.2020.0959","volume":"47","author":"DS Zekan","year":"2021","unstructured":"Zekan DS, Dahman A, Hajiran AJ, Luchey AM, Chahoud J, Spiess PE (2021) Prognostic predictors of lymph-node metastasis in penile cancer: a systematic review. Int Braz J Urol 47:943\u2013956","journal-title":"Int Braz J Urol"},{"key":"4672_CR10","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.3390\/cancers14071683","volume":"14","author":"A Thomas","year":"2022","unstructured":"Thomas A, Slade KS, Blaheta RA, Markowitsch SD, Stenzel P, Tagscherer KE et al (2022) Value of c-MET and associated signaling elements for predicting outcomes and targeted therapy in penile cancer. Cancers 14:1683","journal-title":"Cancers"},{"key":"4672_CR11","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.1038\/s41598-017-06659-1","volume":"7","author":"FA Marchi","year":"2017","unstructured":"Marchi FA, Martins DC, Barros-Filho MC, Kuasne H, Busso Lopes AF, Brentani H et al (2017) Multidimensional integrative analysis uncovers driver candidates and biomarkers in penile carcinoma. Sci Rep 7:6707","journal-title":"Sci Rep"},{"key":"4672_CR12","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1186\/s12885-022-09500-9","volume":"22","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Liu S, Li S, Zhang G, Tian A, Wan Y (2022) BIRC5 regulates inflammatory tumor microenvironment-induced aggravation of penile cancer development in vitro and in vivo. BMC Cancer 22:448","journal-title":"BMC Cancer"},{"key":"4672_CR13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cca.2019.01.011","volume":"491","author":"SS Menon","year":"2019","unstructured":"Menon SS, Guruvayoorappan C, Sakthivel KM, Rasmi RR (2019) Ki-67 protein as a tumor proliferation marker. Clin Chim Acta 491:39\u201345","journal-title":"Clin Chim Acta"},{"key":"4672_CR14","doi-asserted-by":"publisher","first-page":"358","DOI":"10.5152\/tud.2021.21199","volume":"47","author":"J Bowie","year":"2021","unstructured":"Bowie J, Singh S, O\u2019Hanlon C, Shiatis V, Brunckhorst O, Muneer A, Ahmed K (2021) A systematic review of non-HPV prognostic biomarkers used in penile squamous cell carcinoma. Turk J Urol 47:358\u2013365","journal-title":"Turk J Urol"},{"key":"4672_CR15","doi-asserted-by":"publisher","first-page":"289","DOI":"10.12688\/f1000research.21564.1","volume":"9","author":"SM Warli","year":"2020","unstructured":"Warli SM, Siregar GP (2020) Over-expression of Ki-67 as a predictor of lymph-node metastasis in penile cancer patients. F1000Res 9:289","journal-title":"F1000Res"},{"key":"4672_CR16","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.urolonc.2017.10.010","volume":"36","author":"K Zargar-Shoshtari","year":"2018","unstructured":"Zargar-Shoshtari K, Sharma P, Spiess PE (2018) Insight into novel biomarkers in penile cancer: redefining the present and future treatment paradigm? Urol Oncol 36:433\u2013439","journal-title":"Urol Oncol"},{"key":"4672_CR17","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1590\/S1677-55382008000500007","volume":"34","author":"LA Favorito","year":"2008","unstructured":"Favorito LA, Nardi AC, Ronalsa M, Zequi SC, Sampaio FJ, Glina S (2008) Epidemiologic study on penile cancer in Brazil. Int Braz J Urol 34:587\u2013593","journal-title":"Int Braz J Urol"},{"key":"4672_CR18","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1097\/01.MP.0000073868.31297.B0","volume":"16","author":"C Cohen","year":"2003","unstructured":"Cohen C, Lohmann CM, Cotsonis G, Lawson D, Santoianni R (2003) Survivin expression in ovarian carcinoma: correlation with apoptotic markers and prognosis. Mod Pathol 16:574\u2013583","journal-title":"Mod Pathol"},{"key":"4672_CR19","doi-asserted-by":"publisher","first-page":"722","DOI":"10.5858\/arpa.2021-0592-RA","volume":"147","author":"BA Keller","year":"2023","unstructured":"Keller BA, Pastukhova E, Lo B, Sekhon HS, Flood TA (2023) Molecular pathogenesis of penile squamous cell carcinoma: current understanding and potential treatment implications. Arch Pathol Lab Med 147:722\u2013734","journal-title":"Arch Pathol Lab Med"},{"key":"4672_CR20","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1007\/s00345-020-03510-7","volume":"39","author":"J Vanthoor","year":"2020","unstructured":"Vanthoor J, Vos G, Albersen M (2020) Penile cancer: potential target for immunotherapy? World J Urol 39:1405\u20131411","journal-title":"World J Urol"},{"key":"4672_CR21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ucl.2022.09.013","volume":"50","author":"A Yu","year":"2023","unstructured":"Yu A, Chahoud J, Necchi A, Spiess PE (2023) The evolving landscape of viral, immune, and molecular biomarkers in penile cancer. Urol Clin North Am 50:145\u2013150","journal-title":"Urol Clin North Am"},{"key":"4672_CR22","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1186\/s12885-022-10127-z","volume":"22","author":"AAL Teixeira J\u00fanior","year":"2022","unstructured":"Teixeira J\u00fanior AAL, da Costa Melo SP, Pinho JD, Sobrinho TBM, Rocha TMS, Duarte DRD et al (2022) A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease. BMC Cancer 22:1063","journal-title":"BMC Cancer"},{"key":"4672_CR23","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1464-410X.2005.05584.x","volume":"96","author":"N Berdjis","year":"2005","unstructured":"Berdjis N, Meye A, Nippgen J, Dittert D, Hakenberg O, Baretton GB et al (2005) Expression of Ki-67 in squamous cell carcinoma of the penis. BJU Int 96:146\u2013148","journal-title":"BJU Int"},{"key":"4672_CR24","first-page":"1197","volume":"22","author":"C Protzel","year":"2007","unstructured":"Protzel C, Knoedel J, Zimmermann U, Woenckhaus C, Poetsch M, Giebel J (2007) Expression of proliferation marker Ki67 correlates to occurrence of metastasis and prognosis, histological subtypes and HPV DNA detection in penile carcinomas. Histol Histopathol 22:1197\u20131204","journal-title":"Histol Histopathol"},{"key":"4672_CR25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1464-410X.2007.06908.x","volume":"100","author":"Y Zhu","year":"2007","unstructured":"Zhu Y, Zhou XY, Yao XD, Dai B, Ye DW (2007) The prognostic significance of p53, Ki-67, epithelial cadherin and matrix metalloproteinase-9 in penile squamous cell carcinoma treated with surgery. BJU Int 100:204\u2013208","journal-title":"BJU Int"},{"key":"4672_CR26","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1136\/jclinpath-2011-200638","volume":"65","author":"E Stankiewicz","year":"2012","unstructured":"Stankiewicz E, Ng M, Cuzick J, Mesher D, Watkin N, Lam W et al (2012) The prognostic value of Ki-67 expression in penile squamous cell carcinoma. J Clin Pathol 65:534\u2013537","journal-title":"J Clin Pathol"},{"key":"4672_CR27","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1464-410X.2012.11735.x","volume":"112","author":"M May","year":"2013","unstructured":"May M, Burger M, Otto W, Hakenberg OW, Wieland WF, May D et al (2013) Ki-67, mini-chromosome maintenance 2 protein (MCM2) and geminin have no independent prognostic relevance for cancer-specific survival in surgically treated squamous cell carcinoma of the penis. BJU Int 112:383\u2013390","journal-title":"BJU Int"},{"key":"4672_CR28","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.urology.2007.03.003","volume":"70","author":"GC Guimar\u00e3es","year":"2007","unstructured":"Guimar\u00e3es GC, Leal ML, Campos RS, Zequi Sde C, da Fonseca FP, da Cunha IW et al (2007) Do proliferating cell nuclear antigen and MIB-1\/Ki-67 have prognostic value in penile squamous cell carcinoma? Urology 70:137\u2013142","journal-title":"Urology"},{"key":"4672_CR29","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1186\/s13046-019-1362-1","volume":"38","author":"F Li","year":"2019","unstructured":"Li F, Aljahdali I, Ling X (2019) Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study? J Exp Clin Cancer Res 38:368","journal-title":"J Exp Clin Cancer Res"},{"key":"4672_CR30","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1159\/000517310","volume":"106","author":"J Wang","year":"2022","unstructured":"Wang J, Chen M, Dang C, Zhang H, Wang X, Yin J et al (2022) The early diagnostic and prognostic value of BIRC5 in clear-cell renal cell carcinoma based on the cancer genome atlas data. Urol Int 106:344\u2013351","journal-title":"Urol Int"},{"key":"4672_CR31","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.3390\/cancers13092209","volume":"13","author":"N Oparina","year":"2021","unstructured":"Oparina N, Erlandsson MC, F\u00e4ldt Beding A, Parris T, Helou K, Karlsson P et al (2021) Prognostic significance of BIRC5\/survivin in breast cancer: results from three independent cohorts. Cancers 13:2209","journal-title":"Cancers"},{"key":"4672_CR32","doi-asserted-by":"publisher","first-page":"874213","DOI":"10.3389\/fmed.2022.874213","volume":"9","author":"M Montella","year":"2022","unstructured":"Montella M, Sabetta R, Ronchi A et al (2022) Immunotherapy in penile squamous cell carcinoma: present or future? Multi-target analysis of programmed cell death ligand 1 expression and microsatellite instability. Front Med (Lausanne) 9:874213","journal-title":"Front Med (Lausanne)"},{"key":"4672_CR33","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1093\/jnci\/djad155","volume":"115","author":"T El Zarif","year":"2023","unstructured":"El Zarif T, Nassar AH, Pond GR et al (2023) Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors. J Natl Cancer Inst 115:1605\u20131615","journal-title":"J Natl Cancer Inst"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04672-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-025-04672-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04672-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:21:55Z","timestamp":1770042115000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-025-04672-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["4672"],"URL":"https:\/\/doi.org\/10.1007\/s11255-025-04672-2","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"27 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}