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Over the past decade, several studies have investigated its potential impact on cardiovascular outcomes, neurological protection, and clinical tolerability, with sometimes conflicting results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An overview of the literature was conducted using PubMed\u00ae from January 1, 2015 to July 31, 2025, with the search terms\n                      <jats:italic>cooler dialysis<\/jats:italic>\n                      ,\n                      <jats:italic>cooler dialysate<\/jats:italic>\n                      , and\n                      <jats:italic>cooler dialysate and hemodynamic stability<\/jats:italic>\n                      . Randomized and prospective clinical studies assessing the effects of low-temperature hemodialysis on hemodynamic, cardiac, and neurological outcomes were included.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine studies met the inclusion criteria. Small-scale trials reported a significant reduction in intradialytic hypotension episodes and a protective effect on left ventricular function. The large multicenter MyTEMP trial, while showing no significant reduction in major cardiovascular events, confirmed a trend toward improved blood pressure stability, at the expense of increased thermal discomfort. A Bayesian reanalysis of MyTEMP data suggested a high probability of clinical benefit. Effects on cerebral microcirculation and cognitive function remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low-temperature hemodialysis is associated with improved hemodynamic stability and potential myocardial protection in specific patient subgroups; however, consistent effects on major cardiovascular events or cognitive decline in the general population have not been observed. Large, multicenter studies with extended follow-up are needed to better define clinical indications, long-term outcomes, and the identification of \u201cresponder\u201d patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11255-025-04850-2","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:21:20Z","timestamp":1761042080000},"page":"2107-2117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Does low-temperature dialysis still represent an advantage?: a narrative review from the last decade"],"prefix":"10.1007","volume":"58","author":[{"given":"Lorenzo","family":"D\u2019Elia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Di Vico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Otranto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Di Lullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bellasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Barbera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"issue":"9981","key":"4850_CR1","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1016\/S0140-6736(14)61601-9","volume":"16","author":"T Liyanage","year":"2015","unstructured":"Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I et al (2015) Worldwide access to treatment for end-stage kidney disease: a systematic review. 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