{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:05:57Z","timestamp":1790805957273,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the 2022 Hebei Medical Science Research Project","award":["20220226"],"award-info":[{"award-number":["20220226"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-025-04949-6","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:52:39Z","timestamp":1765461159000},"page":"2701-2709","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ferroptosis-related proteins ALOX15 and HMOX1 are upregulated and associated with inflammation in patients with diabetic nephropathy: a prospective cross-sectional study"],"prefix":"10.1007","volume":"58","author":[{"given":"Wei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifa","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"issue":"4","key":"4949_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2024.101848","volume":"71","author":"A Gaddy","year":"2025","unstructured":"Gaddy A, Elrggal M, Madariaga H, Kelly A, Lerma E, Colbert GB (2025) Diabetic kidney disease. Dis Mon 71(4):101848. https:\/\/doi.org\/10.1016\/j.disamonth.2024.101848","journal-title":"Dis Mon"},{"key":"4949_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108314","volume":"241","author":"Q Hu","year":"2023","unstructured":"Hu Q, Jiang L, Yan Q, Zeng J, Ma X, Zhao Y (2023) A natural products solution to diabetic nephropathy therapy. Pharmacol Ther 241:108314. https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108314","journal-title":"Pharmacol Ther"},{"issue":"1","key":"4949_CR3","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/s41467-023-35944-z","volume":"14","author":"TS Huang","year":"2023","unstructured":"Huang TS, Wu T, Wu YD, Li XH, Tan J, Shen CH, Xiong SJ, Feng ZQ, Gao SF, Li H, Cai WB (2023) Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice. Nat Commun 14(1):390. https:\/\/doi.org\/10.1038\/s41467-023-35944-z","journal-title":"Nat Commun"},{"issue":"9","key":"4949_CR4","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.7150\/ijbs.81892","volume":"19","author":"H Wang","year":"2023","unstructured":"Wang H, Liu D, Zheng B, Yang Y, Qiao Y, Li S, Pan S, Liu Y, Feng Q, Liu Z (2023) Emerging role of ferroptosis in diabetic kidney disease: molecular mechanisms and therapeutic opportunities. Int J Biol Sci 19(9):2678\u20132694. https:\/\/doi.org\/10.7150\/ijbs.81892","journal-title":"Int J Biol Sci"},{"key":"4949_CR5","doi-asserted-by":"publisher","first-page":"1435139","DOI":"10.3389\/fimmu.2024.1435139","volume":"15","author":"Z Long","year":"2024","unstructured":"Long Z, Luo Y, Yu M, Wang X, Zeng L, Yang K (2024) Targeting ferroptosis: a new therapeutic opportunity for kidney diseases. Front Immunol 15:1435139. https:\/\/doi.org\/10.3389\/fimmu.2024.1435139","journal-title":"Front Immunol"},{"issue":"2","key":"4949_CR6","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1152\/physrev.00031.2024","volume":"105","author":"J Zheng","year":"2025","unstructured":"Zheng J, Conrad M (2025) Ferroptosis: when metabolism meets cell death. Physiol Rev 105(2):651\u2013706. https:\/\/doi.org\/10.1152\/physrev.00031.2024","journal-title":"Physiol Rev"},{"key":"4949_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2023.100243","volume":"18","author":"MA Mengstie","year":"2023","unstructured":"Mengstie MA, Seid MA, Gebeyehu NA, Adella GA, Kassie GA, Bayih WA, Gesese MM, Anley DT, Feleke SF, Zemene MA, Dessie AM, Solomon Y, Bantie B, Dejenie TA, Teshome AA, Abebe EC (2023) Ferroptosis in diabetic nephropathy: mechanisms and therapeutic implications. Metabol Open 18:100243. https:\/\/doi.org\/10.1016\/j.metop.2023.100243","journal-title":"Metabol Open"},{"issue":"9","key":"4949_CR8","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/s41419-023-06144-w","volume":"14","author":"J Li","year":"2023","unstructured":"Li J, Zheng S, Fan Y, Tan K (2023) Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases. Cell Death Dis 14(9):628. https:\/\/doi.org\/10.1038\/s41419-023-06144-w","journal-title":"Cell Death Dis"},{"issue":"1","key":"4949_CR9","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2025.2498629","volume":"47","author":"G Lyu","year":"2025","unstructured":"Lyu G, Liao H, Li R (2025) Ferroptosis and renal fibrosis: mechanistic insights and emerging therapeutic targets. Ren Fail 47(1):2498629. https:\/\/doi.org\/10.1080\/0886022x.2025.2498629","journal-title":"Ren Fail"},{"key":"4949_CR10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.plipres.2018.11.001","volume":"73","author":"NK Singh","year":"2019","unstructured":"Singh NK, Rao GN (2019) Emerging role of 12\/15-Lipoxygenase (ALOX15) in human pathologies. Prog Lipid Res 73:28\u201345. https:\/\/doi.org\/10.1016\/j.plipres.2018.11.001","journal-title":"Prog Lipid Res"},{"issue":"10","key":"4949_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70628","volume":"29","author":"J Liu","year":"2025","unstructured":"Liu J, Liu B, Fan E, Zhang H, Yin Z, Lv S, Wen W, Min F, Zhang Z, Cui H (2025) Qianshi mixture treats diabetic nephropathy by regulating lipid metabolism reprogramming and inhibiting oxidative stress damage. J Cell Mol Med 29(10):e70628. https:\/\/doi.org\/10.1111\/jcmm.70628","journal-title":"J Cell Mol Med"},{"key":"4949_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.146272","volume":"321","author":"Y Ma","year":"2025","unstructured":"Ma Y, Zhang D, Li Z (2025) Dual role of Heme oxygenase-1 in disease progression and treatment: a literature review. Int J Biol Macromol 321:146272. https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.146272","journal-title":"Int J Biol Macromol"},{"issue":"11","key":"4949_CR13","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1111\/jcmm.12900","volume":"20","author":"X Xu","year":"2016","unstructured":"Xu X, Sun J, Chang X, Wang J, Luo M, Wintergerst KA, Miao L, Cai L (2016) Genetic variants of nuclear factor erythroid-derived 2-like 2 associated with the complications in Han descents with type 2 diabetes mellitus of Northeast China. J Cell Mol Med 20(11):2078\u20132088. https:\/\/doi.org\/10.1111\/jcmm.12900","journal-title":"J Cell Mol Med"},{"issue":"4","key":"4949_CR14","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.3934\/mbe.2022166","volume":"19","author":"YM Han","year":"2022","unstructured":"Han YM, Yang H, Huang QL, Sun ZJ, Li ML, Zhang JB, Deng KJ, Chen S, Lin H (2022) Risk prediction of diabetes and pre-diabetes based on physical examination data. Math Biosci Eng 19(4):3597\u20133608. https:\/\/doi.org\/10.3934\/mbe.2022166","journal-title":"Math Biosci Eng"},{"issue":"4","key":"4949_CR15","doi-asserted-by":"publisher","first-page":"553","DOI":"10.2337\/cd22-0110","volume":"41","author":"J Morales","year":"2023","unstructured":"Morales J, Dagogo-Jack S, Fonseca V, Neumiller JJ, Rosas SE (2023) Perspectives on chronic kidney disease with type 2 diabetes and risk management: practical viewpoints and a paradigm shift using a pillar approach. Clin Diabetes 41(4):553\u2013566. https:\/\/doi.org\/10.2337\/cd22-0110","journal-title":"Clin Diabetes"},{"key":"4949_CR16","doi-asserted-by":"publisher","first-page":"1513008","DOI":"10.3389\/fendo.2025.1513008","volume":"16","author":"X Ma","year":"2025","unstructured":"Ma X, Liu R, Xi X, Zhuo H, Gu Y (2025) Global burden of chronic kidney disease due to diabetes mellitus, 1990\u20132021, and projections to 2050. Front Endocrinol (Lausanne) 16:1513008. https:\/\/doi.org\/10.3389\/fendo.2025.1513008","journal-title":"Front Endocrinol (Lausanne)"},{"key":"4949_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1647064","volume":"16","author":"L Zhang","year":"2025","unstructured":"Zhang L, Jiang L, Xu R, Zhang X, Zhang B, Yue R (2025) Epidemiological research on diabetic nephropathy at global, regional, and national levels from 1990 to 2021: an analysis derived from the global burden of disease 2021 study. Front Endocrinol (Lausanne) 16:1647064. https:\/\/doi.org\/10.3389\/fendo.2025.1647064","journal-title":"Front Endocrinol (Lausanne)"},{"key":"4949_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/248563","volume":"2013","author":"A Mima","year":"2013","unstructured":"Mima A (2013) Inflammation and oxidative stress in diabetic nephropathy: new insights on its inhibition as new therapeutic targets. J Diabetes Res 2013:248563. https:\/\/doi.org\/10.1155\/2013\/248563","journal-title":"J Diabetes Res"},{"issue":"4","key":"4949_CR19","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/2211-5463.12400","volume":"8","author":"A Mima","year":"2018","unstructured":"Mima A, Yasuzawa T, King GL, Ueshima S (2018) Obesity-associated glomerular inflammation increases albuminuria without renal histological changes. FEBS Open Bio 8(4):664\u2013670. https:\/\/doi.org\/10.1002\/2211-5463.12400","journal-title":"FEBS Open Bio"},{"issue":"11","key":"4949_CR20","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.2337\/db11-1824","volume":"61","author":"A Mima","year":"2012","unstructured":"Mima A, Hiraoka-Yamomoto J, Li Q, Kitada M, Li C, Geraldes P, Matsumoto M, Mizutani K, Park K, Cahill C, Nishikawa S, Rask-Madsen C, King GL (2012) Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKC\u03b2 activation in diabetes. Diabetes 61(11):2967\u20132979. https:\/\/doi.org\/10.2337\/db11-1824","journal-title":"Diabetes"},{"issue":"8","key":"4949_CR21","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/ki.2010.526","volume":"79","author":"A Mima","year":"2011","unstructured":"Mima A, Ohshiro Y, Kitada M, Matsumoto M, Geraldes P, Li C, Li Q, White GS, Cahill C, Rask-Madsen C, King GL (2011) Glomerular-specific protein kinase C-\u03b2-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int 79(8):883\u2013896. https:\/\/doi.org\/10.1038\/ki.2010.526","journal-title":"Kidney Int"},{"issue":"1","key":"4949_CR22","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1038\/s41598-022-06848-7","volume":"12","author":"SS Xie","year":"2022","unstructured":"Xie SS, Deng Y, Guo SL, Li JQ, Zhou YC, Liao J, Wu DD, Lan WF (2022) Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation. Sci Rep 12(1):3056. https:\/\/doi.org\/10.1038\/s41598-022-06848-7","journal-title":"Sci Rep"},{"issue":"1","key":"4949_CR23","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s41401-023-01156-w","volume":"45","author":"B Wang","year":"2024","unstructured":"Wang B, Yang LN, Yang LT, Liang Y, Guo F, Fu P, Ma L (2024) Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis. Acta Pharmacol Sin 45(1):150\u2013165. https:\/\/doi.org\/10.1038\/s41401-023-01156-w","journal-title":"Acta Pharmacol Sin"},{"issue":"15","key":"4949_CR24","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i15.102752","volume":"31","author":"D Kirkik","year":"2025","unstructured":"Kirkik D, Kalkanli Tas S (2025) Arachidonate 15-lipoxygenase: a promising therapeutic target for alleviating inflammation in acute pancreatitis. World J Gastroenterol 31(15):102752. https:\/\/doi.org\/10.3748\/wjg.v31.i15.102752","journal-title":"World J Gastroenterol"},{"issue":"1","key":"4949_CR25","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41392-022-01090-z","volume":"7","author":"XH Ma","year":"2022","unstructured":"Ma XH, Liu JH, Liu CY, Sun WY, Duan WJ, Wang G, Kurihara H, He RR, Li YF, Chen Y, Shang H (2022) ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage. Signal Transduct Target Ther 7(1):288. https:\/\/doi.org\/10.1038\/s41392-022-01090-z","journal-title":"Signal Transduct Target Ther"},{"key":"4949_CR26","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16239","volume":"11","author":"K He","year":"2023","unstructured":"He K, Zhou X, Du H, Zhao J, Deng R, Wang J (2023) A review on the relationship between arachidonic acid 15-lipoxygenase (ALOX15) and diabetes mellitus. PeerJ 11:e16239. https:\/\/doi.org\/10.7717\/peerj.16239","journal-title":"PeerJ"},{"issue":"1","key":"4949_CR27","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41420-024-02205-x","volume":"10","author":"JJ Zhang","year":"2024","unstructured":"Zhang JJ, Ni P, Song Y, Gao MJ, Guo XY, Zhao BQ (2024) Effective protective mechanisms of HO-1 in diabetic complications: a narrative review. Cell Death Discov 10(1):433. https:\/\/doi.org\/10.1038\/s41420-024-02205-x","journal-title":"Cell Death Discov"},{"issue":"1","key":"4949_CR28","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1186\/s12905-024-03309-3","volume":"24","author":"J Huang","year":"2024","unstructured":"Huang J, Tan R (2024) HMOX1: a pivotal regulator of prognosis and immune dynamics in ovarian cancer. BMC Womens Health 24(1):476. https:\/\/doi.org\/10.1186\/s12905-024-03309-3","journal-title":"BMC Womens Health"},{"issue":"1","key":"4949_CR29","doi-asserted-by":"publisher","first-page":"18949","DOI":"10.1038\/s41598-025-03757-3","volume":"15","author":"C Ji","year":"2025","unstructured":"Ji C, Wang Y, Ju Y, Liu S, Chen X, Wang J, Sun N, Tang Z, Gu P, Ji J (2025) The role of HMOX1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium. Sci Rep 15(1):18949. https:\/\/doi.org\/10.1038\/s41598-025-03757-3","journal-title":"Sci Rep"},{"issue":"9","key":"4949_CR30","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1016\/j.apsb.2024.05.007","volume":"14","author":"R Li","year":"2024","unstructured":"Li R, Wei R, Liu C, Zhang K, He S, Liu Z, Huang J, Tang Y, An Q, Lin L, Gan L, Zhao L, Zou X, Wang F, Ping Y, Ma Q (2024) Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke. Acta Pharm Sin B 14(9):3983\u20134000. https:\/\/doi.org\/10.1016\/j.apsb.2024.05.007","journal-title":"Acta Pharm Sin B"},{"key":"4949_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13081012","author":"L Yuan","year":"2024","unstructured":"Yuan L, Wang Y, Li N, Yang X, Sun X, Tian H, Zhang Y (2024) Mechanism of action and therapeutic implications of Nrf2\/HO-1 in inflammatory bowel disease. Antioxidants (Basel). https:\/\/doi.org\/10.3390\/antiox13081012","journal-title":"Antioxidants (Basel)"},{"key":"4949_CR32","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.2147\/dmso.S458263","volume":"17","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Zhang Y, Yang M, Tang N, Liu L, Wu J, Yang Y (2024) Machine learning-based predictive modeling of diabetic nephropathy in type 2 diabetes using integrated biomarkers: a single-center retrospective study. Diabetes Metab Syndr Obes 17:1987\u20131997. https:\/\/doi.org\/10.2147\/dmso.S458263","journal-title":"Diabetes Metab Syndr Obes"},{"key":"4949_CR33","doi-asserted-by":"publisher","first-page":"1605841","DOI":"10.3389\/fnut.2025.1605841","volume":"12","author":"Z Lin","year":"2025","unstructured":"Lin Z, Hong T, Wang W, Xie S, Chen C, Yang F, Jiang D, Wan J, Xie Z, Xu Y (2025) Development and validation of a predictive nomogram for differentiating diabetic nephropathy from non-diabetic nephropathy in patients with T2DM: a multicenter study. Front Nutr 12:1605841. https:\/\/doi.org\/10.3389\/fnut.2025.1605841","journal-title":"Front Nutr"},{"issue":"1","key":"4949_CR34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.4239\/wjd.v15.i1.43","volume":"15","author":"SS Cai","year":"2024","unstructured":"Cai SS, Zheng TY, Wang KY, Zhu HP (2024) Clinical study of different prediction models in predicting diabetic nephropathy in patients with type 2 diabetes mellitus. World J Diabetes 15(1):43\u201352. https:\/\/doi.org\/10.4239\/wjd.v15.i1.43","journal-title":"World J Diabetes"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04949-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-025-04949-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-025-04949-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:19:14Z","timestamp":1782483554000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-025-04949-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["4949"],"URL":"https:\/\/doi.org\/10.1007\/s11255-025-04949-6","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]},"assertion":[{"value":"22 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study involving human participants was conducted in accordance with the Declaration of Helsinki and received ethical approval from the Bethune International Peace Hospital (Approval Number: 2021-KY-16). Written informed consent was obtained from all participants, ensuring their confidentiality and anonymity throughout the research process.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}