{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:12:37Z","timestamp":1790194357306,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Fujian Medical University Qihang Fund","award":["2022QH1130"],"award-info":[{"award-number":["2022QH1130"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-026-05054-y","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T09:43:03Z","timestamp":1772530983000},"page":"3813-3826","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploration of symptom clusters and their trajectories in maintenance hemodialysis patients"],"prefix":"10.1007","volume":"58","author":[{"given":"Xiaorong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuMei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changda","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"issue":"2","key":"5054_CR1","doi-asserted-by":"publisher","first-page":"e97","DOI":"10.1016\/j.kisu.2020.09.001","volume":"10","author":"L Zhang","year":"2011","unstructured":"Zhang L, Zhao MH, Zuo L et al (2011) 2020 China kidney disease network (CK-NET) 2016 annual data report[J]. Kidney Int Suppl 10(2):e97\u2013e185","journal-title":"Kidney Int Suppl"},{"key":"5054_CR2","unstructured":"Medical Administration Department of National Health Commission.Blood purification case information registration system[EB\/OL]. [2024\u201308\u201302]."},{"issue":"1","key":"5054_CR3","first-page":"25","volume":"16","author":"LI Jh","year":"2016","unstructured":"Jh LI, Huang LZ, Ren XH et al (2016) Correlation between symptom burden and sleep quality, quality of life in maintenance hemodialysis patients [J]. Chinese Nurs Manag 16(1):25\u201329","journal-title":"Chinese Nurs Manag"},{"issue":"01","key":"5054_CR4","first-page":"24","volume":"21","author":"LJ Wang","year":"2024","unstructured":"Wang LJ, Zhang M, Xiao WY (2024) Research progress on symptom groups of hemodialysis patients. Chin J Nurs Educ 21(01):24\u2013128","journal-title":"Chin J Nurs Educ"},{"issue":"1","key":"5054_CR5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jpainsymman.2019.08.013","volume":"59","author":"MSN Ng","year":"2020","unstructured":"Ng MSN, So WKW, Wong CL et al (2020) Stability and impact of symptom clusters in patients with end-stage renal disease undergoing dialysis. J Pain Symptom Manage 59(1):67\u201376","journal-title":"J Pain Symptom Manage"},{"issue":"10","key":"5054_CR6","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1089\/jpm.2010.0507","volume":"14","author":"J Kirkova","year":"2011","unstructured":"Kirkova J, Aktas A, Walsh D et al (2011) Cancer symptom clusters clinical and research methodology. J Palliat Med 14(10):1149\u20131166","journal-title":"J Palliat Med"},{"issue":"4","key":"5054_CR7","doi-asserted-by":"publisher","first-page":"E107","DOI":"10.1188\/20.ONF.E107-E119","volume":"47","author":"SF Sheikh-Wu","year":"2020","unstructured":"Sheikh-Wu SF, Downs CA, Anglade D (2020) Interventions for managing a symptom cluster of pain, fatigue, and sleep disturbances during cancer survivorship: a systematic review. Oncol Nurs Forum 47(4):E107\u2013E119","journal-title":"Oncol Nurs Forum"},{"key":"5054_CR8","volume-title":"Latent variable modeling and Mplus application","author":"MC Wang","year":"2018","unstructured":"Wang MC, Bi XY (2018) Latent variable modeling and Mplus application. Chongqing University Press, Chongqing"},{"key":"5054_CR9","unstructured":"National Medical Quality Control Center for Kidney Disease.Blood purification standard operating procedures(2021 version) No. 552[S]. Official Letter from the Medical Administration Office of the National Health Commission, 2021."},{"key":"5054_CR10","volume-title":"Study of symptom in hemodialysis patients","author":"YH Hao","year":"2016","unstructured":"Hao YH (2016) Study of symptom in hemodialysis patients. Peking Union Medical College, Beijing"},{"issue":"3","key":"5054_CR11","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jpainsymman.2003.07.004","volume":"27","author":"SD Weisbord","year":"2004","unstructured":"Weisbord SD, Fried LF, Arnold RM et al (2004) Development of a symptom assessment instrument for chronic hemodialysis patients: the Dialysis Symptom Index. J Pain Symptom Manage 27(3):226\u2013240","journal-title":"J Pain Symptom Manage"},{"key":"5054_CR12","volume-title":"Symptom clusters, relevancy between symptom burden and quality of life of patients on maintenance hemodialysis","author":"XJ Zhou","year":"2013","unstructured":"Zhou XJ (2013) Symptom clusters, relevancy between symptom burden and quality of life of patients on maintenance hemodialysis. Medical University of Chongqing, Beijing"},{"issue":"5","key":"5054_CR13","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.jpainsymman.2007.11.011","volume":"36","author":"H Kim","year":"2008","unstructured":"Kim H, Barsevick AM, Tulman L et al (2008) Treatment-related symptom clusters in breast cancer: a secondary analysis J Pain Symptom Manage [J]. J Pain Symptom Manage 36(5):468\u2013479","journal-title":"J Pain Symptom Manage"},{"issue":"22","key":"5054_CR14","first-page":"2029","volume":"33","author":"NN Li","year":"2018","unstructured":"Li NN, Wu J, Xu M et al (2018) Analysis of symptom groups and influencing factors for patients with lung cancer chemotherapy[J]. Journal of Nurses Training 33(22):2029\u20132032","journal-title":"Journal of Nurses Training"},{"issue":"23","key":"5054_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182312374","volume":"18","author":"KH Park","year":"2021","unstructured":"Park KH, Yoo EY, Kim J et al (2021) Applying latent profile analysis to identify lifestyle profiles and their association with loneliness and quality of life among community-dwelling middle- and older-aged adults in South Korea. Int J Environ Res Public Health 18(23):12374","journal-title":"Int J Environ Res Public Health"},{"issue":"18","key":"5054_CR16","first-page":"3281","volume":"37","author":"R Li","year":"2023","unstructured":"Li R, Wu Y, Zheng XF et al (2023) Longitudinal study of symptom cluster trajectory in peridialysis patients[J]. Chin Nurs Res 37(18):3281\u20133286","journal-title":"Chin Nurs Res"},{"issue":"4","key":"5054_CR17","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1016\/j.apnr.2015.03.004","volume":"28","author":"SJ Lee","year":"2015","unstructured":"Lee SJ, Jeon J (2015) Relationship between symptom clusters and quality of life in patients at stages 2 to 4 chronic kidney disease in Korea. Appl Nurs Res 28(4):e13\u2013e19","journal-title":"Appl Nurs Res"},{"key":"5054_CR18","volume-title":"Mediating role of perceived life meaning in symptom group and quality of life in hemodialysis patients","author":"X Sun","year":"2021","unstructured":"Sun X (2021) Mediating role of perceived life meaning in symptom group and quality of life in hemodialysis patients. Shandong University, Jinan"},{"issue":"17","key":"5054_CR19","first-page":"19","volume":"35","author":"AQ Chu","year":"2020","unstructured":"Chu AQ, Zhang HL, Chen J et al (2020) Symptom clusters in stay-at-home kidney transplant recipients and the influencing factors[J]. J Nurs Sci 35(17):19\u201323","journal-title":"J Nurs Sci"},{"issue":"12","key":"5054_CR20","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1007\/s11136-021-02866-6","volume":"30","author":"J Chen","year":"2021","unstructured":"Chen J, Liu L, Chen J et al (2021) The cross-lagged association between depressive symptoms and health-related quality of life in patients receiving maintenance hemodialysis: a three-wave longitudinal study[J]. Qual Life Res 30(12):3463\u20133473","journal-title":"Qual Life Res"},{"issue":"06","key":"5054_CR21","first-page":"420","volume":"19","author":"T Chen","year":"2020","unstructured":"Chen T, Cheng H, Chen XH (2020) The influence of building a continuous health education model based on patients\u2019 empathy on improving the negative emotion and quality of life in hemodialysis patients. Chin J Blood Purif 19(06):420\u2013423","journal-title":"Chin J Blood Purif"},{"issue":"12","key":"5054_CR22","first-page":"1853","volume":"46","author":"HY Huo","year":"2024","unstructured":"Huo HY, Liiu XD, Fu GH et al (2024) Effect of quantified physical exercise on psychological state of patients with maintenance hemodialysis[J]. Hebei Medical Journal 46(12):1853\u20131855","journal-title":"Hebei Medical Journal"},{"issue":"10","key":"5054_CR23","first-page":"621","volume":"14","author":"ZF Shi","year":"2022","unstructured":"Shi ZF, Tong H, Wang LS (2022) Effects of narrative nursing on negative emotions and life quality of patients undergoing maintenance hemodialysis. Chin Clin Nurs 14(10):621\u2013624","journal-title":"Chin Clin Nurs"},{"issue":"5","key":"5054_CR24","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1007\/s40620-022-01313-0","volume":"35","author":"AS You","year":"2022","unstructured":"You AS, Kalantar SS, Norris KC et al (2022) Dialysis symptom index burden and symptom clusters in a prospective cohort of dialysis patients. J Nephrol 35(5):1427\u20131436","journal-title":"J Nephrol"},{"issue":"1","key":"5054_CR25","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/jgh.15110","volume":"36","author":"R Niikura","year":"2021","unstructured":"Niikura R, Aoki T, Kojima T et al (2021) Natural history of upper and lower gastrointestinal bleeding in hemodialysis patients: A dual-center long-term cohort study[J]. J Gastroenterol Hepatol 36(1):112\u2013117","journal-title":"J Gastroenterol Hepatol"},{"issue":"02","key":"5054_CR26","first-page":"116","volume":"23","author":"Q Liang","year":"2024","unstructured":"Liang Q, Wang BJ, Liu Y et al (2024) Factors for gastrointestinal bleeding in maintenance hemodialysis patients: a meta-analysis[J]. Chinese Journal of Blood Purification 23(02):116\u2013120","journal-title":"Chinese Journal of Blood Purification"},{"issue":"08","key":"5054_CR27","first-page":"555","volume":"16","author":"M Shi","year":"2017","unstructured":"Shi M, Cao XY, Chen YH et al (2017) Symptom clusters and their development in hemodialysis patients[J]. Chinese Journal of Blood Purification 16(08):555\u2013557","journal-title":"Chinese Journal of Blood Purification"},{"issue":"3","key":"5054_CR28","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/hdi.12158","volume":"18","author":"N Kimata","year":"2014","unstructured":"Kimata N, Fuller DS, Saito A et al (2014) Pruritus in hemodialysis patients: results from the Japanese Dialysis Outcomes and Practice Patterns Study (JDOPPS). Hemodial Int 18(3):657\u2013667","journal-title":"Hemodial Int"},{"issue":"06","key":"5054_CR29","first-page":"563","volume":"25","author":"XQ Zhao","year":"2024","unstructured":"Zhao XQ, Liu ZR (2024) Progress in the treatment of chronic kidney disease-related pruritus in patients with maintenance hemodialysis. Chin J Integr Tradit West Nephrol 25(06):563\u2013564","journal-title":"Chin J Integr Tradit West Nephrol"},{"issue":"29","key":"5054_CR30","first-page":"3712","volume":"23","author":"MJ Liu","year":"2020","unstructured":"Liu MJ, Cui WP, Miao LN et al (2020) Advances in the Researches of Somnipathy in Patients Underwent Hemodialysis[J]. Chinese General Practice 23(29):3712\u20133718","journal-title":"Chinese General Practice"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-026-05054-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-026-05054-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-026-05054-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:40:14Z","timestamp":1787654414000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-026-05054-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["5054"],"URL":"https:\/\/doi.org\/10.1007\/s11255-026-05054-y","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"assertion":[{"value":"29 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the institutional review board at The Second Affiliated Hospital of Fujian Medical University (2022\u2013159). This study has been performed in accordance with the Declaration of Helsinki. This is a retrospective study; therefore, an exemption from informed consent was applied to the ethics committee and approved.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research protocol, including the waiver of informed consent, was reviewed and approved by the Institutional Review Board (IRB) of The Second Affiliated Hospital of Fujian Medical University.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}