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MKD received speaking and consulting honoraria from Ferring. TN received research\/educational funds from Abbvie, Astellas, Bayer, Janssen, Amgen, Sanofi, Astrazeneca, TerSera, and Tolmar, and honoraria from Abbvie, Astellas, Bayer, Janssen, Amgen, Sanofi, Astrazeneca, TerSera, Knight Therapeutics, Paladin, Watson, Merck, Ferring, and Tolmar. JBS received research grants from Biotronik, Sanofi, Pfizer, and Attralus, speaker fees from AstraZeneca, Boehringer-Ingelheim, Novartis, Abbott, Bayer, Sanofi, Biotronik, CircleCVI, Takeda, and Amicus, and advising fees from BMS, Sanofi, and Attralus. ED received bursary awards from Fonds de Recherche en Sante, and research grants for investigator-initiated projects from Roche Diagnostics, Diagnoptics, and Abbott Laboratories. DL received consulting fees from Abbvie, Novartis, Antev, Ipsen, Bayer, Boston Scientific, and Xfacto, speaker fees from Ferring, and Pfizer, advising fees from Janssen, Jazz Pharmaceuticals, and Sanofi, research support from Novartis, and Tolmar, and is on the steering committee for Myovant. No other authors have conflicts of interest to disclose relevant to this manuscript.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors confirm that this study was approved by the appropriate institutional and\/or national research ethics committee (CTO-0743 in Ontario, Canada) and certify that the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}