{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:54:38Z","timestamp":1781502878337,"version":"3.54.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012921","name":"Royal College of Surgeons in Ireland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012921","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate patients with suspected prostate cancer, multiparametric MRI (mpMRI) has been the standard imaging modality employed. However, mpMRI is costly and not universally available. Microultrasound (mUS), a novel 29-MHz modality, offers high-resolution, real-time prostate imaging and may guide biopsy with comparable diagnostic accuracy. This systematic review and meta-analysis compares mUS-guided and mpMRI-guided prostate biopsy for the detection of prostate cancer (PCa).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted up to April 2025, in accordance with the PRISMA guidelines (PROSPERO ID CRD420251033768). Comparative studies reporting PCa detection between mUS and mpMRI were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve studies comprising 4318 patients (3475 mUS; 3615 mpMRI) were included. There was no significant difference between modalities in the detection of clinically significant prostate cancer (csPCa), both overall (RR 0.97; 95%CI 0.90\u20131.05) and with targeted biopsy (RR 1.05; 95%CI 0.97\u20131.14). Overall cancer detection was also comparable (RR 1.00; 95%CI 0.87\u20131.15), as was Grade Group 1 prostate cancer detection, whether assessed across all biopsies (RR 1.00; 95%CI 0.72\u20131.39) or with targeted biopsy alone (RR 0.90; 95%CI 0.64\u20131.27). Weighted pooled values showed mUS had a sensitivity of 93.2%, specificity of 23.3%, positive predictive value (PPV) of 46.4%, and negative predictive value (NPV) of 81.2%, compared with mpMRI\u2019s sensitivity of 87.5%, specificity of 25.7%, PPV of 44.6%, and NPV of 73.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>mUS-guided biopsy demonstrates diagnostic performance comparable to mpMRI-guided biopsy for PCa detection and represents a promising alternative or adjunct to mpMRI in prostate cancer diagnostic pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11255-026-05227-9","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:27:14Z","timestamp":1781501234000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Micro-ultrasound guided versus multiparametric MRI-guided prostate biopsy: a systematic review and meta-analysis"],"prefix":"10.1007","author":[{"given":"Niamh","family":"Moynagh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Bruinsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Mac Curtain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin G.","family":"Calpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elfaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rostyslav","family":"Nikolenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Deshwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Benour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo C.","family":"Temperley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lawlor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Keane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu","family":"Cozman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Chien","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padraig J.","family":"Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"issue":"1","key":"5227_CR1","first-page":"12","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A (2024) Cancer statistics, 2024. 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