{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:21:07Z","timestamp":1792783267841,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["82370768"],"award-info":[{"award-number":["82370768"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Urol Nephrol"],"DOI":"10.1007\/s11255-026-05401-z","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:31:04Z","timestamp":1789979464000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of key molecules and pathways in CaOx crystal-induced renal injury based on metabolomics and proteomics"],"prefix":"10.1007","author":[{"given":"Yuexian","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"5401_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.8","volume":"2","author":"SR Khan","year":"2016","unstructured":"Khan SR, Pearle MS, Robertson WG, Gambaro G, Canales BK, Doizi S, Traxer O, Tiselius HG (2016) Kidney stones. Nat Rev Dis Primers 2:16008. https:\/\/doi.org\/10.1038\/nrdp.2016.8","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"5401_CR2","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1097\/JU.0000000000002331","volume":"207","author":"AJ Hill","year":"2022","unstructured":"Hill AJ, Basourakos SP, Lewicki P, Wu X, Arenas-Gallo C, Chuang D, Bodner D, Jaeger I, Nevo A, Zell M, Markt SC, Eisner BH, Shoag JE (2022) Incidence of kidney stones in the United States: the Continuous National Health and Nutrition Examination Survey. J Urol 207(4):851\u2013856. https:\/\/doi.org\/10.1097\/JU.0000000000002331","journal-title":"J Urol"},{"issue":"1","key":"5401_CR3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/bju.16179","volume":"133","author":"S Tan","year":"2024","unstructured":"Tan S, Yuan D, Su H, Chen W, Zhu S, Yan B, Sun F, Jiang K, Zhu J (2024) Prevalence of urolithiasis in China: a systematic review and meta-analysis. BJU Int 133(1):34\u201343. https:\/\/doi.org\/10.1111\/bju.16179","journal-title":"BJU Int"},{"key":"5401_CR4","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2147\/RRU.S517758","volume":"17","author":"M Akram","year":"2025","unstructured":"Akram M, Somani B (2025) Epidemiology and management of kidney stone disease - current insights. Res Rep Urol 17:449\u2013459. https:\/\/doi.org\/10.2147\/RRU.S517758","journal-title":"Res Rep Urol"},{"issue":"7","key":"5401_CR5","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1681\/ASN.2018121241","volume":"30","author":"MR D\u2019Costa","year":"2019","unstructured":"D\u2019Costa MR, Haley WE, Mara KC, Enders FT, Vrtiska TJ, Pais VM, Jacobsen SJ, McCollough CH, Lieske JC, Rule AD (2019) Symptomatic and radiographic manifestations of kidney stone recurrence and their prediction by risk factors: a prospective cohort study. J Am Soc Nephrol 30(7):1251\u20131260. https:\/\/doi.org\/10.1681\/ASN.2018121241","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"5401_CR6","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00240-017-1022-x","volume":"46","author":"DA Wollin","year":"2018","unstructured":"Wollin DA, Preminger GM (2018) Percutaneous nephrolithotomy: complications and how to deal with them. Urolithiasis 46(1):87\u201397. https:\/\/doi.org\/10.1007\/s00240-017-1022-x","journal-title":"Urolithiasis"},{"issue":"8","key":"5401_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007044.pub4","volume":"8","author":"V Setthawong","year":"2023","unstructured":"Setthawong V, Srisubat A, Potisat S, Lojanapiwat B, Pattanittum P (2023) Extracorporeal shock wave lithotripsy (ESWL) versus percutaneous nephrolithotomy (PCNL) or retrograde intrarenal surgery (RIRS) for kidney stones. Cochrane Database Syst Rev 8(8):CD007044. https:\/\/doi.org\/10.1002\/14651858.CD007044.pub4","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"5401_CR8","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/bju.14765","volume":"125","author":"Z Ye","year":"2020","unstructured":"Ye Z, Zeng G, Yang H, Li J, Tang K, Wang G, Wang S, Yu Y, Wang Y, Zhang T, Long Y, Li W, Wang C, Wang W, Gao S, Shan Y, Huang X, Bai Z, Lin X, Cheng Y, Wang Q, Xu Z, Xie L, Yuan J, Ren S, Fan Y, Pan T, Wang J, Li X, Chen X, Gu X, Sun Z, Xiao K, Jia J, Zhang Q, Wang G, Sun T, Li X, Xu C, Xu C, Shi G, He J, Song L, Sun G, Wang D, Liu Y, Wang C, Han Y, Liang P, Wang Z, He W, Chen Z, Xing J, Xu H (2020) The status and characteristics of urinary stone composition in China. BJU Int 125(6):801\u2013809. https:\/\/doi.org\/10.1111\/bju.14765","journal-title":"BJU Int"},{"issue":"9","key":"5401_CR9","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1007\/s00345-021-03680-y","volume":"39","author":"S Zhang","year":"2021","unstructured":"Zhang S, Huang Y, Wu W, He Z, Ou L, Tiselius HG, Zeng G, Wu W (2021) Trends in urinary stone composition in 23,182 stone analyses from 2011 to 2019: a high-volume center study in China. World J Urol 39(9):3599\u20133605. https:\/\/doi.org\/10.1007\/s00345-021-03680-y","journal-title":"World J Urol"},{"issue":"16","key":"5401_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/nu16162688","volume":"16","author":"R Siener","year":"2024","unstructured":"Siener R, Ernsten C, Welchowski T, Hesse A (2024) Metabolic profile of calcium oxalate stone patients with enteric hyperoxaluria and impact of dietary intervention. Nutrients 16(16):2688. https:\/\/doi.org\/10.3390\/nu16162688","journal-title":"Nutrients"},{"issue":"3","key":"5401_CR11","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1681\/ASN.2016040486","volume":"28","author":"SR Mulay","year":"2017","unstructured":"Mulay SR, Eberhard JN, Desai J, Marschner JA, Kumar SV, Weidenbusch M, Grigorescu M, Lech M, Eltrich N, M\u00fcller L, Hans W, Hrab\u011b de Angelis M, Vielhauer V, Hoppe B, Asplin J, Burzlaff N, Herrmann M, Evan A, Anders HJ (2017) Hyperoxaluria requires TNF receptors to initiate crystal adhesion and kidney stone disease. J Am Soc Nephrol 28(3):761\u2013768. https:\/\/doi.org\/10.1681\/ASN.2016040486","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"5401_CR12","first-page":"1481","volume":"21","author":"S Hamamoto","year":"2011","unstructured":"Hamamoto S, Taguchi K, Fujii Y (2011) Molecular mechanism of renal stone formation. Clin Calcium 21(10):1481\u20131487","journal-title":"Clin Calcium"},{"issue":"1","key":"5401_CR13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s10020-022-00494-5","volume":"28","author":"S Ming","year":"2022","unstructured":"Ming S, Tian J, Ma K, Pei C, Li L, Wang Z, Fang Z, Liu M, Dong H, Li W, Zeng J, Peng Y, Gao X (2022) Oxalate-induced apoptosis through ERS-ROS-NF-\u03baB signalling pathway in renal tubular epithelial cell. Mol Med 28(1):88. https:\/\/doi.org\/10.1186\/s10020-022-00494-5","journal-title":"Mol Med"},{"issue":"3","key":"5401_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00240-022-01315-4","volume":"50","author":"A Singh","year":"2022","unstructured":"Singh A, Tandon S, Kumar D, Kaur T, Kesari KK, Tandon C (2022) Insights into the cytoprotective potential of Bergenia ligulata against oxalate-induced oxidative stress and epithelial-mesenchymal transition (EMT) via TGF\u03b21\/p38MAPK pathway in human renal epithelial cells. Urolithiasis 50(3):259\u2013278. https:\/\/doi.org\/10.1007\/s00240-022-01315-4","journal-title":"Urolithiasis"},{"issue":"4","key":"5401_CR15","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1097\/MNH.0000000000000987","volume":"33","author":"B Cellini","year":"2024","unstructured":"Cellini B (2024) A molecular journey on the pathogenesis of primary hyperoxaluria. Curr Opin Nephrol Hypertens 33(4):398\u2013404. https:\/\/doi.org\/10.1097\/MNH.0000000000000987","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"1","key":"5401_CR16","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2302963","volume":"46","author":"J Mao","year":"2024","unstructured":"Mao J, Li C, Wu F, Wang Y, Zhu J, Wen C (2024) The relationship between kidney disease and mitochondria: a bibliometric study. Ren Fail 46(1):2302963. https:\/\/doi.org\/10.1080\/0886022X.2024.2302963","journal-title":"Ren Fail"},{"issue":"1","key":"5401_CR17","doi-asserted-by":"publisher","first-page":"415","DOI":"10.7150\/ijbs.104311","volume":"21","author":"J Pan","year":"2025","unstructured":"Pan J, Zhang Y, Yao R, Yang M, Mao X, Song Z, Xu Y, Chen Y, Hou B, Liu X, Wang W, Hao Z (2025) IGF1R enhances calcium oxalate monohydrate-induced epithelial-mesenchymal transition by reprogramming metabolism via the JAK2\/STAT3 signaling. Int J Biol Sci 21(1):415\u2013432. https:\/\/doi.org\/10.7150\/ijbs.104311","journal-title":"Int J Biol Sci"},{"issue":"12","key":"5401_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413937","volume":"12","author":"Z Ye","year":"2025","unstructured":"Ye Z, Sun Y, Yang S, Li L, Li B, Xia Y, Yuan T, Yu W, Chen L, Zhou X, Cheng F (2025) Lgals3 promotes calcium oxalate crystal formation and kidney injury through histone lactylation-mediated FGFR4 activation. Adv Sci (Weinh) 12(12):e2413937. https:\/\/doi.org\/10.1002\/advs.202413937","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"5401_CR19","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41419-025-07888-3","volume":"16","author":"T Yuan","year":"2025","unstructured":"Yuan T, Ye Z, Mei S, Zhang M, Wu M, Lin F, Yu W, Li W, Zhou X, Cheng F (2025) PRMT1-mediated methylation of UBE2m promoting calcium oxalate crystal-induced kidney injury by inhibiting fatty acid metabolism. Cell Death Dis 16(1):579. https:\/\/doi.org\/10.1038\/s41419-025-07888-3","journal-title":"Cell Death Dis"},{"key":"5401_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106524","volume":"186","author":"G Anan","year":"2022","unstructured":"Anan G, Hirose T, Kikuchi D, Takahashi C, Endo A, Ito H, Sato S, Nakayama S, Hashimoto H, Ishiyama K, Kimura T, Takahashi K, Sato M, Mori T (2022) Inhibition of sodium-glucose cotransporter 2 suppresses renal stone formation. Pharmacol Res 186:106524. https:\/\/doi.org\/10.1016\/j.phrs.2022.106524","journal-title":"Pharmacol Res"},{"issue":"5","key":"5401_CR21","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.kint.2020.01.042","volume":"97","author":"K Taguchi","year":"2020","unstructured":"Taguchi K, Chen L, Usawachintachit M, Hamamoto S, Kang M, Sugino T, Unno R, Tzou DT, Sherer BA, Okada A, Yasui T, Ho SP, Stoller ML, Chi T (2020) Fatty acid-binding protein 4 downregulation drives calcification in the development of kidney stone disease. Kidney Int 97(5):1042\u20131056. https:\/\/doi.org\/10.1016\/j.kint.2020.01.042","journal-title":"Kidney Int"},{"issue":"1","key":"5401_CR22","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s12894-020-00709-z","volume":"20","author":"Z Wang","year":"2020","unstructured":"Wang Z, Li MX, Xu CZ, Zhang Y, Deng Q, Sun R, Hu QY, Zhang SP, Zhang JW, Liang H (2020) Comprehensive study of altered proteomic landscape in proximal renal tubular epithelial cells in response to calcium oxalate monohydrate crystals. BMC Urol 20(1):136. https:\/\/doi.org\/10.1186\/s12894-020-00709-z","journal-title":"BMC Urol"},{"issue":"1","key":"5401_CR23","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12951-025-03246-9","volume":"23","author":"Y Sun","year":"2025","unstructured":"Sun Y, Li B, Song B, Xia Y, Zhou X, Lin F, Rao T, Cheng F (2025) CREB1\/CRTC2 regulated tubular epithelial-derived exosomal miR-93-3p promotes kidney injury induced by calcium oxalate via activating M1 polarization and macrophage extracellular trap formation. J Nanobiotechnology 23(1):204. https:\/\/doi.org\/10.1186\/s12951-025-03246-9","journal-title":"J Nanobiotechnology"},{"key":"5401_CR24","doi-asserted-by":"publisher","first-page":"0690","DOI":"10.34133\/research.0690","volume":"8","author":"X Jin","year":"2025","unstructured":"Jin X, Jian Z, Ma Y, Wen J, Chao N, Chen X, Xiang L, Yuan Y, Liu L, Li Y, Wei J, Liao B, Zhang L, Wang K (2025) Single-Cell RNA sequencing analysis reveals the role of macrophage-mediated CD44-AKT-CCL2 pathways in renal tubule injury during calcium oxalate crystal formation. Research 8:0690. https:\/\/doi.org\/10.34133\/research.0690","journal-title":"Research"},{"issue":"4","key":"5401_CR25","doi-asserted-by":"publisher","first-page":"472","DOI":"10.23736\/S2724-6051.25.06296-2","volume":"77","author":"N Veronese","year":"2025","unstructured":"Veronese N, Ciriminna S, Errera CM, Garlisi MC, Tulone O, Sapienza V, Ciuppa ME, Capitummino R, Giannettino C, Plano OG, Contarino SF, Guagenti G, Cottone C, Cardillo F, Gilante M, Campo L, Tulone G, Simonato A, Barbagallo M, Pavan N (2025) Preventing and treating kidney stones: an umbrella review of meta-analyses of non-surgical randomized controlled trials. Minerva Urol Nephrol 77(4):472\u2013478. https:\/\/doi.org\/10.23736\/S2724-6051.25.06296-2","journal-title":"Minerva Urol Nephrol"},{"issue":"1","key":"5401_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-025-06137-8","volume":"44","author":"AV Oliveira","year":"2025","unstructured":"Oliveira AV, Sampaio A, Mascarenhas RW Jr, Pinto L, Andriolo RB (2025) Thiazide and thiazide-like diuretics for kidney stones recurrence: a systematic review and network meta-analysis of randomised controlled trials. World J Urol 44(1):41. https:\/\/doi.org\/10.1007\/s00345-025-06137-8","journal-title":"World J Urol"},{"issue":"22","key":"5401_CR27","doi-asserted-by":"publisher","first-page":"8532","DOI":"10.3390\/ijms21228532","volume":"21","author":"M Abyadeh","year":"2020","unstructured":"Abyadeh M, Meyfour A, Gupta V, Zabet Moghaddam M, Fitzhenry MJ, Shahbazian S, Hosseini Salekdeh G, Mirzaei M (2020) Recent advances of functional proteomics in gastrointestinal cancers- a path towards the identification of candidate diagnostic, prognostic, and therapeutic molecular biomarkers. Int J Mol Sci 21(22):8532. https:\/\/doi.org\/10.3390\/ijms21228532","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5401_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48096-5","volume":"15","author":"FF Dressler","year":"2024","unstructured":"Dressler FF, Diedrichs F, Sabtan D, Hinrichs S, Krisp C, Gemoll T, Hennig M, Mackedanz P, Schlotfeldt M, Vo\u00df H, Offermann A, Kirfel J, Roesch MC, Struck JP, Kramer MW, Merseburger AS, Gratzke C, Schoeb DS, Miernik A, Schl\u00fcter H, Wetterauer U, Zubarev R, Perner S, Wolf P, V\u00e9gv\u00e1ri \u00c1 (2024) Proteomic analysis of the urothelial cancer landscape. Nat Commun 15(1):4513. https:\/\/doi.org\/10.1038\/s41467-024-48096-5","journal-title":"Nat Commun"},{"issue":"1","key":"5401_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s44320-025-00168-4","volume":"22","author":"A Makhmut","year":"2026","unstructured":"Makhmut A, Dragomir MP, Fritzsche S, Moebs M, Schmitt WD, Taube ET, Coscia F (2026) Spatial proteomics of ovarian cancer precursors delineates early disease changes and drug targets. Mol Syst Biol 22(1):7\u201341. https:\/\/doi.org\/10.1038\/s44320-025-00168-4","journal-title":"Mol Syst Biol"},{"key":"5401_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1416978","volume":"15","author":"T Tao","year":"2024","unstructured":"Tao T, Mo X, Zhao L (2024) Identifying novel potential drug targets for endometriosis via plasma proteome screening. Front Endocrinol (Lausanne) 15:1416978. https:\/\/doi.org\/10.3389\/fendo.2024.1416978","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"5401_CR31","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.molmed.2014.01.005","volume":"20","author":"N Raimundo","year":"2014","unstructured":"Raimundo N (2014) Mitochondrial pathology: stress signals from the energy factory. Trends Mol Med 20(5):282\u2013292. https:\/\/doi.org\/10.1016\/j.molmed.2014.01.005","journal-title":"Trends Mol Med"},{"issue":"22","key":"5401_CR32","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1182\/blood.2023020142","volume":"142","author":"Y Liu","year":"2023","unstructured":"Liu Y, Kimpara S, Hoang NM, Daenthanasanmak A, Li Y, Lu L, Ngo VN, Bates PD, Song L, Gao X, Bebel S, Chen M, Chen R, Zhang X, Selberg PE, Kenkre VP, Waldmann TA, Capitini CM, Rui L (2023) EGR1-mediated metabolic reprogramming to oxidative phosphorylation contributes to ibrutinib resistance in B-cell lymphoma. Blood 142(22):1879\u20131894. https:\/\/doi.org\/10.1182\/blood.2023020142","journal-title":"Blood"},{"issue":"6","key":"5401_CR33","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/s42255-025-01289-8","volume":"7","author":"BT Jackson","year":"2025","unstructured":"Jackson BT, Montero AM, Chakraborty S, Brunner JS, Arnold PK, Bridgeman AE, Todorova PK, Paras KI, Finley L (2025) Intracellular metabolic gradients dictate dependence on exogenous pyruvate. Nat Metab 7(6):1168\u20131182. https:\/\/doi.org\/10.1038\/s42255-025-01289-8","journal-title":"Nat Metab"},{"issue":"1","key":"5401_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1006\/jmbi.2001.5378","volume":"317","author":"DD Leipe","year":"2002","unstructured":"Leipe DD, Wolf YI, Koonin EV, Aravind L (2002) Classification and evolution of P-loop GTPases and related ATPases. J Mol Biol 317(1):41\u201372. https:\/\/doi.org\/10.1006\/jmbi.2001.5378","journal-title":"J Mol Biol"},{"issue":"5","key":"5401_CR35","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s10930-018-9785-7","volume":"37","author":"BP Jain","year":"2018","unstructured":"Jain BP, Pandey S (2018) WD40 repeat proteins: signalling scaffold with diverse functions. Protein J 37(5):391\u2013406. https:\/\/doi.org\/10.1007\/s10930-018-9785-7","journal-title":"Protein J"},{"issue":"3","key":"5401_CR36","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.cell.2018.08.046","volume":"175","author":"A Sreelatha","year":"2018","unstructured":"Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urba\u0144ska M, \u0141obocka M, Grishin NV, Orth K, Kucharczyk R, Paw\u0142owski K, Tomchick DR, Tagliabracci VS (2018) Protein AMPylation by an evolutionarily conserved pseudokinase. Cell 175(3):809-821.e19. https:\/\/doi.org\/10.1016\/j.cell.2018.08.046","journal-title":"Cell"},{"issue":"630","key":"5401_CR37","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abk2756","volume":"14","author":"G Wang","year":"2022","unstructured":"Wang G, Qiu M, Xing X, Zhou J, Yao H, Li M, Yin R, Hou Y, Li Y, Pan S, Huang Y, Yang F, Bai F, Nie H, Di S, Guo L, Meng Z, Wang J, Yin Y (2022) Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis. Sci Transl Med 14(630):eabk2756. https:\/\/doi.org\/10.1126\/scitranslmed.abk2756","journal-title":"Sci Transl Med"},{"issue":"6","key":"5401_CR38","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.1002\/alz.13851","volume":"20","author":"RS Pandey","year":"2024","unstructured":"Pandey RS, Arnold M, Batra R, Krumsiek J, Kotredes KP, Garceau D, Williams H, Sasner M, Howell GR, Kaddurah-Daouk R, Carter GW (2024) Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer\u2019s disease. Alzheimers Dement 20(6):3987\u20134001. https:\/\/doi.org\/10.1002\/alz.13851","journal-title":"Alzheimers Dement"},{"issue":"8","key":"5401_CR39","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/j.ccell.2024.07.005","volume":"42","author":"Y Sun","year":"2024","unstructured":"Sun Y, Zhang X, Hang D, Lau HC, Du J, Liu C, Xie M, Pan Y, Wang L, Liang C, Zhou X, Chen D, Rong J, Zhao Z, Cheung AH, Wu Y, Gou H, Wong CC, Du L, Deng J, Hu Z, Shen H, Miao Y, Yu J (2024) Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers. Cancer Cell 42(8):1386-1400.e8. https:\/\/doi.org\/10.1016\/j.ccell.2024.07.005","journal-title":"Cancer Cell"},{"issue":"1","key":"5401_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-024-01395-4","volume":"16","author":"M van Vugt","year":"2024","unstructured":"van Vugt M, Finan C, Chopade S, Providencia R, Bezzina CR, Asselbergs FW, van Setten J, Schmidt AF (2024) Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation. Genome Med 16(1):120. https:\/\/doi.org\/10.1186\/s13073-024-01395-4","journal-title":"Genome Med"},{"issue":"Pt 3","key":"5401_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135209","volume":"279","author":"S Shi","year":"2024","unstructured":"Shi S, Tian X, Gong Y, Sun M, Liu J, Zhang J, Liu Y, Li L, Jiang S (2024) Pivotal role of JNK protein in the therapeutic efficacy of parthenolide against breast cancer: novel and comprehensive evidences from network pharmacology, single-cell RNA sequencing and metabolomics. Int J Biol Macromol 279(Pt 3):135209. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.135209","journal-title":"Int J Biol Macromol"},{"issue":"10","key":"5401_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102279","volume":"12","author":"S Pan","year":"2024","unstructured":"Pan S, Yuan T, Xia Y, Yu W, Li H, Rao T, Ye Z, Li L, Zhou X, Cheng F (2024) SMYD2 promotes calcium oxalate-induced glycolysis in renal tubular epithelial cells via PTEN methylation. Biomedicines 12(10):2279. https:\/\/doi.org\/10.3390\/biomedicines12102279","journal-title":"Biomedicines"},{"issue":"10","key":"5401_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403992","volume":"12","author":"C Dong","year":"2025","unstructured":"Dong C, He Z, Liao W, Jiang Q, Song C, Song Q, Su X, Xiong Y, Wang Y, Meng L, Yang S (2025) CHAC1 mediates endoplasmic reticulum stress-dependent ferroptosis in calcium oxalate kidney stone formation. Adv Sci (Weinh) 12(10):e2403992. https:\/\/doi.org\/10.1002\/advs.202403992","journal-title":"Adv Sci (Weinh)"},{"key":"5401_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.119481","volume":"308","author":"H Xiang","year":"2025","unstructured":"Xiang H, Yang Y, Chen L, He Z, Zhou Q, Dong C, Jiang Q, Chen Q, Su X, Yang S (2025) Cadmium exposure upregulates TXNIP and aggravates calcium oxalate kidney stone formation by promoting cell-crystal adhesion, apoptosis and macrophage M1 polarization. Ecotoxicol Environ Saf 308:119481. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.119481","journal-title":"Ecotoxicol Environ Saf"},{"issue":"8","key":"5401_CR45","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1186\/2047-783x-16-8-349","volume":"16","author":"PO Schwille","year":"2011","unstructured":"Schwille PO, Schmiedl A, Manoharan M, Wipplinger J (2011) Idiopathic recurrent calcium urolithiasis (IRCU): pathophysiology evaluated in light of oxidative metabolism, without and with variation of several biomarkers in fasting urine and plasma\u2013a comparison of stone-free and -bearing male patients, emphasizing mineral, acid-base, blood pressure and protein status. Eur J Med Res 16(8):349\u2013366. https:\/\/doi.org\/10.1186\/2047-783x-16-8-349","journal-title":"Eur J Med Res"},{"issue":"1","key":"5401_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02557-y","volume":"11","author":"K Ye","year":"2025","unstructured":"Ye K, Lan R, Chen Z, Lai K, Song Y, Li G, Ma H, Chen H, Xu Y (2025) Roles of ACSL4\/GPX4 and FSP1 in oxalate-induced acute kidney injury. Cell Death Discov 11(1):279. https:\/\/doi.org\/10.1038\/s41420-025-02557-y","journal-title":"Cell Death Discov"},{"key":"5401_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102919","volume":"67","author":"P Kumar","year":"2023","unstructured":"Kumar P, Laurence E, Crossman DK, Assimos DG, Murphy MP, Mitchell T (2023) Oxalate disrupts monocyte and macrophage cellular function via interleukin-10 and mitochondrial reactive oxygen species (ROS) signaling. Redox Biol 67:102919. https:\/\/doi.org\/10.1016\/j.redox.2023.102919","journal-title":"Redox Biol"},{"key":"5401_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1658989","volume":"16","author":"M Chu","year":"2025","unstructured":"Chu M, Jiang S, Xue J, Li W, Jing G, Li H, Zhang J, Xu W (2025) Premature renal epithelial cell senescence promoted by LXN\/Rps3\/p53 signaling pathway activation increases calcium oxalate crystal deposition by altering macrophage polarization. Front Immunol 16:1658989. https:\/\/doi.org\/10.3389\/fimmu.2025.1658989","journal-title":"Front Immunol"},{"issue":"Pt 1","key":"5401_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113284","volume":"143","author":"R Yao","year":"2024","unstructured":"Yao R, Pan JS, He RB, Hou BB, Suo XG, Li GX, Xia KG, Hu DK, Mao XK, Li W, Hao ZY (2024) Pectolinarigenin alleviates calcium oxalate-induced renal inflammation and oxidative stress by binding to HIF-1\u03b1. Int Immunopharmacol 143(Pt 1):113284. https:\/\/doi.org\/10.1016\/j.intimp.2024.113284","journal-title":"Int Immunopharmacol"},{"key":"5401_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/srep45740","volume":"7","author":"MB Convento","year":"2017","unstructured":"Convento MB, Pessoa EA, Cruz E, da Gl\u00f3ria MA, Schor N, Borges FT (2017) Calcium oxalate crystals and oxalate induce an epithelial-to-mesenchymal transition in the proximal tubular epithelial cells: contribution to oxalate kidney injury. Sci Rep 7:45740. https:\/\/doi.org\/10.1038\/srep45740","journal-title":"Sci Rep"},{"issue":"1","key":"5401_CR51","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12943-024-02093-w","volume":"23","author":"K Asada","year":"2024","unstructured":"Asada K, Kaneko S, Takasawa K, Shiraishi K, Shinkai N, Shimada Y, Takahashi S, Machino H, Kobayashi K, Bolatkan A, Komatsu M, Yamada M, Miyake M, Watanabe H, Tateishi A, Mizuno T, Okubo Y, Mukai M, Yoshida T, Yoshida Y, Horinouchi H, Watanabe SI, Ohe Y, Yatabe Y, Kohno T, Hamamoto R (2024) Multi-omics and clustering analyses reveal the mechanisms underlying unmet needs for patients with lung adenocarcinoma and identify potential therapeutic targets. Mol Cancer 23(1):182. https:\/\/doi.org\/10.1186\/s12943-024-02093-w","journal-title":"Mol Cancer"},{"issue":"1","key":"5401_CR52","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s10194-024-01828-w","volume":"25","author":"X Sun","year":"2024","unstructured":"Sun X, Chen B, Qi Y, Wei M, Chen W, Wu X, Wang Q, Li J, Lei X, Luo G (2024) Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine. J Headache Pain 25(1):117. https:\/\/doi.org\/10.1186\/s10194-024-01828-w","journal-title":"J Headache Pain"},{"key":"5401_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-69510-0","author":"L Meng","year":"2026","unstructured":"Meng L, Lv J, Yi Y, Lan X, Yan C, Zhu L, Yang J, Jiang W (2026) TGF\u03b2-activated PDHB promotes mitochondrial pyruvate metabolism and contributes to human endoderm differentiation via ATP-dependent BRG1. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-026-69510-0","journal-title":"Nat Commun"},{"key":"5401_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155559","volume":"143","author":"H Wang","year":"2023","unstructured":"Wang H, Xiong Q, He G, Tang J, Sun L, Cheng S, Ke M, Chen S, Hu Y, Feng J, Song L, Tong B, Zhang Z, Dai Z, Xu Y (2023) Hepatic IDH2 regulates glycolysis and gluconeogenesis. Metabolism 143:155559. https:\/\/doi.org\/10.1016\/j.metabol.2023.155559","journal-title":"Metabolism"},{"issue":"1","key":"5401_CR55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19743-4","volume":"11","author":"P Gut","year":"2020","unstructured":"Gut P, Matilainen S, Meyer JG, P\u00e4llijeff P, Richard J, Carroll CJ, Euro L, Jackson CB, Isohanni P, Minassian BA, Alkhater RA, \u00d8stergaard E, Civiletto G, Parisi A, Thevenet J, Rardin MJ, He W, Nishida Y, Newman JC, Liu X, Christen S, Moco S, Locasale JW, Schilling B, Suomalainen A, Verdin E (2020) SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. Nat Commun 11(1):5927. https:\/\/doi.org\/10.1038\/s41467-020-19743-4","journal-title":"Nat Commun"},{"key":"5401_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104231","volume":"83","author":"L Wischhof","year":"2022","unstructured":"Wischhof L, Scifo E, Ehninger D, Bano D (2022) AIFM1 beyond cell death: an overview of this OXPHOS-inducing factor in mitochondrial diseases. EBioMedicine 83:104231. https:\/\/doi.org\/10.1016\/j.ebiom.2022.104231","journal-title":"EBioMedicine"},{"issue":"1","key":"5401_CR57","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/s12276-023-00928-y","volume":"55","author":"J Mao","year":"2023","unstructured":"Mao J, Wang D, Wang D, Wu Q, Shang Q, Gao C, Wang H, Wang H, Du M, Peng P, Jia H, Xu X, Wang J, Yang L, Luo Z (2023) SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis. Exp Mol Med 55(1):253\u2013268. https:\/\/doi.org\/10.1038\/s12276-023-00928-y","journal-title":"Exp Mol Med"}],"container-title":["International Urology and Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-026-05401-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11255-026-05401-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11255-026-05401-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:31:06Z","timestamp":1789979466000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11255-026-05401-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":57,"alternative-id":["5401"],"URL":"https:\/\/doi.org\/10.1007\/s11255-026-05401-z","relation":{},"ISSN":["1573-2584"],"issn-type":[{"value":"1573-2584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments in this study were carried out following the standard ethical requirements, and were approved by the Animal Welfare and Ethics Committee of Anhui Medical University (Approval No.: LLSC20242201).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors supported the publication of the manuscript.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}