{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:04:32Z","timestamp":1744257872991,"version":"3.40.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2010,7,31]],"date-time":"2010-07-31T00:00:00Z","timestamp":1280534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,7,31]],"date-time":"2010-07-31T00:00:00Z","timestamp":1280534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1007\/s11259-010-9435-9","type":"journal-article","created":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T23:17:48Z","timestamp":1280445468000},"page":"607-617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["N-acetylpenicillamine inhibits the replication of porcine reproductive and respiratory syndrome virus in vitro"],"prefix":"10.1007","volume":"34","author":[{"given":"Yunbo","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liurong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaobo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,7,31]]},"reference":[{"key":"9435_CR1","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1128\/JVI.79.3.1966-1969.2005","volume":"79","author":"S \u00c5kerstr\u00f6m","year":"2005","unstructured":"\u00c5kerstr\u00f6m S, Mousavi-Jazi M, Klingstr\u00f6m J, Leijon M, Lundkvist \u00c5, Mirazimi A (2005) Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus. J Virol 79: 1966\u20131969.","journal-title":"J Virol"},{"key":"9435_CR2","doi-asserted-by":"publisher","first-page":"5838","DOI":"10.1021\/bi952996+","volume":"35","author":"EZ Baum","year":"1996","unstructured":"Baum EZ, Siegel MM, Bebernitz GA, Hulmes JD, Sridharan L, K-Tabei LS, Johnston SH, Wildey MJ, Nygaard J, Jones TR, Gluzman Y (1996) Inhibition of human cytomegalovirus UL80 protease by specific intramolecular disulfide bond formation. Biochemistry 35: 5838\u20135846.","journal-title":"Biochemistry"},{"key":"9435_CR3","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/0042-6822(80)90517-6","volume":"100","author":"ST Beatrice","year":"1980","unstructured":"Beatrice ST, Wagner RR (1980) Effect of sulfhydryl reagents on the infectivity of vesicular stomatitis virus. Virology 100: 246\u2013251.","journal-title":"Virology"},{"key":"9435_CR4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/104063879200400202","volume":"4","author":"DA Benfield","year":"1992","unstructured":"Benfield DA, Nelson E, Collins JE, Harris L, Goyal SM, Robison D, Christianson WT, Morrison RB, Gorcyca D, Chladek D (1992) Characterization of swine infertility and respiratory syndrome (SIRS) virus (isolate ATCC VR-2332). J Vet Diagn Invest 4: 127\u2013133.","journal-title":"J Vet Diagn Invest"},{"key":"9435_CR5","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1128\/jvi.69.4.2208-2213.1995","volume":"69","author":"Z Bi","year":"1995","unstructured":"Bi Z, Reiss CS (1995) Inhibition of vesicular stomatitis virus infection by nitric oxide. J Virol 69: 2208\u20132213.","journal-title":"J Virol"},{"key":"9435_CR6","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1038\/ni1001-907","volume":"2","author":"C Bogdan","year":"2001","unstructured":"Bogdan C (2001) Nitric oxide and the immune response. Nat Immunol 2: 2907\u20132916.","journal-title":"Nat Immunol"},{"key":"9435_CR7","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1006\/niox.1998.0189","volume":"2","author":"JP Boissel","year":"1998","unstructured":"Boissel JP, Schwarz PM, F\u00f6rstermann U (1998) Neuronal-type NO synthase: transcript diversity and expressional regulation. Nitric Oxide 2: 337\u2013349.","journal-title":"Nitric Oxide"},{"key":"9435_CR8","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/0014-5793(88)80038-3","volume":"236","author":"A Chandra","year":"1988","unstructured":"Chandra A, Demirhan I, Arya SK, Chandra P (1988) D-penicillamine inhibits transactivation of human immunodeficiency virus type-1 (HIV-1) LTR by transactivtor protein. FEBS Lett. 236: 282\u2013286.","journal-title":"FEBS Lett."},{"key":"9435_CR9","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/S1286-4579(01)01428-9","volume":"3","author":"BJ Cherayil","year":"2001","unstructured":"Cherayil BJ, Antos D (2001) Inducible nitric oxide synthase and Salmonella infection. Microbes Infect 3: 771\u2013776.","journal-title":"Microbes Infect"},{"key":"9435_CR10","doi-asserted-by":"publisher","first-page":"6470","DOI":"10.1128\/JVI.00117-08","volume":"82","author":"L Chyan-Jang","year":"2008","unstructured":"Chyan-Jang L, Hui-Ru L, Ching-Len L, Yi-Ling L (2008) Cholesterol effectively blocks entry of flavivirus. J Virol 82: 6470\u20136480.","journal-title":"J Virol"},{"key":"9435_CR11","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/jmv.20093","volume":"73","author":"G Gamba","year":"2004","unstructured":"Gamba G, Cavalier H, Courreges MC, Massouh EJ, Benencia F (2004) Early inhibition of nitric oxide production increases HSV-1 intranasal infection. J Med Virol 73: 313\u2013322.","journal-title":"J Med Virol"},{"key":"9435_CR12","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1128\/jvi.69.2.910-915.1995","volume":"69","author":"N Harris","year":"1995","unstructured":"Harris N, Buller RML, Karupiah G (1995) Gamma interferon-induced nitric oxide-mediated inhibition of vaccinia virus replication. J Virol 69: 910\u2013915.","journal-title":"J Virol"},{"key":"9435_CR13","doi-asserted-by":"publisher","first-page":"4062","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<4062::AID-IMMU4062>3.0.CO;2-K","volume":"28","author":"FP Huang","year":"1998","unstructured":"Huang FP, Niedbala W, Wei XQ, Xu D, Feng GJ, Robinson JH, Lam C, Liew FY (1998) Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur J Immunol 28: 4062\u20134070.","journal-title":"Eur J Immunol"},{"key":"9435_CR14","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1128\/jvi.65.7.3924-3927.1991","volume":"65","author":"KS Jeng","year":"1991","unstructured":"Jeng KS, Hu CP, Chang CM (1991)Differential formation of disulfide linkages in the core antigen of extracellular and intracellular hepatitis B virus core particles. J Virol 65: 3924\u20133927.","journal-title":"J Virol"},{"key":"9435_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2010.03.022","author":"K Jung","year":"2010","unstructured":"Jung K, Gurnani A, Renukaradhya GJ, Saif LJ (2010) Nitric Oxide is elicited and inhibits viral replication in pigs infected with porcine respiratory coronavirus but not porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol doi:10.1016\/j.vetimm.2010.03.022.","journal-title":"Vet Immunol Immunopathol"},{"key":"9435_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0014-5793(02)02468-7","volume":"516","author":"DM Kanyalkar","year":"2002","unstructured":"Kanyalkar DM, Chandra A, Doerr HW, Coutinho E, Loewer J, Saran LA, Chandra P (2002) Docking studies reveal a selective binding of D-penicillamine to the transactivator protein of human immunodeficiency virus type 1. FEBS Lett 516: 43\u201346.","journal-title":"FEBS Lett"},{"key":"9435_CR17","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1021\/jm051064t","volume":"49","author":"U Koch","year":"2006","unstructured":"Koch U, Attenni B, Malancona S, Colarusso S, Conte I, Di-Filippo M, Harper S, Pacini B, Giomini C, Thomas S, Incitti I, Tomei L, De-Francesco R, Altamura S, Matassa VG, Narjes F (2006) 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem 49: 1693\u20131705.","journal-title":"J Med Chem"},{"key":"9435_CR18","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1073\/pnas.032668699","volume":"99","author":"PP Li","year":"2002","unstructured":"Li PP, Nakanishi A, Clark SW, Kasamatsu H (2002) Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerzation of simian virus 40 Vp1 in the cytoplasm. Proc Natl Acad Sci USA 99: 1353\u20131358.","journal-title":"Proc Natl Acad Sci USA"},{"key":"9435_CR19","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1128\/jvi.71.7.5227-5235.1997","volume":"71","author":"YL Lin","year":"1997","unstructured":"Lin YL, Huang YL, Ma SH, Yeh CT, Chiou SY, Chen LK, Liao CL (1997) Inhibition of Japanese Encephalitis virus infection by nitric oxide: antiviral effect of nitric oxide on RNA virus replication. J Virol 71: 5227\u20135235.","journal-title":"J Virol"},{"key":"9435_CR20","first-page":"11","volume":"31","author":"JJ Meulenberg","year":"2000","unstructured":"Meulenberg JJ (2000) PRRSV, the Virus. Vet Res 31: 11\u201321.","journal-title":"Vet Res"},{"key":"9435_CR21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","volume":"43","author":"S Moncada","year":"1991","unstructured":"Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109\u2013142.","journal-title":"Pharmacol Rev"},{"key":"9435_CR22","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/0092-8674(94)90266-6","volume":"78","author":"C Nathan","year":"1994","unstructured":"Nathan C, Xie QW (1994) Nitric oxide synthase: roles, tolls, and controls. Cell 78: 915\u2013918.","journal-title":"Cell"},{"key":"9435_CR23","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0147-9571(97)00010-6","volume":"20","author":"Z Pejsak","year":"1997","unstructured":"Pejsak Z, Markowska-Daniel I (1997) Losses due to porcine reproductive and respiratory syndrome in a large swine farm. Comp Immunol Microbiol Infect Dis 20:345\u2013352.","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"9435_CR24","doi-asserted-by":"crossref","first-page":"7084","DOI":"10.1128\/JVI.72.9.7084-7090.1998","volume":"72","author":"M Pope","year":"1998","unstructured":"Pope M, Marsden PA, Sloan S, Fung LS, Ning Q, Ding JW, Leibowitz JL, Phillips MJ, Levy GA (1998) Resistance to murine hepatitis virus strain 3 is dependent on production of nitric oxide. J Virol 72:7084\u20137090.","journal-title":"J Virol"},{"key":"9435_CR25","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1128\/JVI.72.6.4547-4551.1998","volume":"72","author":"CS Reiss","year":"1998","unstructured":"Reiss CS, Komatsu T (1998) Does nitric oxide play a critical role in viral infections? J Virol 72:4547\u20134551.","journal-title":"J Virol"},{"key":"9435_CR26","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1128\/JVI.73.10.8880-8883.1999","volume":"73","author":"GF Rimmelzwaan","year":"1999","unstructured":"Rimmelzwaan GF, Baars MMJW, de-Lijster P, Fouchier RAM, Osterhaus AME (1999) Inhibition of influenza virus replication by nitric oxide. J Virol 73:8880\u20138883","journal-title":"J Virol"},{"key":"9435_CR27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.vetmic.2009.03.003","volume":"138","author":"ZJ Tian","year":"2009","unstructured":"Tian ZJ, An TQ, Zhou YJ, Peng JM, Hu SP, Wei TC, Jiang YF, Xiao Y, Tong GZ (2009) An attenuated live vaccine based on highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) protects piglets against HP-PRRS. Vet Microbiol 138: 34\u201340.","journal-title":"Vet Microbiol"},{"key":"9435_CR28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S1386-6532(00)00122-0","volume":"20","author":"BS Van-Asbeck","year":"2000","unstructured":"Van-Asbeck BS, Georgiou VNA, van der-Bruggen T, Oudshoorn M, Nottet HS, Marx JJ (2000) Anti-HIV effect of iron chelators: different mechanisms involved. J Clin Virol 20: 141\u2013147","journal-title":"J Clin Virol"},{"key":"9435_CR29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/01652176.1991.9694296","volume":"13","author":"G Wensvoort","year":"1991","unstructured":"Wensvoort G, Terpstra JM, Pol EA, tea-Laak M, Bloemraad EP, Kluyver C, Kragten C, van-Buiten L, den-Besten A, Wagenaar F (1991) Mystery swine disease in the Netherlands: the isolation of Lelystad virus. Vet Q 13:121\u2013130","journal-title":"Vet Q"},{"key":"9435_CR30","doi-asserted-by":"publisher","first-page":"4546","DOI":"10.1128\/JVI.77.8.4546-4557.2003","volume":"77","author":"SK Wootton","year":"2003","unstructured":"Wootton SK, Yoo DW (2003) Homo-oligomerization of the porcine reproductive and respiratory syndrome virus nucleocapsid protein and the role of disulfide linkages. J Virol 77: 4546\u20134557.","journal-title":"J Virol"},{"key":"9435_CR31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1006\/viro.2001.1034","volume":"287","author":"WH Wu","year":"2001","unstructured":"Wu WH, Fang Y, Farwell R, Steffen-Bien M, Rowland RR, Christopher-Hennings J, Nelson A (2001) A 10\u00a0kDa structural protein of porcine reproductive and respiratory syndrome virus encoded by ORF2b. Virology 287: 183\u2013191.","journal-title":"Virology"},{"key":"9435_CR32","doi-asserted-by":"publisher","first-page":"8709","DOI":"10.1128\/JVI.78.16.8709-8719.2004","volume":"78","author":"J Yoshitake","year":"2004","unstructured":"Yoshitake J, Akaike T, Akuta T, Tamura F, Ogura T, Esumi H, Maeda H (2004) Nitric oxide as an endogenous mutagen for Sendai virus without antiviral activity. J Virol 78: 8709\u20138719.","journal-title":"J Virol"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-010-9435-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-010-9435-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-010-9435-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-010-9435-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:22:09Z","timestamp":1744168929000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11259-010-9435-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,31]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["9435"],"URL":"https:\/\/doi.org\/10.1007\/s11259-010-9435-9","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"type":"print","value":"0165-7380"},{"type":"electronic","value":"1573-7446"}],"subject":[],"published":{"date-parts":[[2010,7,31]]},"assertion":[{"value":"21 July 2010","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2010","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}