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Due to rapid viral and environmental changes variants (Lagovirus europaeus\/GI.1a and GI.2) have appeared and few immunological studies were performed. The aim of the study was to determine innate and adaptive immunity parameters in rabbits infected with six <jats:italic>Lagovirus europeus<\/jats:italic>\/GI.1a viruses. To achieve the goal several methods were used, i.e. cytometry, microscopy, biochemical and cytochemical tests, spectrophotometry. The results show that three immunotypes exists among the studied strains and they differ in innate (mainly) and adaptive immunity, partly depending on hemagglutination. The peak of changes is 24\u00a0h post infection in phagocytosis markers of polymorphonuclear cells and CD8<jats:sup>+<\/jats:sup> T cells. <jats:italic>Lagovirus europaeus<\/jats:italic>\/GI.1a strains differ from <jats:italic>Lagovirus europaeus<\/jats:italic>\/GI.1 in terms of immunological response based on our previous work concerning the same parameters in immunological response against this disease.<\/jats:p>","DOI":"10.1007\/s11259-021-09851-x","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T03:31:24Z","timestamp":1635478284000},"page":"233-242","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reactivity of selected markers of innate and adaptive immunity in rabbits experimentally infected with antigenic variants of RHD (Lagovirus europaeus\/GI.1a)"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4065-3842","authenticated-orcid":false,"given":"Paulina","family":"Nied\u017awiedzka-Rystwej","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Tokarz-Deptu\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wies\u0142aw","family":"Deptu\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"issue":"2","key":"9851_CR1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00705-007-1084-0","volume":"153","author":"J Abrantes","year":"2008","unstructured":"Abrantes J, Esteves PJ, van der Loo W (2008) Evidence for recombination in the major capsid gene VP60 of the rabbit haemorrhagic disease virus (RHDV). 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All procedures involving animals were carried out in accordance with Polish legislation on animal welfare. The study was carried out in compliance with the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}