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The available vaccines for<jats:italic>Mycoplasma hyopneumoniae<\/jats:italic>(Mhyo) or Porcine circovirus type 2 (PCV2) are mostly administered intramuscularly in association to prevent Porcine respiratory disease complex (PRDC). MHYOSPHERE\u00ae PCV ID is the first vaccine protecting from both agents by intradermal route. This randomized, blind-field trial aimed to compare the effects of MHYOSPHERE\u00ae PCV ID with those of three different intramuscular associations of commercially available vaccines. A total of 7072 21-day-old piglets from 12 consecutive batches in one farm were randomly vaccinated with MHYOSPHERE\u00ae PCV ID (G1) or Ingelvac CircoFLEX\u00ae\u2009+\u2009Hyogen\u00ae (G2), Porcilis\u00ae PCV\u2009+\u2009M\u2009+\u2009PAC\u00ae (G3), and Porcilis\u00ae PCV\u2009+\u2009Hyogen\u00ae (G4). Growth performance during the nursery period and adverse reactions (ARs) after vaccine administration were monitored. Average Daily Weight Gain (ADWG) during the first 7\u00a0days post-weaning in G1 was 10.92, 3.03, and 20.08\u00a0g\/day higher than in G2, G3, and G4, respectively, and 0.65, 4.06, and 9.58\u00a0g\/day higher than in G2, G3, and G4 during the entire nursery period, respectively. G1 ADWG was significantly higher than G4 during both periods and significantly higher than G2 during the first 7\u00a0days post-weaning. Incidence of systemic ARs in G2 and G4 was 0.03% and 0.32%, respectively; none were recorded in G1 and G3. Replacing the usual intramuscular vaccination with MHYOSPHERE\u00ae PCV ID results in higher growth performance during the first weeks after weaning with no systemic ARs.<\/jats:p>","DOI":"10.1007\/s11259-022-09971-y","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T15:04:09Z","timestamp":1657724649000},"page":"1167-1173","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of effects of a single dose of MHYOSPHERE\u00ae PCV ID with three commercial porcine vaccine associations against Mycoplasma hyopneumoniae (Mhyo) and porcine circovirus type 2 (PCV2) on piglet growth during the nursery period under field conditions"],"prefix":"10.1007","volume":"46","author":[{"given":"Ainhoa","family":"Puig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sabat\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Ballar\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Montan\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Nodar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Angelats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Jord\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"9971_CR1","volume-title":"Mycoplasmal diseases. 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For this reason, this study did not require approval by an ethics committee. Consent to participate was not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All the authors are currently employees of Laboratorios Hipra.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}