{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:46:20Z","timestamp":1791999980173,"version":"4.4.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s11259-022-10031-8","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T08:06:01Z","timestamp":1667549161000},"page":"707-712","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessment of circulating immune complexes in canine leishmaniosis and dirofilariosis"],"prefix":"10.1007","volume":"47","author":[{"given":"Roberta","family":"Iatta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Paltrinieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alfonsa","family":"Cavalera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Scavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Otranto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"10031_CR1","first-page":"1","volume":"104","author":"CR Abramowsky","year":"1981","unstructured":"Abramowsky CR, Powers KG, Aikawa M, Swinehart G (1981) Dirofilaria immitis. 5. Immunopathology of filarial nephropathy in dogs. Am J Pathol 104:1\u201312","journal-title":"Am J Pathol"},{"key":"10031_CR2","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/S00296-018-4206-Y","volume":"39","author":"M Baba","year":"2019","unstructured":"Baba M, Ichinose K, Tamai M, Kawakami A, Ohyama K (2019) Similarity of autoimmune diseases based on the profile of immune complex antigens. Rheumatol Int 39:323\u2013325. https:\/\/doi.org\/10.1007\/S00296-018-4206-Y","journal-title":"Rheumatol Int"},{"key":"10031_CR3","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/J.1365-2362.2008.01985.X","volume":"38","author":"L Beneduce","year":"2008","unstructured":"Beneduce L, Pesce G, Gallotta A, Zampieri F, Biasiolo A, Tono N, Boscato N, Gatta A, Pontisso P, Fassina G (2008) Tumour-specific induction of immune complexes: DCP-IgM in hepatocellular carcinoma. Eur J Clin Invest 38:571\u2013577. https:\/\/doi.org\/10.1111\/J.1365-2362.2008.01985.X","journal-title":"Eur J Clin Invest"},{"key":"10031_CR4","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.vaccine.2019.10.078","volume":"38","author":"C Cacheiro-Llaguno","year":"2020","unstructured":"Cacheiro-Llaguno C, Parody N, Renshaw-Calder\u00f3n A, Osuna C, Alonso C, Carn\u00e9s J (2020) Vaccination with LetiFend\u00ae reduces circulating immune complexes in dogs experimentally infected with L. infantum. Vaccine 38:890\u2013896. https:\/\/doi.org\/10.1016\/j.vaccine.2019.10.078","journal-title":"Vaccine"},{"key":"10031_CR5","doi-asserted-by":"publisher","unstructured":"Cacheiro-Llaguno C, Parody N, Escutia MR, Carn\u00e9s J (2021) Role of circulating immune complexes in the pathogenesis of canine Leishmaniasis: new players in vaccine development. Microorganisms 9. https:\/\/doi.org\/10.3390\/MICROORGANISMS9040712","DOI":"10.3390\/MICROORGANISMS9040712"},{"key":"10031_CR6","doi-asserted-by":"publisher","unstructured":"Cavalera MA, Iatta R, Panarese R, Mendoza-Roldan JA, Gernone F, Otranto D, Paltrinieri S, Zatelli A (2021) Seasonal variation in canine anti-Leishmania infantum antibody titres. Vet J 271. https:\/\/doi.org\/10.1016\/j.tvjl.2021.105638","DOI":"10.1016\/j.tvjl.2021.105638"},{"key":"10031_CR7","volume-title":"Immunopathological mechanisms, clinical immunology of the dog and cat","author":"M Day","year":"1999","unstructured":"Day M (1999) Immunopathological mechanisms, clinical immunology of the dog and cat, 1st edn. Iowa State University Press\/Manson Publishing, Ames","edition":"1"},{"key":"10031_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-016-1798-5","volume":"9","author":"MJ Day","year":"2016","unstructured":"Day MJ (2016) Cats are not small dogs: Is there an immunological explanation for why cats are less affected by arthropod-borne disease than dogs? Parasites Vectors 9:1\u20139. https:\/\/doi.org\/10.1186\/s13071-016-1798-5","journal-title":"Parasites Vectors"},{"key":"10031_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fvets.2020.00273","volume":"7","author":"M Gizzarelli","year":"2020","unstructured":"Gizzarelli M, Fiorentino E, Ben Fayala NEH, Montagnaro S, Torras R, Gradoni L, Oliva G, Foglia Manzillo V (2020) Assessment of circulating immune complexes during natural and experimental canine leishmaniasis. Front Vet Sci 7:1\u20137. https:\/\/doi.org\/10.3389\/fvets.2020.00273","journal-title":"Front Vet Sci"},{"key":"10031_CR10","doi-asserted-by":"publisher","first-page":"588","DOI":"10.4269\/AJTMH.1987.37.588","volume":"37","author":"GF Grauer","year":"1987","unstructured":"Grauer GF, Culham CA, Cooley AJ, Poff BC, Oberley TD, Brownfield MS, Grieve RB (1987) Clinicopathologic and histologic evaluation of Dirofilaria immitis-induced nephropathy in dogs. Am J Trop Med Hyg 37:588\u2013596. https:\/\/doi.org\/10.4269\/AJTMH.1987.37.588","journal-title":"Am J Trop Med Hyg"},{"key":"10031_CR11","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0378-1135(01)00431-X","volume":"83","author":"S Harrus","year":"2001","unstructured":"Harrus S, Day MJ, Waner T, Bark H (2001) Presence of immune-complexes, and absence of antinuclear antibodies, in sera of dogs naturally and experimentally infected with Ehrlichia canis Vet Microbiol 83:343\u2013349. https:\/\/doi.org\/10.1016\/S0378-1135(01)00431-X","journal-title":"Vet Microbiol"},{"key":"10031_CR12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.vetpar.2018.02.006","volume":"253","author":"MS Latrofa","year":"2018","unstructured":"Latrofa MS, Iatta R, Dantas-Torres F, Annoscia G, Gabrielli S, Pombi M, Gradoni L, Otranto D (2018) Detection of Leishmania infantum DNA in phlebotomine sand flies from an area where canine leishmaniosis is endemic in southern Italy. Vet Parasitol 253:39\u201342. https:\/\/doi.org\/10.1016\/j.vetpar.2018.02.006","journal-title":"Vet Parasitol"},{"key":"10031_CR13","doi-asserted-by":"publisher","first-page":"095","DOI":"10.1055\/s-0041-1725157","volume":"08","author":"P Madki","year":"2021","unstructured":"Madki P, Tejasvi MLA, Paramkusam G, Khan R (2021) Evaluation of serum immunoglobulins (IgG, IgA, IgM) and circulating immune complexes in oral precancer and cancer patients. Global Med Genet 08:095\u2013099. https:\/\/doi.org\/10.1055\/s-0041-1725157","journal-title":"Global Med Genet"},{"key":"10031_CR14","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1017\/S0022149X0002616X","volume":"60","author":"K Matsumura","year":"1986","unstructured":"Matsumura K, Kazuta Y, Endo R, Tanaka K, Inoue T (1986) Detection of circulating immune complexes in the sera of dogs infected with Dirofilaria immitis, by Clq-binding enzyme-linked immunosorbent assay. J Helminthol 60:239\u2013243. https:\/\/doi.org\/10.1017\/S0022149X0002616X","journal-title":"J Helminthol"},{"key":"10031_CR15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0065-308X(08)00204-2","volume":"66","author":"JW McCall","year":"2008","unstructured":"McCall JW, Genchi C, Kramer LH, Guerrero J, Venco L (2008) Heartworm disease in animals and humans. Adv Parasitol 66:193\u2013285. https:\/\/doi.org\/10.1016\/S0065-308X(08)00204-2","journal-title":"Adv Parasitol"},{"key":"10031_CR16","doi-asserted-by":"publisher","unstructured":"Mendoza-Roldan J, Benelli G, Panarese R, Iatta R, Furlanello T, Beugnet F, Zatelli A, Otranto D (2020) Leishmania infantum and Dirofilaria immitis infections in Italy, 2009\u20132019: Changing distribution patterns. Parasites Vectors 13. https:\/\/doi.org\/10.1186\/s13071-020-04063-9","DOI":"10.1186\/s13071-020-04063-9"},{"key":"10031_CR17","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.2460\/javma.236.11.1192","volume":"236","author":"G Oliva","year":"2010","unstructured":"Oliva G, Roura X, Crotti A, Maroli M, Castagnaro M, Gradoni L, Lubas G, Paltrinieri S, Zatelli A, Zini E (2010) Guidelines for treatment of leishmaniasis in dogs. J Am Vet Med Assoc 236:1192\u20131198. https:\/\/doi.org\/10.2460\/javma.236.11.1192","journal-title":"J Am Vet Med Assoc"},{"key":"10031_CR18","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1128\/CVI.00268-08","volume":"16","author":"D Otranto","year":"2009","unstructured":"Otranto D, Paradies P, De Caprariis D, Stanneck D, Testini G, Grimm F, Deplazes P, Capelli G (2009) Toward diagnosing Leishmania infantum infection in asymptomatic dogs in an area where leishmaniasis is endemic. Clin Vaccine Immunol 16:337\u2013343. https:\/\/doi.org\/10.1128\/CVI.00268-08","journal-title":"Clin Vaccine Immunol"},{"key":"10031_CR19","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0304-4017(03)00020-7","volume":"113","author":"EC Paes-De-Almeida","year":"2003","unstructured":"Paes-De-Almeida EC, Ferreira AMR, Labarthe NV, Caldas MLR, McCall JW (2003) Kidney ultrastructural lesions in dogs experimentally infected with Dirofilaria immitis (Leidy, 1856). Vet Parasitol 113:157\u2013168. https:\/\/doi.org\/10.1016\/S0304-4017(03)00020-7","journal-title":"Vet Parasitol"},{"key":"10031_CR20","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.2460\/javma.236.11.1184","volume":"236","author":"S Paltrinieri","year":"2010","unstructured":"Paltrinieri S, Solano-Gallego L, Fondati A, Lubas G, Gradoni L, Castagnaro M, Crotti A, Maroli M, Oliva G, Roura X, Zatelli A, Zini E (2010) Guidelines for diagnosis and clinical classification of leishmaniasis in dogs. J Am Vet Med Assoc 236:1184\u20131191. https:\/\/doi.org\/10.2460\/javma.236.11.1184","journal-title":"J Am Vet Med Assoc"},{"key":"10031_CR21","doi-asserted-by":"publisher","unstructured":"Panarese R, Iatta R, Latrofa MS, Zatelli A, \u0106upina AI, Montarsi F, Pombi M, Mendoza Roldan JA, Beugnet F, Otranto D (2020) Hyperendemic Dirofilaria immitis infection in a sheltered dog population: an expanding threat in the Mediterranean region. Int J Parasitol 50(8):555\u2013559. https:\/\/doi.org\/10.1016\/j.ijpara.2020.04.002","DOI":"10.1016\/j.ijpara.2020.04.002"},{"key":"10031_CR22","doi-asserted-by":"publisher","unstructured":"Panarese R, Iatta R, Beugnet F, Otranto D (2022) Incidence of Dirofilaria immitis and Leishmania infantum infections in sheltered dogs from Southern Italy. Transbound Emerg Dis 69. https:\/\/doi.org\/10.1111\/tbed.14025","DOI":"10.1111\/tbed.14025"},{"key":"10031_CR23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3904\/KJIM.1998.13.1.51","volume":"13","author":"HS Park","year":"1998","unstructured":"Park HS, Nahm DH (1998) Role of circulating immune complex in aspirin-sensitive asthma. Korean J Intern Med 13:51\u201355. https:\/\/doi.org\/10.3904\/KJIM.1998.13.1.51","journal-title":"Korean J Intern Med"},{"key":"10031_CR24","doi-asserted-by":"publisher","first-page":"108921","DOI":"10.1016\/j.vetpar.2019.108921","volume":"274","author":"N Parody","year":"2019","unstructured":"Parody N, Cacheiro-Llaguno C, Osuna C, Renshaw-Calder\u00f3n A, Alonso C, Carn\u00e9s J (2019) Circulating immune complexes levels correlate with the progression of canine leishmaniosis in naturally infected dogs. Vet Parasitol 274:108921. https:\/\/doi.org\/10.1016\/j.vetpar.2019.108921","journal-title":"Vet Parasitol"},{"key":"10031_CR25","doi-asserted-by":"publisher","first-page":"412808","DOI":"10.1155\/2014\/412808","volume":"2014","author":"D Proverbio","year":"2014","unstructured":"Proverbio D, Spada E, Bagnagatti De Giorgi G, Perego R, Valena E (2014) Relationship between Leishmania IFAT titer and clinicopathological manifestations (clinical score) in dogs. Biomed Res Int 2014:412808. https:\/\/doi.org\/10.1155\/2014\/412808","journal-title":"Biomed Res Int"},{"key":"10031_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13071-017-2587-5","volume":"11","author":"RJ Quinnell","year":"2018","unstructured":"Quinnell RJ, Soremekun S, Bates PA, Rogers ME, Garcez LM, Courtenay O (2018) Antibody response to sand fly saliva is a marker of transmission intensity but not disease progression in dogs naturally infected with Leishmania infantum. Parasitesa Vectors 11:7. https:\/\/doi.org\/10.1186\/s13071-017-2587-5","journal-title":"Parasitesa Vectors"},{"key":"10031_CR27","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/J.VETMIC.2014.07.007","volume":"173","author":"U Ravnik","year":"2014","unstructured":"Ravnik U, Bajuk BP, Lusa L, Tozon N (2014) Serum protein profiles, circulating immune complexes and proteinuria in dogs naturally infected with Anaplasma phagocytophilum Vet Microbiol 173:160\u2013165. https:\/\/doi.org\/10.1016\/J.VETMIC.2014.07.007","journal-title":"Vet Microbiol"},{"key":"10031_CR28","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0009-8981(98)00187-9","volume":"280","author":"C Ric\u00f3s","year":"1999","unstructured":"Ric\u00f3s C, Juvany R, Sim\u00f3n M, Hern\u00e1ndez A, \u00c1lvarez V, Jim\u00e9nez CV, Minchinela J, Perich C (1999) Commutability and traceability: their repercussions on analytical bias and inaccuracy. Clin Chim Acta 280:135\u2013145. https:\/\/doi.org\/10.1016\/S0009-8981(98)00187-9","journal-title":"Clin Chim Acta"},{"key":"10031_CR29","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1111\/jsap.13237","volume":"62","author":"X Roura","year":"2021","unstructured":"Roura X, Cortadellas O, Day MJ, Benali SL, D\u2019Anna N, Fondati A, Gradoni L, Lubas G, Maroli M, Paltrinieri S, Zini E, Zatelli A (2021) Canine leishmaniosis and kidney disease: Q&A for an overall management in clinical practice. J Small Anim Pract 62:E1\u2013E19. https:\/\/doi.org\/10.1111\/jsap.13237","journal-title":"J Small Anim Pract"},{"key":"10031_CR30","first-page":"251","volume":"67","author":"G Weissmann","year":"2009","unstructured":"Weissmann G (2009) Rheumatoid arthritis and systemic lupus erythematosus as immune complex diseases. Bull NYU Hosp Joint Dis 67:251\u2013253","journal-title":"Bull NYU Hosp Joint Dis"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-022-10031-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-022-10031-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-022-10031-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T10:30:18Z","timestamp":1684924218000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11259-022-10031-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10031"],"URL":"https:\/\/doi.org\/10.1007\/s11259-022-10031-8","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"value":"0165-7380","type":"print"},{"value":"1573-7446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,4]]},"assertion":[{"value":"5 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the Department of Veterinary Medicine, University of Bari, Italy (approval number 12\/20).\u00a0","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competitive interests"}}]}}