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All the animals were handled according to the principles of animal care published by Spanish Royal Decree 1201\/2005 (BOE, 2005; BOE\u2009=\u2009Official Spanish State Gazette).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}