{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:36:22Z","timestamp":1740123382867,"version":"3.37.3"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004721","name":"The University of Tokyo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Feline morbillivirus (FeMV) was identified for the first time in cats in 2012 in Hong Kong. Although its association with chronic kidney disease in cats has attracted the attention of researchers, its clinical significance as an acute infection has not been reported. Previously, we reported FeMV detection using next-generation sequence-based comprehensive genomic analysis of plasma samples from cats with suspected acute febrile infections. Here, we conducted an epidemiological survey to detect FeMV by quantitative reverse transcription polymerase chain reaction (qRT-PCR) using blood samples from cats in Japan. FeMV was detected in 32\/102 blood samples (31.4%) from cats with suspected acute viral infections. Most of the FeMV-positive cats had clinical findings consistent with acute viral infections, including fever, leukopenia, thrombocytopenia and jaundice. No FeMV was detected in healthy cats or clinically ill cats that visited veterinary hospitals. Phylogenetic analysis classified FeMV L genes into various FeMV subtypes. We also necropsied a FeMV-positive cat that died of a suspected acute infection. On necropsy, FeMV was detected in systemic organs, including the kidneys, lymph nodes and spleen by qRT-PCR and immunohistochemical staining. These results suggest that FeMV infections may cause acute symptomatic febrile infections in cats. A limitation of this study was that the involvement of other pathogens that cause febrile illnesses could not be ruled out and this prevented a definitive conclusion that FeMV causes febrile disease in infected cats. Further studies that include experimental infections are warranted to determine the pathogenicity of FeMV in cats.<\/jats:p>","DOI":"10.1007\/s11259-023-10214-x","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:01:47Z","timestamp":1693994507000},"page":"569-578","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Detection of feline morbillivirus in cats with symptoms of acute febrile infection"],"prefix":"10.1007","volume":"48","author":[{"given":"Genta","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Matsuu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Hatai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Goto-Koshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohide","family":"Kuramoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakiko","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Momoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"issue":"8","key":"10214_CR1","doi-asserted-by":"publisher","first-page":"578","DOI":"10.3390\/v13040578","volume":"13","author":"J Busch","year":"2021","unstructured":"Busch J, Heilmann RM, Vahlenkamp TW, Sieg M (2021) Seroprevalence of infection with feline morbilliviruses is associated with FLUTD and increased blood creatinine concentrations in domestic cats. Viruses 13(8):578. https:\/\/doi.org\/10.3390\/v13040578","journal-title":"Viruses"},{"issue":"1","key":"10214_CR2","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1177\/03009858211045441","volume":"59","author":"S Chaiyasak","year":"2022","unstructured":"Chaiyasak S, Piewbang C, Yostawonkul J, Boonrungsiman S, Kasantikul T, Rungsipipat A, Techangamsuwan S (2022) Renal epitheliotropism of feline morbillivirus in two cats. Vet Pathol 59(1):127\u2013131. https:\/\/doi.org\/10.1177\/03009858211045441","journal-title":"Vet Pathol"},{"issue":"5","key":"10214_CR3","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3390\/v12050501","volume":"12","author":"EJ Choi","year":"2020","unstructured":"Choi EJ, Ortega V, Aguilar HC (2020) Feline Morbillivirus, a new paramyxovirus possibly associated with feline kidney disease. Viruses 12(5):501. https:\/\/doi.org\/10.3390\/v12050501","journal-title":"Viruses"},{"issue":"5","key":"10214_CR4","doi-asserted-by":"publisher","first-page":"828","DOI":"10.3390\/ani10050828","volume":"10","author":"PE Crisi","year":"2020","unstructured":"Crisi PE, Dondi F, De Luca E, Di Tommaso M, Vasylyeva K, Ferlizza E, Savini G, Luciani A, Malatesta D, Lorusso A, Boari A (2020) Early renal involvement in cats with natural feline morbillivirus infection. Animals 10(5):828. https:\/\/doi.org\/10.3390\/ani10050828","journal-title":"Animals"},{"key":"10214_CR5","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00705-016-3124-0","volume":"162","author":"GM Darold","year":"2017","unstructured":"Darold GM, Alfieri AA, Muraro LS, Amude AM, Zanatta R, Ito Yamauchi KC, Alfieri AF, Lunardi M (2017) First report of feline morbillivirus in South America. 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Vet Microbiol 240(4):108484. https:\/\/doi.org\/10.1016\/j.vetmic.2019.108484","journal-title":"Vet Microbiol"},{"issue":"8","key":"10214_CR7","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.3390\/v13081449","volume":"13","author":"G Donato","year":"2021","unstructured":"Donato G, Masucci M, De Luca E, Alibrandi A, De Majo M, Berjaoui S, Martino C, Mangano C, Lorusso A, Pennisi MG (2021) Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats. Viruses 13(8):1449. https:\/\/doi.org\/10.3390\/v13081449","journal-title":"Viruses"},{"issue":"2","key":"10214_CR8","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00705-013-1813-5","volume":"159","author":"T Furuya","year":"2014","unstructured":"Furuya T, Sassa Y, Omatsu T, Nagai M, Fukushima R, Shibutani M, Yamaguchi T, Uematsu Y, Shirota K, Mizutani T (2014) Existence of feline morbillivirus infection in Japanese cat populations. 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J Vet Daignostic Investig 33(2):279\u2013282. https:\/\/doi.org\/10.1177\/1040638720967506","journal-title":"J Vet Daignostic Investig"},{"issue":"43","key":"10214_CR14","doi-asserted-by":"publisher","first-page":"e2209405119","DOI":"10.1073\/pnas.2209405119","volume":"119","author":"S Nambulli","year":"2022","unstructured":"Nambulli S, Rennick LJ, Acciardo AS, Tilston-Lunel NL, Ho G, Crossland NA, Hardcastle K, Nieto B, Bainbridge G, Williams T, Sharp CR, Duprex WP (2022) FeMV is a cathepsin-dependent unique morbillivirus infecting the kidneys of domestic cats. 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New England J Med 364:1523\u20131532. https:\/\/doi.org\/10.1056\/NEJMoa1010095","journal-title":"New England J Med"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-023-10214-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-023-10214-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-023-10214-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T12:05:46Z","timestamp":1706184346000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11259-023-10214-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,6]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10214"],"URL":"https:\/\/doi.org\/10.1007\/s11259-023-10214-x","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"type":"print","value":"0165-7380"},{"type":"electronic","value":"1573-7446"}],"subject":[],"published":{"date-parts":[[2023,9,6]]},"assertion":[{"value":"4 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was conducted using leftover SFTS-tested specimens. Permission to use the sample and clinical data for other purposes was obtained at the time of the test. For the animals that visited veterinary teaching hospitals, written permission was obtained from the client at the first visit to use residual specimens for scientific purposes.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"This research did not involve human subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and publish"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}