{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:04:11Z","timestamp":1791821051237,"version":"4.3.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"crossref","award":["1399.548"],"award-info":[{"award-number":["1399.548"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"crossref","award":["1399.548"],"award-info":[{"award-number":["1399.548"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"crossref","award":["1399.548"],"award-info":[{"award-number":["1399.548"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"crossref","award":["1399.548"],"award-info":[{"award-number":["1399.548"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"crossref","award":["1399.548"],"award-info":[{"award-number":["1399.548"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"crossref","award":["1399.548"],"award-info":[{"award-number":["1399.548"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"crossref","award":["1399.548"],"award-info":[{"award-number":["1399.548"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"crossref","award":["1399.548"],"award-info":[{"award-number":["1399.548"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"crossref","award":["1399.548"],"award-info":[{"award-number":["1399.548"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"crossref","award":["1399.548"],"award-info":[{"award-number":["1399.548"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s11259-023-10241-8","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T05:01:31Z","timestamp":1719291691000},"page":"2563-2581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Brain \u2013cyst-driven genes expression in Toxoplasma Gondii Tehran strain: a parasitic-immunogenicity assessment by dint of RNA-Seq"],"prefix":"10.1007","volume":"48","author":[{"given":"Marzieh","family":"Asadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Babaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Afgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Banabazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naser","family":"ZiaAli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Daryani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Aghajani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milad","family":"Mahdavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamadreza","family":"Attari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Zarrinkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"10241_CR1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/ni915","volume":"4","author":"J Aliberti","year":"2003","unstructured":"Aliberti J, Valenzuela JG, Carruthers VB et al (2003) Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells. Nat Immunol 4:485\u2013490","journal-title":"Nat Immunol"},{"key":"10241_CR2","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nsmb.3378","volume":"24","author":"K Arimoto","year":"2017","unstructured":"Arimoto K, L\u00f6chte S, Stoner SA et al (2017) STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling. Nat Struct Mol Biol 24:279\u2013289","journal-title":"Nat Struct Mol Biol"},{"key":"10241_CR3","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1007\/s12035-018-1180-z","volume":"56","author":"NB Bottari","year":"2019","unstructured":"Bottari NB, Schetinger MRC, Pillat MM et al (2019) Resveratrol as a therapy to restore neurogliogenesis of neural progenitor cells infected by Toxoplasma Gondii. Mol Neurobiol 56:2328\u20132338","journal-title":"Mol Neurobiol"},{"key":"10241_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-022-32225-z","volume":"13","author":"S Chandrasekaran","year":"2022","unstructured":"Chandrasekaran S, Kochanowsky JA, Merritt EF et al (2022) IFN-\u03b3 stimulated murine and human neurons mount anti-parasitic defenses against the intracellular parasite Toxoplasma Gondii. Nat Commun 13:1\u201313","journal-title":"Nat Commun"},{"key":"10241_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-018-2983-5","volume":"11","author":"L-F Chen","year":"2018","unstructured":"Chen L-F, Han X-L, Li F-X et al (2018) Comparative studies of Toxoplasma Gondii transcriptomes: insights into stage conversion based on gene expression profiling and alternative splicing. Parasit Vectors 11:1\u201311","journal-title":"Parasit Vectors"},{"key":"10241_CR6","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2020.58.3.237","volume":"58","author":"HG Choi","year":"2020","unstructured":"Choi HG, Gao F-F, Zhou W et al (2020) The role of PI3K\/AKT pathway and NADPH oxidase 4 in host ROS manipulation by Toxoplasma Gondii. Korean J Parasitol 58:237","journal-title":"Korean J Parasitol"},{"key":"10241_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-022-28730-w","volume":"13","author":"C Christiansen","year":"2022","unstructured":"Christiansen C, Maus D, Hoppenz E et al (2022) In vitro maturation of Toxoplasma Gondii bradyzoites in human myotubes and their metabolomic characterization. Nat Commun 13:1\u201315","journal-title":"Nat Commun"},{"key":"10241_CR8","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41418-020-00708-5","volume":"28","author":"PE Cockram","year":"2021","unstructured":"Cockram PE, Kist M, Prakash S et al (2021) Ubiquitination in the regulation of inflammatory cell death and cancer. Cell Death Differ 28:591\u2013605","journal-title":"Cell Death Differ"},{"key":"10241_CR9","doi-asserted-by":"crossref","unstructured":"Cowan MN, Sethi I, Harris TH (2022) Microglia in CNS Infections: insights from Toxoplasma Gondii and other pathogens. Trends Parasitol","DOI":"10.1016\/j.pt.2021.12.004"},{"key":"10241_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10111351","volume":"10","author":"D Daher","year":"2021","unstructured":"Daher D, Shaghlil A, Sobh E et al (2021) Comprehensive overview of Toxoplasma Gondii-induced and associated Diseases. Pathogens 10:1351","journal-title":"Pathogens"},{"key":"10241_CR11","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1007\/s00436-021-07282-w","volume":"120","author":"G de Lima Bessa","year":"2021","unstructured":"de Lima Bessa G, de Almeida Vitor RW, dos Santos Martins-Duarte E (2021) Toxoplasma Gondii in South America: a differentiated pattern of spread, population structure and clinical manifestations. Parasitol Res 120:3065\u20133076","journal-title":"Parasitol Res"},{"key":"10241_CR12","doi-asserted-by":"crossref","unstructured":"Dian S, Ganiem AR, Ekawardhani S (2022) Cerebral toxoplasmosis in HIV-infected patients: a review. Pathog Glob Health 1\u201310","DOI":"10.1080\/20477724.2022.2083977"},{"key":"10241_CR13","doi-asserted-by":"crossref","unstructured":"Elzeky SM, Nabih N, Abdel-Magied AA, et al (2022) Seroprevalence and genetic characterization of toxoplasma gondii among children with neurodevelopmental disorders in Egypt. J Trop Med 2022","DOI":"10.1155\/2022\/2343679"},{"key":"10241_CR14","doi-asserted-by":"publisher","first-page":"ftab058","DOI":"10.1093\/femspd\/ftab058","volume":"79","author":"D Fisch","year":"2021","unstructured":"Fisch D, Clough B, Khan R et al (2021) Toxoplasma-proximal and distal control by GBPs in human macrophages. Pathog Dis 79:ftab058","journal-title":"Pathog Dis"},{"key":"10241_CR15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ajme.2017.06.003","volume":"54","author":"M Foroutan","year":"2018","unstructured":"Foroutan M, Dalvand S, Daryani A et al (2018) Rolling up the pieces of a puzzle: a systematic review and meta-analysis of the prevalence of toxoplasmosis in Iran. Alexandria J Med 54:189\u2013196","journal-title":"Alexandria J Med"},{"key":"10241_CR16","doi-asserted-by":"crossref","unstructured":"Garfoot AL, Cervantes PW, Knoll LJ (2019) Transcriptional analysis shows a robust host response to Toxoplasma Gondii during early and late chronic Infection in both male and female mice. Infect Immun 87:e00024\u2013e00019","DOI":"10.1128\/IAI.00024-19"},{"key":"10241_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-016-1716-x","volume":"9","author":"J-J He","year":"2016","unstructured":"He J-J, Ma J, Elsheikha HM et al (2016) Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii Infection. Parasit Vectors 9:1\u201313","journal-title":"Parasit Vectors"},{"key":"10241_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12941-018-0298-1","volume":"17","author":"Z Hu","year":"2018","unstructured":"Hu Z, Weng X, Xu C et al (2018) Metagenomic next-generation sequencing as a diagnostic tool for toxoplasmic encephalitis. Ann Clin Microbiol Antimicrob 17:1\u20136","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"10241_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-3305-6-161","volume":"6","author":"B Jia","year":"2013","unstructured":"Jia B, Lu H, Liu Q et al (2013) Genome-wide comparative analysis revealed significant transcriptome changes in mice after Toxoplasma Gondii Infection. Parasit Vectors 6:1\u201312","journal-title":"Parasit Vectors"},{"key":"10241_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2022.102226","volume":"77","author":"IA Khan","year":"2022","unstructured":"Khan IA, Moretto M (2022) Immune responses to Toxoplasma Gondii. Curr Opin Immunol 77:102226","journal-title":"Curr Opin Immunol"},{"key":"10241_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-15-1168","volume":"15","author":"A Khan","year":"2014","unstructured":"Khan A, Shaik JS, Behnke M et al (2014) NextGen sequencing reveals short double crossovers contribute disproportionately to genetic diversity in Toxoplasma Gondii. BMC Genomics 15:1\u201315","journal-title":"BMC Genomics"},{"key":"10241_CR22","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3389\/fmicb.2019.00181","volume":"10","author":"G Lu","year":"2019","unstructured":"Lu G, Zhou J, Zhao YH et al (2019) Transcriptome sequencing investigated the tumor-related factors changes after T. Gondii Infection. Front Microbiol 10:181","journal-title":"Front Microbiol"},{"key":"10241_CR23","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1007\/s00436-021-07204-w","volume":"120","author":"S Mahmoudzadeh","year":"2021","unstructured":"Mahmoudzadeh S, Nozad Charoudeh H, Marques CS et al (2021) The role of IL-12 in stimulating NK cells against Toxoplasma gondii Infection: a mini-review. Parasitol Res 120:2303\u20132309","journal-title":"Parasitol Res"},{"key":"10241_CR24","doi-asserted-by":"publisher","first-page":"e01393","DOI":"10.1128\/mBio.01393-18","volume":"9","author":"SK Matta","year":"2018","unstructured":"Matta SK, Patten K, Wang Q et al (2018) NADPH oxidase and guanylate binding protein 5 restrict survival of avirulent type III strains of Toxoplasma Gondii in naive macrophages. MBio 9:e01393\u2013e01318","journal-title":"MBio"},{"key":"10241_CR25","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.cbpa.2012.12.008","volume":"17","author":"PA McGettigan","year":"2013","unstructured":"McGettigan PA (2013) Transcriptomics in the RNA-seq era. Curr Opin Chem Biol 17:4\u201311","journal-title":"Curr Opin Chem Biol"},{"key":"10241_CR26","doi-asserted-by":"publisher","first-page":"e01307","DOI":"10.1128\/mBio.01307-21","volume":"12","author":"FJB Miranda","year":"2021","unstructured":"Miranda FJB, Rocha BC, Pereira MCA et al (2021) Toxoplasma Gondii-Induced neutrophil extracellular traps amplify the innate and adaptive response. MBio 12:e01307\u2013e01321","journal-title":"MBio"},{"key":"10241_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41182-020-00222-x","volume":"48","author":"M Mousavi-Hasanzadeh","year":"2020","unstructured":"Mousavi-Hasanzadeh M, Sarmadian H, Ghasemikhah R et al (2020) Evaluation of toxoplasma gondii Infection in western Iran: seroepidemiology and risk factors analysis. Trop Med Health 48:1\u20137","journal-title":"Trop Med Health"},{"key":"10241_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-15-806","volume":"15","author":"KJ Pittman","year":"2014","unstructured":"Pittman KJ, Aliota MT, Knoll LJ (2014) Dual transcriptional profiling of mice and Toxoplasma Gondii during acute and chronic Infection. BMC Genomics 15:1\u201319","journal-title":"BMC Genomics"},{"key":"10241_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0353-9","volume":"51","author":"M Sasai","year":"2019","unstructured":"Sasai M, Yamamoto M (2019) Innate, adaptive, and cell-autonomous immunity against Toxoplasma Gondii Infection. Exp Mol Med 51:1\u201310","journal-title":"Exp Mol Med"},{"key":"10241_CR30","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/j.chom.2021.06.010","volume":"29","author":"LA Shallberg","year":"2021","unstructured":"Shallberg LA, Hunter CA (2021) Long live the king: Toxoplasma Gondii nucleomodulin inhibits necroptotic cell death. Cell Host Microbe 29:1165\u20131166","journal-title":"Cell Host Microbe"},{"key":"10241_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.634610","volume":"11","author":"PM Sikorski","year":"2021","unstructured":"Sikorski PM, Commodaro AG, Grigg ME (2021) A protective and pathogenic role for complement during acute Toxoplasma gondii Infection. Front Cell Infect Microbiol 11:634610","journal-title":"Front Cell Infect Microbiol"},{"key":"10241_CR32","doi-asserted-by":"publisher","first-page":"e00459","DOI":"10.1128\/IAI.00459-18","volume":"86","author":"SD Splitt","year":"2018","unstructured":"Splitt SD, Souza SP, Valentine KM et al (2018) PD-L1, TIM-3, and CTLA-4 blockade fails to promote resistance to secondary Infection with virulent strains of Toxoplasma Gondii. Infect Immun 86:e00459\u2013e00418","journal-title":"Infect Immun"},{"key":"10241_CR33","doi-asserted-by":"crossref","unstructured":"Suwancharoen C, Phuangsri C, Prakhammin K, Japa O (2022) Molecular detection and dense granule antigen 6 genotyping of feline Toxoplasma Gondii in Phayao, Thailand. Vet World 15","DOI":"10.14202\/vetworld.2022.2309-2314"},{"key":"10241_CR34","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1128\/IAI.00439-13","volume":"81","author":"S Tanaka","year":"2013","unstructured":"Tanaka S, Nishimura M, Ihara F et al (2013) Transcriptome analysis of mouse brain infected with Toxoplasma Gondii. Infect Immun 81:3609\u20133619","journal-title":"Infect Immun"},{"key":"10241_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187703","volume":"12","author":"K Umeda","year":"2017","unstructured":"Umeda K, Tanaka S, Ihara F et al (2017) Transcriptional profiling of toll-like receptor 2-deficient primary murine brain cells during Toxoplasma Gondii Infection. PLoS ONE 12:e0187703","journal-title":"PLoS ONE"},{"key":"10241_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175572","volume":"27","author":"Z Yan","year":"2022","unstructured":"Yan Z, Yuan H, Wang J et al (2022) Four Chemotherapeutic compounds that Limit Blood-Brain-Barrier Invasion by Toxoplasma Gondii. Molecules 27:5572","journal-title":"Molecules"},{"key":"10241_CR37","doi-asserted-by":"crossref","unstructured":"Yu L, Shwab K, Hill RD et al (2019) Dynamics of gene expression in mice infected with different genotypes of Toxoplasma gondii","DOI":"10.21203\/rs.2.18699\/v1"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-023-10241-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-023-10241-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-023-10241-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T18:30:24Z","timestamp":1723228224000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11259-023-10241-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10241"],"URL":"https:\/\/doi.org\/10.1007\/s11259-023-10241-8","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"value":"0165-7380","type":"print"},{"value":"1573-7446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"11 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee in accordance with the instructions of the Ethics Commission of Kerman University of Medical Sciences (Project ethic number: IR.KMU.REC.1399.548).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}