{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:22:56Z","timestamp":1784690576108,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s11259-023-10255-2","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:02:02Z","timestamp":1699840922000},"page":"839-847","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Changes in free amino acid profile in goats with pregnancy toxemia"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-1825","authenticated-orcid":false,"given":"Murat","family":"Uztim\u00fcr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7852-4352","authenticated-orcid":false,"given":"Abdullah","family":"Gazio\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8276-4498","authenticated-orcid":false,"given":"\u00d6kke\u015f","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"issue":"4","key":"10255_CR1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.jbiosc.2010.04.010","volume":"110","author":"K Bando","year":"2010","unstructured":"Bando K, Kawahara R, Kunimatsu T, Sakai J, Kimura J, Funabashi H, Fukusaki E (2010) Influences of biofluid sample collection and handling procedures on GC\u2013MS based metabolomic studies. J Biosci Bioeng 110(4):491\u2013499","journal-title":"J Biosci Bioeng"},{"issue":"4","key":"10255_CR2","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1111\/j.1939-165X.2008.00076.x","volume":"37","author":"ZA Bani Ismail","year":"2008","unstructured":"Bani Ismail ZA, Al-Majali AM, Amireh F, Al-Rawashdeh OF (2008) Metabolic profiles in goat does in late pregnancy with and without subclinical pregnancy toxemia. Vet Clin Pathol 37(4):434\u2013437","journal-title":"Vet Clin Pathol"},{"issue":"1","key":"10255_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01652176.2019.1707907","volume":"40","author":"A Basoglu","year":"2020","unstructured":"Basoglu A, Baspinar N, Tenor L, Licari C, Gulersoy E (2020) Nuclear magnetic resonance (NMR)-based metabolome profile evaluation in dairy cows with and without displaced abomasum. Vet Q 40(1):1\u201315","journal-title":"Vet Q"},{"issue":"12","key":"10255_CR4","doi-asserted-by":"publisher","first-page":"844","DOI":"10.3390\/metabo11120844","volume":"11","author":"MA Brunetto","year":"2021","unstructured":"Brunetto MA, Halfen DP, Risolia LW, Pedrinelli V, Caragelasco DS, Vendramini THA, Kogika MM (2021) Evaluation of serum and urine amino acids in dogs with chronic kidney disease and healthy dogs fed a renal diet. Metabolites 11(12):844","journal-title":"Metabolites"},{"key":"10255_CR5","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1016\/j.pss.2006.05.041","volume":"54","author":"DP Buch","year":"2006","unstructured":"Buch DP, Glavin R, Sternberg C, Szopa C, Rodier R, Navarro-Gonzalez F, Raulin M, Cabane, Mahaffy PR (2006) A new extraction technique for in situ analyses of amino and carboxylic acids on Mars by gas chromatography mass spectrometry. Planet Space Sci 54:1592\u20131599","journal-title":"Planet Space Sci"},{"issue":"9","key":"10255_CR6","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.3168\/jds.S0022-0302(02)74312-9","volume":"85","author":"L Doepel","year":"2002","unstructured":"Doepel L, Lapierre H, Kennelly JJ (2002) Peripartum performance and metabolism of dairy cows in response to prepartum energy and protein intake. J Dairy Sci 85(9):2315\u20132334","journal-title":"J Dairy Sci"},{"issue":"2","key":"10255_CR7","doi-asserted-by":"publisher","first-page":"247","DOI":"10.5187\/jast.2022.e14","volume":"64","author":"JS Eom","year":"2022","unstructured":"Eom JS, Lee SJ, Kim HS, Choi Y, Jo SU, Lee SS, Lee SS (2022) Metabolic profiling of serum and urine in lactating dairy cows affected by subclinical ketosis using proton nuclear magnetic resonance spectroscopy. J Anim Sci Biotechnol 64(2):247","journal-title":"J Anim Sci Biotechnol"},{"issue":"5","key":"10255_CR8","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s00125-013-2839-7","volume":"56","author":"RN Feng","year":"2013","unstructured":"Feng RN, Niu YC, Sun XW, Li Q, Zhao C, Wang C, Li Y (2013) Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial. Diabetologia 56(5):985\u2013994","journal-title":"Diabetologia"},{"issue":"2","key":"10255_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000057641","volume":"46","author":"A F\u0131rat","year":"2002","unstructured":"F\u0131rat A, \u00d6zp\u0131nar A (2002) Metabolic profile of pre-pregnancy, pregnancy and early lactation in multiple lambing sak\u0131z ewes. Ann Nutr Metab 46(2):57\u201361","journal-title":"Ann Nutr Metab"},{"issue":"1","key":"10255_CR10","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/0002-9610(74)90009-9","volume":"127","author":"JE Fischer","year":"1974","unstructured":"Fischer JE, Yoshimura N, Aguirre A, James JH, Cummings MG, Aybel RM, Deindoerfer F (1974) Plasma amino acids in patients with hepatic encephalopathy: effects of amino acid infusions. Am J Surg 127(1):40\u201347","journal-title":"Am J Surg"},{"issue":"2","key":"10255_CR11","first-page":"15","volume":"81","author":"A G\u00fcnl\u00fc","year":"2010","unstructured":"G\u00fcnl\u00fc A, Ala\u015fahan S (2010) T\u00fcrkiye\u2019de ke\u00e7i yeti\u015ftiricili\u011fi ve gelece\u011fi \u00fczerine baz\u0131 de\u011ferlendirmeler. Vet Hekim Der Derg 81(2):15\u201320","journal-title":"Vet Hekim Der Derg"},{"issue":"9","key":"10255_CR12","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3390\/vetsci9090455","volume":"9","author":"V Habermaass","year":"2022","unstructured":"Habermaass V, Gori E, Abramo F, Bartoli F, Pierini A, Mariti C, Marchetti V (2022) Serum amino acids imbalance in canine chronic hepatitis: results in 16 dogs. Vet Sci 9(9):455","journal-title":"Vet Sci"},{"issue":"10","key":"10255_CR13","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1292\/jvms.09-0239","volume":"72","author":"M Hamana","year":"2010","unstructured":"Hamana M, Ohtsuka H, Oikawa M, Kawamura S (2010) Blood free amino acids in the postpartum dairy cattle with left displaced abomasum. J Vet Med Sci 72(10):1355\u20131358","journal-title":"J Vet Med Sci"},{"issue":"1","key":"10255_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-09056-5","volume":"12","author":"CA Imbery","year":"2022","unstructured":"Imbery CA, Dieterle F, Ottka C, Weber C, Schlotterbeck G, M\u00fcller E, Giger U (2022) Metabolomic serum abnormalities in dogs with hepatopathies. Sci Rep 12(1):1\u201314","journal-title":"Sci Rep"},{"issue":"3","key":"10255_CR15","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1111\/jvim.15479","volume":"33","author":"YA Lawrence","year":"2019","unstructured":"Lawrence YA, Bishop MA, Honneffer JB, Cook AK, Rodrigues-Hoffmann A, Steiner JM, Lidbury JA (2019) Untargeted metabolomic profiling of serum from dogs with chronic hepatic disease. J Vet Intern Med 33(3):1344\u20131352","journal-title":"J Vet Intern Med"},{"issue":"4","key":"10255_CR16","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1111\/jvim.15512","volume":"33","author":"R Leela-arporn","year":"2019","unstructured":"Leela-arporn R, Ohta H, Tamura M, Nagata N, Sasaoka K, Dermlim A, Takiguchi M (2019) Plasma-free amino acid profiles in dogs with hepatocellular carcinoma. J Vet Intern Med 33(4):1653\u20131659","journal-title":"J Vet Intern Med"},{"issue":"3","key":"10255_CR17","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1080\/01652176.2014.962116","volume":"34","author":"Y Li","year":"2014","unstructured":"Li Y, Xu C, Xia C, Zhang HY, Sun LW, Gao Y (2014) Plasma metabolic profiling of dairy cows affected with clinical ketosis using LC\/MS technology. Vet Q 34(3):152\u2013158","journal-title":"Vet Q"},{"key":"10255_CR18","doi-asserted-by":"publisher","first-page":"16463","DOI":"10.1038\/s41598-022-20371-9","volume":"12","author":"A Lisuzzo","year":"2022","unstructured":"Lisuzzo A, Laghi L, Fiore F, Harvatine K, Mazzotta E, Faillace V, Fiore E (2022) Evaluation of the metabolomic profile through 1H-NMR spectroscopy in ewes affected by hyperketonemia. Sci Rep 12:16463","journal-title":"Sci Rep"},{"key":"10255_CR19","unstructured":"Little TM, Hills FJ (1978) Agricultural experimentation design and analysis. New York, NY John Wiley & Sons\u00a0United States"},{"issue":"1","key":"10255_CR20","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"H Lowry Oliver","year":"1951","unstructured":"Lowry Oliver H, Nira J, Rosebrough A, Farr Lewis, Randall RJ (1951) Protein measurement with the Folin phenol reagent. The J Biol Chem 193(1):265\u2013275","journal-title":"The J Biol Chem"},{"issue":"1","key":"10255_CR21","first-page":"149","volume":"21","author":"J Marczuk","year":"2018","unstructured":"Marczuk J, Brodzki P, Brodzki A, Kurek \u0141 (2018) The concentration of free amino acids in blood serum of dairy cows with primary ketosis. Pol J Vet Sci 21(1):149\u2013156","journal-title":"Pol J Vet Sci"},{"key":"10255_CR22","doi-asserted-by":"publisher","first-page":"882487","DOI":"10.3389\/fmolb.2022.882487","volume":"9","author":"S Moco","year":"2022","unstructured":"Moco S (2022) Studying metabolism by NMR-based metabolomics. Front Mol Biosci 9:882487","journal-title":"Front Mol Biosci"},{"issue":"4","key":"10255_CR23","doi-asserted-by":"publisher","first-page":"954","DOI":"10.3390\/ijms19040954","volume":"19","author":"C Nie","year":"2018","unstructured":"Nie C, He T, Zhang W, Zhang G, Ma X (2018) Branched chain amino acids: beyond nutrition metabolism. Int J Mol Sci 19(4):954","journal-title":"Int J Mol Sci"},{"key":"10255_CR24","first-page":"254","volume-title":"Harper\u2019s Illustrated Biochemistry","author":"VW Rodwell","year":"2006","unstructured":"Rodwell VW (2006) Catabolism of the carbon skeletons of amino acids. In: Murray RK, Granner DK, Rodwell VW (eds) Harper\u2019s Illustrated Biochemistry, 27th edn. McGraw-Hill, New York, pp 254\u2013269","edition":"27"},{"issue":"2","key":"10255_CR25","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0749-0720(15)30107-9","volume":"16","author":"JS Rook","year":"2000","unstructured":"Rook JS (2000) Pregnancy toxemia of ewes, does, and beef cows. Vet Clin N Am - Food Anim Pract 16(2):293\u2013317","journal-title":"Vet Clin N Am - Food Anim Pract"},{"issue":"2","key":"10255_CR26","first-page":"197","volume":"155","author":"PR Scott","year":"1998","unstructured":"Scott PR, Sargison ND, Penny CD (1998) Evaluation of recombinant bovine somatotropin in the treatment of ovine pregnancy toxemia. J Vet Med 155(2):197\u2013199","journal-title":"J Vet Med"},{"issue":"4","key":"10255_CR27","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1292\/jvms.68.393","volume":"68","author":"KI Shibano","year":"2006","unstructured":"Shibano KI, Kawamura S (2006) Serum free amino acid concentration in hepatic lipidosis of dairy cows in the periparturient period. J Vet Med Sci 68(4):393\u2013396","journal-title":"J Vet Med Sci"},{"issue":"2","key":"10255_CR28","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1292\/jvms.67.191","volume":"67","author":"KI Shibano","year":"2005","unstructured":"Shibano KI, Kawamura S, Hakamada R, Kawamura Y (2005) The relationship between changes in serum glycine and alanine concentrations in non-essential amino acid and milk production in the transition period in dairy cows. J Vet Med Sci 67(2):191\u2013193","journal-title":"J Vet Med Sci"},{"issue":"1","key":"10255_CR29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.15407\/agrisp3.01.073","volume":"3","author":"M Simonov","year":"2016","unstructured":"Simonov M, Vlizlo V (2016) The effect of Remivital on plasma amino acid composition in dairy cows with ketosis. J Agric Sci Pract 3(1):73\u201379","journal-title":"J Agric Sci Pract"},{"key":"10255_CR30","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/9780813818825","volume-title":"Goat medicine","author":"MC Smith","year":"2009","unstructured":"Smith MC, Sherman DM (2009) Goat medicine, 1st edn. Wiley-Blackwell Publication, Oxford, pp 48\u201360","edition":"1"},{"issue":"2","key":"10255_CR31","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/vetsci9020084","volume":"9","author":"SC Summers","year":"2022","unstructured":"Summers SC, Quimby J, Blake A, Keys D, Steiner JM, Suchodolski J (2022) Serum and fecal amino acid profiles in cats with chronic kidney disease. Vet Sci 9(2):84","journal-title":"Vet Sci"},{"issue":"3","key":"10255_CR32","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.3168\/jds.2013-6757","volume":"97","author":"LW Sun","year":"2014","unstructured":"Sun LW, Zhang HY, Wu L, Shu S, Xia C, Xu C, Zheng JS (2014) 1H-Nuclear magnetic resonance-based plasma metabolic profiling of dairy cows with clinical and subclinical ketosis. J Dairy Sci 97(3):1552\u20131562","journal-title":"J Dairy Sci"},{"issue":"1","key":"10255_CR33","first-page":"67","volume":"77","author":"K Tsukano","year":"2015","unstructured":"Tsukano K, Suzuki K, Shimamori T, Sato A, Kudo K, Asano R, Lakritz J (2015) Profiles of serum amino acids to screen for catabolic and inflammation status in calves with Mycoplasma bronchopneumonia. J Vet Med 77(1):67\u201373","journal-title":"J Vet Med"},{"key":"10255_CR34","volume-title":"Body condition scores in goats","author":"M Villaquiran","year":"2004","unstructured":"Villaquiran M, Gipson TA, Merkel RC, Goetsch AL, Tahlu T (2004) Body condition scores in goats. American Institute for Goat Research, Langston University"},{"issue":"3","key":"10255_CR35","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1080\/1828051X.2016.1180643","volume":"15","author":"Y Wang","year":"2016","unstructured":"Wang Y, Gao Y, Xia C, Zhang H, Qian W, Cao Y (2016) Pathway analysis of plasma different metabolites for dairy cow ketosis. Ital J Anim Sci 15(3):545\u2013551","journal-title":"Ital J Anim Sci"},{"issue":"2","key":"10255_CR36","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0928-4346(94)00159-3","volume":"3","author":"M Yamato","year":"1995","unstructured":"Yamato M, Muto Y, Yoshida T, Kato M, Moriwaki H (1995) Clearance rate of plasma branched-chain amino acids correlates significantly with blood ammonia level in patients with liver cirrhosis. Int Hepatol Commun 3(2):91\u201396","journal-title":"Int Hepatol Commun"},{"key":"10255_CR37","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.rvsc.2016.06.012","volume":"107","author":"G Zhang","year":"2016","unstructured":"Zhang G, Hailemariam D, Dervishi E, Goldansaz SA, Deng Q, Dunn SM, Ametaj BN (2016) Dairy cows affected by ketosis show alterations in innate immunity and lipid and carbohydrate metabolism during the dry off period and postpartum. Res Vet Sci 107:246\u2013256","journal-title":"Res Vet Sci"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-023-10255-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-023-10255-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-023-10255-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T08:10:41Z","timestamp":1712391041000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11259-023-10255-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10255"],"URL":"https:\/\/doi.org\/10.1007\/s11259-023-10255-2","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"value":"0165-7380","type":"print"},{"value":"1573-7446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,13]]},"assertion":[{"value":"5 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors are informed and agree with the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}