{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:53:31Z","timestamp":1768701211084,"version":"3.49.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007041","name":"Universidad de Zaragoza","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007041","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leishmaniosis is a vector-borne disease caused by different <jats:italic>Leishmania<\/jats:italic> species and transmitted by phlebotomine sand flies under natural conditions in Europe. Scientific information related to <jats:italic>Leishmania infantum<\/jats:italic> in dogs is extensive, where less information is available in cats and other companion animals. Recently, first clinical cases of <jats:italic>L.infantum<\/jats:italic> infection in domestic ferrrets (<jats:italic>Mustela putorius furo<\/jats:italic>) have been described. However, clinical information on leishmaniosis in this species is limited A 15-month-old male neutered domestic ferret was presented with chronic weight loss and the presence of coalescent, erythematous and firm subcutaneous nodules in the ventral abdominal subcutis. A fine-needle aspiration of these nodules was performed and the cytological examination revealed a granulomatous inflammation with the presence of macrophages contained a number of oval organisms with an eccentric nucleus and pale cytoplasm, compatible with <jats:italic>Leishmania<\/jats:italic> spp. amastigotes compatible with Leishmania spp. amastigotes. The nodules were surgically excised and histological examination showed a severe multifocal pyogranulomatous panniculitis. Specific immunohistochemistry and qPCR for <jats:italic>L. infantum<\/jats:italic> from excised nodules were positive. Additionally, <jats:italic>L. infantum<\/jats:italic> was cultured and isolated from the nodules by a fine-needle aspiration. An in-house Western Blot test for <jats:italic>L. infantum<\/jats:italic> was performed in serum sample and a positive result was obtained. This is the first reported case of nodular pyogranulomatous panniculitis due to <jats:italic>L. infantum<\/jats:italic> infection in a domestic ferret. Further studies are necessary to determine the relevance of domestic ferrets in the transmission of leishmaniosis. The description of new clinical forms of the disease is important as it can assist veterinarians in identifying these new clinical presentations.<\/jats:p>","DOI":"10.1007\/s11259-023-10276-x","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T08:02:28Z","timestamp":1702540948000},"page":"1245-1251","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nodular pyogranulomatous panniculitis due to Leishmania infantum infection in a domestic ferret (Mustela putorius furo)"],"prefix":"10.1007","volume":"48","author":[{"given":"Jacobo","family":"Giner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rodr\u00edguez-Largo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carles","family":"Juan-Sall\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Riera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roser","family":"Fisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Villanueva-Saz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"10276_CR1","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1186\/s13071-022-05517-y","volume":"15","author":"MM Alcover","year":"2022","unstructured":"Alcover MM, Giner J, Rabasedas J, Roca-Geron\u00e9s X, Verde M, Fern\u00e1ndez A, Riera C, Fisa R, Villanueva-Saz S (2022) First epidemiological survey of Leishmania infantum in the domestic ferret (Mustela putorius furo) in a canine leishmaniosis endemic area using serology and PCR. Parasit Vectors 15:372","journal-title":"Parasit Vectors"},{"key":"10276_CR2","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.patbio.2008.03.007","volume":"57","author":"E Chouihi","year":"2009","unstructured":"Chouihi E, Amri F, Bouslimi N, Siala E, Selmi K, Zallagua N, Ben Abdallah R, Bouratbine A, Aoun K (2009) Cultures on NNN medium for the diagnosis of Leishmaniasis. Pathol Biol 57:219\u2013224. https:\/\/doi.org\/10.1016\/j.patbio.2008.03.007","journal-title":"Pathol Biol"},{"key":"10276_CR3","first-page":"100369","volume":"19","author":"J Giner","year":"2020","unstructured":"Giner J, Basurco A, Alcover MM, Riera C, Fisa R, L\u00f3pez RA, Juan-Sall\u00e9s C, Verde MT, Fern\u00e1ndez A, Yzuel A, Villanueva-Saz S (2020a) First report on natural Infection with Leishmania infantum in a domestic ferret (Mustela putorius furo) in Spain. 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No additional ethical approval was required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}