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In an in vivo study, 51-day-old New Zealand rabbits were treated with a solution containing 1\u2009\u00d7\u200910<jats:sup>7<\/jats:sup> CFUs of <jats:italic>B. bronchiseptica<\/jats:italic> and 250\u00a0\u03bcg of one of the following carbohydrates: N acetylglucosamine (GlcNAc), N acetylgalactosamine (GalNAc), alpha methyl mannose (AmeMan), alpha methyl glucose (AmeGlc) and sialic acid (Neu5AC). Positive (<jats:italic>B. bronchiseptica<\/jats:italic>) and negative (Physiological Saline Solution (PSS)) controls were included. Animals treated with GlcNAc or AmeGlc showed no clinical signs of infection and exhibited a significant reduction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in the severity of microscopic lesions evaluated in the nasal cavity and lung compared with the positive controls. Additionally, the presence of bacteria was not detected through microbiological isolation or PCR in the lungs of animals treated with these sugars. Use of a mixture of GlcNAc and AmeGlc resulted in greater inhibition of microscopic lesions, with a significant reduction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in the severity of these lesions compared to the results obtained using individual sugars. Furthermore, the bacterium was not detected through microbiological isolation, Polymerase Chain Reaction (PCR) or indirect immunoperoxidase (IIP) in this group.<\/jats:p>","DOI":"10.1007\/s11259-024-10307-1","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T04:20:50Z","timestamp":1707538850000},"page":"1481-1495","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of carbohydrates on the adhesion of Bordetella bronchiseptica to the respiratory epithelium in rabbits"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9833-601X","authenticated-orcid":false,"given":"Pilar","family":"Pati\u00f1o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7744-2585","authenticated-orcid":false,"given":"Carolina","family":"Gallego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-4218","authenticated-orcid":false,"given":"Nhora","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-8305","authenticated-orcid":false,"given":"Carlos","family":"Iregui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-7503","authenticated-orcid":false,"given":"Alba","family":"Rey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,10]]},"reference":[{"key":"10307_CR1","doi-asserted-by":"publisher","first-page":"112507","DOI":"10.1016\/j.biopha.2021.112507","volume":"146","author":"MN Ahmed","year":"2022","unstructured":"Ahmed MN, Jahan R, Nissapatorn V, Wilairatana P, Rahmatullah M (2022) Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies. 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This committee is based on international and national guidelines that govern the use, care and welfare of animals used for scientific purposes, in accordance with Law 84 of 1989 of the Congress of the Republic of Colombia: National Statute for the Protection of Animals, Chapter V: On the sacrifice of animals, article 17, literal j.: For experimental, investigative or scientific purposes and Chapter VI: On the use of live animals in experiments and research, Articles 23 and 24 and Resolution 8430 of 1993 of the Ministry of Health, which establishes the scientific, technical and administrative standards for health research: Title V: Biomedical research with animals, articles 87 and 88.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of animal ethics"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing of interest"}}]}}