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Seventeen CBC indices were calculated and correlated with the measurements of inflammatory, APPs, and antioxidant biomarkers, as well as selected echocardiographic variables in all dogs. At stage-C, CBC indices were evaluated 14 days after the treatment.\u00a0Statistically significant changes were observed only for RDW\/PLT and neutrophil-to-lymphocyte ratio (NLR) between groups. NLR increased, but RDW\/PLT deceased in dogs with HF, compared to controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There were no statistically differences between pre- and post-treatment CBC indices. There were significantly positive and negative correlations between the CBC indices, serum parameters and selected echocardiographic variables in dogs with HF(<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). ROC analysis showed the best sensitivity (57% and 68%) and specificity (100% and 57%) for NLR\u2009&gt;\u20095.8 and RDW\/PLT\u2009\u2264\u20090.057 for predicting the severity of HF, respectively.\u00a0Results showed that NLR and RDW\/PLT may have potential for monitoring severity of the disease and the effect of treatment in dogs with HF. Imbalances between indices of circulating blood cells can contribute to immunoinflammatory and antioxidant responses in pathogenesis of canine HF, which may provide us alternative targets to develop new diagnostic and therapeutic strategies in veterinary medicine.<\/jats:p>","DOI":"10.1007\/s11259-024-10431-y","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T02:01:46Z","timestamp":1717812106000},"page":"2477-2487","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neutrophil-to-lymphocyte ratio and red blood cell distribution width to platelet ratio and their relationships with inflammatory and antioxidant status in dogs with different stages of heart failure due to myxomatous mitral valve disease"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-1222","authenticated-orcid":false,"given":"Meri\u00e7","family":"Kocaturk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1094-880X","authenticated-orcid":false,"given":"Ahmet","family":"Saril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1425-3919","authenticated-orcid":false,"given":"Abdullah Do\u011fukan","family":"Oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9293-4147","authenticated-orcid":false,"given":"Camila Peres","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8654-1793","authenticated-orcid":false,"given":"Jose Joaquin","family":"Ceron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9836-0749","authenticated-orcid":false,"given":"Zeki","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"10431_CR1","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.cardfail.2009.11.003","volume":"16","author":"LA Allen","year":"2010","unstructured":"Allen LA, Felker GM, Mehra MR, Chiong JR, Dunlap SH, Ghali JK, Lenihan DJ, Oren RM, Wagoner LE, Schwartz TA, Adams KF (2010) Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure. 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