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These investigations aimed to identify the expression and distribution of cannabinoid receptors in healthy and pathologic organs and tissues of different animal species and to define the interactions of phytocannabinoids with these receptors. In the last decade, pharmacokinetics, efficacy and tolerability of many Cannabis derivatives formulations, mainly containing cannabidiol, in the main species of veterinary interest, have been also investigated. This manuscript summarizes the findings reported by the scientific studies published so far on the molecular mode of action of the main phytocannabinoids, the localization of cannabinoid receptors in organs and tissues, as well as the pharmacokinetics, efficacy and tolerability of Cannabis derivatives in dogs, cats, horses and other species of veterinary interest. A deep knowledge of these issues is crucial for the use of phytocannabinoids for therapeutic purposes in animal species.<\/jats:p>","DOI":"10.1007\/s11259-024-10509-7","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T09:02:44Z","timestamp":1724144564000},"page":"2915-2941","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5934-5853","authenticated-orcid":false,"given":"Alessandra","family":"Di Salvo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0958-9187","authenticated-orcid":false,"given":"Elisabetta","family":"Chiaradia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-6540","authenticated-orcid":false,"given":"Monica","family":"Sforna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-5469","authenticated-orcid":false,"given":"Giorgia","family":"della Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"10509_CR1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.brainres.2006.02.119","volume":"1087","author":"ME Alonso-Ferrero","year":"2006","unstructured":"Alonso-Ferrero ME, Paniagua MA, Mostany R, Pilar-Cu\u00e9llar F, D\u00edez-Alarcia R, Pazos A, Fern\u00e1ndez-L\u00f3pez A (2006) Cannabinoid system in the budgerigar brain. 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