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An in vitro digestion followed by total phenolic content (TPC) and total antioxidant activity (TAC) assessment was performed before the in vivo application. At weaning, a total of 210 piglets were randomly allocated to two experimental treatments (7 replicates\/15 piglets for each replicate). Control group (CTR) was fed a standard basal diet while the treated group (T) was fed the basal diet mixed with 1.500\u00a0mg\/kg of blend. After in vitro digestion, TPC and TAC evidenced peaks at the end of oral and gastric phases in comparison to the intestinal one in line with the high content of phenolic compound (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Treatment conditioned body weight and average daily gain (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), fecal score on 6, 7, and 8 d after weaning (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). At 35d, the T group showed a decrease in salivary cortisol compared to CTR (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Duodenum and jejunum sections of T piglets revealed higher villi (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), deeper crypts (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01), and increased V\/C ratio (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01). CTR showed a higher expression of duodenal Occludin (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Jejunal E-cadherin and Occludin were more expressed in T jejunum sections (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). Twelve differentially abundant genera were identified in T group caecal samples. Potentially harmful\n                    <jats:italic>Clostridium sensu stricto 13<\/jats:italic>\n                    was reduced by the treatment (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). In conclusion, the tested blend positively affected salivary stress markers and the gut health of weaned piglets.\n                  <\/jats:p>","DOI":"10.1007\/s11259-024-10539-1","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T04:12:40Z","timestamp":1726200760000},"page":"3773-3791","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dietary supplementation with a blend composed of carvacrol, tannic acid derived from Castanea sativa and Glycyrrhiza glabra, and glycerides of medium chain fatty acids for weanling piglets raised in commercial farm"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7258-7694","authenticated-orcid":false,"given":"Luca","family":"Marchetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0731-2408","authenticated-orcid":false,"given":"Raffaella","family":"Rebucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8233-659X","authenticated-orcid":false,"given":"Davide","family":"Lanzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3717-5336","authenticated-orcid":false,"given":"Carlotta","family":"Giromini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-9122","authenticated-orcid":false,"given":"Lucia","family":"Aidos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-3020","authenticated-orcid":false,"given":"Alessia","family":"Di Giancamillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-5549","authenticated-orcid":false,"given":"Paola","family":"Cremonesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3901-2354","authenticated-orcid":false,"given":"Filippo","family":"Biscarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-6701","authenticated-orcid":false,"given":"Bianca","family":"Castiglioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-0179","authenticated-orcid":false,"given":"Valentino","family":"Bontempo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"10539_CR1","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1590\/1519-6984.232270","volume":"81","author":"MA Abdelaleem","year":"2020","unstructured":"Abdelaleem MA, Elbassiony KRA (2020) Evaluation of phytochemicals and antioxidant activity of gamma irradiated quinoa (Chenopodium quinoa). 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