{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:51:54Z","timestamp":1792857114846,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s11259-025-10849-y","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:55:29Z","timestamp":1756371329000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic application of canine adipose tissue-derived mesenchymal stromal cells in a dog with refractory immune-mediated thrombocytopenia, with diabetic ketoacidosis, and gastrointestinal bleeding induced by immunosuppressive treatment"],"prefix":"10.1007","volume":"49","author":[{"given":"Hee-Won","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga-Hyun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Young","family":"Jeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Gon","family":"Ah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-8163","authenticated-orcid":false,"given":"Sung-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"10849_CR1","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s10439-012-0639-8","volume":"40","author":"OS Beane","year":"2012","unstructured":"Beane OS, Darling EM (2012) Isolation, characterization, and differentiation of stem cells for cartilage regeneration. Ann Biomed Eng 40:2079\u20132097. https:\/\/doi.org\/10.1007\/s10439-012-0639-8","journal-title":"Ann Biomed Eng"},{"issue":"7","key":"10849_CR2","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.autrev.2011.01.005","volume":"10","author":"E Ben-Ami","year":"2011","unstructured":"Ben-Ami E, Sonia Berrih-Aknin, and Ariel Miller (2011) Mesenchymal stem cells as an immunomodulatory therapeutic strategy for autoimmune diseases. Autoimmun Rev 10(7):410\u2013415. https:\/\/doi.org\/10.1016\/j.autrev.2011.01.005","journal-title":"Autoimmun Rev"},{"issue":"3","key":"10849_CR3","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/cei.13475","volume":"201","author":"R Castelli","year":"2020","unstructured":"Castelli R et al (2020) Complement activation in patients with immune thrombocytopenic purpura according to phases of disease course. Clin Experimental Immunol 201(3):258\u2013265. https:\/\/doi.org\/10.1111\/cei.13475","journal-title":"Clin Experimental Immunol"},{"key":"10849_CR4","doi-asserted-by":"publisher","unstructured":"Cha S et al (2024) Remission of diabetes mellitus induced by prednisolone in combination with cyclosporine toxicity in a Cat. Veterinary Med Sci 10(5):e1552. https:\/\/doi.org\/10.1002\/vms3.1552","DOI":"10.1002\/vms3.1552"},{"key":"10849_CR5","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1186\/s12917-024-04216-3","volume":"20","author":"H-S Cho","year":"2024","unstructured":"Cho H-S et al (2024) Intravenous injection of allogenic canine mesenchymal stem cells in 40 dogs: a safety assessment in veterinary clinical trials. BMC Vet Res 20:375. https:\/\/doi.org\/10.1186\/s12917-024-04216-3","journal-title":"BMC Vet Res"},{"key":"10849_CR6","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3389\/fimmu.2015.00648","volume":"6","author":"SFH De Witte","year":"2016","unstructured":"De Witte SFH et al (2016) Toward development of iMesenchymal stem cells for Immunomodulatory therapy. Front Immunol 6:648. https:\/\/doi.org\/10.3389\/fimmu.2015.00648","journal-title":"Front Immunol"},{"key":"10849_CR7","doi-asserted-by":"publisher","unstructured":"Dias IE et al (2019) Mesenchymal stem cells therapy in companion animals: useful for immune-mediated diseases? BMC Vet Res 15:1\u201314. https:\/\/doi.org\/10.1186\/s12917-019-2087-2","DOI":"10.1186\/s12917-019-2087-2"},{"key":"10849_CR8","doi-asserted-by":"publisher","unstructured":"Ebbo M et al (2017) NK cell compartment in the peripheral blood and spleen in adult patients with primary immune thrombocytopenia. Clin Immunol 177:18\u201328. https:\/\/doi.org\/10.1016\/j.clim.2015.11.005","DOI":"10.1016\/j.clim.2015.11.005"},{"key":"10849_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.2785","author":"AM Heeley","year":"2023","unstructured":"Heeley AM et al (2023) Assessment of glucocorticoid and antibiotic exposure as risk factors for diabetes mellitus in selected dog breeds attending UK primary-care clinics. Vet Rec. https:\/\/doi.org\/10.1002\/vetr.2785","journal-title":"Vet Rec"},{"key":"10849_CR10","doi-asserted-by":"publisher","unstructured":"Huang H-P et al (1999) Iatrogenic hyperadrenocorticism in 28 dogs. J Am Anim Hosp Assoc 35(3):200\u2013207. https:\/\/doi.org\/10.5326\/15473317-35-3-200","DOI":"10.5326\/15473317-35-3-200"},{"key":"10849_CR11","doi-asserted-by":"publisher","unstructured":"Jeung S-Y et al (2024) Safety of gonadal tissue-derived mesenchymal stem cell therapy in geriatric dogs with chronic disease. Animals 14(14):2134. https:\/\/doi.org\/10.3390\/ani14142134","DOI":"10.3390\/ani14142134"},{"issue":"11","key":"10849_CR12","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1182\/blood-2017-09-807248","volume":"131","author":"Y Kong","year":"2018","unstructured":"Kong Y et al (2018) Atorvastatin enhances bone marrow endothelial cell function in corticosteroid-resistant immune thrombocytopenia patients. Blood 131(11):1219\u20131233. https:\/\/doi.org\/10.1182\/blood-2017-09-807248","journal-title":"Blood"},{"key":"10849_CR13","doi-asserted-by":"publisher","unstructured":"Kristiansen PS, Nielsen LN (2021) Immunomodulatory and immunosuppressive drug protocols in the treatment of canine primary immune thrombocytopenia, a scoping review. Acta Vet Scand 63(1):54. https:\/\/doi.org\/10.1186\/s13028-021-00620-z","DOI":"10.1186\/s13028-021-00620-z"},{"key":"10849_CR14","doi-asserted-by":"publisher","unstructured":"LeVine DN, Brooks MB (2019) Immune thrombocytopenia (ITP): pathophysiology update and diagnostic dilemmas. Vet Clin Pathol 48:17\u201328. https:\/\/doi.org\/10.1111\/vcp.12774","DOI":"10.1111\/vcp.12774"},{"key":"10849_CR15","doi-asserted-by":"publisher","unstructured":"LeVine DN et al (2024) ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats. J Vet Intern Med 38(4):1958\u20131981. https:\/\/doi.org\/10.1111\/jvim.16996","DOI":"10.1111\/jvim.16996"},{"issue":"3","key":"10849_CR16","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3109\/09537104.2014.903392","volume":"26","author":"H-Y Li","year":"2015","unstructured":"Li H-Y et al (2015) Interleukin-7 is decreased and maybe plays a pro-inflammatory function in primary immune thrombocytopenia. Platelets 26(3):243\u2013249. https:\/\/doi.org\/10.3109\/09537104.2014.903392","journal-title":"Platelets"},{"key":"10849_CR17","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1053\/j.seminhematol.2013.03.018","volume":"50","author":"T Nishimoto","year":"2013","unstructured":"Nishimoto T, Kuwana M (2013) CD4\u2009+\u2009CD25\u2009+\u2009Foxp3\u2009+\u2009regulatory T cells in the pathophysiology of immune thrombocytopenia. Semin Hematol 50:S43\u2013S49. https:\/\/doi.org\/10.1053\/j.seminhematol.2013.03.018","journal-title":"Semin Hematol"},{"key":"10849_CR18","doi-asserted-by":"publisher","unstructured":"Park H-J et al (2015) Application of vincristine-loaded platelet therapy in three dogs with refractory immune-mediated thrombocytopenia. J Vet Sci 16(1):127\u2013130. https:\/\/doi.org\/10.4142\/jvs.2015.16.1.127","DOI":"10.4142\/jvs.2015.16.1.127"},{"key":"10849_CR19","doi-asserted-by":"publisher","unstructured":"P\u00e9rez-Sim\u00f3n JA et al (2009) Mesenchymal stem cells are functionally abnormal in patients with immune thrombocytopenic purpura. Taylor & Francis. https:\/\/doi.org\/10.3109\/14653240903051558","DOI":"10.3109\/14653240903051558"},{"issue":"2","key":"10849_CR20","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1182\/blood-2009-06-225565","volume":"115","author":"D Provan","year":"2010","unstructured":"Provan D et al (2010) International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 115(2):168\u2013186. https:\/\/doi.org\/10.1182\/blood-2009-06-225565","journal-title":"Blood"},{"issue":"10","key":"10849_CR21","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1160\/TH17-03-0155","volume":"117","author":"J Qi","year":"2017","unstructured":"Qi J et al (2017) Downregulation of hypoxia-inducible factor-1\u03b1 contributes to impaired megakaryopoiesis in immune thrombocytopenia. Thromb Haemost 117(10):1875\u20131886. https:\/\/doi.org\/10.1160\/TH17-03-0155","journal-title":"Thromb Haemost"},{"issue":"2","key":"10849_CR22","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1590\/1678-4162-12445","volume":"75","author":"PR Santi","year":"2023","unstructured":"Santi PR, Fran\u00e7a MR, Milistetd M (2023) Treatment of chronic immunomediated thrombocytopenia with mesenquimal stem cells in dog-case report. Arq Bras Med Vet Zootec 75(2):221\u2013226. https:\/\/doi.org\/10.1590\/1678-4162-12445","journal-title":"Arq Bras Med Vet Zootec"},{"issue":"4","key":"10849_CR23","doi-asserted-by":"publisher","first-page":"e13136","DOI":"10.1590\/1678-4162-13136","volume":"76","author":"LG Santos","year":"2024","unstructured":"Santos LG et al (2024) Stem cell therapy as adjunctive in the management of anemia and thrombocytopenia partially responsive to corticosteroid in a dog treated with Phenobarbital-case report. Arq Bras Med Vet Zootec 76(4):e13136. https:\/\/doi.org\/10.1590\/1678-4162-13136","journal-title":"Arq Bras Med Vet Zootec"},{"issue":"5","key":"10849_CR24","first-page":"514","volume":"57","author":"M Scuderi","year":"2016","unstructured":"Scuderi M, Ann et al (2016) Outcome based on treatment protocol in patients with primary canine immune-mediated thrombocytopenia: 46 cases (2000\u20132013). Can Veterinary J 57(5):514","journal-title":"Can Veterinary J"},{"issue":"Suppl 1","key":"10849_CR25","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00277-009-0882-8","volume":"89","author":"JW Semple","year":"2010","unstructured":"Semple JW (2010) Animal models of immune thrombocytopenia (ITP). Ann Hematol 89(Suppl 1):37\u201344","journal-title":"Ann Hematol"},{"issue":"9","key":"10849_CR26","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s00277-009-0882-8","volume":"41","author":"N Song","year":"2020","unstructured":"Song N, Scholtemeijer M, Shah K (2020) Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential. Trends Pharmacol Sci 41(9):653\u2013664. https:\/\/doi.org\/10.1007\/s00277-009-0882-8","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"10849_CR27","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.cvsm.2022.01.009","volume":"52","author":"KR Viviano","year":"2022","unstructured":"Viviano KR (2022) Glucocorticoids, cyclosporine, azathioprine, chlorambucil, and mycophenolate in dogs and cats: clinical uses, pharmacology, and side effects. Vet Clin North Am Small Anim Pract 52(3):797\u2013817. https:\/\/doi.org\/10.1016\/j.cvsm.2022.01.009","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"10849_CR28","doi-asserted-by":"publisher","unstructured":"Wang Kun-jie et al (2004) Safety of mycophenolate mofetil versus azathioprine in renal transplantation: a systematic review. Transpl Proc 36:2068\u20132070. Elsevier. https:\/\/doi.org\/10.1016\/j.transproceed.2004.07.057","DOI":"10.1016\/j.transproceed.2004.07.057"},{"issue":"6","key":"10849_CR29","doi-asserted-by":"publisher","first-page":"2618","DOI":"10.1111\/jvim.15630","volume":"33","author":"JC Whittemore","year":"2019","unstructured":"Whittemore JC et al (2019) Clinical, clinicopathologic, and gastrointestinal changes from administration of clopidogrel, prednisone, or combination in healthy dogs: a double-blind randomized trial. J Vet Intern Med 33(6):2618\u20132627. https:\/\/doi.org\/10.1111\/jvim.15630","journal-title":"J Vet Intern Med"},{"issue":"1","key":"10849_CR30","doi-asserted-by":"publisher","first-page":"316351","DOI":"10.1155\/2015\/316351","volume":"2015","author":"M Wu","year":"2015","unstructured":"Wu M et al (2015) Mesenchymal stem cells immunosuppressed IL-22 in patients with immune thrombocytopenia via soluble cellular factors. J Immunol Res 2015(1):316351. https:\/\/doi.org\/10.1155\/2015\/316351","journal-title":"J Immunol Res"},{"issue":"1","key":"10849_CR31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13287-023-03323-6","volume":"14","author":"F Wu","year":"2023","unstructured":"Wu F et al (2023) Therapeutic potential of MSCs and MSC-derived extracellular vesicles in immune thrombocytopenia. Stem Cell Res Ther 14(1):79. https:\/\/doi.org\/10.1186\/s13287-023-03323-6","journal-title":"Stem Cell Res Ther"},{"issue":"12","key":"10849_CR32","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1111\/j.1537-2995.2012.03642.x","volume":"52","author":"J Xiao","year":"2012","unstructured":"Xiao J et al (2012) Transplantation of adipose-derived mesenchymal stem cells into a murine model of passive chronic immune thrombocytopenia. Transfusion 52(12):2551\u20132558. https:\/\/doi.org\/10.1111\/j.1537-2995.2012.03642.x","journal-title":"Transfusion"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-025-10849-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-025-10849-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-025-10849-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:35:38Z","timestamp":1761068138000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11259-025-10849-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10849"],"URL":"https:\/\/doi.org\/10.1007\/s11259-025-10849-y","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"value":"0165-7380","type":"print"},{"value":"1573-7446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]},"assertion":[{"value":"3 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is an observational study. The XYZ Research Ethics Committee has confirmed that no ethical approval is required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of animal ethics"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"294"}}