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Treatment is currently insufficient. The study aimed to assess the potential therapeutic effects of Sage (\n                    <jats:italic>Salvia officinalis<\/jats:italic>\n                    ) leaves extract in comparison to albendazole against\n                    <jats:italic>Trichinella spiralis<\/jats:italic>\n                    infection in mice. Seventy mice were classified into six groups, non-infected control, non-infected receiving\n                    <jats:italic>Salvia officinalis<\/jats:italic>\n                    extract, infected control, infected and treated with albendazole (50\u00a0mg\/kg), infected and received\n                    <jats:italic>Salvia officinalis<\/jats:italic>\n                    extract (250\u00a0mg\/kg), and infected and treated with combination of 25\u00a0mg\/kg albendazole and 250\u00a0mg\/kg\n                    <jats:italic>S. officinalis<\/jats:italic>\n                    extract. Mice were sacrificed at 7- and 37-days post-infection for intestinal and muscle phases, respectively. Efficacy was assessed through parasitological parameters, anti-inflammatory and oxidative stress markers. Our finding revealed a significant reduction in the adult worms and larvae counts of\n                    <jats:italic>T. spiralis<\/jats:italic>\n                    in albendazole (97.3% (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01), 74.19% (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05),\n                    <jats:italic>S. officinalis<\/jats:italic>\n                    extract (80% (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), 60% (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) and combined treatment led to the highest reduction rate (91.9% (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), 81.4% (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01).\n                    <jats:italic>S. officinalis<\/jats:italic>\n                    extract boosted the immune response by reducing NO and MDA levels while increasing SOD, CAT and GSH in intestinal and muscular tissues. Additionally, it improved the inflammatory response, Albendazole and\n                    <jats:italic>S. officinalis<\/jats:italic>\n                    , especially in combination, have effectively suppress inflammatory and fibrotic gene expression (FN1, TNF\u03b1, TGF-\u03b2, and IL-10) indicating synergistic therapeutic efficacy. In conclusion,\n                    <jats:italic>S. officinalis<\/jats:italic>\n                    extract can be considered a practical and effective alternative herbal drug in treating trichinellosis.\n                  <\/jats:p>","DOI":"10.1007\/s11259-025-10875-w","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:53:00Z","timestamp":1759207980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Potential antioxidant and anti-inflammatory impacts of Salvia officinalis leaves extract on mice experimentally infected with Trichinella spiralis"],"prefix":"10.1007","volume":"49","author":[{"given":"Marwa","family":"Safi-eldin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M.","family":"Abdelfattah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa","family":"Barghash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameen A.","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-1063","authenticated-orcid":false,"given":"Hoda A.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"issue":"5","key":"10875_CR1","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3724\/SP.J.1009.2011.00354","volume":"9","author":"ANA Abad","year":"2011","unstructured":"Abad ANA, Nouri MHK, Tavakkoli F (2011) Effect of Salvia officinalis hydroalcoholic extract on vincristine-induced neuropathy in mice. 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