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Hong Kong genotype,\n                      <jats:italic>Candidatus<\/jats:italic>\n                      Dirofilaria hongkongensis, or\n                      <jats:italic>Dirofilaria<\/jats:italic>\n                      sp. \u201chongkongensis\u201d) is an emerging zoonotic filarioid nematode, initially described in human subcutaneous nodules in Hong Kong and later demonstrated in dogs and cats. This report includes the first description of clinical signs, diagnostic findings, including comparative clinicopathology, treatment and associated clinical complications in a feline infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An 18-month-old, indoor-only spayed female Domestic Shorthair cat presented with subcutaneous nodules and microfilariae in blood smears. Diagnostic work-up included a PCR from blood, a quantitative modified Knott test, haematology, echocardiography, and abdominal ultrasonography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PCR confirmed the presence of\n                      <jats:italic>Dirofilaria asiatica<\/jats:italic>\n                      . Haematology revealed neutrophilia (11.35\u2009\u00d7\u200910\u00b3\/\u00b5L) with left shift, and hyperproteinaemia (80\u00a0g\/L). A quantitative modified Knott test revealed a microfilaremia of 36,907 per ml. Treatment with oral doxycycline and transdermal moxidectin triggered an acute onset of respiratory distress, managed with oxygen and dexamethasone. Nodules regressed, and microfilariae cleared by day 70.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This case supports that indoor feline pets are susceptible to infection with\n                      <jats:italic>Dirofilaria asiatica<\/jats:italic>\n                      . In addition, we describe for the first time, the clinical and clinicopathological findings associated with infection and highlight the risks of anaphylactic reactions to microfilaricidal therapy. Moxidectin and doxycycline were critical for resolution, but pre-treatment with corticosteroids is recommended. Exorbitant microfilaremia might be a critical feature in cats. The zoonotic potential of this parasite warrants heightened surveillance in endemic regions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11259-025-10916-4","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T07:50:28Z","timestamp":1759218628000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling Dirofilaria Asiatica infection: first clinical insights and treatment challenges for this feline zoonotic parasitosis"],"prefix":"10.1007","volume":"49","author":[{"given":"Angel","family":"Almendros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Traub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"10916_CR1","doi-asserted-by":"publisher","first-page":"100625","DOI":"10.1016\/j.onehlt.2023.100625","volume":"17","author":"U Atapattu","year":"2023","unstructured":"Atapattu U, Koehler AV, Huggins LG, Wiethoelter A, Traub RJ, Colella V (2023) Dogs are reservoir hosts of the zoonotic dirofilaria sp. \u2018hongkongensis\u2019 and potentially of Brugia sp. 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