{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:41:58Z","timestamp":1774057318685,"version":"3.50.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100017637","name":"Uniwersytet Przyrodniczy we Wroclawiu","doi-asserted-by":"publisher","award":["B030\/0039\/20"],"award-info":[{"award-number":["B030\/0039\/20"]}],"id":[{"id":"10.13039\/501100017637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11259-025-10926-2","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T02:09:20Z","timestamp":1760580560000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abnormal Fetuin-A levels in obese horses are associated with activated TLR4\/NF-\u0199B\/MAPK axis and depleted FBXW7 E3 ubiquitin ligase"],"prefix":"10.1007","volume":"49","author":[{"given":"Lynda","family":"Bourebaba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miko\u0142aj","family":"Panek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilibeth Carolina C\u00e1rdenas","family":"Piedra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabila","family":"Bourebaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"10926_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3803\/EnM.2012.27.1.12","volume":"27","author":"S Bhattacharya","year":"2012","unstructured":"Bhattacharya S, Kundu R, Dasgupta S, Bhattacharya S (2012) Mechanism of lipid induced insulin resistance: an overview. Endocrinol Metab 27:12. https:\/\/doi.org\/10.3803\/EnM.2012.27.1.12","journal-title":"Endocrinol Metab"},{"key":"10926_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.918702","author":"S Blondy","year":"2022","unstructured":"Blondy S, Durand S, Lacroix A et al (2022) Detection of glycosylated markers from cancer stem cells with colostem Dx kit for earlier prediction of colon cancer aggressiveness. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2022.918702","journal-title":"Front Oncol"},{"key":"10926_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122033","volume":"8","author":"L Bourebaba","year":"2019","unstructured":"Bourebaba L, Marycz K (2019) Pathophysiological implication of Fetuin-A glycoprotein in the development of metabolic disorders: a concise review. J Clin Med 8:2033. https:\/\/doi.org\/10.3390\/jcm8122033","journal-title":"J Clin Med"},{"key":"10926_CR4","doi-asserted-by":"publisher","unstructured":"Chekol Abebe E, Tilahun Muche Z, Behaile T, Mariam A et al (2022) The structure, biosynthesis, and biological roles of fetuin-A: A review. Front Cell Dev Biol 10. https:\/\/doi.org\/10.3389\/fcell.2022.945287","DOI":"10.3389\/fcell.2022.945287"},{"key":"10926_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.64292\/ijes.14","volume":"1","author":"G Counotte","year":"2022","unstructured":"Counotte G, Durham A, Vandendriessche V, Wollenberg van den L (2022) Haptoglobin, Magnesium, Adiponectin, and leptin as biomarkers for obesity and insulin dysregulation in horses. Int J Equine Sci 1:3\u201310. https:\/\/doi.org\/10.64292\/ijes.14","journal-title":"Int J Equine Sci"},{"key":"10926_CR6","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.3390\/life11121406","volume":"11","author":"Z Daradics","year":"2021","unstructured":"Daradics Z, Crecan CM, Rus MA et al (2021) Obesity-related metabolic dysfunction in dairy cows and horses: comparison to human metabolic syndrome. Life 11:1406. https:\/\/doi.org\/10.3390\/life11121406","journal-title":"Life"},{"key":"10926_CR7","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1042\/BJ20100330","volume":"429","author":"S Dasgupta","year":"2010","unstructured":"Dasgupta S, Bhattacharya S, Biswas A et al (2010) NF-\u03baB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance. Biochem J 429:451\u2013462. https:\/\/doi.org\/10.1042\/BJ20100330","journal-title":"Biochem J"},{"key":"10926_CR8","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/9781119169239.ch36","volume":"27","author":"AE Durham","year":"2016","unstructured":"Durham AE (2016) Equine metabolic syndrome. Equine Laminitis 27:329\u2013333. https:\/\/doi.org\/10.1002\/9781119169239.ch36","journal-title":"Equine Laminitis"},{"key":"10926_CR9","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/jvim.15423","volume":"33","author":"AE Durham","year":"2019","unstructured":"Durham AE, Frank N, McGowan CM et al (2019) Eceim consensus statement on equine metabolic syndrome. J Vet Intern Med 33:335\u2013349. https:\/\/doi.org\/10.1111\/jvim.15423","journal-title":"J Vet Intern Med"},{"key":"10926_CR10","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1186\/s12917-025-04879-6","volume":"21","author":"EM Espinosa-L\u00f3pez","year":"2025","unstructured":"Espinosa-L\u00f3pez EM, Ortiz-Guisado B, Diez de Castro E et al (2025) Quantitative proteomics unveils potential plasma biomarkers and provides insights into the pathophysiological mechanisms underlying equine metabolic syndrome. BMC Vet Res 21:425. https:\/\/doi.org\/10.1186\/s12917-025-04879-6","journal-title":"BMC Vet Res"},{"key":"10926_CR11","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s13000-014-0221-9","volume":"9","author":"N Fedchenko","year":"2014","unstructured":"Fedchenko N, Reifenrath J (2014) Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue \u2013 a review. Diagn Pathol 9:221. https:\/\/doi.org\/10.1186\/s13000-014-0221-9","journal-title":"Diagn Pathol"},{"key":"10926_CR12","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.jevs.2008.10.016","volume":"28","author":"RJ Geor","year":"2008","unstructured":"Geor RJ (2008) Metabolic predispositions to laminitis in horses and ponies: obesity, insulin resistance and metabolic syndromes. J Equine Vet Sci 28:753\u2013759. https:\/\/doi.org\/10.1016\/j.jevs.2008.10.016","journal-title":"J Equine Vet Sci"},{"key":"10926_CR13","doi-asserted-by":"publisher","first-page":"14633","DOI":"10.1038\/s41598-025-93661-7","volume":"15","author":"B Giercuszkiewicz-Hecold","year":"2025","unstructured":"Giercuszkiewicz-Hecold B, Pajuelo D, Steczkiewicz Z et al (2025) Astaxanthin supplementation in Arabian racing horses mitigates oxidative stress and inflammation in peripheral blood mononuclear cells through enhanced mitophagy. Sci Rep 15:14633. https:\/\/doi.org\/10.1038\/s41598-025-93661-7","journal-title":"Sci Rep"},{"key":"10926_CR14","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cellsig.2012.12.011","volume":"25","author":"AS Goustin","year":"2013","unstructured":"Goustin AS, Derar N, Abou-Samra AB (2013) Ahsg-fetuin blocks the metabolic arm of insulin action through its interaction with the 95-kD \u03b2-subunit of the insulin receptor. Cell Signal 25:981\u2013988. https:\/\/doi.org\/10.1016\/j.cellsig.2012.12.011","journal-title":"Cell Signal"},{"key":"10926_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1180622","author":"I Hallman","year":"2023","unstructured":"Hallman I, Karikoski N, Kareskoski M (2023) The effects of obesity and insulin dysregulation on mare reproduction, pregnancy, and foal health: a review. Front Vet Sci. https:\/\/doi.org\/10.3389\/fvets.2023.1180622","journal-title":"Front Vet Sci"},{"key":"10926_CR16","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1530\/EJE-11-0864","volume":"166","author":"JW Haukeland","year":"2012","unstructured":"Haukeland JW, Dahl TB, Yndestad A et al (2012) Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies. Eur J Endocrinol 166:503\u2013510. https:\/\/doi.org\/10.1530\/EJE-11-0864","journal-title":"Eur J Endocrinol"},{"key":"10926_CR17","doi-asserted-by":"publisher","first-page":"e1765","DOI":"10.1371\/journal.pone.0001765","volume":"3","author":"AM Hennige","year":"2008","unstructured":"Hennige AM, Staiger H, Wicke C et al (2008) Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS ONE 3:e1765. https:\/\/doi.org\/10.1371\/journal.pone.0001765","journal-title":"PLoS ONE"},{"key":"10926_CR18","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1161\/CIRCULATIONAHA.105.588723","volume":"113","author":"JH Ix","year":"2006","unstructured":"Ix JH, Shlipak MG, Brandenburg VM et al (2006) Association between human Fetuin-A and the metabolic syndrome. Circulation 113:1760\u20131767. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.588723","journal-title":"Circulation"},{"key":"10926_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/193229680900300119","volume":"3","author":"PJ Johnson","year":"2009","unstructured":"Johnson PJ, Wiedmeyer CE, Messer NT, Ganjam VK (2009) Medical implications of obesity in horses\u2014lessons for human obesity. J Diabetes Sci Technol 3:163\u2013174. https:\/\/doi.org\/10.1177\/193229680900300119","journal-title":"J Diabetes Sci Technol"},{"key":"10926_CR20","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1080\/09712119.2015.1091340","volume":"44","author":"K Kaczmarek","year":"2016","unstructured":"Kaczmarek K, Janicki B, G\u0142owska M (2016) Insulin resistance in the horse: a review. J Appl Anim Res 44:424\u2013430. https:\/\/doi.org\/10.1080\/09712119.2015.1091340","journal-title":"J Appl Anim Res"},{"key":"10926_CR21","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s12944-018-0919-x","volume":"17","author":"A Khadir","year":"2018","unstructured":"Khadir A, Kavalakatt S, Madhu D et al (2018) Fetuin-A levels are increased in the adipose tissue of diabetic obese humans but not in circulation. Lipids Health Dis 17:291. https:\/\/doi.org\/10.1186\/s12944-018-0919-x","journal-title":"Lipids Health Dis"},{"key":"10926_CR22","doi-asserted-by":"publisher","first-page":"14478","DOI":"10.1073\/pnas.97.26.14478","volume":"97","author":"AH Kissebah","year":"2000","unstructured":"Kissebah AH, Sonnenberg GE, Myklebust J et al (2000) Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci U S A 97:14478\u201314483. https:\/\/doi.org\/10.1073\/pnas.97.26.14478","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10926_CR23","doi-asserted-by":"publisher","unstructured":"Komsa-Penkova RS, Golemanov GM, Radionova ZV et al (2018) Fetuin-A \u2013 Alpha2-Heremans-Schmid glycoprotein: from structure to a novel marker of chronic diseases part 1. Fetuin-A as a calcium chaperone and inflammatory marker. J Biomed Clin Res 10:90\u201397. https:\/\/doi.org\/10.1515\/jbcr-2017-0015","DOI":"10.1515\/jbcr-2017-0015"},{"key":"10926_CR24","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1530\/EJE-12-0654","volume":"168","author":"M Kuzmicki","year":"2013","unstructured":"Kuzmicki M, Telejko B, Wawrusiewicz-Kurylonek N et al (2013) The expression of genes involved in NF-\u03baB activation in peripheral blood mononuclear cells of patients with gestational diabetes. Eur J Endocrinol 168:419\u2013427. https:\/\/doi.org\/10.1530\/EJE-12-0654","journal-title":"Eur J Endocrinol"},{"key":"10926_CR25","doi-asserted-by":"publisher","unstructured":"Lihn AS, Richelsen B, Pedersen SB et al (2003) Increased expression of TNF-\u03b1, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels.\u00a0Am J Physiol Endocrinol Metab\u00a0285:E1072\u2013E1080. https:\/\/doi.org\/10.1152\/ajpendo.00206.2003","DOI":"10.1152\/ajpendo.00206.2003"},{"key":"10926_CR26","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0024-3205(98)00250-1","volume":"63","author":"X Lin","year":"1998","unstructured":"Lin X, Braymer HD, Bray GA, York DA (1998) Differential expression of insulin receptor tyrosine kinase inhibitor (fetuin) gene in a model of diet-induced obesity. Life Sci 63:145\u2013153. https:\/\/doi.org\/10.1016\/S0024-3205(98)00250-1","journal-title":"Life Sci"},{"key":"10926_CR27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12902-020-0538-1","volume":"20","author":"S Liu","year":"2020","unstructured":"Liu S, Hu W, He Y et al (2020) Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome. BMC Endocr Disord 20:67. https:\/\/doi.org\/10.1186\/s12902-020-0538-1","journal-title":"BMC Endocr Disord"},{"key":"10926_CR28","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.2337\/diabetes.51.8.2450","volume":"51","author":"ST Mathews","year":"2002","unstructured":"Mathews ST, Singh GP, Ranalletta M et al (2002) Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes 51:2450\u20132458. https:\/\/doi.org\/10.2337\/diabetes.51.8.2450","journal-title":"Diabetes"},{"key":"10926_CR29","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/s41374-018-0057-0","volume":"98","author":"DK Meyerholz","year":"2018","unstructured":"Meyerholz DK, Beck AP (2018) Principles and approaches for reproducible scoring of tissue stains in research. Lab Invest 98:844\u2013855. https:\/\/doi.org\/10.1038\/s41374-018-0057-0","journal-title":"Lab Invest"},{"key":"10926_CR30","doi-asserted-by":"publisher","first-page":"100335","DOI":"10.1016\/j.focha.2023.100335","volume":"3","author":"SM Mohamed","year":"2023","unstructured":"Mohamed SM, Shalaby MA, El-Shiekh RA et al (2023) Metabolic syndrome: risk factors, diagnosis, pathogenesis, and management with natural approaches. Food Chem Adv 3:100335. https:\/\/doi.org\/10.1016\/j.focha.2023.100335","journal-title":"Food Chem Adv"},{"key":"10926_CR31","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s40200-021-00738-x","volume":"20","author":"SK Mohammed","year":"2021","unstructured":"Mohammed SK, Taha EM, Muhi SA (2021) A case-control study to determination FBXW7 and Fetuin-A levels in patients with type 2 diabetes in Iraq. J Diabetes Metab Disord 20:237\u2013243. https:\/\/doi.org\/10.1007\/s40200-021-00738-x","journal-title":"J Diabetes Metab Disord"},{"key":"10926_CR32","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1136\/vr.103226","volume":"177","author":"R Morgan","year":"2015","unstructured":"Morgan R, Keen J, McGowan C (2015) Equine metabolic syndrome. Vet Rec 177:173\u2013179. https:\/\/doi.org\/10.1136\/vr.103226","journal-title":"Vet Rec"},{"key":"10926_CR33","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1038\/s41598-023-27956-y","volume":"13","author":"A Mukhopadhyay","year":"2023","unstructured":"Mukhopadhyay A, Cook SR, SanMiguel P et al (2023) TLR4 and MD2 variation among horses with differential TNF\u03b1 baseline concentrations and response to intravenous lipopolysaccharide infusion. Sci Rep 13:1486. https:\/\/doi.org\/10.1038\/s41598-023-27956-y","journal-title":"Sci Rep"},{"key":"10926_CR34","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1515\/tjb-2024-0235","volume":"50","author":"Y \u00d6ner-\u0130yido\u011fan","year":"2025","unstructured":"\u00d6ner-\u0130yido\u011fan Y, Ko\u00e7ak H (2025) Interaction of fetuin-A with obesity related insulin resistance and diabetes mellitus. Turk J Biochem 50:170\u2013182. https:\/\/doi.org\/10.1515\/tjb-2024-0235","journal-title":"Turk J Biochem"},{"key":"10926_CR35","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.1210\/jc.2012-2414","volume":"97","author":"H-Y Ou","year":"2012","unstructured":"Ou H-Y, Yang Y-C, Wu H-T et al (2012) Increased Fetuin-A concentrations in impaired glucose tolerance with or without nonalcoholic fatty liver disease, but not impaired fasting glucose. J Clin Endocrinol Metab 97:4717\u20134723. https:\/\/doi.org\/10.1210\/jc.2012-2414","journal-title":"J Clin Endocrinol Metab"},{"key":"10926_CR36","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1038\/nm.2851","volume":"18","author":"D Pal","year":"2012","unstructured":"Pal D, Dasgupta S, Kundu R et al (2012) Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 18:1279\u20131285. https:\/\/doi.org\/10.1038\/nm.2851","journal-title":"Nat Med"},{"key":"10926_CR37","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s12020-016-1132-1","volume":"55","author":"D P\u00e9rez-Sotelo","year":"2017","unstructured":"P\u00e9rez-Sotelo D, Roca-Rivada A, Larrosa-Garc\u00eda M et al (2017) Visceral and subcutaneous adipose tissue express and secrete functional alpha2hsglycoprotein (fetuin a) especially in obesity. Endocrine 55:435\u2013446. https:\/\/doi.org\/10.1007\/s12020-016-1132-1","journal-title":"Endocrine"},{"key":"10926_CR38","doi-asserted-by":"publisher","unstructured":"Pratt-Phillips S (2024) Effect of exercise conditioning on countering the effects of obesity and insulin resistance in Horses\u2014a review.\u00a0Anim 14:727. https:\/\/doi.org\/10.3390\/ani14050727","DOI":"10.3390\/ani14050727"},{"key":"10926_CR39","doi-asserted-by":"publisher","first-page":"666","DOI":"10.3390\/ani13040666","volume":"13","author":"S Pratt-Phillips","year":"2023","unstructured":"Pratt-Phillips S, Munjizun A (2023) Impacts of adiposity on exercise performance in horses. Animals 13:666. https:\/\/doi.org\/10.3390\/ani13040666","journal-title":"Animals"},{"key":"10926_CR40","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jevs.2019.06.003","volume":"79","author":"VM Ragno","year":"2019","unstructured":"Ragno VM, Zello GA, Klein CD, Montgomery JB (2019) From table to stable: a comparative review of selected aspects of human and equine metabolic syndrome. J Equine Vet Sci 79:131\u2013138. https:\/\/doi.org\/10.1016\/j.jevs.2019.06.003","journal-title":"J Equine Vet Sci"},{"key":"10926_CR41","doi-asserted-by":"publisher","first-page":"4479","DOI":"10.1210\/jc.2008-1505","volume":"93","author":"T Reinehr","year":"2008","unstructured":"Reinehr T, Roth CL (2008) Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. J Clin Endocrinol Metab 93:4479\u20134485. https:\/\/doi.org\/10.1210\/jc.2008-1505","journal-title":"J Clin Endocrinol Metab"},{"key":"10926_CR42","doi-asserted-by":"publisher","first-page":"E250","DOI":"10.1152\/ajpendo.00089.2018","volume":"317","author":"G Ren","year":"2019","unstructured":"Ren G, Kim T, Papizan JB (2019) Phosphorylation status of fetuin-A is critical for inhibition of insulin action and is correlated with obesity and insulin resistance. American Journal of Physiology-Endocrinology and Metabolism 317:E250\u2013E260. https:\/\/doi.org\/10.1152\/ajpendo.00089.2018","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"10926_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12968\/ukve.2018.2.S2.3","volume":"2","author":"D Rendle","year":"2018","unstructured":"Rendle D, McGregor Argo C, Bowen M et al (2018) Equine obesity: current perspectives. UK-Vet Equine 2:1\u201319. https:\/\/doi.org\/10.12968\/ukve.2018.2.S2.3","journal-title":"UK-Vet Equine"},{"key":"10926_CR44","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1590\/1678-5150-pvb-6343","volume":"40","author":"RM Ribeiro","year":"2020","unstructured":"Ribeiro RM, Ribeiro DSF, Paz CFR et al (2020) Insulin dysregulation in horses with induced obesity. Pesq Vet Bras 40:39\u201345. https:\/\/doi.org\/10.1590\/1678-5150-pvb-6343","journal-title":"Pesq Vet Bras"},{"key":"10926_CR45","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.2337\/diabetes.54.8.2477","volume":"54","author":"A Siddiq","year":"2005","unstructured":"Siddiq A, Lepretre F, Hercberg S et al (2005) A synonymous coding polymorphism in the \u03b12-Heremans-Schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians. Diabetes 54:2477\u20132481. https:\/\/doi.org\/10.2337\/diabetes.54.8.2477","journal-title":"Diabetes"},{"key":"10926_CR46","doi-asserted-by":"publisher","first-page":"853","DOI":"10.2337\/diacare.29.04.06.dc05-1938","volume":"29","author":"N Stefan","year":"2006","unstructured":"Stefan N, Hennige AM, Staiger H et al (2006) \u03b12-Heremans-Schmid Glycoprotein\/ Fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans. Diabetes Care 29:853\u2013857. https:\/\/doi.org\/10.2337\/diacare.29.04.06.dc05-1938","journal-title":"Diabetes Care"},{"key":"10926_CR47","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.2337\/db08-0538","volume":"57","author":"N Stefan","year":"2008","unstructured":"Stefan N, Fritsche A, Weikert C et al (2008) Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes 57:2762\u20132767. https:\/\/doi.org\/10.2337\/db08-0538","journal-title":"Diabetes"},{"key":"10926_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/genes14081544","volume":"14","author":"M Stefaniuk-Szmukier","year":"2023","unstructured":"Stefaniuk-Szmukier M, Pi\u00f3rkowska K, Ropka-Molik K (2023) Equine metabolic syndrome: a complex disease influenced by multifactorial genetic factors. Genes (Basel) 14:1544. https:\/\/doi.org\/10.3390\/genes14081544","journal-title":"Genes (Basel)"},{"key":"10926_CR49","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/01.ATV.0000251608.09329.9a","volume":"27","author":"T Suganami","year":"2007","unstructured":"Suganami T, Tanimoto-Koyama K, Nishida J et al (2007) Role of the toll-like receptor 4\/NF-\u03baB pathway in saturated fatty acid\u2013induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 27:84\u201391. https:\/\/doi.org\/10.1161\/01.ATV.0000251608.09329.9a","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10926_CR50","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3892\/mmr.2012.953","volume":"6","author":"K Tu","year":"2012","unstructured":"Tu K, Zheng X, Yin G et al (2012) Evaluation of Fbxw7 expression and its correlation with expression of SREBP-1 in a mouse model of NAFLD. Mol Med Rep 6:525\u2013530. https:\/\/doi.org\/10.3892\/mmr.2012.953","journal-title":"Mol Med Rep"},{"key":"10926_CR51","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/j.1365-2567.2008.02827.x","volume":"125","author":"L Wang","year":"2008","unstructured":"Wang L, Li D, Yang K et al (2008) Toll-like receptor-4 and mitogen-activated protein kinase signal system are involved in activation of dendritic cells in patients with acute coronary syndrome. Immunology 125:122\u2013130. https:\/\/doi.org\/10.1111\/j.1365-2567.2008.02827.x","journal-title":"Immunology"},{"key":"10926_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/5803639","volume":"2020","author":"K Xiao","year":"2020","unstructured":"Xiao K, Liu C, Tu Z et al (2020) Activation of the NF- \u03ba b and MAPK signaling pathways contributes to the inflammatory responses, but not cell injury, in IPEC-1 cells challenged with hydrogen peroxide. Oxid Med Cell Longev 2020:1\u201314. https:\/\/doi.org\/10.1155\/2020\/5803639","journal-title":"Oxid Med Cell Longev"},{"key":"10926_CR53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s41065-021-00191-z","volume":"158","author":"S-Q Yan","year":"2021","unstructured":"Yan S-Q, Adi D, Liu C et al (2021) FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China. Hereditas 158:27. https:\/\/doi.org\/10.1186\/s41065-021-00191-z","journal-title":"Hereditas"},{"key":"10926_CR54","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s10020-019-0099-9","volume":"25","author":"C Zhang","year":"2019","unstructured":"Zhang C, Chen F, Feng L et al (2019) Fbxw7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease. Mol Med 25:29. https:\/\/doi.org\/10.1186\/s10020-019-0099-9","journal-title":"Mol Med"},{"key":"10926_CR55","doi-asserted-by":"publisher","first-page":"818","DOI":"10.2337\/db17-1348","volume":"67","author":"J Zhao","year":"2018","unstructured":"Zhao J, Xiong X, Li Y et al (2018) Hepatic F-box protein FBXW7 maintains glucose homeostasis through degradation of Fetuin-A. Diabetes 67:818\u2013830. https:\/\/doi.org\/10.2337\/db17-1348","journal-title":"Diabetes"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-025-10926-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-025-10926-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-025-10926-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T10:36:55Z","timestamp":1762425415000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11259-025-10926-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10926"],"URL":"https:\/\/doi.org\/10.1007\/s11259-025-10926-2","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"value":"0165-7380","type":"print"},{"value":"1573-7446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,16]]},"assertion":[{"value":"26 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not Applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"354"}}