{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T21:52:43Z","timestamp":1785707563586,"version":"3.56.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"QIX Corporation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Periodontal disease (PD) is a prevalent infectious condition in companion animals and represents an irreversible oral disorder; therefore, preventive dentistry is strongly recommended to inhibit and delay symptom progression. In this study, we investigated the synergistic effects of cetylpyridinium chloride (CPC) and platinum nanoparticles (PT) on the growth, halitosis, and inflammatory responses of the major canine PD pathogen\n                    <jats:italic>Porphyromonas gulae<\/jats:italic>\n                    (\n                    <jats:italic>P. gulae<\/jats:italic>\n                    ) both in vitro and in a clinical study involving PD-affected dogs following dental scaling. The growth of\n                    <jats:italic>P. gulae<\/jats:italic>\n                    was significantly inhibited by CPC\u2009+\u2009PT treatment. Hydrogen sulfide and methyl mercaptan\u2014key components of halitosis\u2014produced by\n                    <jats:italic>P. gulae<\/jats:italic>\n                    were also significantly suppressed by the CPC and PT mixture, even after short-term treatment. Co-treatment with CPC and PT significantly inhibited\n                    <jats:italic>P. gulae<\/jats:italic>\n                    -induced pro-inflammatory cytokine production and SAPK\/JNK phosphorylation in response to infection. These in vitro findings were corroborated by clinical results, in which daily oral administration of CPC\u2009+\u2009PT significantly suppressed the exacerbation of gingivitis, plaque adherence, halitosis, and PD pathogen activity following dental scaling. Our results suggest that daily CPC\u2009+\u2009PT treatment may be an effective approach to delay the progression of PD symptoms in affected dogs. There is no argument that mechanical dental care including regular brushing and dental scaling is necessary as the best way to prevent dental plaque formation. A dental rinse can be used as a suitable additional treatment to extend the interval between dental scaling procedures.\n                  <\/jats:p>","DOI":"10.1007\/s11259-025-10945-z","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:22:01Z","timestamp":1762838521000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cetylpyridinium chloride and platinum nanoparticles effects in dogs with Porphyromonas gulae-infected periodontal disease"],"prefix":"10.1007","volume":"50","author":[{"given":"Tomoki","family":"Fukuyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So","family":"Shirahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimika","family":"Odajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risako","family":"Kawata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"10945_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/dj11110245","author":"CM Ardila","year":"2023","unstructured":"Ardila CM, Jimenez-Arbelaez GA, Vivares-Builes AM (2023) A systematic review of in vitro studies using microchip platforms for identifying periodontopathogens from the red complex. Dent J Basel. https:\/\/doi.org\/10.3390\/dj11110245","journal-title":"Dent J Basel"},{"key":"10945_CR2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12473","author":"GN Belibasakis","year":"2023","unstructured":"Belibasakis GN, Belstrom D, Eick S, Gursoy UK, Johansson A, Kononen E (2023) Periodontal microbiology and microbial etiology of periodontal diseases: historical concepts and contemporary perspectives. Periodontol 2000. https:\/\/doi.org\/10.1111\/prd.12473","journal-title":"Periodontol 2000"},{"issue":"1","key":"10945_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-025-01377-9","volume":"29","author":"EF De Rossi","year":"2025","unstructured":"De Rossi EF, Iida T, Carpita D, Iorio M, Guzon FMM, Iezzi G, Botticelli D (2025) Overbuilding techniques for thin buccal bone in immediate implant placement: an experimental study in dogs. 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Int Immunopharmacol 146:113805. https:\/\/doi.org\/10.1016\/j.intimp.2024.113805","journal-title":"Int Immunopharmacol"},{"key":"10945_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1022838","volume":"10","author":"S Shirahata","year":"2023","unstructured":"Shirahata S, Iwashita N, Sasaki R, Nomura R, Murakami M, Yasuda J, Yasuda H, Nakajima K, Inaba H, Matsumoto-Nakano M, Nakano K, Uchiyama J, Fukuyama T (2023) Possible association of FimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs. 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The remaining authors declare no relevant financial or non-financial interests. Study design, data collection, analysis, and interpretation were performed totally independently from the sponsor.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"26"}}