{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T03:04:02Z","timestamp":1769569442632,"version":"3.49.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Unit of Scientific Information Resources for Research"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["313577\/2020-0"],"award-info":[{"award-number":["313577\/2020-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades (MCIU)\/Agencia Estatal de Investigaci\u00f3n","award":["JdC2022-048632-I"],"award-info":[{"award-number":["JdC2022-048632-I"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The superorder Xenarthra comprises anteaters, sloths and armadillos, all endemic of the Americas. Despite their distinctive evolutionary history, information regarding viruses affecting this group remains scarce. Herein, we report a gammaherpesvirus infection in a two-toed sloth (\n                    <jats:italic>Choloepus didactylus<\/jats:italic>\n                    ) under human care that presented recurrent oral vesicular lesions and oral candidiasis. The gammaherpesvirus identified in oral swab sample likely represents a novel species, due to the large genetic divergence when compared to the closest sequences available on public databases, and its identification in a novel host species. This finding broadens the herpesvirus host range in Xenarthra, representing the third description in this taxonomic group. Future studies should elucidate the pathogenicity of this novel herpesvirus.\n                  <\/jats:p>","DOI":"10.1007\/s11259-025-10983-7","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:28:36Z","timestamp":1764134916000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel herpesvirus potentially associated with oral lesions in a two-toed sloth (Choloepus didactylus)"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6111-6301","authenticated-orcid":false,"given":"Carlos","family":"Sacrist\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Reisfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-0838","authenticated-orcid":false,"given":"Aricia","family":"Duarte-Benvenuto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4422-321X","authenticated-orcid":false,"given":"Roberta","family":"Zamana-Ramblas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Canedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islene","family":"Silva Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordana","family":"Barros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Padilha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-3395","authenticated-orcid":false,"given":"Jos\u00e9 Luiz","family":"Cat\u00e3o-Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-9287","authenticated-orcid":false,"given":"Ana Carolina","family":"Ewbank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"10983_CR1","doi-asserted-by":"publisher","unstructured":"Brito AF, Baele G, Nahata KD, Grubaugh ND, Pinney JW (2021) Intrahost speciations and host switches played an important role in the evolution of herpesviruses. Virus Evol 7:Article veab025. https:\/\/doi.org\/10.1093\/ve\/veab025","DOI":"10.1093\/ve\/veab025"},{"key":"10983_CR2","doi-asserted-by":"publisher","unstructured":"Coimbra A, D\u2019arc M, Moreira FRR, Cosentino MAC, Schiffler FB, Miranda TS, Mouta R, Girardi DL, Wanderkoke V, Medeiros G, Francisco TM, Soffiati FL, Ferreira SS, Ruiz-Miranda CR, Soares MA, Santos AF (2025) Fecal Virome of southeastern maned sloth (Bradypus crinitus) (Pilosa: Bradypodidae). Genet Mol Biol 48:e20240183.\u00a0https:\/\/doi.org\/10.1590\/1678-4685-GMB-2024-0183","DOI":"10.1590\/1678-4685-GMB-2024-0183"},{"key":"10983_CR3","doi-asserted-by":"publisher","unstructured":"Davison AJ (2010) Herpesvirus systematics. 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In: Thomas NJ, Hunter DB, Atkinson CT (eds) Infectious diseases of wild birds, Wiley, pp 63\u201386","DOI":"10.1002\/9780470344668.ch3"},{"key":"10983_CR8","doi-asserted-by":"publisher","unstructured":"Lee SB, Lee KL, Kim SW, Jung WJ, Park DS, Lee S, Giri SS, Kim SG, Jo SJ, Park JH, Hwang MH, Park EJ, Seo JP, Kim BY, Park SC (2024) Novel gammaherpesvirus infections in narrow-ridged finless porpoise (Neophocaena asiaeorientalis) and false killer whales (Pseudorca crassidens) in the Republic of Korea. Viruses 16:Article 1234.\u00a0https:\/\/doi.org\/10.3390\/v16081234","DOI":"10.3390\/v16081234"},{"key":"10983_CR9","doi-asserted-by":"publisher","unstructured":"Mehrmal S, Mojica R, Guo AM, Missall TA (2024) Diagnostic methods and management strategies of herpes simplex and herpes zoster infections. 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No additional ethical approval required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"50"}}