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We report the case of a 6-years-old, female neutered Border Collie with an ulcered nodule on the right retromandibular region, that had mild serum total calcium elevation (14,1\u00a0mg\/dl; reference range (RR): 8,4 to 11\u00a0mg\/dl) in the absence of clinicopathological abnormalities or imaging finding suggesting any known cause of hypercalcemia. Histologically, the tumor had a tubular epithelial component, admixed with a second, dominant, myoepithelial one; immunohistochemically, the former strongly reacted with anti-Cytokeratin antibodies, while the latter had a weak and patchy immunoreactivity both to Cytokeratin and a-SMA, while Vimentin and Calponin immunostaining was strong and diffuse, suggesting the diagnosis of apocrine gland carcinoma and malignant myoepithelioma. After the excision of the tumor, calcium decreased within limits (8.8\u00a0mg\/dl RR: 8.4 to 11. mg\/dl). In the author\u2019s knowledge, this is the first report of HHM associated with apocrine sweat gland carcinoma in the dog.<\/jats:p>","DOI":"10.1007\/s11259-025-11011-4","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:51:24Z","timestamp":1768906284000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypercalcemia of malignancy in a dog with cutaneous apocrine gland carcinoma and malignant myoepithelioma"],"prefix":"10.1007","volume":"50","author":[{"given":"Ludovica Emiliani","family":"Pescetelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambra Luisa","family":"Misia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Antognoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonello","family":"Bufalari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Scorsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvio","family":"Lepri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"11011_CR1","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/j.1748-5827.1991.tb00887.x","volume":"32","author":"J Elliott","year":"1991","unstructured":"Elliott J (1991) Hypercalcemia in the dog: a study of 40 cases. 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