{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:52:57Z","timestamp":1791474777690,"version":"4.3.4"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001503","name":"Indian Council of Agricultural Research","doi-asserted-by":"publisher","award":["Grant F. No CIBA\/AINP-FH\/2015-16 dated 2nd June 2015"],"award-info":[{"award-number":["Grant F. No CIBA\/AINP-FH\/2015-16 dated 2nd June 2015"]}],"id":[{"id":"10.13039\/501100001503","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11259-025-11041-y","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:41:48Z","timestamp":1769064108000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of risks associated with dietary administration of antiparasitic drug lufenuron in Nile tilapia Oreochromis niloticus by integrated biomarker response"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5846-1974","authenticated-orcid":false,"given":"Arpan","family":"Ghorai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0581-1307","authenticated-orcid":false,"given":"Thangapalam Jawahar","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-7875","authenticated-orcid":false,"given":"Arya","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-7840","authenticated-orcid":false,"given":"Ratnapriya","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1867-5422","authenticated-orcid":false,"given":"Priyanka","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0239-8652","authenticated-orcid":false,"given":"Ranjit Kumar","family":"Nadella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-0579","authenticated-orcid":false,"given":"Niladri Sekhar","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-5863","authenticated-orcid":false,"given":"Prasanna Kumar","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"issue":"11","key":"11041_CR1","doi-asserted-by":"publisher","first-page":"e14580","DOI":"10.1111\/and.14580","volume":"54","author":"HA Abd El-Rahman","year":"2022","unstructured":"Abd El-Rahman HA, Omar AR (2022) Ameliorative effect of avocado oil against lufenuron induced testicular damage and infertility in male rats. Andrologia 54(11):e14580. https:\/\/doi.org\/10.1111\/and.14580","journal-title":"Andrologia"},{"issue":"6","key":"11041_CR3","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1590\/S0103-84782005000600029","volume":"35","author":"LCD Almeida","year":"2005","unstructured":"Almeida LCD, Aguiar LH, Moraes G (2005) Effect of Methyl parathion on the muscle and brain acetylcholinesterase activity of matrinx\u00e3 (Brycon cephalus). Cienc Rural 35(6):1412\u20131416. https:\/\/doi.org\/10.1590\/S0103-84782005000600029","journal-title":"Cienc Rural"},{"issue":"1","key":"11041_CR2","doi-asserted-by":"publisher","first-page":"160","DOI":"10.29261\/pakvetj\/2023.012","volume":"43","author":"FA Al-Saeed","year":"2023","unstructured":"Al-Saeed FA, Naz S, Saeed MH, Hussain R, Iqbal S, Chatha AMM, Ghaffar A, Akram R (2023) Oxidative stress, antioxidant enzymes, genotoxicity, and histopathological profile in Oreochromis niloticus exposed to lufenuron. Pak Vet J 43(1):160\u2013166. https:\/\/doi.org\/10.29261\/pakvetj\/2023.012","journal-title":"Pak Vet J"},{"issue":"3","key":"11041_CR4","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/jfd.12952","volume":"42","author":"CMG Alves","year":"2019","unstructured":"Alves CMG, Nogueira JN, Barriga IB, Dos Santos JR, Santos GG, Tavares-Dias M (2019) Albendazole, levamisole and Ivermectin are effective against monogeneans of Colossoma macropomum (Pisces: Serrasalmidae). J Fish Dis 42(3):405\u2013412. https:\/\/doi.org\/10.1111\/jfd.12952","journal-title":"J Fish Dis"},{"issue":"2","key":"11041_CR5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/s1383-5718(02)00075-x","volume":"518","author":"B Ateeq","year":"2002","unstructured":"Ateeq B, Ali MN, Ahmad W (2002) Induction of micronuclei and erythrocyte alterations in the catfish Clarias batrachus by 2, 4-dichlorophenoxyacetic acid and butachlor. Mutat Res-Genet Toxicol Environ Mutagen 518(2):135\u2013144. https:\/\/doi.org\/10.1016\/s1383-5718(02)00075-x","journal-title":"Mutat Res-Genet Toxicol Environ Mutagen"},{"issue":"2","key":"11041_CR6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/jvp.12735","volume":"42","author":"C Bader","year":"2019","unstructured":"Bader C, Starling DE, Jones DE, Brewer MT (2019) Use of praziquantel to control platyhelminth parasites of fish. J Vet Pharmacol Ther 42(2):139\u2013153. https:\/\/doi.org\/10.1111\/jvp.12735","journal-title":"J Vet Pharmacol Ther"},{"key":"11041_CR7","volume-title":"The Principles of drug disposition in domestic animals: The basis of veterinary clinical pharmacology","author":"JD Baggot","year":"1977","unstructured":"Baggot JD (1977) The Principles of drug disposition in domestic animals: The basis of veterinary clinical pharmacology. Blackwell Science, New Jersey"},{"key":"11041_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2022.738447","volume":"559","author":"A Bardhan","year":"2022","unstructured":"Bardhan A, Abraham TJ, Singha J, Sar TK, Rajisha R, Krishna EKN, Kumar KA, Patil PK (2022) Histopathological aberrations and oxidative stress responses in Nile tilapia Oreochromis niloticus as influenced by dietary florfenicol and its metabolites. Aquaculture 559:738447. https:\/\/doi.org\/10.1016\/j.aquaculture.2022.738447","journal-title":"Aquaculture"},{"key":"11041_CR9","doi-asserted-by":"publisher","first-page":"19544","DOI":"10.1038\/s41598-020-76638-6","volume":"10","author":"W Basal","year":"2020","unstructured":"Basal W, Ahmed AT, Mahmoud A, Omar AR (2020) Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses. Sci Rep 10:19544. https:\/\/doi.org\/10.1038\/s41598-020-76638-6","journal-title":"Sci Rep"},{"issue":"6","key":"11041_CR10","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1002\/etc.5620210629","volume":"21","author":"B Beliaeff","year":"2002","unstructured":"Beliaeff B, Burgeot T (2002) Integrated biomarker response: a useful tool for ecological risk assessment. Environ Toxicol Chem 21(6):1316\u20131322. https:\/\/doi.org\/10.1002\/etc.5620210629","journal-title":"Environ Toxicol Chem"},{"issue":"4","key":"11041_CR11","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1111\/raq.12815","volume":"15","author":"S Bravo","year":"2023","unstructured":"Bravo S, Treasurer J (2023) The management of the sea lice in Chile: a review. Rev Aquacult 15(4):1749\u20131764. https:\/\/doi.org\/10.1111\/raq.12815","journal-title":"Rev Aquacult"},{"key":"11041_CR12","doi-asserted-by":"publisher","first-page":"112030","DOI":"10.1016\/j.envres.2021.112030","volume":"204","author":"K Chinnadurai","year":"2022","unstructured":"Chinnadurai K, Prema P, Veeramanikandan V, Kumar KR, Nguyen VH, Marraiki N, Zaghloul NS, Balaji P (2022) Toxicity evaluation and oxidative stress response of fumaronitrile, a persistent organic pollutant (POP) of industrial wastewater, on tilapia fish (Oreochromis mossambicus). Environ Res 204:112030. https:\/\/doi.org\/10.1016\/j.envres.2021.112030","journal-title":"Environ Res"},{"key":"11041_CR13","doi-asserted-by":"publisher","first-page":"738680","DOI":"10.1016\/j.aquaculture.2022.738680","volume":"561","author":"R Das","year":"2022","unstructured":"Das R, Abraham TJ, Singha J, Bardhan A, Patil PK (2022) Dietary emamectin benzoate induces dose-dependent variations in haemato-biochemical and erythrocyte-metric parameters of Oreochromis niloticus (L). Aquaculture 561:738680. https:\/\/doi.org\/10.1016\/j.aquaculture.2022.738680","journal-title":"Aquaculture"},{"issue":"6","key":"11041_CR14","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1080\/03601234","volume":"58","author":"R Das","year":"2023","unstructured":"Das R, Abraham TJ, Singha J, Bardhan A, Patil PK (2023) In-feed emamectin benzoate abuse affects the biological responses and erythrocytes of nile tilapia Oreochromis niloticus. J Environ Sci Health B 58(6):477\u2013488. https:\/\/doi.org\/10.1080\/03601234","journal-title":"J Environ Sci Health B"},{"key":"11041_CR15","first-page":"1","volume":"37","author":"MM El-Said","year":"2007","unstructured":"El-Said MM (2007) Evaluation of abamectin toxicity on some biochemical constituents and osmoregulation in freshwater fish Oreochromis niloticus (Tilapia niloticus). J Egypt Soc Toxicol 37:1\u201310","journal-title":"J Egypt Soc Toxicol"},{"key":"11041_CR17","unstructured":"El-Sayed AFM (2019) Tilapia culture, 2nd edn. Academic Press, London, p 293"},{"issue":"3","key":"11041_CR16","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.etap.2007.05.006","volume":"24","author":"YS El-Sayed","year":"2007","unstructured":"El-Sayed YS, Saad TT, El-Bahr SM (2007) Acute intoxication of deltamethrin in monosex Nile tilapia, Oreochromis niloticus, with special reference to the clinical, biochemical, and haematological effects. Environ Toxicol Pharmacol 24(3):212\u2013217. https:\/\/doi.org\/10.1016\/j.etap.2007.05.006","journal-title":"Environ Toxicol Pharmacol"},{"key":"11041_CR18","unstructured":"EMA (2015) Committee for medicinal products for veterinary use. Lufenuron (finfish). European public MRL assessment report (EPMAR). Doc. EMA\/CVPM\/651740\/2013. European Medicines Agency, Available at http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Maximum_Residue_Limits_-_Report\/2015\/01\/WC500180373.pdf. Accessed 25\u00a0Apr 2017"},{"key":"11041_CR19","unstructured":"FAO (2003) Software-based workbook for statistical evaluation of residue depletion data for veterinary drugs. Food and Agriculture Organization, Rome. Available at: http:\/\/www.fao.org\/food\/food-safety-quality\/scientificadvice\/jecfa\/guidelines0\/residue-depletion\/en\/ Accessed 8 July 2024"},{"key":"11041_CR20","unstructured":"FAO (2018) Residue evaluation of certain veterinary drugs. Joint FAO\/WHO Expert Committee on Food Additives 85th meeting 2017. FAO JECFA Monographs 21. Food and Agriculture Organization of the United Nations, Rome, p.357. https:\/\/openknowledge.fao.org\/server\/api\/core\/bitstreams\/ac5c0b4f-f127-489e-904f-285f66c58749\/content Accessed 18 June 2025"},{"key":"11041_CR21","doi-asserted-by":"publisher","DOI":"10.4060\/cd0683en","volume-title":"The State of World Fisheries and Aquaculture 2024 \u2013 Blue Transformation in action","author":"FAO","year":"2024","unstructured":"FAO (2024) The State of World Fisheries and Aquaculture 2024 \u2013 Blue Transformation in action. Food and Agriculture Organization of the United Nations, Rome. https:\/\/doi.org\/10.4060\/cd0683en"},{"key":"11041_CR22","unstructured":"FAO\/WHO (2018) Evaluation of certain veterinary drug residues in food: eighty-fifth report of the joint FAO\/WHO Expert Committee on Food Additives. The Food and Agriculture Organization of the United Nations (FAO) and World Health Organization (WHO), WHO Technical Report Series 1008. WHO Press, Geneva, p.164"},{"key":"11041_CR24","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s10695-015-0121-2","volume":"42","author":"JM Forwood","year":"2016","unstructured":"Forwood JM, Bubner EJ, Landos M, D\u2019Antignana T, Deveney MR (2016) Praziquantel treatment for Yellowtail kingfish (Seriola lalandi): dose and duration safety study. Fish Physiol Biochem 42:103\u2013109. https:\/\/doi.org\/10.1007\/s10695-015-0121-2","journal-title":"Fish Physiol Biochem"},{"issue":"3","key":"11041_CR23","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s10695-011-9466-3","volume":"37","author":"\u00d6 F\u0131rat","year":"2011","unstructured":"F\u0131rat \u00d6, Cogun HY, Y\u00fczerero\u011flu TA, G\u00f6k G, F\u0131rat \u00d6, Kargin F, K\u00f6temen Y (2011) A comparative study on the effects of a pesticide (cypermethrin) and two metals (copper, lead) to serum biochemistry of nile tilapia, Oreochromis niloticus. Fish Physiol Biochem 37(3):657\u2013666. https:\/\/doi.org\/10.1007\/s10695-011-9466-3","journal-title":"Fish Physiol Biochem"},{"issue":"4","key":"11041_CR27","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1080\/15569543.2019.1684321","volume":"40","author":"A Ghaffar","year":"2021","unstructured":"Ghaffar A, Hussain R, Abbas G, Khan R, Akram K, Latif H, Ali S, Baig S, Du X, Khan A (2021) Assessment of genotoxic and pathologic potentials of fipronil insecticide in Labeo rohita (Hamilton, 1822). Toxin Rev 40(4):1289\u20131300. https:\/\/doi.org\/10.1080\/15569543.2019.1684321","journal-title":"Toxin Rev"},{"issue":"2","key":"11041_CR26","doi-asserted-by":"publisher","first-page":"289","DOI":"10.4194\/1303-2712-v16_2_09","volume":"16","author":"A Ghaffar","year":"2016","unstructured":"Ghaffar A, Hussain R, Aslam M, Abbas G, Khan A (2016) Arsenic and urea in combination alters the hematology, biochemistry, and protoplasm in exposed Rohu fish (Labeo rohita) (Hamilton, 1822). Turk J Fish Aquat Sci 16(2):289\u2013296. https:\/\/doi.org\/10.4194\/1303-2712-v16_2_09","journal-title":"Turk J Fish Aquat Sci"},{"issue":"2","key":"11041_CR25","first-page":"201","volume":"35","author":"A Ghaffar","year":"2015","unstructured":"Ghaffar A, Hussain R, Khan A, Abbas RZ, Asad M (2015) Butachlor induced clinico-hematological and cellular changes in freshwater fish Labeo Rohita (Rohu). Pak Vet J 35(2):201\u2013206","journal-title":"Pak Vet J"},{"issue":"1","key":"11041_CR28","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.sjbs.2020.10.049","volume":"28","author":"S Ghayyur","year":"2021","unstructured":"Ghayyur S, Khan M, Tabassum S, Ahmad M, Sajid M, Badshah K, Khan MA, Saira, Ghayyur S, Khan NA, Ahmad B, Qamer S (2021) A comparative study on the effects of selected pesticides on hematobiochemistry and tissue histology of freshwater fish Cirrhinus Mrigala (Hamilton, 1822). Saudi J Biol Sci 28(1):603\u2013611. https:\/\/doi.org\/10.1016\/j.sjbs.2020.10.049","journal-title":"Saudi J Biol Sci"},{"issue":"4","key":"11041_CR29","doi-asserted-by":"publisher","first-page":"195","DOI":"10.22034\/ijab.v7i4.662","volume":"7","author":"M Ghelichpour","year":"2019","unstructured":"Ghelichpour M, Mirghaed AT (2019) Effects of sublethal exposure to new pesticides lufenuron and flonicamid on common carp, Cyprinus carpio, hydromineral balance, and to further saltwater exposure. Int J Aquat Biol 7(4):195\u2013201. https:\/\/doi.org\/10.22034\/ijab.v7i4.662","journal-title":"Int J Aquat Biol"},{"key":"11041_CR30","doi-asserted-by":"publisher","first-page":"734634","DOI":"10.1016\/j.aquaculture.2019.734634","volume":"516","author":"M Ghelichpour","year":"2020","unstructured":"Ghelichpour M, Mirghaed AT, Hoseini SM, Jimenez AP (2020) Plasma antioxidant and hepatic enzymes activity, thyroid hormones alterations and health status of liver tissue in common carp (Cyprinus carpio) exposed to Lufenuron. Aquaculture 516:734634. https:\/\/doi.org\/10.1016\/j.aquaculture.2019.734634","journal-title":"Aquaculture"},{"key":"11041_CR31","doi-asserted-by":"publisher","first-page":"735044","DOI":"10.1016\/j.aquaculture.2020.735044","volume":"521","author":"R Hannisdal","year":"2020","unstructured":"Hannisdal R, N\u00f8stbakken OJ, Hove H, Madsen L, Horsberg TE, Lunestad BT (2020) Anti-sea lice agents in Norwegian aquaculture; surveillance, treatment trends and possible implications for food safety. Aquaculture 521:735044. https:\/\/doi.org\/10.1016\/j.aquaculture.2020.735044","journal-title":"Aquaculture"},{"key":"11041_CR32","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1577\/1548-8659(1960)22[164:MFRFH]2.0.CO;2","volume":"22","author":"EF Hesser","year":"1960","unstructured":"Hesser EF (1960) Methods for routine fish hematology. Prog Fish-Cult 22:164\u2013171. https:\/\/doi.org\/10.1577\/1548-8659(1960)22[164:MFRFH]2.0.CO;2","journal-title":"Prog Fish-Cult"},{"issue":"6","key":"11041_CR33","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.2174\/138920112800399158","volume":"13","author":"TE Horsberg","year":"2012","unstructured":"Horsberg TE (2012) Avermectin use in aquaculture. Curr Pharm Biotechnol 13(6):1095\u20131102. https:\/\/doi.org\/10.2174\/138920112800399158","journal-title":"Curr Pharm Biotechnol"},{"key":"11041_CR34","unstructured":"ICAR-CIBA (2016) Proceedings of the workshop on responsible use of antimicrobials in Indian aquaculture: Opportunities and challenges. ICAR-Central Institute of Brackishwater Aquaculture. Chennai, Tamil Nadu, India, p 44"},{"issue":"1","key":"11041_CR35","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s10499-023-01198-1","volume":"32","author":"SI Islam","year":"2024","unstructured":"Islam SI, Rodkhum C, Taweethavonsawat P (2024) An overview of parasitic co-infections in tilapia culture. Aquacult Int 32(1):899\u2013927. https:\/\/doi.org\/10.1007\/s10499-023-01198-1","journal-title":"Aquacult Int"},{"issue":"6","key":"11041_CR36","first-page":"178","volume":"5","author":"C Jayaprakash","year":"2013","unstructured":"Jayaprakash C, Shettu N (2013) Changes in the hematology of the freshwater fish, Channa punctatus (Bloch), exposed to the toxicity of deltamethrin. J Chem Pharm Res 5(6):178\u2013183","journal-title":"J Chem Pharm Res"},{"key":"11041_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2020.103348","volume":"75","author":"RB Julinta","year":"2020","unstructured":"Julinta RB, Abraham TJ, Roy A, Singha J, Bardhan A, Sar TK, Patil PK, Kumar KA (2020b) Safety of emamectin benzoate administered in feed to Nile tilapia Oreochromis niloticus (L.). Environ Toxicol Pharmacol 75:103348. https:\/\/doi.org\/10.1016\/j.etap.2020.103348","journal-title":"Environ Toxicol Pharmacol"},{"issue":"5","key":"11041_CR37","doi-asserted-by":"publisher","first-page":"973","DOI":"10.22438\/jeb\/41\/5\/MRN-1222","volume":"41","author":"RB Julinta","year":"2020","unstructured":"Julinta RB, Abraham TJ, Roy A, Singha J, Dash G, Sar TK, Patil PK (2020a) Effects of oral-dosing of an antiparasitic drug, emamectin benzoate, on the growth and serum biomarkers of Oreochromis niloticus (L.) juveniles. J Environ Biol 41(5):973\u2013979. https:\/\/doi.org\/10.22438\/jeb\/41\/5\/MRN-1222","journal-title":"J Environ Biol"},{"key":"11041_CR39","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.aquatox.2013.10.035","volume":"146","author":"CJ Kennedy","year":"2014","unstructured":"Kennedy CJ, Tierney KB, Mittelstadt M (2014) Inhibition of P-glycoprotein in the blood\u2013brain barrier alters avermectin neurotoxicity and swimming performance in rainbow trout. Aquat Toxicol 146:176\u2013185. https:\/\/doi.org\/10.1016\/j.aquatox.2013.10.035","journal-title":"Aquat Toxicol"},{"key":"11041_CR40","unstructured":"Komar C, Wendover N (2007) Parasitic diseases of tilapia. Intervet aquatic animal health newsletter. MSD Animal Health, pp 1\u201310"},{"issue":"1","key":"11041_CR41","doi-asserted-by":"publisher","DOI":"10.1080\/23312025.2020.1761277","volume":"6","author":"S Kushwaha","year":"2020","unstructured":"Kushwaha S, Anerao I, Rajput S, Bhagriya P, Roy H (2020) Evaluation of abamectin-induced hepatotoxicity in Oreochromis mossambicus. Cogent Biol 6(1):1761277. https:\/\/doi.org\/10.1080\/23312025.2020.1761277","journal-title":"Cogent Biol"},{"issue":"1","key":"11041_CR42","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1053\/j.jepm.2012.12.010","volume":"22","author":"J Mayer","year":"2013","unstructured":"Mayer J, Hensel P, Mejia-Fava J, Brand\u00e3o J, Divers S (2013) The use of lufenuron to treat fish lice (Argulus sp.) in Koi (Cyprinus carpio). J Exot Pet Med 22(1):65\u201369. https:\/\/doi.org\/10.1053\/j.jepm.2012.12.010","journal-title":"J Exot Pet Med"},{"key":"11041_CR43","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ijpddr.2022.02.001","volume":"18","author":"LJ Norbury","year":"2022","unstructured":"Norbury LJ, Shirakashi S, Power C, Nowak BF, Bott NJ (2022) Praziquantel use in aquaculture\u2013current status and emerging issues. Int J Parasitol Drugs Drug Resist 18:87\u2013102. https:\/\/doi.org\/10.1016\/j.ijpddr.2022.02.001","journal-title":"Int J Parasitol Drugs Drug Resist"},{"issue":"2","key":"11041_CR44","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.13880","volume":"47","author":"PA Olsvik","year":"2024","unstructured":"Olsvik PA, Brokke KE, Samuelsen OB, Hannisdal R (2024) Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon. J Fish Dis 47(2):e13880. https:\/\/doi.org\/10.1111\/jfd.13880","journal-title":"J Fish Dis"},{"issue":"4","key":"11041_CR46","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1111\/raq.12688","volume":"14","author":"PK Patil","year":"2022","unstructured":"Patil PK, Mishra SS, Pradhan PK, Manna SK, Abraham TJ, Solanki HG, Shahi N, Swain P, Sahoo SN, Avunje S, Sharma KSR, Geetha R, Priyadharshini R, Nagaraju VT, Paniprasad K, Kumar A, Debnath D, Panikkar P, Raja RA, Saraswathy R, Bhuvaneswari T, Mallik SK, Sood N, Kumar CB, Sanil NK, Vinoth SP, Alavandi SV, Vijayan KK, Jithendran KP, Jena JK (2022) Usage pattern of chemicals, biologicals and veterinary medicinal products in Indian aquaculture. Rev Aquacult 14(4):2038\u20132063. https:\/\/doi.org\/10.1111\/raq.12688","journal-title":"Rev Aquacult"},{"issue":"2","key":"11041_CR47","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.ijpddr.2018.02.007","volume":"8","author":"JD Poley","year":"2018","unstructured":"Poley JD, Braden LM, Messmer AM, Igboeli OO, Whyte SK, Macdonald A, Rodriguez J, Gameiro M, Rufener L, Bouvier J, Wadowska DW, Koop BF, Hosking BC, Fast MD (2018) High-level efficacy of lufenuron against sea lice (Lepeophtheirus salmonis) linked to rapid impact on moulting processes. Int J Parasitol Drugs Drug Resist 8(2):174\u2013188. https:\/\/doi.org\/10.1016\/j.ijpddr.2018.02.007","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"11041_CR48","unstructured":"Rath S, Erdely H, Reuss R (2017) Lufenuron: residue monograph prepared by the meeting of the joint FAO\/WHO Expert Committee on Food Additives (JECFA) in the 85th meeting. JECFA Monographs 21, FAO, Rome. p 51. https:\/\/openknowledge.fao.org\/items\/a94dad10-e19d-4ea7-8e3b-e61f81d888b9"},{"key":"11041_CR49","unstructured":"R\u00f8iom AT (2024) The distribution and elimination of lufenuron in Atlantic salmon (Salmo salar). Master\u2019s thesis, The University of Bergen, Bergen"},{"issue":"1\u20138","key":"11041_CR50","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.envpol.2016.09.066","volume":"219","author":"IM Sadiqul","year":"2016","unstructured":"Sadiqul IM, Ferdous Z, Nannu MTA, Mostakim GM, Rahman MK (2016) Acute exposure to a quinalphos-containing insecticide (convoy) causes genetic damage and nuclear changes in peripheral erythrocytes of silver barb, Barbonymus gonionotus. Environ Pollut 219(1\u20138):949\u2013956. https:\/\/doi.org\/10.1016\/j.envpol.2016.09.066","journal-title":"Environ Pollut"},{"key":"11041_CR51","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.envpol.2017.10.061","volume":"233","author":"P Samanta","year":"2018","unstructured":"Samanta P, Im H, Na J, Jung J (2018) Ecological risk assessment of a contaminated stream using multi-level integrated biomarker response in Carassius auratus. Environ Pollut 233:429\u2013438. https:\/\/doi.org\/10.1016\/j.envpol.2017.10.061","journal-title":"Environ Pollut"},{"key":"11041_CR52","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1365-2885.2004.00629.x","volume":"28","author":"S Sevatdal","year":"2005","unstructured":"Sevatdal S, Magnusson \u00c5, Ingebrigtsen K, Haldorsen R, Horsberg TE (2005) Distribution of emamectin benzoate in Atlantic salmon (Salmo Salar L). J Vet Pharmacol Ther 28:101\u2013107. https:\/\/doi.org\/10.1111\/j.1365-2885.2004.00629.x","journal-title":"J Vet Pharmacol Ther"},{"key":"11041_CR53","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/raq.12742","volume":"15","author":"AP Shinn","year":"2023","unstructured":"Shinn AP, Avenant-Oldewage A, Bondad\u2010Reantaso MG, Cruz\u2010Laufer AJ, Garc\u00eda\u2010V\u00e1squez A, Hern\u00e1ndez\u2010Orts JS, Kuchta R, Longshaw M, Metselaar M, Pariselle A, de Le\u00f3n GP-P, Pradhan PK, Rubio-Godoy M, Sood N, Vanhove MPM, Deveney MR (2023) A global bibliography review of problematic and pathogenic parasites of farmed tilapia. Rev Aquacult 15:92\u2013153. https:\/\/doi.org\/10.1111\/raq.12742","journal-title":"Rev Aquacult"},{"issue":"3","key":"11041_CR54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0319157","volume":"20","author":"AB Siddique","year":"2025","unstructured":"Siddique AB, Hussain R, Bhutta ZA, Ahmad MZ, Khan I, Alam S, Malik RM, Mammadov A, Ataya FS (2025) Impact of lufenuron on haematology, serum biochemistry, antioxidant enzymes, and histopathology in broiler chickens. PLoS One 20(3):e0319157. https:\/\/doi.org\/10.1371\/journal.pone.0319157","journal-title":"PLoS One"},{"key":"11041_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2021.109223","volume":"252","author":"J Singha","year":"2022","unstructured":"Singha J, Abraham TJ, Roy A, Bardhan A, Sar TK, Rajisha R, Krishna EKN, Kumar KA, Patil PK (2022) Influence of dietary emamectin benzoate on the biological responses of monosex (all-male) Oreochromis niloticus (L.) fries. Comp Biochem Physiol C Toxicol Pharmacol 252:109223. https:\/\/doi.org\/10.1016\/j.cbpc.2021.109223","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"issue":"6","key":"11041_CR56","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3390\/antiox12061223","volume":"12","author":"C Song","year":"2023","unstructured":"Song C, Sun C, Liu B, Xu P (2023) Oxidative stress in aquatic organisms. Antioxidants 12(6):1223. https:\/\/doi.org\/10.3390\/antiox12061223","journal-title":"Antioxidants"},{"issue":"9","key":"11041_CR57","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2754\/avb201079S9S073","volume":"79","author":"E Sudov\u00e1","year":"2010","unstructured":"Sudov\u00e1 E, Pia\u010dkov\u00e1 V, Vel\u00ed\u0161ek J, Pij\u00e1\u010dek M, Svobodov\u00e1 Z (2010) Efficacy testing of orally administered praziquantel to common carp naturally infected by caryophyllidean tapeworms (Platyhelminthes: Eucestoda). Acta Vet Brno 79(9):73\u201378. https:\/\/doi.org\/10.2754\/avb201079S9S073","journal-title":"Acta Vet Brno"},{"issue":"1","key":"11041_CR58","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2754\/avb200372010079","volume":"72","author":"Z Svobodova","year":"2003","unstructured":"Svobodova Z, Luskova V, Drastichova J, Svoboda M, \u017dl\u00e1bek V (2003) Effect of deltamethrin on haematological indices of common carp (Cyprinus Carpio L). Acta Vet Brno 72(1):79\u201385","journal-title":"Acta Vet Brno"},{"key":"11041_CR59","unstructured":"USFDA (2017) In: Aquaculture. Silver spring: United States Food and Drug Administration. https:\/\/www.fda.gov\/AnimalVeterinary\/DevelopmentApprovalProcess\/Aquaculture\/efault.htm"},{"key":"11041_CR67","unstructured":"USFDA (2025) Approved Aquaculture Drugs. United States Food and Drug Administration. https:\/\/www.fda.gov\/animal-veterinary\/aquaculture\/approved-aquaculture-drugs"},{"issue":"1","key":"11041_CR60","doi-asserted-by":"publisher","first-page":"32","DOI":"10.22606\/epp.2016.11004","volume":"1","author":"B Velmurugan","year":"2016","unstructured":"Velmurugan B, Cengiz EI, Senthilkumaar P, Uysal E, Satar A (2016) Hematological parameters of freshwater fish Anabas testudineus after sublethal exposure to cypermethrin. Environmental Pollution and Protection 1(1):32\u201339. https:\/\/doi.org\/10.22606\/epp.2016.11004","journal-title":"Environmental Pollution and Protection"},{"issue":"1","key":"11041_CR61","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.pestbp.2007.07.009","volume":"90","author":"B Ventura","year":"2008","unstructured":"Ventura B, de Angelis DDF, Marin-Morales MA (2008) Mutagenic and genotoxic effects of the Atrazine herbicide in Oreochromis niloticus (Perciformes, Cichlidae) bibliography lix detected by the micronuclei test and the comet assay. Pestic Biochem Physiol 90(1):42\u201351. https:\/\/doi.org\/10.1016\/j.pestbp.2007.07.009","journal-title":"Pestic Biochem Physiol"},{"key":"11041_CR62","unstructured":"VICH (2020) VICH guideline for the determination of withdrawal periods for veterinary medicinal products in food-producing animals. Veterinary International Conference on Harmonization, VICH GH 58. Retrieved from https:\/\/www.vichsec.org\/en\/"},{"key":"11041_CR63","first-page":"164","volume-title":"Contaminant effects on fisheries","author":"G Wedemeyer","year":"1984","unstructured":"Wedemeyer G, McLeay D, Goodyear CP (1984) Assessing the tolerance of fish and fish populations to environmental stress: the problems and methods of monitoring. In: Carins VW, Hodson PV, Nriagu J (eds) Contaminant effects on fisheries. Wiley, USA, pp 164\u2013195"},{"key":"11041_CR64","doi-asserted-by":"publisher","first-page":"737498","DOI":"10.1016\/j.aquaculture.2021.737498","volume":"547","author":"M Witeska","year":"2022","unstructured":"Witeska M, Kondera E, \u0141ugowska K, Bojarski B (2022) Hematological methods in fish\u2013not only for beginners. Aquaculture 547:737498. https:\/\/doi.org\/10.1016\/j.aquaculture.2021.737498","journal-title":"Aquaculture"},{"issue":"1","key":"11041_CR65","doi-asserted-by":"publisher","first-page":"75","DOI":"10.17576\/jsm-2019-4801-09","volume":"48","author":"M Yasir","year":"2019","unstructured":"Yasir M, Sagheer M, Abbas SK, Ul-Hasan M, Ahmad S, Ijaz M (2019) Bioactivity of lufenuron against Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae). Sains Malays 48(1):75\u201380. https:\/\/doi.org\/10.17576\/jsm-2019-4801-09","journal-title":"Sains Malays"},{"key":"11041_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2022.106280","volume":"251","author":"J Yu","year":"2022","unstructured":"Yu J, Wang X, Qian S, Liu P, Li X, Li J (2022) Exposure to nitrate induces alterations in blood parameter responses, liver immunity, and lipid metabolism in juvenile turbot (Scophthalmus maximus). Aquat Toxicol 251:106280. https:\/\/doi.org\/10.1016\/j.aquatox.2022.106280","journal-title":"Aquat Toxicol"},{"issue":"4","key":"11041_CR45","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3906\/zoo-0907-77","volume":"35","author":"F \u00d6zkan","year":"2011","unstructured":"\u00d6zkan F, G\u00fcnd\u00fcz SG, Berk\u00f6z M, Hunt A\u00d6 (2011) Induction of micronuclei and other nuclear abnormalities in peripheral erythrocytes of Nile tilapia, Oreochromis niloticus, following exposure to sublethal cadmium doses. Turk J Zool 35(4):585\u2013592. https:\/\/doi.org\/10.3906\/zoo-0907-77","journal-title":"Turk J Zool"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-025-11041-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-025-11041-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-025-11041-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T09:49:33Z","timestamp":1772876973000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11259-025-11041-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["11041"],"URL":"https:\/\/doi.org\/10.1007\/s11259-025-11041-y","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"value":"0165-7380","type":"print"},{"value":"1573-7446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"1 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The current study was performed in compliance with the guidelines of the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Government of India. The experimental protocols were approved by the ICAR, Government of India, New Delhi, under the All-India Network Project on Fish Health (F. No. CIBA\/AINP-FH\/2015-16 dated 16th July 2015).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"124"}}