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Tissue samples from the nasal mass were examined histologically using H&amp;E staining. Immunohistochemical (IHC) analysis was performed to detect JSRV capsid protein expression and to assess cellular proliferation markers (Ki-67 and PCNA). Molecular screening via PCR was carried out using primers specific for JSRV, ENTV-1, ENTV-2. The JSRV-positive PCR amplicon was sequenced and subjected to phylogenetic analysis.<\/jats:p>\n                  <jats:p>PCR analysis confirmed the presence of JSRV proviral DNA (385\u00a0bp) in the tumor tissue, while results for ENTV-1 and ENTV-2 were negative. Histopathological examination identified a mixed glandular adenocarcinoma arising from the surface and glandular epithelium, with evidence of turbinate bone invasion. IHC revealed multifocal positivity for JSRV capsid antigen and indicated a high proliferation index (30\u201335%). Phylogenetic analysis classified the detected viral strain within the exogenous JSRV group. The infected goat originated from a herd with no documented contact with sheep.<\/jats:p>\n                  <jats:p>This case provides the first conclusive evidence of JSRV-induced nasal adenocarcinoma in a goat, indicating a potential expansion of the virus\u2019s host and tissue tropism. These findings highlight the necessity for further investigation into the viral envelope-receptor interactions and promoter elements that govern JSRV tropism.<\/jats:p>","DOI":"10.1007\/s11259-026-11272-7","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:04:52Z","timestamp":1778648692000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nasal adenocarcinoma induced by jaagsiekte sheep retrovirus in a juvenile goat: first report on pathological and molecular findings"],"prefix":"10.1007","volume":"50","author":[{"given":"Yesari","family":"Eroksuz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ozkan","family":"Timurkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin","family":"Berber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Karabulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Kara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrunnisa","family":"Bostan-Yoru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Eroksuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"11272_CR1","doi-asserted-by":"publisher","first-page":"5387","DOI":"10.1128\/jvi.76.11.5387-5394.2002","volume":"76","author":"A Alberti","year":"2002","unstructured":"Alberti A, Murgia C, Liu SL, Mura M, Cousens C, Sharp M, Palmarini M (2002) Envelope-induced cell transformation by ovine betaretroviruses. 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No live-animal experimentation requiring committee approval was conducted.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Owner consent for publication of clinical images and case details was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"319"}}