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This study reports a bovine abortion associated with co-infection by\n                    <jats:italic>Anaplasma marginale<\/jats:italic>\n                    ,\n                    <jats:italic>Babesia bovis<\/jats:italic>\n                    and\n                    <jats:italic>Babesia bigemina.<\/jats:italic>\n                    in the Midwestern region of Brazil. Fetal necropsy was performed, followed by cytological, histopathological, immunohistochemical, and molecular analyses. Gross findings included jaundice, splenomegaly, hepatomegaly, and renal discoloration, consistent with severe hemolytic disease. Blood smear evaluation revealed intraerythrocytic inclusions compatible with\n                    <jats:italic>(A) marginale<\/jats:italic>\n                    and\n                    <jats:italic>Babesia<\/jats:italic>\n                    -like merozoites, and PCR confirmed\n                    <jats:italic>(B) bovis<\/jats:italic>\n                    and\n                    <jats:italic>B. bigemina<\/jats:italic>\n                    , and\n                    <jats:italic>Anaplasma<\/jats:italic>\n                    spp. infection was confirmed by sequencing. Histologically, lesions consisted of erythrophagocytosis, hemosiderosis, hemoglobin casts, and marked intravascular leukocytostasis in multiple organs. Immunohistochemistry demonstrated accumulation of macrophages and T lymphocytes, suggesting activation of a fetal inflammatory response. These findings emphasize the importance of including hemoparasitic infections in the differential diagnosis of bovine abortion and support a role for fetal immune responses in lesion development.\n                  <\/jats:p>","DOI":"10.1007\/s11259-026-11414-x","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:38:42Z","timestamp":1784799522000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abortion caused by hemolytic disease associated with co-infection by Anaplasma marginale and Babesia spp. in dairy cattle"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-8070","authenticated-orcid":false,"given":"\u00cdcaro Guilherme","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5894-4588","authenticated-orcid":false,"given":"Let\u00edcia Perri Almeida","family":"Luciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-8236","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"da Silva Cavasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-439X","authenticated-orcid":false,"given":"Marlon","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6657-0511","authenticated-orcid":false,"given":"Rafaela Mallmann","family":"Bohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo Nassau","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-6569","authenticated-orcid":false,"given":"Jo\u00e3o Fabio","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo Coelho","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-9491","authenticated-orcid":false,"given":"Em\u00edlio C\u00e9sar Martins","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7912-9648","authenticated-orcid":false,"given":"Marcos","family":"de Almeida Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0048-9702","authenticated-orcid":false,"given":"Edson Moleta","family":"Colodel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-1478","authenticated-orcid":false,"given":"Caroline Argenta","family":"Pescador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"11414_CR1","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/S0140-6736(96)07524-1","volume":"349","author":"DH Adams","year":"1997","unstructured":"Adams DH, Lloyd AR (1997) Chemokines: leucocyte recruitment and activation cytokines. 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