{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:21:08Z","timestamp":1792783268499,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universidade De S\u00e3o Paulo","id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study characterized the bacterial epidemiology and antimicrobial resistance profiles of 448 isolates recovered from feline urine cultures in Rio de Janeiro, Brazil, between 2020 and 2024. Antimicrobial susceptibility was assessed by disk diffusion and interpreted according to CLSI VET01S and Brazilian Committee on Antimicrobial Susceptibility Testing (BrCAST) breakpoints.\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    was the predominant pathogen (45.1%), followed by\n                    <jats:italic>Proteus<\/jats:italic>\n                    spp. (16.3%) and\n                    <jats:italic>Klebsiella<\/jats:italic>\n                    spp. (12.5%). Resistance to antimicrobials recommended as first-line options by the ISCAID guidelines was frequent among\n                    <jats:italic>E. coli<\/jats:italic>\n                    isolates, including trimethoprim-sulfamethoxazole (57.2%), cephalexin (52.5%), and amoxicillin-clavulanate (43.9%). Veterinary fluoroquinolones showed moderate resistance (enrofloxacin 28.5%, marbofloxacin 20.9%), while nitrofurantoin resistance reached 37.7%. Third-generation cephalosporins and carbapenems retained the highest activity (ceftazidime 13.2%; meropenem 0%). Multidrug resistance (MDR) was observed in 55.8% of all isolates, with the highest prevalence in\n                    <jats:italic>Proteus<\/jats:italic>\n                    spp. (79.5%) and\n                    <jats:italic>E. coli<\/jats:italic>\n                    (57.9%). Resistance to third-generation cephalosporins was detected in 22.8% of\n                    <jats:italic>E. coli<\/jats:italic>\n                    isolates, and carbapenem resistance was detected in 5 isolates from different species. These findings indicate that resistance to first-line agents is common in feline uropathogens in this setting and support the routine use of urine culture and antibiotic susceptibility testing to guide antimicrobial therapy.\n                  <\/jats:p>","DOI":"10.1007\/s11259-026-11415-w","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:38:21Z","timestamp":1784799501000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial resistance profiles of bacterial pathogens from feline urinary tract infections in Rio de Janeiro, Brazil"],"prefix":"10.1007","volume":"50","author":[{"given":"Barbara Barreto","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Alves Maia","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella Brito","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Gomes","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Costa","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Rodrigues Pellegrina","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Silva","family":"do Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Abrantes","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio Martins Ambrosio","family":"Aquino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemir Silva","family":"de Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-4985","authenticated-orcid":false,"given":"Mariana Severo","family":"Ramundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"11415_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11121730","volume":"11","author":"S Aurich","year":"2022","unstructured":"Aurich S, Prenger-Berninghoff E, Ewers C (2022) Prevalence and antimicrobial resistance of bacterial uropathogens isolated from dogs and cats. Antibiotics (Basel) 11:1730. https:\/\/doi.org\/10.3390\/antibiotics11121730","journal-title":"Antibiotics (Basel)"},{"key":"11415_CR2","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.3390\/antibiotics11091140","volume":"11","author":"OSK Chan","year":"2022","unstructured":"Chan OSK, Baranger-Ete M, Lam WWT et al (2022) A retrospective study of antimicrobial resistant bacteria associated with feline and canine urinary tract infection in Hong Kong SAR, China. Antibiotics 11:1140. https:\/\/doi.org\/10.3390\/antibiotics11091140","journal-title":"Antibiotics"},{"key":"11415_CR3","unstructured":"CLSI (2024) Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated From Animals. 7th ed. CLSI supplement VET01S. Clinical and Laboratory Standards Institute, Wayne, PA"},{"key":"11415_CR4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1136\/vr.102630","volume":"176","author":"R Dorsch","year":"2015","unstructured":"Dorsch R, von Vopelius-Feldt C, Wolf G, Straubinger RK, Hartmann K (2015) Feline urinary tract pathogens: prevalence of bacterial species and antimicrobial resistance over a 10-year period. Vet Rec 176:201. https:\/\/doi.org\/10.1136\/vr.102630","journal-title":"Vet Rec"},{"key":"11415_CR5","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1177\/1098612X19880435","volume":"21","author":"R Dorsch","year":"2019","unstructured":"Dorsch R, Teichmann-Knorrn S, Sjetne Lund H (2019) Urinary tract infection and subclinical bacteriuria in cats: a clinical update. J Feline Med Surg 21:1023\u20131038. https:\/\/doi.org\/10.1177\/1098612X19880435","journal-title":"J Feline Med Surg"},{"key":"11415_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcam.2021.100512","volume":"43","author":"E Hernando","year":"2021","unstructured":"Hernando E, Vila A, D\u2019Ippolito P, Rico AJ, Rodon J, Roura X (2021) Prevalence and characterization of urinary tract infection in owned dogs and cats from Spain. Top Companion Anim Med 43:100512. https:\/\/doi.org\/10.1016\/j.tcam.2021.100512","journal-title":"Top Companion Anim Med"},{"key":"11415_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26167717","volume":"26","author":"I Horodyska","year":"2025","unstructured":"Horodyska I, Kasperska P, Michalski K, Bubak J, Herman I, Miszczak M (2025) Natural microbiota of dogs and cats as a source and vector of resistance genes: clinical significance. Int J Mol Sci 26:7717. https:\/\/doi.org\/10.3390\/ijms26167717","journal-title":"Int J Mol Sci"},{"key":"11415_CR8","doi-asserted-by":"publisher","first-page":"178","DOI":"10.26444\/aaem\/176843","volume":"31","author":"D Janczak","year":"2024","unstructured":"Janczak D, Gorecki P, Stryjek R, Zasada A (2024) Multidrug resistance of Escherichia coli isolated from the urinary bladder of dogs and cats with suspected urinary tract infections. Ann Agric Environ Med 31:178\u2013184. https:\/\/doi.org\/10.26444\/aaem\/176843","journal-title":"Ann Agric Environ Med"},{"key":"11415_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1080\/00480169.2019.1689196","volume":"68","author":"T Johnstone","year":"2020","unstructured":"Johnstone T (2020) A clinical approach to multidrug-resistant urinary tract infection and subclinical bacteriuria in dogs and cats. N Z Vet J 68:69\u201383. https:\/\/doi.org\/10.1080\/00480169.2019.1689196","journal-title":"N Z Vet J"},{"key":"11415_CR10","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/zph.13040","volume":"70","author":"A Jolley","year":"2023","unstructured":"Jolley A, Love W, Frey E, Lanzas C (2023) Impacts of the COVID-19 pandemic on antimicrobial use in companion animals in an academic veterinary hospital in North Carolina. Zoonoses Public Health 70:393\u2013402. https:\/\/doi.org\/10.1111\/zph.13040","journal-title":"Zoonoses Public Health"},{"key":"11415_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ani15152235","volume":"15","author":"K Lapcharoen","year":"2025","unstructured":"Lapcharoen K, Bumrungpun C, Chumpol W, Lunha K, Yongkiettrakul S, Lekcharoensuk P, Pruksakorn C (2025) Investigation of bacterial species and their antimicrobial drug resistance profile in feline urinary tract infection in Thailand. Animals (Basel) 15:2235. https:\/\/doi.org\/10.3390\/ani15152235","journal-title":"Animals (Basel)"},{"key":"11415_CR12","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.vetmic.2011.03.009","volume":"151","author":"M Maaland","year":"2011","unstructured":"Maaland M, Guardabassi L (2011) In vitro antimicrobial activity of nitrofurantoin against Escherichia coli and Staphylococcus pseudintermedius isolated from dogs and cats. Vet Microbiol 151:396\u2013399. https:\/\/doi.org\/10.1016\/j.vetmic.2011.03.009","journal-title":"Vet Microbiol"},{"key":"11415_CR13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1093\/jac\/dkx401","volume":"73","author":"C Marques","year":"2018","unstructured":"Marques C, Belas A, Franco A, Aboim C, Gama LT, Pomba C (2018) Increase in antimicrobial resistance and emergence of major international high-risk clonal lineages in dogs and cats with urinary tract infection: 16 year retrospective study. J Antimicrob Chemother 73:377\u2013384. https:\/\/doi.org\/10.1093\/jac\/dkx401","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"11415_CR14","doi-asserted-by":"publisher","first-page":"e011721","DOI":"10.24857\/rgsa.v19n3-114","volume":"19","author":"ABM Medeiros","year":"2025","unstructured":"Medeiros ABM, Diniz LAS, Galdino IS et al (2025) Antimicrobial resistance and One Health: companion animals as reservoirs of bacteria and resistance genes in Brazil. Rev Gestao Soc Ambient 19:e011721. https:\/\/doi.org\/10.24857\/rgsa.v19n3-114","journal-title":"Rev Gestao Soc Ambient"},{"key":"11415_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jgar.2018.01.011","volume":"13","author":"E Rampacci","year":"2018","unstructured":"Rampacci E, Bottinelli M, Stefanetti V, Hyatt DR, Sgariglia E, Coletti M, Passamonti F (2018) Antimicrobial susceptibility survey on bacterial agents of canine and feline urinary tract infections: weight of the empirical treatment. J Glob Antimicrob Resist 13:192\u2013196. https:\/\/doi.org\/10.1016\/j.jgar.2018.01.011","journal-title":"J Glob Antimicrob Resist"},{"key":"11415_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13060500","volume":"13","author":"R Temmerman","year":"2024","unstructured":"Temmerman R, Berlamont H, El Garch F, Rose M, Simjee S, Meschi S, de Jong A (2024) Antimicrobial susceptibility of canine and feline urinary tract infection pathogens isolated from animals with clinical signs in European veterinary practices during the period 2013\u20132018. Antibiotics (Basel, Switzerland) 13:500. https:\/\/doi.org\/10.3390\/antibiotics13060500","journal-title":"Antibiotics (Basel, Switzerland)"},{"key":"11415_CR17","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1093\/jac\/dkab300","volume":"76","author":"S Tomczyk","year":"2021","unstructured":"Tomczyk S, Taylor A, Brown A et al (2021) Impact of the COVID-19 pandemic on the surveillance, prevention and control of antimicrobial resistance: a global survey. J Antimicrob Chemother 76:3045\u20133058. https:\/\/doi.org\/10.1093\/jac\/dkab300","journal-title":"J Antimicrob Chemother"},{"key":"11415_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12050911","volume":"12","author":"C Vercelli","year":"2023","unstructured":"Vercelli C, Amadori M, Gambino G, Re G (2023) Does nitrofurantoin improve the portfolio of vets against resistant bacteria in companion animals? Antibiotics (Basel) 12:911. https:\/\/doi.org\/10.3390\/antibiotics12050911","journal-title":"Antibiotics (Basel)"},{"key":"11415_CR19","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.tvjl.2019.02.008","volume":"247","author":"JS Weese","year":"2019","unstructured":"Weese JS, Blondeau J, Boothe D, Guardabassi LG, Gumley N, Papich M, Jessen LR, Lappin M, Rankin S, Westropp JL, Sykes J (2019) International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet J 247:8\u201325. https:\/\/doi.org\/10.1016\/j.tvjl.2019.02.008","journal-title":"Vet J"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-026-11415-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-026-11415-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-026-11415-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:54:15Z","timestamp":1789790055000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11259-026-11415-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["11415"],"URL":"https:\/\/doi.org\/10.1007\/s11259-026-11415-w","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"value":"0165-7380","type":"print"},{"value":"1573-7446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"29 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"477"}}