{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:21:08Z","timestamp":1792783268433,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universidade Federal De Santa Maria","id":[{"id":"https:\/\/ror.org\/01b78mz79","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cutaneous mast cell tumors have been described in all species of domestic mammals. However, information about these tumors in free-ranging and captive wild mammals is limited, with no reports in procyonids. This report aims to describe a case of disseminated cutaneous mast cell tumor in a captive South American coati (\n                    <jats:italic>Nasua nasua<\/jats:italic>\n                    ). The animal was submitted to euthanasia and necropsy. On external examination, multiple papules, nodules, and plaques were distributed over the body surface. On cut section, they were soft and white. Histologically, they were composed of dense sheets of neoplastic cells interspersed with a delicate collagenous stroma. Cells were round and had a finely granular cytoplasm. Mast cell tumors were diagnosed based on histological features, positive staining with toluidine blue, and immunohistochemical labelling for the KIT protein. To the best of our knowledge, this is the first report of disseminated cutaneous mast cell tumor in this animal species.\n                  <\/jats:p>","DOI":"10.1007\/s11259-026-11443-6","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:51:32Z","timestamp":1785469892000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disseminated cutaneous mast cell tumor in a South American coati (Nasua nasua)"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-4862","authenticated-orcid":false,"given":"Renata Dalcol","family":"Mazaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-3053","authenticated-orcid":false,"given":"Gabriela","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0569-5799","authenticated-orcid":false,"given":"Tereza Cristina","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1388-7240","authenticated-orcid":false,"given":"Bruno","family":"Cogliati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-3015","authenticated-orcid":false,"given":"Glaucia Denise","family":"Kommers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3391-5955","authenticated-orcid":false,"given":"Rafael Almeida","family":"Fighera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"11443_CR1","first-page":"275","volume":"12","author":"G Avallone","year":"2016","unstructured":"Avallone G, Forlani A, Tecilla M et al (2016) Neoplastic diseases in the domestic ferret (Mustela putorius furo) in Italy: classification and tissue distribution of 856 cases (2000\u20132010). Vet Res 12:275\u2013282. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5139086\/","journal-title":"Vet Res"},{"key":"11443_CR2","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1177\/030098589002700511","volume":"27","author":"CA Brown","year":"1990","unstructured":"Brown CA, Chalmers SA (1990) Diffuse cutaneous mastocytosis in a cat. Vet Pathol 27:366\u2013369. https:\/\/journals.sagepub.com\/doi\/10.1177\/030098589002700511?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.","journal-title":"Vet Pathol"},{"key":"11443_CR3","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1638\/2020-0006.full","volume":"51","author":"ML Campbell-Ward","year":"2021","unstructured":"Campbell-Ward ML, Bryant BR, Peaston A et al (2021) Mast cell tumors in cheetah (Acinonix jubatus): a case series. J Zoo Wild Med 51:1025\u20131034. https:\/\/bioone.org\/journals\/journal-of-zoo-and-wildlife-medicine\/volume-51\/issue-4\/2020-0006\/MAST-CELL-TUMORS-IN-CHEETAH-ACINONYX-JUBATUS--A-CASE\/https:\/\/doi.org\/10.1638\/2020-0006.full","journal-title":"J Zoo Wild Med"},{"key":"11443_CR4","doi-asserted-by":"crossref","unstructured":"Chastain CB, Turk MAM, O\u2019Brien D (1988) Benign cutaneous mastocytomas in two litters of Siamese kittens. J Am Vet Med Assoc 15:959\u2013960. https:\/\/avmajournals.avma.org\/view\/journals\/javma\/193\/8\/javma.1988.193.08.959.xml","DOI":"10.2460\/javma.1988.193.08.959"},{"key":"11443_CR5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/B978-0-12-805306-5.00012-2","volume-title":"Pathology of Wildlife and Zoo Animals","author":"ME Church","year":"2018","unstructured":"Church ME, Terio KA, Keel MK (2018) Procyonidae, Viverridae, Hyenidae, Herpestidae, Eupleridae, and Prionodontidae. In: Terio KA, McAloose D, Lager S J (eds) Pathology of Wildlife and Zoo Animals, 1st edn. Academic, London, pp 305\u2013322","edition":"1"},{"key":"11443_CR6","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1177\/030098589202900415","volume":"29","author":"BJ Davis","year":"1992","unstructured":"Davis BJ, Page R, Meuten DJ (1992) Cutaneous mastocytosis in a dog. Vet Pathol 29:363\u2013365. https:\/\/journals.sagepub.com\/doi\/10.1177\/030098589202900415?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.","journal-title":"Vet Pathol"},{"key":"11443_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/9780470752487","volume-title":"Skin Diseases of the Dog and Cat, Clinical and Histopathologic Diagnosis","author":"TL Gross","year":"2005","unstructured":"Gross TL, Ihrke PJ, Walder EJ, Affolter VK (2005) Skin Diseases of the Dog and Cat, Clinical and Histopathologic Diagnosis. Blackwell Publishing, Oxford"},{"key":"11443_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1177\/104063870902100128","volume":"21","author":"XJ He","year":"2009","unstructured":"He XJ, Uchida K, Tochitani T et al (2009) Spontaneous cutaneous mast cell tumor with lymph node metastasis in a Richardson\u2019s ground squirrel (Spermophilus richardsonii). J Vet Diagn Invest 21:156\u2013159. https:\/\/journals.sagepub.com\/doi\/full\/https:\/\/doi.org\/10.1177\/104063870902100128","journal-title":"J Vet Diagn Invest"},{"key":"11443_CR9","first-page":"176","volume-title":"Tumors in Domestic Animals","author":"M Kiupel","year":"2017","unstructured":"Kiupel M (2017) Mast Cell Tumors. In: Meuten DJ (ed) Tumors in Domestic Animals, 5th edn. John Wiley & Sons Inc, Ames, pp 176\u2013202","edition":"5"},{"key":"11443_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jcpa.2018.10.178","volume":"166","author":"HM Kloft","year":"2019","unstructured":"Kloft HM, Ramsay EC, Sula MM (2019) Neoplasia in captive Panthera species. J Comp Pathol 166:35\u201344. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S002199751830255X?via%3Dihub","journal-title":"J Comp Pathol"},{"key":"11443_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms22052586","volume":"22","author":"M Lange","year":"2021","unstructured":"Lange M, Hartmann K, Carter ML et al (2021) Molecular background, clinical features and management of pediatric mastocytosis: status 2021. Int J Mol Sci 22:1\u201323. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7961542\/","journal-title":"Int J Mol Sci"},{"key":"11443_CR12","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1177\/104063871002200531","volume":"22","author":"TY Lin","year":"2010","unstructured":"Lin TY, Hamberg A, Pentecost R et al (2010) Mast cell tumors in a llama (Lama glama). J Vet Diagn Invest 22:808\u2013811. https:\/\/journals.sagepub.com\/doi\/10.1177\/104063871002200531?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.","journal-title":"J Vet Diagn Invest"},{"key":"11443_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/B978-0-12-804310-3.00002-8","volume-title":"Ecology and Evolution of Cancer","author":"T Madsen","year":"2017","unstructured":"Madsen T, Arnal A, Vittecoq M et al (2017) Cancer prevalence and etiology in wild and captive animals. In: Ujvari B, Roche B, Thomas F (eds) Ecology and Evolution of Cancer, 1st edn. Academic, Cambridge, pp 11\u201346","edition":"1"},{"key":"11443_CR14","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.iac.2018.04.001","volume":"38","author":"A Matito","year":"2018","unstructured":"Matito A, Azana JM, Torrelo A et al (2018) Cutaneous mastocytosis in adults and children new classification and prognostic factors. Immunol Allergy Clin N Am 38:351\u2013363. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0889856118300274?via%3Dihub","journal-title":"Immunol Allergy Clin N Am"},{"key":"11443_CR15","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1177\/1098612X18776141","volume":"21","author":"J Ngo","year":"2018","unstructured":"Ngo J, Morren M-A, Bodemer C et al (2018) Feline maculopapular cutaneous mastocytosis: a retrospective study of 13 cases and proposal for a new classification. J Fel Med Sur 21:394\u2013404. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10814638\/","journal-title":"J Fel Med Sur"},{"key":"11443_CR16","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1538\/expanim.49.127","volume":"49","author":"K Nishizumi","year":"2000","unstructured":"Nishizumi K, Fujiwara K, Hasegawa A (2000) Cutaneous mastocytomas in Djungarian hamsters. Exp Anim 49:127\u2013130. https:\/\/www.jstage.jst.go.jp\/article\/expanim\/49\/2\/49_2_127\/_article","journal-title":"Exp Anim"},{"key":"11443_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms25031401","volume":"25","author":"A Rydz","year":"2024","unstructured":"Rydz A, Lange M, Lugowska-Umer H et al (2024) Diffuse cutaneous mastocytosis: a current understanding of a rare disease. Int J Mol Sci 25:1\u201318. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11154339\/","journal-title":"Int J Mol Sci"},{"key":"11443_CR19","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1748-5827.2007.00472.x","volume":"49","author":"I Skorinsky","year":"2008","unstructured":"Skorinsky I, Papadogiannakis E, Horowitz I et al (2008) Epitheliotropic cutaneous lymphoma (mycosis fungoides) in a coati. J Small Anim Pract 49:204\u2013207. https:\/\/onlinelibrary.wiley.com\/doi\/https:\/\/doi.org\/10.1111\/j.1748-5827.2007.00472.x","journal-title":"J Small Anim Pract"},{"key":"11443_CR20","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0021-9975(05)80044-1","volume":"113","author":"M Stolte","year":"1995","unstructured":"Stolte M, Welle M (1995) Cutaneous mast cell tumours in a lion (Panthera leo): a light and transmission electron microscopical study. J Comp Pathol 113:291\u2013294. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021997505800441?via%3Dihub","journal-title":"J Comp Pathol"},{"key":"11443_CR21","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/vco.12962","volume":"22","author":"EK Wyatt","year":"2024","unstructured":"Wyatt EK, Affolter V, Borio S et al (2024) Mastocytosis in the skin in dogs: a multicentric case series. Vet Comp Oncol 22:136\u2013148. https:\/\/onlinelibrary.wiley.com\/doi\/https:\/\/doi.org\/10.1111\/vco.12962","journal-title":"Vet Comp Oncol"},{"key":"11443_CR22","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1177\/03009858231174452","volume":"60","author":"C Yang","year":"2023","unstructured":"Yang C, Bradley CW, Preziosi D et al (2023) Cutaneous mastocytosis in 8 young dogs and review of literature. Vet Pathol 60:849\u2013856. https:\/\/journals.sagepub.com\/doi\/10.1177\/03009858231174452?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed","journal-title":"Vet Pathol"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-026-11443-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-026-11443-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-026-11443-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:54:08Z","timestamp":1789790048000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11259-026-11443-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["11443"],"URL":"https:\/\/doi.org\/10.1007\/s11259-026-11443-6","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"value":"0165-7380","type":"print"},{"value":"1573-7446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"11 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable because the South American coati was observed following normal diagnostic procedures for assessment of suspected pathological conditions of the integument.","order":1,"name":"Ethics","label":"Ethics declaration","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"496"}}