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The animal was euthanized due to an extensive mandibular fracture caused by squamous cell carcinoma. Macroscopically, a 3\u2009\u00d7\u20091.5\u00a0cm, elevated, well-defined, ulcerated, lobulated, reddish-white, solid \u2013 occasionally cystic \u2013 and firm nodule was observed in the right inguinal mammary gland. Microscopically, an expansive neoplastic proliferation composed of myoepithelial and epithelial cells arranged predominantly in a papillary pattern was observed. Immunohistochemistry was performed for the markers C-Kit, pan-cytokeratin (CK-AE1\/AE3), cytokeratin 7 (CK7), P63, estrogen receptor (ER), progesterone receptor (PR), Ki67, cyclooxygenase-2 (Cox-2), and GATA3. The neoplastic cells were positive for CK AE1\/AE3 and 7 (epithelial cells), P63 (myoepithelial cells), Cox-2 (epithelial and myoepithelial cells), and PR (epithelial cells). Positive results for CK-AE1\/AE3, CK7, and P63 confirmed the epithelial and myoepithelial nature of the tumor, the mitotic index and elevated Ki-67 expression supported the interpretation of a malignant proliferative phenotype and contributed to the classification of the lesion as a noninvasive malignant adenomyoepithelioma. Based on the macroscopic, microscopic, and immunohistochemical findings, a diagnosis of noninvasive malignant mammary adenomyoepithelioma was established.<\/jats:p>","DOI":"10.1007\/s11259-026-11493-w","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:30:28Z","timestamp":1788499828000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Noninvasive malignant mammary adenomyoepithelioma in a male cat"],"prefix":"10.1007","volume":"50","author":[{"given":"Felipe Martins","family":"Pastor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enio","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana Yively Os\u00f3rio","family":"Taborda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara Toledo","family":"da Silva Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geovanni Dantas","family":"Cassali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9ria","family":"Serakides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Melo","family":"Ocarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"11493_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.09.035","author":"R Asch-Kendrick","year":"2016","unstructured":"Asch-Kendrick R, Cimino-Mathews A (2016) The role of GATA3 in breast carcinomas: a review. 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