{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:37:14Z","timestamp":1793104634653,"version":"4.5.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Vet Res Commun"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s11259-026-11564-y","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:11:02Z","timestamp":1791515462000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cervico-vaginal ISGs and interferon tau: emerging biomarkers for early pregnancy detection in cattle"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-8801","authenticated-orcid":false,"given":"Anup K.","family":"Talukder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"issue":"3","key":"11564_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s12522-011-0117-2","volume":"11","author":"H Bai","year":"2012","unstructured":"Bai H, Sakurai T, Fujiwara H, Ideta A, Aoyagi Y, Godkin JD, Imakawa K (2012) Functions of interferon tau as an immunological regulator for establishment of pregnancy. Reproductive Med Biology 11(3):109\u2013116. https:\/\/doi.org\/10.1007\/s12522-011-0117-2","journal-title":"Reproductive Med Biology"},{"issue":"5","key":"11564_CR1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1262\/jrd.2022-061","volume":"68","author":"H Bai","year":"2022","unstructured":"Bai H, Kawahara M, Takahashi M, Imakawa K (2022) Recent progress of interferon-tau research and potential direction beyond pregnancy recognition. J Reprod Dev 68(5):299\u2013306. https:\/\/doi.org\/10.1262\/jrd.2022-061","journal-title":"J Reprod Dev"},{"issue":"14","key":"11564_CR3","doi-asserted-by":"publisher","first-page":"5681","DOI":"10.1073\/pnas.0811841106","volume":"106","author":"S Bauersachs","year":"2009","unstructured":"Bauersachs S, Ulbrich SE, Zakhartchenko V, Minten M, Reichenbach M, Reichenbach HD, Blum H, Spencer TE, Wolf E (2009) The endometrium responds differently to cloned versus fertilized embryos. Proc Natl Acad Sci U S A 106(14):5681\u20135686. https:\/\/doi.org\/10.1073\/pnas.0811841106","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"11564_CR5","doi-asserted-by":"publisher","first-page":"F11","DOI":"10.1530\/REP-17-0257","volume":"154","author":"FW Bazer","year":"2017","unstructured":"Bazer FW, Thatcher WW (2017) Chronicling the discovery of interferon tau. Reprod (Cambridge England) 154(5):F11","journal-title":"Reprod (Cambridge England)"},{"issue":"1","key":"11564_CR4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0093-691X(05)80052-4","volume":"41","author":"FW Bazer","year":"1994","unstructured":"Bazer FW, Ott TL, Spencer TE (1994) Pregnancy recognition in ruminants, pigs and horses: Signals from the trophoblast. Theriogenology 41(1):79\u201394. https:\/\/doi.org\/10.1016\/S0093-691X(05)80052-4","journal-title":"Theriogenology"},{"issue":"1","key":"11564_CR6","doi-asserted-by":"publisher","first-page":"24149","DOI":"10.1038\/s41598-025-08741-5","volume":"15","author":"M Bedir","year":"2025","unstructured":"Bedir M, Marouf S, Sayed RH, El-Diasty M, Hassan HM, Shahien MA, Eid S, Aboul-Ella H, Eljakee J (2025) Development and evaluation of a novel lateral flow immunoassay for rapid diagnosis of brucellosis across different animal species. Sci Rep 15(1):24149. https:\/\/doi.org\/10.1038\/s41598-025-08741-5","journal-title":"Sci Rep"},{"issue":"11","key":"11564_CR7","doi-asserted-by":"publisher","first-page":"9253","DOI":"10.3168\/jds.2021-21773","volume":"105","author":"DK Berg","year":"2022","unstructured":"Berg DK, Ledgard A, Donnison M, McDonald R, Henderson HV, Meier S, Juengel JL, Burke CR (2022) The first week following insemination is the period of major pregnancy failure in pasture-grazed dairy cows. J Dairy Sci 105(11):9253\u20139270. https:\/\/doi.org\/10.3168\/jds.2021-21773","journal-title":"J Dairy Sci"},{"issue":"5","key":"11564_CR8","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1093\/biolre\/ioaf066","volume":"112","author":"JV Bishop","year":"2025","unstructured":"Bishop JV, Guzeloglu A, Scheller T, Docheff JJ, Gonzalez-Berrios CL, Van Campen H, Nett TM, Zezeski AL, Geary TW, Thatcher WW, Hansen TR (2025) Early identification of bovine pregnancy status and embryonic mortality\u2020. Biol Reprod 112(5):981\u2013995. https:\/\/doi.org\/10.1093\/biolre\/ioaf066","journal-title":"Biol Reprod"},{"issue":"4","key":"11564_CR9","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1095\/biolreprod65.4.1038","volume":"65","author":"Y Choi","year":"2001","unstructured":"Choi Y, Johnson GA, Burghardt RC, Berghman LR, Joyce MM, Taylor KM, David Stewart M, Bazer FW, Spencer TE (2001) Interferon regulatory factor-two restricts expression of interferon-stimulated genes to the endometrial stroma and glandular epithelium of the ovine uterus. Biol Reprod 65(4):1038\u20131049","journal-title":"Biol Reprod"},{"key":"11564_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13620-017-0112-y","volume":"71","author":"MA Crowe","year":"2018","unstructured":"Crowe MA, Hostens M, Opsomer G (2018) Reproductive management in dairy cows - the future. Ir Vet J 71:1. https:\/\/doi.org\/10.1186\/s13620-017-0112-y","journal-title":"Ir Vet J"},{"key":"11564_CR11","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.theriogenology.2020.04.001","volume":"152","author":"G Dalmaso de Melo","year":"2020","unstructured":"Dalmaso de Melo G, Mello BP, Ferreira CA, Souto Godoy Filho CA, Rocha CC, Silva AG, Reese ST, Madureira EH, Pohler KG, Pugliesi G (2020) Applied use of interferon-tau stimulated genes expression in polymorphonuclear cells to detect pregnancy compared to other early predictors in beef cattle. Theriogenology 152:94\u2013105. https:\/\/doi.org\/10.1016\/j.theriogenology.2020.04.001","journal-title":"Theriogenology"},{"issue":"1\u20132","key":"11564_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1071\/RD15366","volume":"28","author":"MG Diskin","year":"2016","unstructured":"Diskin MG, Waters SM, Parr MH, Kenny DA (2016) Pregnancy losses in cattle: potential for improvement. Reprod Fertil Dev 28(1\u20132):83\u201393. https:\/\/doi.org\/10.1071\/RD15366","journal-title":"Reprod Fertil Dev"},{"issue":"3","key":"11564_CR13","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/biolre\/ioad164","volume":"110","author":"RR Domingues","year":"2024","unstructured":"Domingues RR, Andrade JPN, Cunha TO, Madureira G, Hoppman AS, Teixeira NN, Monteiro PLJ, Gomez-Leon VH, Martins JPN, Wiltbank MC (2024) Profiles of interferon-stimulated genes in multiple tissues and circulating pregnancy-associated glycoproteins and their association with pregnancy loss in dairy cows\u2020. Biol Reprod 110(3):558\u2013568. https:\/\/doi.org\/10.1093\/biolre\/ioad164","journal-title":"Biol Reprod"},{"issue":"1","key":"11564_CR14","doi-asserted-by":"publisher","first-page":"17548","DOI":"10.1038\/s41598-025-01996-y","volume":"15","author":"IR Feltrin","year":"2025","unstructured":"Feltrin IR, Melo GD, Freitas PP, Morelli KG, Binelli M, Membrive CMB, Pugliesi G (2025) Conceptus signaling markers in immune cells enhance pregnancy prediction in beef cattle. Sci Rep 15(1):17548. https:\/\/doi.org\/10.1038\/s41598-025-01996-y","journal-title":"Sci Rep"},{"issue":"3","key":"11564_CR15","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3168\/jdsc.2020-0062","volume":"2","author":"PA Ferraz","year":"2021","unstructured":"Ferraz PA, Filho C, Rocha CC, Neto AL, de Andrade Bruni G, Oshiro TSI, Baruselli PS, Lima FS, Pugliesi G (2021) Feasibility and accuracy of using different methods to detect pregnancy by conceptus-stimulated genes in dairy cattle. JDS Commun 2(3):153\u2013158. https:\/\/doi.org\/10.3168\/jdsc.2020-0062","journal-title":"JDS Commun"},{"key":"11564_CR16","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.theriogenology.2019.09.014","volume":"141","author":"RVO Filho","year":"2020","unstructured":"Filho RVO, Franco GA, Reese ST, Dantas FG, Fontes PLP, Cooke RF, Rhinehart JD, Thompson KW, Pohler KG (2020) Using pregnancy associated glycoproteins (PAG) for pregnancy detection at day 24 of gestation in beef cattle. Theriogenology 141:128\u2013133. https:\/\/doi.org\/10.1016\/j.theriogenology.2019.09.014","journal-title":"Theriogenology"},{"issue":"4","key":"11564_CR17","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1095\/biolreprod.108.074336","volume":"81","author":"N Forde","year":"2009","unstructured":"Forde N, Carter F, Fair T, Crowe MA, Evans AC, Spencer TE, Bazer FW, McBride R, Boland MP, O\u2019Gaora P, Lonergan P, Roche JF (2009) Progesterone-regulated changes in endometrial gene expression contribute to advanced conceptus development in cattle. Biol Reprod 81(4):784\u2013794. https:\/\/doi.org\/10.1095\/biolreprod.108.074336","journal-title":"Biol Reprod"},{"issue":"1","key":"11564_CR18","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1095\/biolreprod.110.090019","volume":"85","author":"N Forde","year":"2011","unstructured":"Forde N, Carter F, Spencer T, Bazer F, Sandra O, Mansouri-Attia N, Okumu L, McGettigan P, Mehta J, McBride R (2011) Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant? Biol Reprod 85(1):144\u2013156","journal-title":"Biol Reprod"},{"issue":"1","key":"11564_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cvfa.2015.09.006","volume":"32","author":"PM Fricke","year":"2016","unstructured":"Fricke PM, Ricci A, Giordano JO, Carvalho PD (2016) Methods for and Implementation of Pregnancy Diagnosis in Dairy Cows. Veterinary Clinics: Food Anim Pract 32(1):165\u2013180. https:\/\/doi.org\/10.1016\/j.cvfa.2015.09.006","journal-title":"Veterinary Clinics: Food Anim Pract"},{"issue":"1\u20132","key":"11564_CR20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.anireprosci.2010.05.010","volume":"121","author":"JC Green","year":"2010","unstructured":"Green JC, Okamura CS, Poock SE, Lucy MC (2010) Measurement of interferon-tau (IFN-tau) stimulated gene expression in blood leukocytes for pregnancy diagnosis within 18-20d after insemination in dairy cattle. Anim Reprod Sci 121(1\u20132):24\u201333. https:\/\/doi.org\/10.1016\/j.anireprosci.2010.05.010","journal-title":"Anim Reprod Sci"},{"issue":"4","key":"11564_CR21","doi-asserted-by":"publisher","first-page":"e14566","DOI":"10.1111\/rda.14566","volume":"59","author":"LS Gui","year":"2024","unstructured":"Gui LS, Dai TS, Guo XR, Wei SH, Ma ZM, Yang D, Ding BL, Xiang H, Yu YT, Dan XG (2024) Recent advances in early pregnancy loss diagnosis in dairy cows: New approaches. Reprod Domest Anim 59(4):e14566. https:\/\/doi.org\/10.1111\/rda.14566","journal-title":"Reprod Domest Anim"},{"key":"11564_CR22","doi-asserted-by":"publisher","unstructured":"Johnson GA, Bazer FW, Burghardt RC, Seo H, Wu G, Cain JW, Pohler KG (2024) The history of interferon-stimulated genes in pregnant cattle, sheep, and pigs. Reproduction 168(4). https:\/\/doi.org\/10.1530\/rep-24-0130","DOI":"10.1530\/rep-24-0130"},{"issue":"4","key":"11564_CR23","doi-asserted-by":"publisher","first-page":"e71022","DOI":"10.1002\/vms3.71022","volume":"12","author":"MC Kara","year":"2026","unstructured":"Kara MC, K\u00f6se AM (2026) Validation of a Pregnancy-Associated Glycoprotein-Based Lateral Flow Assay for Early Pregnancy Detection in Goats. Vet Med Sci 12(4):e71022. https:\/\/doi.org\/10.1002\/vms3.71022","journal-title":"Vet Med Sci"},{"key":"11564_CR24","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1477-7827-11-6","volume":"11","author":"K Kizaki","year":"2013","unstructured":"Kizaki K, Shichijo-Kizaki A, Furusawa T, Takahashi T, Hosoe M, Hashizume K (2013) Differential neutrophil gene expression in early bovine pregnancy. Reprod Biol Endocrinol 11:6. https:\/\/doi.org\/10.1186\/1477-7827-11-6","journal-title":"Reprod Biol Endocrinol"},{"issue":"7","key":"11564_CR25","doi-asserted-by":"publisher","first-page":"e0306325","DOI":"10.1371\/journal.pone.0306325","volume":"19","author":"AC Kline","year":"2024","unstructured":"Kline AC, Menegatti Zoca S, Epperson KM, Quail LK, Ketchum JN, Andrews TN, Rich JJJ, Rhoades JR, Walker JA, Perry GA (2024) Evaluation of pregnancy associated glycoproteins assays for on farm determination of pregnancy status in beef cattle. PLoS ONE 19(7):e0306325. https:\/\/doi.org\/10.1371\/journal.pone.0306325","journal-title":"PLoS ONE"},{"issue":"9","key":"11564_CR26","doi-asserted-by":"publisher","first-page":"8396","DOI":"10.3168\/jds.2017-14251","volume":"101","author":"H Kunii","year":"2018","unstructured":"Kunii H, Koyama K, Ito T, Suzuki T, Balboula AZ, Shirozu T, Bai H, Nagano M, Kawahara M, Takahashi M (2018) Hot topic: Pregnancy-induced expression of interferon-stimulated genes in the cervical and vaginal mucosal membranes. J Dairy Sci 101(9):8396\u20138400. https:\/\/doi.org\/10.3168\/jds.2017-14251","journal-title":"J Dairy Sci"},{"issue":"17","key":"11564_CR27","doi-asserted-by":"publisher","first-page":"9677","DOI":"10.1073\/pnas.171305398","volume":"98","author":"MA Larson","year":"2001","unstructured":"Larson MA, Kimura K, Kubisch HM, Roberts RM (2001) Sexual dimorphism among bovine embryos in their ability to make the transition to expanded blastocyst and in the expression of the signaling molecule IFN-tau. Proc Natl Acad Sci U S A 98(17):9677\u20139682. https:\/\/doi.org\/10.1073\/pnas.171305398","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"18","key":"11564_CR28","doi-asserted-by":"publisher","first-page":"13544","DOI":"10.1016\/S0021-9258(17)36865-5","volume":"269","author":"J Li","year":"1994","unstructured":"Li J, Roberts RM (1994) Interferon-tau and interferon-alpha interact with the same receptors in bovine endometrium. Use of a readily iodinatable form of recombinant interferon-tau for binding studies. J Biol Chem 269(18):13544\u201313550","journal-title":"J Biol Chem"},{"issue":"14","key":"11564_CR29","doi-asserted-by":"publisher","first-page":"5687","DOI":"10.1073\/pnas.0812722106","volume":"106","author":"N Mansouri-Attia","year":"2009","unstructured":"Mansouri-Attia N, Sandra O, Aubert J, Degrelle S, Everts RE, Giraud-Delville C, Heyman Y, Galio L, Hue I, Yang X, Tian XC, Lewin HA, Renard JP (2009) Endometrium as an early sensor of in vitro embryo manipulation technologies. Proc Natl Acad Sci U S A 106(14):5687\u20135692. https:\/\/doi.org\/10.1073\/pnas.0812722106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11564_CR30","doi-asserted-by":"publisher","unstructured":"Mathew DJ, Peterson KD, Senn LK, Oliver MA, Ealy AD (2022) Ruminant conceptus-maternal interactions: interferon-tau and beyond. J Anim Sci 100(7). https:\/\/doi.org\/10.1093\/jas\/skac123","DOI":"10.1093\/jas\/skac123"},{"key":"11564_CR31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1477-7827-10-21","volume":"10","author":"S Matsuyama","year":"2012","unstructured":"Matsuyama S, Kojima T, Kato S, Kimura K (2012) Relationship between quantity of IFNT estimated by IFN-stimulated gene expression in peripheral blood mononuclear cells and bovine embryonic mortality after AI or ET. Reprod Biol Endocrinol 10:21. https:\/\/doi.org\/10.1186\/1477-7827-10-21","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"11564_CR32","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3168\/jdsc.2024-0596","volume":"6","author":"GR Mendina","year":"2025","unstructured":"Mendina GR, de Brun V, de Lourdes Adrien M, Pons V, Vivian Paradizo R, Gil J, Rocha CC, Binelli M, Meikle A (2025) Increased expression of interferon-stimulated gene 15 (ISG15) in cervical cells on day 14 of pregnancy in Holstein heifers. JDS Commun 6(1):165\u2013170. https:\/\/doi.org\/10.3168\/jdsc.2024-0596","journal-title":"JDS Commun"},{"issue":"1","key":"11564_CR33","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/rda.12638","volume":"51","author":"MM Meyerholz","year":"2016","unstructured":"Meyerholz MM, Mense K, Knaack H, Sandra O, Schmicke M (2016) Pregnancy-Induced ISG-15 and MX-1 Gene Expression is Detected in the Liver of Holstein-Friesian Heifers During Late Peri-Implantation Period. Reprod Domest Anim 51(1):175\u2013177. https:\/\/doi.org\/10.1111\/rda.12638","journal-title":"Reprod Domest Anim"},{"issue":"8","key":"11564_CR34","doi-asserted-by":"publisher","first-page":"7570","DOI":"10.3168\/jds.2018-15961","volume":"102","author":"EL Middleton","year":"2019","unstructured":"Middleton EL, Pursley JR (2019) Short communication: Blood samples before and after embryonic attachment accurately determine non-pregnant lactating dairy cows at 24 d post-artificial insemination using a commercially available assay for pregnancy-specific protein B. J Dairy Sci 102(8):7570\u20137575. https:\/\/doi.org\/10.3168\/jds.2018-15961","journal-title":"J Dairy Sci"},{"key":"11564_CR35","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaf251","author":"ML Newman","year":"2025","unstructured":"Newman ML, Primo VAB, Marin MBU, Peixoto PMG, Gonzalez TD, Bennett A, Rocha CC, Binelli M, Bishop JV, Guzeloglu A, Hansen TR, Thatcher WW, Bisinotto RS (2025) Interferon-tau concentration at the vaginal fornix and cervical ostium predicted early pregnancy outcomes in lactating dairy cows\u2020. Biol Reprod. https:\/\/doi.org\/10.1093\/biolre\/ioaf251","journal-title":"Biol Reprod"},{"issue":"2","key":"11564_CR36","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00580-023-03539-1","volume":"33","author":"MA Oropeza","year":"2024","unstructured":"Oropeza MA, de la Sota RL, Bedolla MA, Ju\u00e1rez N, Ar\u00e9chiga CF, Hern\u00e1ndez-Cer\u00f3n J (2024) Association between polymorphonuclear leukocytes in the cervical mucosa and fertility in dairy cows. Comp Clin Pathol 33(2):201\u2013205. https:\/\/doi.org\/10.1007\/s00580-023-03539-1","journal-title":"Comp Clin Pathol"},{"issue":"3","key":"11564_CR38","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1530\/REP-18-0188","volume":"156","author":"C Passaro","year":"2018","unstructured":"Passaro C, Tutt D, Mathew DJ, Sanchez JM, Browne JA, Boe-Hansen GB, Fair T, Lonergan P (2018) Blastocyst-induced changes in the bovine endometrial transcriptome. Reproduction 156(3):219\u2013229. https:\/\/doi.org\/10.1530\/REP-18-0188","journal-title":"Reproduction"},{"issue":"3","key":"11564_CR37","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1530\/REP-19-0064","volume":"158","author":"C Passaro","year":"2019","unstructured":"Passaro C, Tutt D, Bages-Arnal S, Maicas C, Laguna-Barraza R, Gutierrez-Adan A, Browne JA, Rath D, Behura SK, Spencer TE, Fair T, Lonergan P (2019) Global transcriptomic response of bovine endometrium to blastocyst-stage embryos. Reproduction 158(3):223\u2013235. https:\/\/doi.org\/10.1530\/REP-19-0064","journal-title":"Reproduction"},{"issue":"5","key":"11564_CR39","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nri1604","volume":"5","author":"LC Platanias","year":"2005","unstructured":"Platanias LC (2005) Mechanisms of type-I-and type-II-interferon-mediated signalling. Nat Rev Immunol 5(5):375\u2013386","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"11564_CR40","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1095\/biolreprod.114.121525","volume":"91","author":"G Pugliesi","year":"2014","unstructured":"Pugliesi G, Miagawa BT, Paiva YN, Fran\u00e7a MR, Silva LA, Binelli M (2014) Conceptus-induced changes in the gene expression of blood immune cells and the ultrasound-accessed luteal function in beef cattle: how early can we detect pregnancy? Biol Reprod 91(4):95. https:\/\/doi.org\/10.1095\/biolreprod.114.121525","journal-title":"Biol Reprod"},{"issue":"10","key":"11564_CR41","doi-asserted-by":"publisher","first-page":"8642","DOI":"10.3168\/jds.2024-24899","volume":"107","author":"C Rial","year":"2024","unstructured":"Rial C, Hussain I, Hoff R, Tompkins S, Erickson D, Branen J, Giordano JO (2024) Development and evaluation of a lateral flow-based portable optical system for determination of the pregnancy status of dairy cows. J Dairy Sci 107(10):8642\u20138653. https:\/\/doi.org\/10.3168\/jds.2024-24899","journal-title":"J Dairy Sci"},{"issue":"3","key":"11564_CR42","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1071\/RD11139","volume":"24","author":"D Rizos","year":"2012","unstructured":"Rizos D, Scully S, Kelly AK, Ealy AD, Moros R, Duffy P, Al Naib A, Forde N, Lonergan P (2012) Effects of human chorionic gonadotrophin administration on day 5 after oestrus on corpus luteum characteristics, circulating progesterone and conceptus elongation in cattle. Reprod Fertil Dev 24(3):472\u2013481. https:\/\/doi.org\/10.1071\/RD11139","journal-title":"Reprod Fertil Dev"},{"issue":"5\u20136","key":"11564_CR43","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.cytogfr.2007.06.010","volume":"18","author":"RM Roberts","year":"2007","unstructured":"Roberts RM (2007) Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy. Cytokine Growth Factor Rev 18(5\u20136):403\u2013408. https:\/\/doi.org\/10.1016\/j.cytogfr.2007.06.010","journal-title":"Cytokine Growth Factor Rev"},{"key":"11564_CR44","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.theriogenology.2017.07.051","volume":"104","author":"B Ruhmann","year":"2017","unstructured":"Ruhmann B, Giller K, Hankele AK, Ulbrich SE, Schmicke M (2017) Interferon-\u03c4 induced gene expression in bovine hepatocytes during early pregnancy. Theriogenology 104:198\u2013204. https:\/\/doi.org\/10.1016\/j.theriogenology.2017.07.051","journal-title":"Theriogenology"},{"issue":"1","key":"11564_CR45","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/biolre\/ioz060","volume":"101","author":"JM Sanchez","year":"2019","unstructured":"Sanchez JM, Mathew DJ, Behura SK, Passaro C, Charpigny G, Butler ST, Spencer TE, Lonergan P (2019) Bovine endometrium responds differentially to age-matched short and long conceptusesdagger. Biol Reprod 101(1):26\u201339. https:\/\/doi.org\/10.1093\/biolre\/ioz060","journal-title":"Biol Reprod"},{"issue":"5","key":"11564_CR46","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.3168\/jds.2022-22553","volume":"106","author":"A Santos","year":"2023","unstructured":"Santos A, Minela T, Branen J, Pursley JR (2023) Time to increase in pregnancy-specific protein B following artificial insemination is a direct determinant of subsequent pregnancy loss in lactating dairy cows. J Dairy Sci 106(5):3734\u20133747. https:\/\/doi.org\/10.3168\/jds.2022-22553","journal-title":"J Dairy Sci"},{"issue":"1","key":"11564_CR47","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1071\/rd09221","volume":"22","author":"R Sartori","year":"2010","unstructured":"Sartori R, Bastos MR, Wiltbank MC (2010) Factors affecting fertilisation and early embryo quality in single- and superovulated dairy cattle. Reprod Fertil Dev 22(1):151\u2013158. https:\/\/doi.org\/10.1071\/rd09221","journal-title":"Reprod Fertil Dev"},{"issue":"1","key":"11564_CR48","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1262\/jrd.11-094k","volume":"58","author":"K Shirasuna","year":"2012","unstructured":"Shirasuna K, Matsumoto H, Kobayashi E, Nitta A, Haneda S, Matsui M, Kawashima C, Kida K, Shimizu T, Miyamoto A (2012) Upregulation of interferon-stimulated genes and interleukin-10 in peripheral blood immune cells during early pregnancy in dairy cows. J Reprod Dev 58(1):84\u201390. https:\/\/doi.org\/10.1262\/jrd.11-094k","journal-title":"J Reprod Dev"},{"issue":"4","key":"11564_CR49","doi-asserted-by":"publisher","first-page":"e0175954","DOI":"10.1371\/journal.pone.0175954","volume":"12","author":"M Sponchiado","year":"2017","unstructured":"Sponchiado M, Gomes NS, Fontes PK, Martins T, Del Collado M, Pastore AA, Pugliesi G, Nogueira MFG, Binelli M (2017) Pre-hatching embryo-dependent and -independent programming of endometrial function in cattle. PLoS ONE 12(4):e0175954. https:\/\/doi.org\/10.1371\/journal.pone.0175954","journal-title":"PLoS ONE"},{"issue":"6","key":"11564_CR50","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.3390\/ani11061666","volume":"11","author":"O Szenci","year":"2021","unstructured":"Szenci O (2021) Recent Possibilities for the Diagnosis of Early Pregnancy and Embryonic Mortality in Dairy Cows. Animals 11(6):1666","journal-title":"Animals"},{"issue":"4","key":"11564_CR57","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1262\/jrd.2017-056","volume":"63","author":"AK Talukder","year":"2017","unstructured":"Talukder AK, Yousef MS, Rashid MB, Awai K, Acosta TJ, Shimizu T, Okuda K, Shimada M, Imakawa K, Miyamoto A (2017) Bovine embryo induces an anti-inflammatory response in uterine epithelial cells and immune cells in vitro: possible involvement of interferon tau as an intermediator. J Reprod Dev 63(4):425\u2013434. https:\/\/doi.org\/10.1262\/jrd.2017-056","journal-title":"J Reprod Dev"},{"issue":"1","key":"11564_CR56","doi-asserted-by":"publisher","first-page":"7850","DOI":"10.1038\/s41598-018-26224-8","volume":"8","author":"AK Talukder","year":"2018","unstructured":"Talukder AK, Rashid MB, Yousef MS, Kusama K, Shimizu T, Shimada M, Suarez SS, Imakawa K, Miyamoto A (2018) Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells. Sci Rep 8(1):7850. https:\/\/doi.org\/10.1038\/s41598-018-26224-8","journal-title":"Sci Rep"},{"issue":"2","key":"11564_CR55","doi-asserted-by":"publisher","first-page":"e13069","DOI":"10.1111\/aji.13069","volume":"81","author":"AK Talukder","year":"2019","unstructured":"Talukder AK, Rashid MB, Takedomi T, Moriyasu S, Imakawa K, Miyamoto A (2019) Day-7 embryos generate an anti-inflammatory immune response in peripheral blood immune cells in superovulated cows. Am J Reprod Immunol 81(2):e13069. https:\/\/doi.org\/10.1111\/aji.13069","journal-title":"Am J Reprod Immunol"},{"key":"11564_CR52","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.theriogenology.2020.01.071","volume":"150","author":"AK Talukder","year":"2020","unstructured":"Talukder AK, Marey MA, Shirasuna K, Kusama K, Shimada M, Imakawa K, Miyamoto A (2020) Roadmap to pregnancy in the first 7 days post-insemination in the cow: Immune crosstalk in the corpus luteum, oviduct, and uterus. Theriogenology 150:313\u2013320. https:\/\/doi.org\/10.1016\/j.theriogenology.2020.01.071","journal-title":"Theriogenology"},{"key":"11564_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.theriogenology.2023.07.033","volume":"211","author":"AK Talukder","year":"2023","unstructured":"Talukder AK, Rabaglino MB, Browne JA, Charpigny G, Lonergan P (2023) Dose- and time-dependent effects of interferon tau on bovine endometrial gene expression. Theriogenology 211:1\u201310. https:\/\/doi.org\/10.1016\/j.theriogenology.2023.07.033","journal-title":"Theriogenology"},{"key":"11564_CR53","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.theriogenology.2024.08.026","volume":"229","author":"AK Talukder","year":"2024","unstructured":"Talukder AK, McDonald M, Browne JA, Charpigny G, Rizos D, Lonergan P (2024) Response of bovine endometrium to interferon tau in the presence of lipopolysaccharide. Theriogenology 229:169\u2013177. https:\/\/doi.org\/10.1016\/j.theriogenology.2024.08.026","journal-title":"Theriogenology"},{"key":"11564_CR51","doi-asserted-by":"publisher","first-page":"117856","DOI":"10.1016\/j.theriogenology.2026.117856","volume":"256","author":"AK Talukder","year":"2026","unstructured":"Talukder AK, Browne JA, McDonald M, Rizos D, Lonergan P (2026) Expression of interferon-stimulated genes in the endometrium, cervix and vagina on Day 15 of pregnancy in cattle. Theriogenology 256:117856. https:\/\/doi.org\/10.1016\/j.theriogenology.2026.117856","journal-title":"Theriogenology"},{"key":"11564_CR58","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/s0378-4320(00)00098-1","volume":"60\u201361","author":"G Vanroose","year":"2000","unstructured":"Vanroose G, de Kruif A, Van Soom A (2000) Embryonic mortality and embryo-pathogen interactions. Anim Reprod Sci 60\u201361:131\u2013143. https:\/\/doi.org\/10.1016\/s0378-4320(00)00098-1","journal-title":"Anim Reprod Sci"},{"key":"11564_CR59","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2025-27981","author":"R Vivi\u00e1n","year":"2026","unstructured":"Vivi\u00e1n R, de Brun V, Naya H, Gil J, de Lourdes Adrien M, Wiltbank MC, Meikle A (2026) Timing of pregnancy losses in grazing lactating dairy cows based on cervical interferon-stimulated gene-15 mRNA, pregnancy-associated glycoproteins, and progesterone dynamics: an exploratory study. J Dairy Sci. https:\/\/doi.org\/10.3168\/jds.2025-27981","journal-title":"J Dairy Sci"},{"key":"11564_CR60","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1186\/1471-2164-11-474","volume":"11","author":"CG Walker","year":"2010","unstructured":"Walker CG, Meier S, Littlejohn MD, Lehnert K, Roche JR, Mitchell MD (2010) Modulation of the maternal immune system by the pre-implantation embryo. BMC Genomics 11:474. https:\/\/doi.org\/10.1186\/1471-2164-11-474","journal-title":"BMC Genomics"},{"issue":"3","key":"11564_CR61","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1530\/rep-14-0485","volume":"149","author":"RM Wallace","year":"2015","unstructured":"Wallace RM, Pohler KG, Smith MF, Green JA (2015) Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy. Reproduction 149(3):R115\u2013R126. https:\/\/doi.org\/10.1530\/rep-14-0485","journal-title":"Reproduction"},{"issue":"1","key":"11564_CR62","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.theriogenology.2016.04.037","volume":"86","author":"MC Wiltbank","year":"2016","unstructured":"Wiltbank MC, Baez GM, Garcia-Guerra A, Toledo MZ, Monteiro PL, Melo LF, Ochoa JC, Santos JE, Sartori R (2016) Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows. Theriogenology 86(1):239\u2013253. https:\/\/doi.org\/10.1016\/j.theriogenology.2016.04.037","journal-title":"Theriogenology"},{"issue":"1","key":"11564_CR63","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/(sici)1098-2795(199905)53:1<8","volume":"53","author":"C Wrenzycki","year":"1999","unstructured":"Wrenzycki C, Herrmann D, Carnwath JW, Niemann H (1999) Alterations in the relative abundance of gene transcripts in preimplantation bovine embryos cultured in medium supplemented with either serum or PVA. Mol Reprod Dev 53(1):8\u201318. https:\/\/doi.org\/10.1002\/(sici)1098-2795(199905)53:1%3C8::Aid-mrd2>3.0.Co;2-k","journal-title":"Mol Reprod Dev"},{"issue":"3","key":"11564_CR64","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.3168\/jds.2009-2529","volume":"93","author":"L Yang","year":"2010","unstructured":"Yang L, Wang XL, Wan PC, Zhang LY, Wu Y, Tang DW, Zeng SM (2010) Up-regulation of expression of interferon-stimulated gene 15 in the bovine corpus luteum during early pregnancy. J Dairy Sci 93(3):1000\u20131011. https:\/\/doi.org\/10.3168\/jds.2009-2529","journal-title":"J Dairy Sci"},{"key":"11564_CR65","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.theriogenology.2017.11.014","volume":"107","author":"H Yoshino","year":"2018","unstructured":"Yoshino H, Toji N, Sasaki K, Koshi K, Yamagishi N, Takahashi T, Ishiguro-Oonuma T, Matsuda H, Yamanouchi T, Hashiyada Y, Imai K, Izaike Y, Kizaki K, Hashizume K (2018) A predictive threshold value for the diagnosis of early pregnancy in cows using interferon-stimulated genes in granulocytes. Theriogenology 107:188\u2013193. https:\/\/doi.org\/10.1016\/j.theriogenology.2017.11.014","journal-title":"Theriogenology"}],"container-title":["Veterinary Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-026-11564-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-026-11564-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11259-026-11564-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:05:41Z","timestamp":1793102741000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11259-026-11564-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11564"],"URL":"https:\/\/doi.org\/10.1007\/s11259-026-11564-y","relation":{},"ISSN":["0165-7380","1573-7446"],"issn-type":[{"value":"0165-7380","type":"print"},{"value":"1573-7446","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"7 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"622"}}