{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:07:04Z","timestamp":1771657624266,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,11,23]],"date-time":"2013-11-23T00:00:00Z","timestamp":1385164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virus Genes"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s11262-013-1010-3","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T06:17:18Z","timestamp":1385101038000},"page":"209-217","source":"Crossref","is-referenced-by-count":7,"title":["Subtyping genotype 2 hepatitis C viruses from Tunisia: identification of two putative new subtypes"],"prefix":"10.1007","volume":"48","author":[{"given":"Mouna","family":"Rajhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Mejri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlem","family":"Djebbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soufiene","family":"Chouaieb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imed","family":"Cheikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlem","family":"Ben Yahia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Sadraoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid","family":"Hammami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Msaddak","family":"Azouz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Ben Mami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henda","family":"Triki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,11,23]]},"reference":[{"key":"1010_CR1","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1073\/pnas.88.6.2451","volume":"88","author":"QL Choo","year":"1991","unstructured":"Q.L. Choo, K.H. Richman, H.J. Han, K. Berger, C. Lee, C. Dong, C. Gallegos, D. Coit, R. Medina-Selby, P.J. Barr, A. Weiner, D.W. Bradley, G. Kuo, M. Houghton, Genetic organization and diversity of the hepatitis C virus. Proc. Natl Acad. Sci. USA 88, 2451\u20132455 (1991)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1010_CR2","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/hep.20819","volume":"42","author":"P Simmonds","year":"2005","unstructured":"P. Simmonds, J. Bukh, C. Combet, G. Deleage, N. Enomoto, S. Feinstone, P. Halfon, G. Inchausp\u00e9, C. Kuiken, G. Maertens, M. Mizokami, D.G. Murphy, H. Okamoto, J.M. Pawlotsky, F. Penin, E. Sablon, T. Shin-I, L.J. Stuyver, H.J. Thiel, S. Viazov, A.J. Weiner, A. Widell, Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Hepatology 42, 962\u2013973 (2005)","journal-title":"Hepatology"},{"key":"1010_CR3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-1-59745-394-3_4","volume":"510","author":"C Kuiken","year":"2009","unstructured":"C. Kuiken, P. Simmonds, Nomenclature and numbering of the hepatitis C virus. Methods Mol. Biol. 510, 33\u201353 (2009)","journal-title":"Methods Mol. Biol."},{"key":"1010_CR4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1055\/s-2007-1007262","volume":"15","author":"J Bukh","year":"1995","unstructured":"J. Bukh, R.H. Miller, R.H. Purcell, Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes. Semin. Liver Dis. 15, 41\u201363 (1995)","journal-title":"Semin. Liver Dis."},{"key":"1010_CR5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1099\/0022-1317-73-3-673","volume":"73","author":"H Okamoto","year":"1992","unstructured":"H. Okamoto, Y. Sugiyama, S. Okada, K. Kurai, Y. Akahane, Y. Sugai, T. Tanaka, K. Sato, F. Tsuda, Y. Miyakawa, M. Mayum, Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J. Gen. Virol. 73, 673\u2013679 (1992)","journal-title":"J. Gen. Virol."},{"key":"1010_CR6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0168-1702(95)00052-R","volume":"38","author":"L Stuyver","year":"1995","unstructured":"L. Stuyver, A. Wyseur, W. Van Arnhem, F. Lunel, L. Stuyver, A. Wyseur, W. Van Arnhem, F. Lunel, P. Laurent-Puig, J.M. Pawlotsky, B. Kleter, L. Bassit, J. Nkengasong, A.J. Van Doorn, G. Maertens, Hepatitis C virus genotyping by means of 5\u2032UR\/core line probe assays and molecular analysis of untypable samples. Virus Res. 38, 137\u2013157 (1995)","journal-title":"Virus Res."},{"key":"1010_CR7","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1099\/0022-1317-76-5-1197","volume":"76","author":"F Davidson","year":"1995","unstructured":"F. Davidson, P. Simmonds, J.C. Ferguson, L.M. Jarvis, B.C. Dow, E.A. Follett, C.R. Seed, T. Krusius, C. Lin, G.A. Medgyesi, Survey of major genotypes and subtypes of hepatitis C virus using RFLP of sequences amplified from the 5\u2032 non-coding region. J. Gen. Virol. 76, 1197\u20131204 (1995)","journal-title":"J. Gen. Virol."},{"key":"1010_CR8","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1056\/NEJM199811193392102","volume":"339","author":"GL Davis","year":"1998","unstructured":"G.L. Davis, R. Esteban-Mur, V. Rustgi, J. Hoefs, S.C. Gordon, C. Trepo, M.L. Shiffman, S. Zeuzem, A. Craxi, M.H. Ling, J. Albrecht, Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group. N. Engl. J. Med. 339, 1493\u20131499 (1998)","journal-title":"N. Engl. J. Med."},{"key":"1010_CR9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/(SICI)1096-9071(199802)54:2<86::AID-JMV3>3.0.CO;2-K","volume":"54","author":"J Izopet","year":"1998","unstructured":"J. Izopet, J.L. Payen, L. Alric, K. Sandres, J.P. Charlet, J.P. Vinel, M. Duffaut, J.P. Pascal, J. Puel, Baseline level and early suppression of serum HCV RNA for predicting sustained complete response to alpha-interferon therapy. J. Med. Virol. 54, 86\u201391 (1998)","journal-title":"J. Med. Virol."},{"key":"1010_CR10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/hep.510310131","volume":"31","author":"T Poynard","year":"2000","unstructured":"T. Poynard, J. McHutchison, Z. Goodman, M.H. Ling, J. Albrecht, Is an \u201ca la carte\u201d combination interferon alfa-2b plus ribavirin regimen possible for the first line treatment in patients with chronic hepatitis C? The ALGOVIRC Project Group. Hepatology 31, 211\u2013218 (2000)","journal-title":"Hepatology"},{"key":"1010_CR11","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1099\/vir.0.80401-0","volume":"85","author":"P Simmonds","year":"2004","unstructured":"P. Simmonds, Genetic diversity and evolution of hepatitis C virus\u201415\u00a0years on. J. Gen. Virol. 85, 3173\u20133188 (2004)","journal-title":"J. Gen. Virol."},{"key":"1010_CR12","unstructured":"HCV sequence Databases. http:\/\/hcv.lanl.gov\/content\/sequence\/HCV\/classification\/genotable.html"},{"key":"1010_CR13","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S095026880300846X","volume":"130","author":"A Djebbi","year":"2003","unstructured":"A. Djebbi, H. Triki, O. Bahri, I. Cheikh, A. Sadraoui, A. Ben Ammar, K. Dellagi, Genotypes of hepatitis C virus circulating in Tunisia. Epidemiol. Infect. 130, 501\u2013505 (2003)","journal-title":"Epidemiol. Infect."},{"key":"1010_CR14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jviromet.2004.03.002","volume":"119","author":"S Ben Othman","year":"2004","unstructured":"S. Ben Othman, A. Trabelsi, A. Monnet, N. Bouzgarrou, F. Grattard, A. Beyou, T. Bourlet, B. Pozzetto, Evaluation of a prototype HCV NS5b assay for typing strains of hepatitis C virus isolated from Tunisian haemodialysis patients. J. Virol. Methods 119, 177\u2013181 (2004)","journal-title":"J. Virol. Methods"},{"key":"1010_CR15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jmv.20342","volume":"76","author":"S Mejri","year":"2005","unstructured":"S. Mejri, A.B. Salah, H. Triki, N.B. Alaya, A. Djebbi, K. Dellagi, Contrasting patterns of hepatitis C virus infection in two regions from Tunisia. J. Med. Virol. 76, 185\u2013193 (2005)","journal-title":"J. Med. Virol."},{"key":"1010_CR16","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1023\/B:EJEP.0000032348.83087.01","volume":"19","author":"A Djebbi","year":"2004","unstructured":"A. Djebbi, S. Mejri, V. Thiers, H. Triki, Phylogenetic analysis of hepatitis C virus isolates from Tunisian patients. Eur. J. Epidemiol. 19, 555\u2013562 (2004)","journal-title":"Eur. J. Epidemiol."},{"key":"1010_CR17","first-page":"473","volume":"3","author":"A Djebbi","year":"2008","unstructured":"A. Djebbi, O. Bahri, H. Langar, A. Sadraoui, S. Mejri, H. Triki, Genetic variability of genotype 1 hepatitis C virus isolates from Tunisian haemophiliacs. New Microbiol. 3, 473\u2013480 (2008)","journal-title":"New Microbiol."},{"key":"1010_CR18","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/jmv.21641","volume":"81","author":"N Bouzgarrou","year":"2009","unstructured":"N. Bouzgarrou, E. Hassen, W. Mahfoudh, S. Gabbouj, E. Schvoerer, A. Ben Yahia, N. Ben Mami, H. Triki, L. Chouchane, NS5A(ISDR-V3) region genetic variability of Tunisian HCV-1b strains: correlation with the response to the combined interferon\/ribavirin therapy. J. Med. Virol. 81, 2021\u20132028 (2009)","journal-title":"J. Med. Virol."},{"key":"1010_CR19","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1128\/JCM.02366-06","volume":"45","author":"DG Murphy","year":"2007","unstructured":"D.G. Murphy, B. Willems, M. Deschenes, N. Hilzenart, R. Mousseau, S. Sabbah, Use of sequence analysis of the NS5B region for routine genotyping of hepatitis C with reference to C\/E1 and 5\u2032 untranslated region sequences. J. Clin. Microbiol. 45, 1102\u20131112 (2007)","journal-title":"J. Clin. Microbiol."},{"key":"1010_CR20","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1099\/0022-1317-77-9-2073","volume":"77","author":"A Ruggieri","year":"1996","unstructured":"A. Ruggieri, C. Argentini, F. Kouruma, P. Chionne, E. D\u2019Ugo, E. Spada, S. Dettori, S. Sabbatani, M. Rapicetta, Heterogeneity of hepatitis C virus genotype 2 variants in West Central Africa (Guinea Conakry). J. Gen. Virol. 77, 2073\u20132076 (1996)","journal-title":"J. Gen. Virol."},{"key":"1010_CR21","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1128\/JCM.42.2.784-791.2004","volume":"42","author":"J Martial","year":"2004","unstructured":"J. Martial, Y. Morice, S. Abel, A. Cabi\u00e9, C. Rat, F. Lombard, A. Edouard, S. Pierre-Louis, P. Garsaud, O. B\u00e9ra, R. Chout, E. Gordien, P. Deny, R. C\u00e9saire, Hepatitis C virus (HCV) genotypes in the Caribbean island of Martinique: evidence for a large radiation of HCV-2 and for recent introduction from Europe of HCV-4. J. Clin. Microbiol. 42, 784\u2013791 (2004)","journal-title":"J. Clin. Microbiol."},{"key":"1010_CR22","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/jmv.20468","volume":"77","author":"C Pasquier","year":"2005","unstructured":"C. Pasquier, R. Njouom, A. Ayouba, M. Dubois, M.T. Sartre, A. Vessi\u00e8re, I. Timba, J. Thonnon, J. Izopet, E. Nerrienet, Distribution and heterogeneity of hepatitis C genotypes in hepatitis patients in Cameroon. J. Med. Virol. 77, 390\u2013398 (2005)","journal-title":"J. Med. Virol."},{"key":"1010_CR23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/jmv.20765","volume":"79","author":"F Thomas","year":"2007","unstructured":"F. Thomas, F. Nicot, K. Sandres-Saune, M. Dubois, F. Legrand-Abravanel, L. Alric, J.M. Peron, C. Pasquier, J. Izopet, Genetic diversity of HCV genotype 2 strains in south western France. J. Med. Virol. 79, 26\u201334 (2007)","journal-title":"J. Med. Virol."},{"key":"1010_CR24","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1099\/vir.0.038315-0","volume":"93","author":"C Li","year":"2012","unstructured":"C. Li, H. Cao, L. Lu, D. Murphy, Full-length sequences of 11 hepatitis C virus genotype 2 isolates representing five subtypes and six unclassified lineages with unique geographical distribution and genetic variation patterns. J. Gen. Virol. 93, 1173\u20131184 (2012)","journal-title":"J. Gen. Virol."},{"key":"1010_CR25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1099\/0022-1317-75-5-1053","volume":"75","author":"P Simmonds","year":"1994","unstructured":"P. Simmonds, D.B. Smith, F. McOmish, P.L. Yap, J. Kolberg, M.S. Urdea, E.C. Holme, Identification of genotypes of hepatitis C virus by sequence comparisons in the core, E1 and NS-5 regions. J. Gen. Virol. 75, 53\u201356 (1994)","journal-title":"J. Gen. Virol."},{"key":"1010_CR26","doi-asserted-by":"crossref","first-page":"10134","DOI":"10.1073\/pnas.91.21.10134","volume":"91","author":"L Stuyver","year":"1994","unstructured":"L. Stuyver, W. van Arnhem, A. Wyseur, F. Hernandez, E. Delaporte, G. Maertens, Classification of hepatitis C viruses based on phylogenetic analysis of the envelope 1 and nonstructural 5B regions and identification of five additional subtypes. Proc. Natl Acad. Sci. USA 91, 10134\u201310138 (1994)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1010_CR27","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1128\/JCM.02463-05","volume":"44","author":"JF Cantaloube","year":"2006","unstructured":"J.F. Cantaloube, S. Laperche, P. Gallian, F. Bouchardeau, X. Lamballerie, P. Micco, Analysis of the 5\u2032 noncoding region versus the NS5b region in genotyping hepatitis C virus isolates from blood donors in France. J. Clin. Microbiol. 44, 2051\u20132056 (2006)","journal-title":"J. Clin. Microbiol."},{"key":"1010_CR28","doi-asserted-by":"crossref","first-page":"658","DOI":"10.7326\/0003-4819-125-8-199610150-00006","volume":"125","author":"AI Sharara","year":"1996","unstructured":"A.I. Sharara, C.M. Hunt, J.D. Hamilton, Hepatitis C. Ann. Intern. Med. 125, 658\u2013668 (1996)","journal-title":"Ann. Intern. Med."},{"key":"1010_CR29","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/hep.510310328","volume":"31","author":"D Conte","year":"2000","unstructured":"D. Conte, M. Fraquelli, D. Prati, A. Colucci, E. Minola, Prevalence and clinical course of chronic hepatitis C virus (HCV) infection and rate of HCV vertical transmission in a cohort of 15,250 pregnant women. Hepatology 31, 751\u2013755 (2000)","journal-title":"Hepatology"},{"key":"1010_CR30","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/jmv.10300","volume":"69","author":"R Njouom","year":"2003","unstructured":"R. Njouom, C. Pasquier, A. Ayouba, K. Sandres-Saun\u00e9, J. Mfoupouendoun, M. Mony Lobe, G. Tene, J. Thonnon, J. Izopet, E. Nerrienet, Hepatitis C virus infection among pregnant women in Yaounde, Cameroon: prevalence, viremia, and genotypes. J. Med. Virol. 69, 384\u2013390 (2003)","journal-title":"J. Med. Virol."},{"key":"1010_CR31","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1128\/JVI.76.8.4034-4043.2002","volume":"76","author":"O Kalinina","year":"2002","unstructured":"O. Kalinina, H. Norder, S. Mukomolov, L.O. Magnius, A natural intergenotypic recombinant of hepatitis C virus identified in St, Petersburg. J. Virol. 76, 4034\u20134043 (2002)","journal-title":"J. Virol."},{"key":"1010_CR32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1099\/vir.0.19472-0","volume":"85","author":"R Colina","year":"2004","unstructured":"R. Colina, D. Casane, S. Vasquez, L. Garc\u00eda-Aguirre, A. Chunga, H. Romero, B. Khan, J. Cristina, Evidence of intratypic recombination in natural populations of hepatitis C virus. J. Gen. Virol. 85, 31\u201337 (2004)","journal-title":"J. Gen. Virol."},{"key":"1010_CR33","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/jmv.20714","volume":"78","author":"S Kageyama","year":"2006","unstructured":"S. Kageyama, D.M. Agdamag, E.T. Alesna, P.S. Lea\u00f1o, A.M. Heredia, I.P. Abellanosa-Tac-An, L.D. Jereza, T. Tanimoto, J. Yamamura, H. Ichimura, A natural inter-genotypic (2b\/1b) recombinant of hepatitis C virus in the Philippines. J. Med. Virol. 78, 1423\u20131428 (2006)","journal-title":"J. Med. Virol."},{"key":"1010_CR34","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1128\/JVI.00312-06","volume":"80","author":"S Noppornpanth","year":"2006","unstructured":"S. Noppornpanth, T.X. Lien, Y. Poovorawan, S.L. Smits, A.D. Osterhaus, B.L. Haagmans, Identification of a naturally occurring recombinant genotype 2\/6 hepatitis C virus. J. Virol. 80, 7569\u20137577 (2006)","journal-title":"J. Virol."},{"key":"1010_CR35","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1128\/JVI.02639-06","volume":"81","author":"F Legrand-Abravanel","year":"2007","unstructured":"F. Legrand-Abravanel, J. Claudinon, F. Nicot, M. Dubois, S. Chapuy-Regaud, K. Sandres-Saune, C. Pasquier, J. Izopet, New natural intergenotypic (2\/5) recombinant of hepatitis C virus. J. Virol. 81, 4357\u20134362 (2007)","journal-title":"J. Virol."},{"key":"1010_CR36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1128\/CMR.13.2.223-235.2000","volume":"13","author":"NN Zein","year":"2000","unstructured":"N.N. Zein, Clinical significance of hepatitis C virus genotypes. Clin. Microbiol. Rev. 13, 223\u2013235 (2000)","journal-title":"Clin. Microbiol. Rev."}],"container-title":["Virus Genes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11262-013-1010-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11262-013-1010-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11262-013-1010-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T08:13:37Z","timestamp":1559376817000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11262-013-1010-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,23]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["1010"],"URL":"https:\/\/doi.org\/10.1007\/s11262-013-1010-3","relation":{},"ISSN":["0920-8569","1572-994X"],"issn-type":[{"value":"0920-8569","type":"print"},{"value":"1572-994X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,23]]}}}